Home Quinolines 91300-60-6
91300-60-6,MFCD00210756
Catalog No.:AA006ORR

91300-60-6 | 6-Anilino-5,8-quinolinedione

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1mg
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5mg
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$93.00   $65.00
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10mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA006ORR
Chemical Name:
6-Anilino-5,8-quinolinedione
CAS Number:
91300-60-6
Molecular Formula:
C15H10N2O2
Molecular Weight:
250.2521
MDL Number:
MFCD00210756
SMILES:
O=C1C=C(Nc2ccccc2)C(=O)c2c1nccc2
Properties
Computed Properties
 
Complexity:
410  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
2.5  

Literature

Title: Mechanisms of carbon monoxide attenuation of tubuloglomerular feedback.

Journal: Hypertension (Dallas, Tex. : 1979) 20120601

Title: Brain-derived neurotrophic factor increases expression of MnSOD in human circulating angiogenic cells.

Journal: Microvascular research 20120501

Title: Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity.

Journal: PLoS biology 20120301

Title: Multiple pathways from three types of sugar receptor sites to metabotropic transduction pathways of the blowfly: study by the whole cell-clamp experiments.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20110901

Title: Identification of LY83583 as a specific inhibitor of Candida albicans MPS1 protein kinase.

Journal: Biochemical and biophysical research communications 20110610

Title: Heme oxygenase metabolites inhibit tubuloglomerular feedback in vivo.

Journal: American journal of physiology. Heart and circulatory physiology 20110401

Title: Superoxide differentially controls pulmonary and systemic vascular tone through multiple signalling pathways.

Journal: Cardiovascular research 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Effect of dendroaspis natriuretic peptide (DNP) on L-type calcium channel current and its pathway.

Journal: Regulatory peptides 20100924

Title: cGMP is required for seed germination in Arabidopsis thaliana.

Journal: Journal of plant physiology 20100715

Title: A soluble guanylate cyclase mediates negative signaling by ammonium on expression of nitrate reductase in Chlamydomonas.

Journal: The Plant cell 20100501

Title: CNGA2 contributes to ATP-induced noncapacitative Ca2+ influx in vascular endothelial cells.

Journal: Journal of vascular research 20100101

Title: Effects of Dendroaspis natriuretic peptide on delayed rectifier potassium currents and its mechanism.

Journal: Regulatory peptides 20090605

Title: The role of telencephalic NO and cGMP in avoidance conditioning in goldfish (Carassius auratus).

Journal: Behavioral neuroscience 20090601

Title: Highly specific responses to amine odorants of individual olfactory receptor neurons in situ.

Journal: The European journal of neuroscience 20090601

Title: Cyclic guanosine monophosphate signaling cascade mediates pigment aggregation in freshwater shrimp chromatophores.

Journal: The Biological bulletin 20090401

Title: Modification of the cardiovascular response of posterior hypothalamic adenosine A(2A) receptor stimulation by adenylate cyclase and KATP channel blockade in anesthetized rats.

Journal: Autonomic neuroscience : basic & clinical 20090312

Title: On the requirement of nitric oxide signaling in the amygdala for consolidation of inhibitory avoidance memory.

Journal: Neurobiology of learning and memory 20090301

Title: Superoxide constricts rat pulmonary arteries via Rho-kinase-mediated Ca(2+) sensitization.

Journal: Free radical biology & medicine 20090301

Title: Calmodulin and guanylyl cyclase inhibitors block the in vivo expression of gLTP in sympathetic ganglia from chronically stressed rats.

Journal: Neuroscience research 20090201

Title: Involvement of NO and KATP channel in adenosine A2B receptors induced cardiovascular regulation in the posterior hypothalamus of rats.

Journal: Journal of cardiovascular pharmacology 20090201

Title: ATP and NO dually control migration of microglia to nerve lesions.

Journal: Developmental neurobiology 20090101

Title: Cathepsin G, a neutrophil protease, induces compact cell-cell adhesion in MCF-7 human breast cancer cells.

Journal: Mediators of inflammation 20090101

Title: Investigation of a possible interaction between the heme oxygenase/biliverdin reductase and nitric oxide synthase pathway in murine gastric fundus and jejunum.

Journal: European journal of pharmacology 20080820

Title: Superoxide-mediated proteasomal degradation of Bcl-2 determines cell susceptibility to Cr(VI)-induced apoptosis.

Journal: Carcinogenesis 20080801

Title: A pulsing electric field (PEF) increases human chondrocyte proliferation through a transduction pathway involving nitric oxide signaling.

