91296-87-6,MFCD24539194
Catalog No.:AA00IGI5

91296-87-6 | Sarafloxacin hydrochloride

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1g
95%
in stock  
$32.00   $23.00
- +
5g
98%
in stock  
$70.00   $49.00
- +
25g
98%
in stock  
$250.00   $175.00
- +
100g
98%
in stock  
$869.00 $608.00
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00IGI5
Chemical Name:
Sarafloxacin hydrochloride
CAS Number:
91296-87-6
Molecular Formula:
C20H18ClF2N3O3
Molecular Weight:
421.8250
MDL Number:
MFCD24539194
SMILES:
Fc1ccc(cc1)n1cc(C(=O)O)c(=O)c2c1cc(N1CCNCC1)c(c2)F.Cl
NSC Number:
758956
Properties
Computed Properties
 
Complexity:
645  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  

Synonyms
 
  
Downstream Synthesis Route
6156-78-1    91296-87-6   
Mn(sarafloxacinato)2*2.5H2O 

[1]InorganicaChimicaActa,2012,vol.385,p.170-177

5743-04-4    787-70-2    91296-87-6   
Cd2(sarafloxacin)2(4,4'-biphenyldicarboxylato)2*4.5H2O 

[1]InorganicaChimicaActa,2012,vol.385,p.170-177

5743-04-4    91296-87-6   
(cadmium(II))2(dichloride)(sarafloxacinate)2pentahydrate 

[1]EuropeanJournalofInorganicChemistry,2012,p.1783-1789

[1]Patent:CN104892507,2018,B.Locationinpatent:Page/Pagecolumn4;5;6

[1]CurrentPatentAssignee:SHENYANGPHARMACEUTICALUNIVERSITY-CN113527288,2021,ALocationinpatent:Paragraph0086-0088;0179

Literature

Title: A new mathematical approach for the estimation of the AUC and its variability under different experimental designs in preclinical studies.

Journal: Pharmaceutical statistics 20120101

Title: Persistence of the fluoroquinolone antibiotic difloxacin in soil and lacking effects on nitrogen turnover.

Journal: Journal of environmental quality 20120101

Title: Comparison of different sample treatments for the analysis of quinolones in milk by capillary-liquid chromatography with laser induced fluorescence detection.

Journal: Journal of chromatography. A 20110729

Title: Tobacco-associated pulmonary vascular dysfunction in smokers: role of the ET-1 pathway.

Journal: American journal of physiology. Lung cellular and molecular physiology 20110601

Title: Bufferized solvent extraction and HPLC fluorometric detection method for sarafloxacin in pig and chicken muscles.

Journal: Biomedical chromatography : BMC 20110301

Title: Effects of fluoroquinolones on CYP4501A and 3A in male broilers.

Journal: Research in veterinary science 20110201

Title: Plasma disposition and tissue depletion of difloxacin and its metabolite sarafloxacin in the food producing animals, chickens for fattening.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110201

Title: Determination of ciprofloxacin in human plasma using high-performance liquid chromatography coupled with fluorescence detection: application to a population pharmacokinetics study in children with severe malnutrition.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110115

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Simultaneous determination of quinolones for veterinary use by high-performance liquid chromatography with electrochemical detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100201

Title: In vitro residual anti-bacterial activity of difloxacin, sarafloxacin and their photoproducts after photolysis in water.

Journal: Environmental pollution (Barking, Essex : 1987) 20091001

Title: Photolysis of difloxacin and sarafloxacin in aqueous systems.

Journal: Chemosphere 20091001

Title: Quantification of danofloxacin and difloxacin in chicken tissues in the presence of sarafloxacin as interference.

Journal: Journal of agricultural and food chemistry 20090909

Title: Quantitation and identity confirmation of residues of quinolones in tilapia fillets by LC-ESI-MS-MS QToF.

Journal: Analytical and bioanalytical chemistry 20090801

Title: Metabolism and excretion kinetics of 14C-labeled and non-labeled difloxacin in pigs after oral administration, and antimicrobial activity of manure containing difloxacin and its metabolites.

Journal: Environmental research 20090401

Title: Primary photoprocesses in a fluoroquinolone antibiotic sarafloxacin.

Journal: Photochemistry and photobiology 20090101

Title: Development and validation of a solid-phase extraction method coupled to liquid chromatography with fluorescence detection for the determination of fluoroquinolone residues in powdered infant formulae. Application to the analysis of samples from the Spanish and Latin American market.

