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916151-99-0,MFCD25976826
Catalog No.:AA00GU17

916151-99-0 | Apto-253

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$36.00   $25.00
- +
5mg
98%
in stock  
$90.00   $63.00
- +
10mg
98%
in stock  
$134.00   $94.00
- +
25mg
98%
in stock  
$212.00   $149.00
- +
50mg
98%
in stock  
$355.00   $249.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00GU17
Chemical Name:
Apto-253
CAS Number:
916151-99-0
Molecular Formula:
C22H14FN5
Molecular Weight:
367.3785
MDL Number:
MFCD25976826
SMILES:
Fc1ccc2c(c1)c(c([nH]2)C)c1nc2c([nH]1)c1cccnc1c1c2cccn1
Properties
Computed Properties
 
Complexity:
589  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
4.3  

Downstream Synthesis Route

[1]CurrentPatentAssignee:APTOSEBIOSCIENCESINC.-US2010/168417,2010,A1Locationinpatent:Page/Pagecolumn31

916151-99-0   
iron(II)sulfate 
 
C66H42F3FeN15(2+)*O4S(2-) 

[1]Tsai,Cheng-Yu;Sun,Si;Zhang,Hongying;Local,Andrea;Su,Yongxuan;Gross,LarryA.;Rice,WilliamG.;Howell,StephenB.[MolecularCancerTherapeutics,2018,vol.17,#6,p.1167-1176]

Literature

Title: Local A, et al. APTO-253 Stabilizes G-quadruplex DNA, Inhibits MYC Expression, and Induces DNA Damage in Acute Myeloid Leukemia Cells. Mol Cancer Ther. 2018 Jun;17(6):1177-1186.

Title: Hongying Zhang, et al. Inhibition of c-Myc By Apto-253 As an Innovative Therapeutic Approach to Induce Cell Cycle Arrest and Apoptosis in Acute Myeloid Leukemia. Blood 2016 128:1716.

Title: Haruka Tsuchiya, et al. Parsing multiomics landscape of activated synovial fibroblasts highlights drug targets linked to genetic risk of rheumatoid arthritis. Ann Rheum Dis. 2020 Nov2;annrheumdis-2020-218189.

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SDS
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