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919351-41-0,MFCD26395344
Catalog No.:AA00GTYD

919351-41-0 | Azd1283

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
≥98%
in stock  
$133.00   $93.00
- +
10mg
≥98%
in stock  
$242.00   $169.00
- +
50mg
95%
in stock  
$347.00   $243.00
- +
100mg
95%
in stock  
$585.00   $410.00
- +
250mg
95%
in stock  
$1,025.00   $718.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00GTYD
Chemical Name:
Azd1283
CAS Number:
919351-41-0
Molecular Formula:
C23H26N4O5S
Molecular Weight:
470.5413
MDL Number:
MFCD26395344
SMILES:
CCOC(=O)c1cc(C#N)c(nc1C)N1CCC(CC1)C(=O)NS(=O)(=O)Cc1ccccc1
Properties
Computed Properties
 
Complexity:
835  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
8  
XLogP3:
2.5  

Literature

Title: Structure of the human P2Y12 receptor in complex with an antithrombotic drug.

Journal: Nature 20140501

Title: 5-alkyl-1,3-oxazole derivatives of 6-amino-nicotinic acids as alkyl ester bioisosteres are antagonists of the P2Y12 receptor.

Journal: Future medicinal chemistry 20131101

Title: Lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the P2Y12 receptor. separation of the antithrombotic effect and bleeding for candidate drug AZD1283.

Journal: Journal of medicinal chemistry 20130912

Title: Hydrophobic interaction determined by partition in aqueous two-phase systems. Partition of proteins in systems containing fatty-acid esters of poly(ethylene glycol).

Journal: European journal of biochemistry 19751201

Title: Kong D, et al. Optimization of P2Y12 Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties. J Med Chem. 2019 Mar 28;62(6):3088-3106.

Title: Bach P, et al. Lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the P2Y12 receptor. separation of the antithrombotic effect and bleeding for candidate drug AZD1283. J Med Chem. 2013 Sep 12;56(17):7015-24.

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SDS
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