Journal: Journal of chromatography. A 20081031

Title: Endotoxemic pulmonary hypertension is largely mediated by endothelin-induced venous constriction.

Journal: Intensive care medicine 20080501

Title: [Determination of 16 quinolone residues in animal tissues using high performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry].

Journal: Se pu = Chinese journal of chromatography 20070701

Title: Simultaneous multiresidue determination of tetracyclines and fluoroquinolones in catfish muscle using high performance liquid chromatography with fluorescence detection.

Journal: Analytica chimica acta 20070314

Title: Development of a new sample pretreatment procedure based on pressurized liquid extraction for the determination of fluoroquinolone residues in table eggs.

Journal: Journal of chromatography. A 20070126

Title: Vibrational spectroscopic characterization of fluoroquinolones.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20050501

Title: [Simultaneous determination of four fluoroquinolone residues in edible chicken tissues by reversed-phase high performance liquid chromatography].

Journal: Se pu = Chinese journal of chromatography 20050501

Title: Kinetic modelling of the intestinal transport of sarafloxacin. Studies in situ in rat and in vitro in Caco-2 cells.

Journal: Journal of drug targeting 20050401

Title: Multiresidue determination of fluoroquinolones in shrimp by liquid chromatography-fluorescence-mass spectrometry.

Journal: Journal of AOAC International 20050101

Title: Multiresidue method for simultaneous determination of ten quinolone antibacterial residues in multimatrix/multispecies animal tissues by liquid chromatography with fluorescence detection: single laboratory validation study.

Journal: Journal of AOAC International 20050101

Title: Multiresidue determination of eleven quinolones in milk by liquid chromatography with fluorescence detection.

Journal: Journal of AOAC International 20050101

Title: [Simultaneous determination of quinolones in foods by LC/MS/MS].

Journal: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20041001

Title: Heat-induced formulation inhomogeneity of a three-component suspension.

Journal: Drug development and industrial pharmacy 20040801

Title: High-performance liquid chromatographic method with fluorescence detection for the screening and quantification of oxolinic acid, flumequine and sarafloxacin in fish.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021125

Title: Liquid chromatographic determination of fluoroquinolones in egg albumen and egg yolk of laying hens using fluorometric detection.

Journal: Journal of agricultural and food chemistry 20020731

Title: Efficacy of sarafloxacin in broilers after experimental infection with Escherichia coli.

Journal: Veterinary research communications 20020601

Title: Determination of difloxacin and sarafloxacin in chicken muscle using solid-phase extraction and capillary electrophoresis.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020215

Title: Development of a topical suspension containing three active ingredients.

Journal: Drug development and industrial pharmacy 20020101

Title: Pharmacokinetics of sarafloxacin in pigs and broilers following intravenous, intramuscular, and oral single-dose applications.

Journal: Journal of veterinary pharmacology and therapeutics 20011001

Title: Determination of fluoroquinolones in serum using an on-line clean-up column coupled to high-performance immunoaffinity-reversed-phase liquid chromatography.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20010415

Title: Metabolism of the veterinary fluoroquinolone sarafloxacin by the fungus Mucor ramannianus.

Journal: Journal of industrial microbiology & biotechnology 20010301

Title: In vitro susceptibility of avian mycoplasmas to enrofloxacin, sarafloxacin, tylosin, and oxytetracycline.

Journal: Avian diseases 20010101

Title: FDA withdraws approval of two poultry drugs.

Journal: FDA consumer 20010101

Title: In-vitro activity of six fluorinated quinolones against Mycobacterium tuberculosis.

Journal: The Journal of antimicrobial chemotherapy 19870501

Title: Marengo, J.R., et al., Aerobic biodegradation of (14C)-sarafloxacin hydrochloride in soil. Environmental Toxicology and Chemistry, 1997. 16(3): p. 462-471.

Title: McConville, M.L., et al., Effects of sarafloxacin hydrochloride on human enteric bacteria under simulated human gut conditions. Vet Q, 1995. 17(1): p. 1-5.

Title: Johnson, M.R., K.L. Smith, and C.R. Boyle, Field efficacy trials of the antibacterial sarafloxacin-hydrochloride (A-56620) for treatment of Edwardsiella ictaluri infections in channel catfish. Journal of aquatic animal health, 1992. 4(4): p. 244-251.