Journal: Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20080601

Title: The effect of guanylate cyclase inhibitors on non-adrenergic and non-cholinergic neurogenic relaxations of the South American opossum lower esophageal sphincter.

Journal: Fundamental & clinical pharmacology 20080601

Title: Downregulation of human colon carcinoma cell (COLO-205) proliferation through PKG-MAP kinase mediated signaling cascade by E. coli heat stable enterotoxin (STa), a potent anti-angiogenic and anti-metastatic molecule.

Journal: Journal of applied toxicology : JAT 20080501

Title: CNGA2 channels mediate adenosine-induced Ca2+ influx in vascular endothelial cells.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20080501

Title: Atrial natriuretic peptide attenuates high glucose-activated transforming growth factor-beta, Smad and collagen synthesis in renal proximal tubular cells.

Journal: Journal of cellular biochemistry 20080415

Title: Lysozyme, a mediator of sepsis that produces vasodilation by hydrogen peroxide signaling in an arterial preparation.

Journal: American journal of physiology. Heart and circulatory physiology 20080401

Title: Effects of dendroaspis natriuretic peptide on calcium-activated potassium current and its mechanism.

Journal: The journal of physiological sciences : JPS 20080201

Title: Hypoxic preconditioning increases survival and angiogenic potency of peripheral blood mononuclear cells via oxidative stress resistance.

Journal: American journal of physiology. Heart and circulatory physiology 20080201

Title: Guanylyl cyclase and protein kinase G mediate nitric oxide suppression of 5-lipoxygenase metabolism in rat alveolar macrophages.

Journal: Biochimica et biophysica acta 20080101

Title: Modulation of p21-activated kinase 1 alters the behavior of renal cell carcinoma.

Journal: International journal of cancer 20071101

Title: Muscarinic activity modulated by C-type natriuretic peptide in gastric smooth muscles of guinea-pig stomach.

Journal: Regulatory peptides 20071004

Title: Involvement of guanylate cyclase in the cardiovascular response induced by adenosine A2B receptor stimulation in the posterior hypothalamus of the anesthetized rats.

Journal: Autonomic neuroscience : basic & clinical 20070731

Title: Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

Journal: Nature chemical biology 20070601

Title: Nitric oxide and cGMP signaling in calcium-dependent development of cell polarity in Ceratopteris richardii.

Journal: Plant physiology 20070501

Title: Ginsenoside Re promotes human sperm capacitation through nitric oxide-dependent pathway.

Journal: Molecular reproduction and development 20070401

Title: Nitric oxide regulates cell survival in purified cultures of avian retinal neurons: involvement of multiple transduction pathways.

Journal: Journal of neurochemistry 20070101

Title: Apoptosis induced by prolonged exposure to odorants in cultured cells from rat olfactory epithelium.

Journal: Brain research 20060804

Title: Induction of apoptosis in renal cell carcinoma by reactive oxygen species: involvement of extracellular signal-regulated kinase 1/2, p38delta/gamma, cyclooxygenase-2 down-regulation, and translocation of apoptosis-inducing factor.

Journal: Molecular pharmacology 20060601

Title: The cGMP/protein kinase G pathway contributes to dihydropyridine-sensitive calcium response and cytokine production in TH2 lymphocytes.

Journal: The Journal of biological chemistry 20060505

Title: Soluble guanylyl cyclase inhibitor prevents Sema3F-induced collapse of axonal and dendritic growth cones of dentate granule cells.

Journal: Biological & pharmaceutical bulletin 20060401

Title: Cyclophilin A is secreted by a vesicular pathway in vascular smooth muscle cells.

Journal: Circulation research 20060331

Title: Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway.

Journal: Nature chemical biology 20060201

Title: Synthetic smooth muscle cell phenotype is associated with increased nicotinamide adenine dinucleotide phosphate oxidase activity: effect on collagen secretion.

Journal: Journal of vascular surgery 20060201

Title: Nitric-oxide-dependent activation of pig oocytes: the role of the cGMP-signalling pathway.

Journal: Zygote (Cambridge, England) 20060201

Title: Calcium and calcium-dependent protein kinases are involved in nitric oxide- and auxin-induced adventitious root formation in cucumber.

Journal: Journal of experimental botany 20060101

Title: Insulin-stimulated NAD(P)H oxidase activity increases migration of cultured vascular smooth muscle cells.

Journal: American journal of hypertension 20051001

Title: Cyclic AMP cascade mediates the inhibitory odor response of isolated toad olfactory receptor neurons.

Journal: Journal of neurophysiology 20050901

Title: Cyclic nucleotide second messengers (cAMP and cGMP) play a central role in signal transduction and regulation of mesenteric postcapillary fluid leak.

