Home Other Building Blocks 918311-87-2
918311-87-2,MFCD00585879
Catalog No.:AA006GD9

918311-87-2 | UCL 2077

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
96%
in stock  
$216.00   $152.00
- +
10mg
96%
in stock  
$300.00   $210.00
- +
25mg
96%
in stock  
$604.00   $423.00
- +
50mg
96%
in stock  
$1,025.00   $718.00
- +
100mg
96%
in stock  
$1,799.00   $1,259.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA006GD9
Chemical Name:
UCL 2077
CAS Number:
918311-87-2
Molecular Formula:
C25H22N2
Molecular Weight:
350.4556
MDL Number:
MFCD00585879
SMILES:
c1ccc(cc1)C(c1ccccc1)(c1ccccc1)NCc1cccnc1
Properties
Properties
 
Form:
Solid  
Storage:
2-8℃;  

Computed Properties
 
Complexity:
371  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
5.1  

Literature

Title: Inhibition of the slow afterhyperpolarization restores the classical spike timing-dependent plasticity rule obeyed in layer 2/3 pyramidal cells of the prefrontal cortex.

Journal: Journal of neurophysiology 20120101

Title: A mathematical model of adult GnRH neurons in mouse brain and its bifurcation analysis.

Journal: Journal of theoretical biology 20110507

Title: The specific slow afterhyperpolarization inhibitor UCL2077 is a subtype-selective blocker of the epilepsy associated KCNQ channels.

Journal: Molecular pharmacology 20101201

Title: Two slow calcium-activated afterhyperpolarization currents control burst firing dynamics in gonadotropin-releasing hormone neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100505

Title: Molecular and cellular basis of small--and intermediate-conductance, calcium-activated potassium channel function in the brain.

Journal: Cellular and molecular life sciences : CMLS 20081001

Title: Enhancement of hippocampal pyramidal cell excitability by the novel selective slow-afterhyperpolarization channel blocker 3-(triphenylmethylaminomethyl)pyridine (UCL2077).

Journal: Molecular pharmacology 20061101

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Shah MM, et al. Enhancement of hippocampal pyramidal cell excitability by the novel selective slow-afterhyperpolarization channel blocker 3-(triphenylmethylaminomethyl)pyridine (UCL2077). Mol Pharmacol. 2006 Nov;70(5):1494-502.

Title: Soh H, et al. The specific slow afterhyperpolarization inhibitor UCL2077 is a subtype-selective blocker of the epilepsy associated KCNQ channels. Mol Pharmacol. 2010 Dec;78(6):1088-95.

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