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SDS
Tags:91296-87-6 Molecular Formula|91296-87-6 MDL|91296-87-6 SMILES|91296-87-6 Sarafloxacin hydrochloride
Catalog No.: AA00IGI5
91296-87-6,MFCD24539194
91296-87-6 | Sarafloxacin hydrochloride
Pack Size: 1g
Purity: 95%
in stock
$32.00 $23.00
Pack Size: 5g
Purity: 98%
in stock
$70.00 $49.00
Pack Size: 25g
Purity: 98%
in stock
$250.00 $175.00
Pack Size: 100g
Purity: 98%
in stock
$869.00 $608.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00IGI5
Chemical Name: Sarafloxacin hydrochloride
CAS Number: 91296-87-6
Molecular Formula: C20H18ClF2N3O3
Molecular Weight: 421.8250
MDL Number: MFCD24539194
SMILES: Fc1ccc(cc1)n1cc(C(=O)O)c(=O)c2c1cc(N1CCNCC1)c(c2)F.Cl
NSC Number: 758956
Properties
Complexity: 645  
Covalently-Bonded Unit Count: 2  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 29  
Hydrogen Bond Acceptor Count: 8  
Hydrogen Bond Donor Count: 3  
Isotope Atom Count: 0  
Rotatable Bond Count: 3  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
84:   
Downstream Synthesis Route
6156-78-1    91296-87-6   
Mn(sarafloxacinato)2*2.5H2O 

[1]InorganicaChimicaActa,2012,vol.385,p.170-177

5743-04-4    787-70-2    91296-87-6   
Cd2(sarafloxacin)2(4,4'-biphenyldicarboxylato)2*4.5H2O 

[1]InorganicaChimicaActa,2012,vol.385,p.170-177

5743-04-4    91296-87-6   
(cadmium(II))2(dichloride)(sarafloxacinate)2pentahydrate 

[1]EuropeanJournalofInorganicChemistry,2012,p.1783-1789

91296-87-6    98105-99-8 

[1]Patent:CN104892507,2018,B.Locationinpatent:Page/Pagecolumn4;5;6

2731734-21-5    91296-87-6 

[1]CurrentPatentAssignee:SHENYANGPHARMACEUTICALUNIVERSITY-CN113527288,2021,ALocationinpatent:Paragraph0086-0088;0179

Literature fold

Title: A new mathematical approach for the estimation of the AUC and its variability under different experimental designs in preclinical studies.

Journal: Pharmaceutical statistics20120101

Title: Persistence of the fluoroquinolone antibiotic difloxacin in soil and lacking effects on nitrogen turnover.

Journal: Journal of environmental quality20120101

Title: Comparison of different sample treatments for the analysis of quinolones in milk by capillary-liquid chromatography with laser induced fluorescence detection.

Journal: Journal of chromatography. A20110729

Title: Tobacco-associated pulmonary vascular dysfunction in smokers: role of the ET-1 pathway.

Journal: American journal of physiology. Lung cellular and molecular physiology20110601

Title: Bufferized solvent extraction and HPLC fluorometric detection method for sarafloxacin in pig and chicken muscles.

Journal: Biomedical chromatography : BMC20110301

Title: Effects of fluoroquinolones on CYP4501A and 3A in male broilers.

Journal: Research in veterinary science20110201

Title: Plasma disposition and tissue depletion of difloxacin and its metabolite sarafloxacin in the food producing animals, chickens for fattening.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association20110201

Title: Determination of ciprofloxacin in human plasma using high-performance liquid chromatography coupled with fluorescence detection: application to a population pharmacokinetics study in children with severe malnutrition.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20110115

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: Simultaneous determination of quinolones for veterinary use by high-performance liquid chromatography with electrochemical detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20100201

Title: In vitro residual anti-bacterial activity of difloxacin, sarafloxacin and their photoproducts after photolysis in water.

Journal: Environmental pollution (Barking, Essex : 1987)20091001

Title: Photolysis of difloxacin and sarafloxacin in aqueous systems.

Journal: Chemosphere20091001

Title: Quantification of danofloxacin and difloxacin in chicken tissues in the presence of sarafloxacin as interference.

Journal: Journal of agricultural and food chemistry20090909

Title: Quantitation and identity confirmation of residues of quinolones in tilapia fillets by LC-ESI-MS-MS QToF.

Journal: Analytical and bioanalytical chemistry20090801

Title: Metabolism and excretion kinetics of 14C-labeled and non-labeled difloxacin in pigs after oral administration, and antimicrobial activity of manure containing difloxacin and its metabolites.

Journal: Environmental research20090401

Title: Primary photoprocesses in a fluoroquinolone antibiotic sarafloxacin.