Journal: The Journal of trauma 20050801

Title: The effects of intracerebroventricular application of 8-Br-cGMP and LY-83,583, a guanylyl cyclase inhibitor, on sleep-wake activity in rats.

Journal: Brain research 20050705

Title: p47phox associates with the cytoskeleton through cortactin in human vascular smooth muscle cells: role in NAD(P)H oxidase regulation by angiotensin II.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20050301

Title: eNOS, nNOS, cGMP and protein kinase G mediate the inhibitory effect of pancreastatin, a chromogranin A-derived peptide, on growth and proliferation of hepatoma cells.

Journal: Regulatory peptides 20050215

Title: Endothelin-1 in osteoarthritic chondrocytes triggers nitric oxide production and upregulates collagenase production.

Journal: Arthritis research & therapy 20050101

Title: 17beta-estradiol stimulates ascorbic acid and LHRH release from the medial basal hypothalamus in adult male rats.

Journal: Experimental biology and medicine (Maywood, N.J.) 20041001

Title: A comparison of oxidized LDL-induced collagen secretion by graft and aortic SMCs: role of PDGF.

Journal: American journal of physiology. Heart and circulatory physiology 20040901

Title: Atrial natriuretic peptide modulates the hyperpolarization-activated current (If) in human atrial myocytes.

Journal: Cardiovascular research 20040815

Title: Differential calcium regulation by hydrogen peroxide and superoxide in vascular smooth muscle cells from spontaneously hypertensive rats.

Journal: Journal of cardiovascular pharmacology 20040801

Title: Inhibition of melatonin-induced ascorbic acid and LHRH release by a nitric oxide synthase and cyclic GMP inhibitor.

Journal: Experimental biology and medicine (Maywood, N.J.) 20040701

Title: NMDA receptors in nucleus tractus solitarii are linked to soluble guanylate cyclase.

Journal: American journal of physiology. Heart and circulatory physiology 20040401

Title: Influence of polyethylene-glycol-superoxide dismutase and combined depletion and repletion of antioxidants on nitrergic relaxation in the pig gastric fundus.

Journal: European journal of pharmacology 20040220

Title: Enzymatic and nonenzymatic formation of reactive oxygen species from 6-anilino-5,8-quinolinequinone.

Journal: Biochimica et biophysica acta 20040105

Title: Contribution of cGMP but not peroxynitrite to negative feedback regulation of penile erection elicited by nitric oxide in the hippocampal formation of the rat.

Journal: Neuropharmacology 20040101

Title: Inhibition of stimulated ascorbic acid and luteinizing hormone-releasing hormone release by nitric oxide synthase or guanyl cyclase inhibitors.

Journal: Experimental biology and medicine (Maywood, N.J.) 20040101

Title: The NO-cGMP-PKG pathway plays an essential role in the acquisition of ethanol resistance by cerebellar granule neurons.

Journal: Neurotoxicology and teratology 20040101

Title: Involvement of a cGMP-dependent pathway in the natriuretic peptide-mediated hormone-sensitive lipase phosphorylation in human adipocytes.

Journal: The Journal of biological chemistry 20031205

Title: Influence of drugs acting on nitric oxide-dependent pathways on ethanol tolerance in rats.

Journal: Psychopharmacology 20031201

Title: Diethyldithiocarbamate inhibits the catalytic activity of xanthine oxidase.

Journal: FEBS letters 20030911

Title: Constitutive and permissive roles of nitric oxide activity in embryonic ciliary cells.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20030801

Title: NO/cyclic GMP pathway mediates the relaxation of feline lower oesophageal sphincter.

Journal: Autonomic & autacoid pharmacology 20030601

Title: Mechanism underlying enhanced endothelium-dependent vasodilatation in thoracic aorta of early stage streptozotocin-induced diabetic mice.

Journal: Acta pharmacologica Sinica 20030501

Title: FGF-2, NGF and IGF-1, but not BDNF, utilize a nitric oxide pathway to signal neurotrophic and neuroprotective effects against alcohol toxicity in cerebellar granule cell cultures.

Journal: Brain research. Developmental brain research 20030110

Title: Nitric oxide inhibits spleen cell proliferative response after burn injury by inducing cytostasis, apoptosis, and necrosis of activated T lymphocytes: role of the guanylate cyclase.

Journal: Cellular immunology 20030101

Title: Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner.

Journal: The Journal of clinical investigation 20021201

Title: The involvement of nitric oxide on the adenosine A(2) receptor-induced cardiovascular inhibitory responses in the posterior hypothalamus of rats.

