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919486-40-1,MFCD24038757
Catalog No.:AA01EAYA

919486-40-1 | As1517499

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
95%
in stock  
$24.00   $17.00
- +
5mg
95%
in stock  
$60.00   $42.00
- +
10mg
95%
in stock  
$83.00   $58.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA01EAYA
Chemical Name:
As1517499
CAS Number:
919486-40-1
Molecular Formula:
C20H20ClN5O2
Molecular Weight:
397.8581
MDL Number:
MFCD24038757
SMILES:
NC(=O)c1cnc(nc1NCc1ccccc1)NCCc1ccc(c(c1)Cl)O
Properties
Computed Properties
 
Complexity:
491  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0  
Rotatable Bond Count:
8  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
4  

Downstream Synthesis Route

[1]Nagashima,Shinya;Yokota,Masaki;Nakai,Ei-ichi;Kuromitsu,Sadao;Ohga,Keiko;Takeuchi,Makoto;Tsukamoto,Shin-ichi;Ohta,Mitsuaki[BioorganicandMedicinalChemistry,2007,vol.15,#2,p.1044-1055]

[2]CurrentPatentAssignee:ASTELLASPHARMAINC-EP1518855,2005,A1Locationinpatent:Page/Pagecolumn23

[1]Nagashima,Shinya;Yokota,Masaki;Nakai,Ei-ichi;Kuromitsu,Sadao;Ohga,Keiko;Takeuchi,Makoto;Tsukamoto,Shin-ichi;Ohta,Mitsuaki[BioorganicandMedicinalChemistry,2007,vol.15,#2,p.1044-1055]

[1]Nagashima,Shinya;Yokota,Masaki;Nakai,Ei-ichi;Kuromitsu,Sadao;Ohga,Keiko;Takeuchi,Makoto;Tsukamoto,Shin-ichi;Ohta,Mitsuaki[BioorganicandMedicinalChemistry,2007,vol.15,#2,p.1044-1055]

[1]Nagashima,Shinya;Yokota,Masaki;Nakai,Ei-ichi;Kuromitsu,Sadao;Ohga,Keiko;Takeuchi,Makoto;Tsukamoto,Shin-ichi;Ohta,Mitsuaki[BioorganicandMedicinalChemistry,2007,vol.15,#2,p.1044-1055]

[1]Nagashima,Shinya;Yokota,Masaki;Nakai,Ei-ichi;Kuromitsu,Sadao;Ohga,Keiko;Takeuchi,Makoto;Tsukamoto,Shin-ichi;Ohta,Mitsuaki[BioorganicandMedicinalChemistry,2007,vol.15,#2,p.1044-1055]

Literature

Title: Synephrine inhibits eotaxin-1 expression via the STAT6 signaling pathway.

Journal: Molecules (Basel, Switzerland) 20140808

Title: Interleukin-4 upregulates RhoA protein via an activation of STAT6 in cultured human bronchial smooth muscle cells.

Journal: Pharmacological research 20100201

Title: A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in mice.

Journal: American journal of respiratory cell and molecular biology 20091101

Title: Identification of 4-benzylamino-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxamide derivatives as potent and orally bioavailable STAT6 inhibitors.

Journal: Bioorganic & medicinal chemistry 20080701

Title: Synthesis and evaluation of 2-{[2-(4-hydroxyphenyl)-ethyl]amino}pyrimidine-5-carboxamide derivatives as novel STAT6 inhibitors.

Journal: Bioorganic & medicinal chemistry 20070115

Title: Suppressor T cells and host resistance to tye 111 pneumococcus after treatment with antilymphocyte serum.

Journal: Infection and immunity 19751201

Title: Nagashima S, et al. Synthesis and evaluation of 2-{-(4-hydroxyphenyl)-ethylamino}pyrimidine-5-carboxamide derivatives as novel STAT6 inhibitors. Bioorg Med Chem. 2007 Jan 15;15(2):1044-55.

Title: Chiba Y, et al. A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in mice. Am J Respir Cell Mol Biol. 2009 Nov;41(5):516-24.

