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917389-32-3,MFCD22572725
Catalog No.:AA00GT9F

917389-32-3 | Letermovir

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$19.00   $14.00
- +
5mg
98%
in stock  
$44.00   $31.00
- +
50mg
98%
in stock  
$167.00   $117.00
- +
100mg
98%
in stock  
$265.00   $185.00
- +
250mg
98%
in stock  
$424.00   $297.00
- +
1g
95%
in stock  
$1,319.00   $923.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00GT9F
Chemical Name:
Letermovir
CAS Number:
917389-32-3
Molecular Formula:
C29H28F4N4O4
Molecular Weight:
572.5506
MDL Number:
MFCD22572725
SMILES:
COc1cccc(c1)N1CCN(CC1)C1=Nc2c(F)cccc2[C@@H](N1c1cc(ccc1OC)C(F)(F)F)CC(=O)O
Properties
Computed Properties
 
Complexity:
931  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
41  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
7  
XLogP3:
4.6  

Downstream Synthesis Route

[1]CurrentPatentAssignee:AICURISGMBH&CO.KG-WO2014/202737,2014,A1Locationinpatent:Page/Pagecolumn53

[2]CurrentPatentAssignee:AICURISGMBH&CO.KG-US2015/45371,2015,A1Locationinpatent:Paragraph0134-0139

[3]CurrentPatentAssignee:AICURISGMBH&CO.KG-US2015/133461,2015,A1Locationinpatent:Paragraph0142;0143

[4]CurrentPatentAssignee:AICURISGMBH&CO.KG-WO2015/88931,2015,A1Locationinpatent:Page/Pagecolumn21-22

[5]CurrentPatentAssignee:AICURISGMBH&CO.KG-WO2006/133822,2006,A1Locationinpatent:Page/Pagecolumn3;30;31-32;36-37

[1]CurrentPatentAssignee:AICURISGMBH&CO.KG-WO2006/133822,2006,A1Locationinpatent:Page/Pagecolumn38

[1]CurrentPatentAssignee:AICURISGMBH&CO.KG-WO2006/133822,2006,A1Locationinpatent:Page/Pagecolumn37

C19H16F4N2O4 
  917389-32-3 

[1]CurrentPatentAssignee:AICURISGMBH&CO.KG-WO2014/202737,2014,A1

[2]CurrentPatentAssignee:AICURISGMBH&CO.KG-WO2015/88931,2015,A1

[1]CurrentPatentAssignee:AICURISGMBH&CO.KG-WO2014/202737,2014,A1

[2]CurrentPatentAssignee:AICURISGMBH&CO.KG-US2015/38514,2015,A1

[3]CurrentPatentAssignee:AICURISGMBH&CO.KG-US2015/45371,2015,A1

[4]CurrentPatentAssignee:AICURISGMBH&CO.KG-US2015/133461,2015,A1

[5]CurrentPatentAssignee:AICURISGMBH&CO.KG-WO2006/133822,2006,A1

[6]CurrentPatentAssignee:AICURISGMBH&CO.KG-WO2006/133822,2006,A1

Literature

Title: In vitro evaluation of the activities of the novel anticytomegalovirus compound AIC246 (letermovir) against herpesviruses and other human pathogenic viruses.

Journal: Antimicrobial agents and chemotherapy 20120201

Title: In vitro and in vivo activities of the novel anticytomegalovirus compound AIC246.

Journal: Antimicrobial agents and chemotherapy 20100301

Title: Marschall M, et al. In vitro evaluation of the activities of the novel anticytomegalovirus compound AIC246 (letermovir) against herpesviruses and other human pathogenic viruses. Antimicrob Agents Chemother. 2012 Feb;56(2):1135-7.

Title: Goldner T, et al. The novel anticytomegalovirus compound AIC246 (Letermovir) inhibits human cytomegalovirus replication through a specific antiviral mechanism that involves the viral terminase. J Virol. 2011 Oct;85(20):10884-93.

Title: Lischka P, et al. In vitro and in vivo activities of the novel anticytomegalovirus compound AIC246. Antimicrob Agents Chemother. 2010 Mar;54(3):1290-7.

Title: Wildum S, et al. In vitro drug combination studies of Letermovir (AIC246, MK-8228) with approved anti-human cytomegalovirus (HCMV) and anti-HIV compounds in inhibition of HCMV and HIV replication. Antimicrob Agents Chemother. 2015;59(6):3140-8.

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