Journal: Neuroscience letters 20020621

Title: Inhibition of guanylate cyclase and protein kinase G impairs retention for the passive avoidance task in the day-old chick.

Journal: Neurobiology of learning and memory 20020501

Title: Nitric oxide and cGMP modulation of extraocular muscle contraction.

Journal: Annals of the New York Academy of Sciences 20020401

Title: Mechanism of inhibition of endothelin-1-stimulated proteoglycan and collagen synthesis in rat articular chondrocytes.

Journal: Cytokine 20020307

Title: Effects of nitric oxide donors and inhibitors of nitric oxide signalling on endothelin- and serotonin-induced contractions in human placental arteries.

Journal: Acta physiologica Scandinavica 20020301

Title: Effect of hypercholesterolemia on expression and function of vascular soluble guanylyl cyclase.

Journal: Circulation 20020219

Title: Influence of antioxidant depletion on nitrergic relaxation in the pig gastric fundus.

Journal: British journal of pharmacology 20020201

Title: Light-induced changes in glutamate release from isolated rat retina is regulated by cyclic guanosine monophosphate.

Journal: Journal of neuroscience research 20020115

Title: Nitric oxide and cyclic GMP are involved in angiotensin II AT(2) receptor effects on neurite outgrowth in NG108-15 cells.

Journal: Neuroendocrinology 20020101

Title: Hexokinase translocation during neutrophil activation, chemotaxis, and phagocytosis: disruption by cytochalasin D, dexamethasone, and indomethacin.

Journal: Cellular immunology 20020101

Title: Glutathione depletion switches nitric oxide neurotrophic effects to cell death in midbrain cultures: implications for Parkinson's disease.

Journal: Journal of neurochemistry 20011201

Title: Evaluation of signal transduction pathways mediating the nuclear exclusion of the androgen receptor by melatonin.

Journal: Cellular and molecular life sciences : CMLS 20011201

Title: Nitric oxide signaling pathway regulates potassium chloride cotransporter-1 mRNA expression in vascular smooth muscle cells.

Journal: The Journal of biological chemistry 20011130

Title: Alpha(2)-adrenergic-mediated tubular NO production inhibits thick ascending limb chloride absorption.

Journal: American journal of physiology. Renal physiology 20011001

Title: Mechanism for muscarinic inhibition of I(Ca(L)) is determined by the path for elevating cyclic AMP in cardiac myocytes.

Journal: Cardiovascular research 20010801

Title: Nitric oxide directly activates GABA(A) receptor function through a cGMP/protein kinase-independent pathway in frog pituitary melanotrophs.

Journal: Journal of neuroendocrinology 20010801

Title: Zinc induces apoptosis that can be suppressed by lanthanum in C6 rat glioma cells.

Journal: Biological chemistry 20010801

Title: Endogenous nitric oxide-mediated relaxation and nitrinergic innervation in the rabbit prostate: the changes with aging.

Journal: The Prostate 20010615

Title: Signaling pathway of nitric oxide-induced acrosome reaction in human spermatozoa.

Journal: Biology of reproduction 20010601

Title: Direct inhibitory effect of adrenomedullin, calcitonin gene-related peptide, calcitonin, and amylin on cholecystokinin-induced contraction of guinea-pig isolated caecal circular smooth muscle cells.

Journal: Peptides 20010601

Title: Stimulation of endogenous nitric oxide production is involved in the inhibitory effect of adrenomedullin on aldosterone secretion in the rat.

Journal: Peptides 20010601

Title: Endothelium dependence and gestational regulation of inhibition of vascular tone by magnesium sulfate in rat aorta.

Journal: American journal of obstetrics and gynecology 20010401

Title: Polyamines, NO and cGMP mediate stimulation of DNA synthesis by tumor necrosis factor and lipopolysaccharide in chick embryo cardiomyocytes.

Journal: Cardiovascular research 20010201

Title: NO Inhibits NaCl absorption by rat thick ascending limb through activation of cGMP-stimulated phosphodiesterase.

Journal: Hypertension (Dallas, Tex. : 1979) 20010201

Title: Buffering action of endogenous nitric oxide on the adrenocortical secretagogue effect of endothelins in the rat.

Journal: International journal of molecular medicine 20010101

Title: [cGMP-independent effect of nitric oxide on contractility and intracellular calcium level of rat tail artery vascular smooth muscles].

Journal: Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20010101

Title: Purification and identification of secreted oxidative stress-induced factors from vascular smooth muscle cells.

Journal: The Journal of biological chemistry 20000107

Title: Nitric oxide ameliorates actinomycin D/endotoxin-induced apoptotic liver failure in mice.

Journal: The Journal of surgical research 19990801

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