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SDS
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Historical Records
1159815-70-9

1159815-70-9
Tags:919486-40-1 Molecular Formula|919486-40-1 MDL|919486-40-1 SMILES|919486-40-1 As1517499
Catalog No.: AA01EAYA
919486-40-1,MFCD24038757
919486-40-1 | As1517499
Pack Size： 1mg
Purity： 95%
in stock
$24.00 $17.00
Pack Size： 5mg
Purity： 95%
in stock
$60.00 $42.00
Pack Size： 10mg
Purity： 95%
in stock
$83.00 $58.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA01EAYA
Chemical Name: As1517499
CAS Number: 919486-40-1
Molecular Formula: C20H20ClN5O2
Molecular Weight: 397.8581
MDL Number: MFCD24038757
SMILES: NC(=O)c1cnc(nc1NCc1ccccc1)NCCc1ccc(c(c1)Cl)O
Properties
Complexity: 491  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 28  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 4  
Isotope Atom Count: 0  
Rotatable Bond Count: 8  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 4  
Downstream Synthesis Route
643086-98-0    35607-19-3    919486-40-1 

[1]Nagashima,Shinya;Yokota,Masaki;Nakai,Ei-ichi;Kuromitsu,Sadao;Ohga,Keiko;Takeuchi,Makoto;Tsukamoto,Shin-ichi;Ohta,Mitsuaki[BioorganicandMedicinalChemistry,2007,vol.15,#2,p.1044-1055]

[2]CurrentPatentAssignee:ASTELLASPHARMAINC-EP1518855,2005,A1Locationinpatent:Page/Pagecolumn23

919486-26-3    919486-40-1 

[1]Nagashima,Shinya;Yokota,Masaki;Nakai,Ei-ichi;Kuromitsu,Sadao;Ohga,Keiko;Takeuchi,Makoto;Tsukamoto,Shin-ichi;Ohta,Mitsuaki[BioorganicandMedicinalChemistry,2007,vol.15,#2,p.1044-1055]

686267-34-5    919486-40-1 

[1]Nagashima,Shinya;Yokota,Masaki;Nakai,Ei-ichi;Kuromitsu,Sadao;Ohga,Keiko;Takeuchi,Makoto;Tsukamoto,Shin-ichi;Ohta,Mitsuaki[BioorganicandMedicinalChemistry,2007,vol.15,#2,p.1044-1055]

5909-24-0    919486-40-1 

[1]Nagashima,Shinya;Yokota,Masaki;Nakai,Ei-ichi;Kuromitsu,Sadao;Ohga,Keiko;Takeuchi,Makoto;Tsukamoto,Shin-ichi;Ohta,Mitsuaki[BioorganicandMedicinalChemistry,2007,vol.15,#2,p.1044-1055]

100973-67-9    919486-40-1 

[1]Nagashima,Shinya;Yokota,Masaki;Nakai,Ei-ichi;Kuromitsu,Sadao;Ohga,Keiko;Takeuchi,Makoto;Tsukamoto,Shin-ichi;Ohta,Mitsuaki[BioorganicandMedicinalChemistry,2007,vol.15,#2,p.1044-1055]

Literature fold

Title: Synephrine inhibits eotaxin-1 expression via the STAT6 signaling pathway.

Journal: Molecules (Basel, Switzerland)20140808

Title: Interleukin-4 upregulates RhoA protein via an activation of STAT6 in cultured human bronchial smooth muscle cells.

Journal: Pharmacological research20100201

Title: A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in mice.

Journal: American journal of respiratory cell and molecular biology20091101

Title: Identification of 4-benzylamino-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxamide derivatives as potent and orally bioavailable STAT6 inhibitors.

Journal: Bioorganic & medicinal chemistry20080701

Title: Synthesis and evaluation of 2-{[2-(4-hydroxyphenyl)-ethyl]amino}pyrimidine-5-carboxamide derivatives as novel STAT6 inhibitors.

Journal: Bioorganic & medicinal chemistry20070115

Title: Suppressor T cells and host resistance to tye 111 pneumococcus after treatment with antilymphocyte serum.

Journal: Infection and immunity19751201

Title: Nagashima S, et al. Synthesis and evaluation of 2-{-(4-hydroxyphenyl)-ethylamino}pyrimidine-5-carboxamide derivatives as novel STAT6 inhibitors. Bioorg Med Chem. 2007 Jan 15;15(2):1044-55.

Title: Chiba Y, et al. A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in mice. Am J Respir Cell Mol Biol. 2009 Nov;41(5):516-24.

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1159815-70-9
1159815-70-9
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