Journal: Photochemistry and photobiology20090101

Title: Development and validation of a solid-phase extraction method coupled to liquid chromatography with fluorescence detection for the determination of fluoroquinolone residues in powdered infant formulae. Application to the analysis of samples from the Spanish and Latin American market.

Journal: Journal of chromatography. A20081031

Title: Endotoxemic pulmonary hypertension is largely mediated by endothelin-induced venous constriction.

Journal: Intensive care medicine20080501

Title: [Determination of 16 quinolone residues in animal tissues using high performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry].

Journal: Se pu = Chinese journal of chromatography20070701

Title: Simultaneous multiresidue determination of tetracyclines and fluoroquinolones in catfish muscle using high performance liquid chromatography with fluorescence detection.

Journal: Analytica chimica acta20070314

Title: Development of a new sample pretreatment procedure based on pressurized liquid extraction for the determination of fluoroquinolone residues in table eggs.

Journal: Journal of chromatography. A20070126

Title: Vibrational spectroscopic characterization of fluoroquinolones.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy20050501

Title: [Simultaneous determination of four fluoroquinolone residues in edible chicken tissues by reversed-phase high performance liquid chromatography].

Journal: Se pu = Chinese journal of chromatography20050501

Title: Kinetic modelling of the intestinal transport of sarafloxacin. Studies in situ in rat and in vitro in Caco-2 cells.

Journal: Journal of drug targeting20050401

Title: Multiresidue determination of fluoroquinolones in shrimp by liquid chromatography-fluorescence-mass spectrometry.

Journal: Journal of AOAC International20050101

Title: Multiresidue method for simultaneous determination of ten quinolone antibacterial residues in multimatrix/multispecies animal tissues by liquid chromatography with fluorescence detection: single laboratory validation study.

Journal: Journal of AOAC International20050101

Title: Multiresidue determination of eleven quinolones in milk by liquid chromatography with fluorescence detection.

Journal: Journal of AOAC International20050101

Title: [Simultaneous determination of quinolones in foods by LC/MS/MS].

Journal: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan20041001

Title: Heat-induced formulation inhomogeneity of a three-component suspension.

Journal: Drug development and industrial pharmacy20040801

Title: High-performance liquid chromatographic method with fluorescence detection for the screening and quantification of oxolinic acid, flumequine and sarafloxacin in fish.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20021125

Title: Liquid chromatographic determination of fluoroquinolones in egg albumen and egg yolk of laying hens using fluorometric detection.

Journal: Journal of agricultural and food chemistry20020731

Title: Efficacy of sarafloxacin in broilers after experimental infection with Escherichia coli.

Journal: Veterinary research communications20020601

Title: Determination of difloxacin and sarafloxacin in chicken muscle using solid-phase extraction and capillary electrophoresis.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20020215

Title: Development of a topical suspension containing three active ingredients.

Journal: Drug development and industrial pharmacy20020101

Title: Pharmacokinetics of sarafloxacin in pigs and broilers following intravenous, intramuscular, and oral single-dose applications.

Journal: Journal of veterinary pharmacology and therapeutics20011001

Title: Determination of fluoroquinolones in serum using an on-line clean-up column coupled to high-performance immunoaffinity-reversed-phase liquid chromatography.

Journal: Journal of chromatography. B, Biomedical sciences and applications20010415

Title: Metabolism of the veterinary fluoroquinolone sarafloxacin by the fungus Mucor ramannianus.

Journal: Journal of industrial microbiology & biotechnology20010301

Title: In vitro susceptibility of avian mycoplasmas to enrofloxacin, sarafloxacin, tylosin, and oxytetracycline.

Journal: Avian diseases20010101

Title: FDA withdraws approval of two poultry drugs.

Journal: FDA consumer20010101

Title: In-vitro activity of six fluorinated quinolones against Mycobacterium tuberculosis.

Journal: The Journal of antimicrobial chemotherapy19870501

Title: Marengo, J.R., et al., Aerobic biodegradation of (14C)-sarafloxacin hydrochloride in soil. Environmental Toxicology and Chemistry, 1997. 16(3): p. 462-471.

Title: McConville, M.L., et al., Effects of sarafloxacin hydrochloride on human enteric bacteria under simulated human gut conditions. Vet Q, 1995. 17(1): p. 1-5.

Title: Johnson, M.R., K.L. Smith, and C.R. Boyle, Field efficacy trials of the antibacterial sarafloxacin-hydrochloride (A-56620) for treatment of Edwardsiella ictaluri infections in channel catfish. Journal of aquatic animal health, 1992. 4(4): p. 244-251.

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