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914454-01-6,MFCD08704781
Catalog No.:AA00GU5O

914454-01-6 | Exendin-4 (Acetate)

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
99%
in stock  
$200.00   $140.00
- +
5mg
99%
in stock  
$390.00   $273.00
- +
10mg
99%
in stock  
$554.00   $388.00
- +
25mg
99%
in stock  
$766.00   $537.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00GU5O
Chemical Name:
Exendin-4 (Acetate)
CAS Number:
914454-01-6
Molecular Formula:
C76H159N22O6
Molecular Weight:
1477.2195
MDL Number:
MFCD08704781
SMILES:
NCCCC[C@H](NC[C@H](CC(C)C)NC[CH]NC[C@H](CCC(=O)O)NC[C@H]([C@H](CC)C)NC[CH]NC[C@H](CC(C)C)NC[CH])CN[C@@H](CC(=O)N)CNCCNCCN1CCC[C@H]1CN[C@H](CN[C@H](CNCCN[CH]CN1CCC[C@H]1CN1CCC[C@H]1CN1CCC[C@H]1CN[C@@H](CO)CN)CO)CO
Properties
Computed Properties
 
Complexity:
2060  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
14  
Heavy Atom Count:
104  
Hydrogen Bond Acceptor Count:
27  
Hydrogen Bond Donor Count:
22  
Rotatable Bond Count:
71  
XLogP3:
-4.3  

Literature

Title: Doyle ME, et al. The importance of the nine-amino acid C-terminal sequence of exendin-4 for binding to the GLP-1 receptor and for biological activity. Regul Pept. 2003 Jul 15;114(2-3):153-8.

Title: Wei R, et al. Exenatide exerts direct protective effects on endothelial cells through the AMPK/Akt/eNOS pathway in a GLP-1 receptor-dependent manner. Am J Physiol Endocrinol Metab. 2016 Jun 1;310(11):E947-57.

Title: Fidan-YaylalI G, et al. Antidiabetic exendin-4 activates apoptotic pathway and inhibits growth of breast cancer cells. Tumour Biol. 2016 Feb;37(2):2647-53.

Title: Ding X, et al. Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/obmice. Hepatology. 2006 Jan;43(1):173-81.

Title: Nachnani JS, et al. Biochemical and histological effects of exendin-4 (exenatide) on the rat pancreas. Diabetologia. 2010 Jan;53(1):153-9.

Title: Sélley E, et al. Exenatide induces aortic vasodilation increasing hydrogen sulphide, carbon monoxide and nitric oxide production. Cardiovasc Diabetol. 2014 Apr 2;13:69.

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Tags:914454-01-6 Molecular Formula|914454-01-6 MDL|914454-01-6 SMILES|914454-01-6 Exendin-4 (Acetate)