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92-43-3,MFCD00003094
Catalog No.:AA00IGWH

92-43-3 | 1-Phenyl-3-pyrazolidinone

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5g
98%
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$7.00   $5.00
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10g
98%
in stock  
$9.00   $7.00
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25g
98%
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$16.00   $11.00
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500g
>98.0%(T)
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00IGWH
Chemical Name:
1-Phenyl-3-pyrazolidinone
CAS Number:
92-43-3
Molecular Formula:
C9H10N2O
Molecular Weight:
162.1885
MDL Number:
MFCD00003094
SMILES:
O=C1CCN(N1)c1ccccc1
NSC Number:
30306
Properties
Computed Properties
 
Complexity:
175  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
0.9  

Literature

Title: The jasmonate pathway mediates salt tolerance in grapevines.

Journal: Journal of experimental botany 20120301

Title: The influence of chronic eicosanoid biosynthesis inhibition on life history of the greater waxmoth, Galleria mellonella and its ectoparasitoid, Bracon hebetor.

Journal: Journal of insect physiology 20110401

Title: Herbivore-induced volatiles of cabbage (Brassica oleracea) prime defence responses in neighbouring intact plants.

Journal: Plant biology (Stuttgart, Germany) 20110301

Title: The endotoxin-induced neuroinflammation model of Parkinson's disease.

Journal: Parkinson's disease 20110101

Title: Flavocoxid inhibits phospholipase A2, peroxidase moieties of the cyclooxygenases (COX), and 5-lipoxygenase, modifies COX-2 gene expression, and acts as an antioxidant.

Journal: Mediators of inflammation 20110101

Title: Selective inhibition of jasmonic acid accumulation by a small α, β-unsaturated carbonyl and phenidone reveals different modes of octadecanoid signalling activation in response to insect elicitors and green leaf volatiles in Zea mays.

Journal: BMC research notes 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Eicosanoids mediate hemolymph oxidative and antioxidative response in larvae of Galleria mellonella L.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20100601

Title: Inhibition of lipoxygenase affects induction of both direct and indirect plant defences against herbivorous insects.

Journal: Oecologia 20100201

Title: The role of jasmonates in floral nectar secretion.

Journal: PloS one 20100101

Title: Involvement of lipoxygenase in elicitor-stimulated sanguinarine accumulation in Papaver somniferum suspension cultures.

Journal: Plant physiology and biochemistry : PPB 20100101

Title: Eicosanoids mediate nodulation reactions to a mollicute bacterium in larvae of the blowfly, Chrysomya megacephala.

Journal: Journal of insect physiology 20090301

Title: Phenidone protects the nigral dopaminergic neurons from LPS-induced neurotoxicity.

Journal: Neuroscience letters 20081107

Title: Activity of the lipoxygenase inhibitor 1-phenyl-3-pyrazolidinone (phenidone) and derivatives on the inhibition of adhesion molecule expression on human umbilical vascular endothelial cells.

Journal: Biologics : targets & therapy 20080301

Title: Potential anti-inflammatory actions of the elmiric (lipoamino) acids.

Journal: Bioorganic & medicinal chemistry 20070515

Title: The role of arachidonic acid and its metabolites in insulin secretion from human islets of langerhans.

Journal: Diabetes 20070101

Title: Eicosanoid biosynthesis inhibitors influence mortality of Pieris brassicae larvae co-injected with fungal conidia.

Journal: Archives of insect biochemistry and physiology 20061101

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Binding investigation of human 5-lipoxygenase with its inhibitors by SPR technology correlating with molecular docking simulation.

Journal: Journal of biochemistry 20060401

Title: Anti-inflammatory and anti-oxidant activity of a new class of phenyl-pyrazolone derivatives.

Journal: Current drug discovery technologies 20060301

Title: Case report: Hydroquinone and/or glutaraldehyde induced acute myeloid leukaemia?

Journal: Journal of occupational medicine and toxicology (London, England) 20060101

Title: Synthesis and biological evaluation of a new class of acyl derivatives of 3-amino-1-phenyl-4,5-dihydro-1H-pyrazol-5-one as potential dual cyclooxygenase (COX-1 and COX-2) and human lipoxygenase (5-LOX) inhibitors.

Journal: Farmaco (Societa chimica italiana : 1989) 20050401

Title: Phenidone, a dual inhibitor of cyclooxygenases and lipoxygenases, ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes.

Journal: Brain research 20050227

Title: Topical antiinflammatory effects of the ether extract from Protium kleinii and alpha-amyrin pentacyclic triterpene.

Journal: European journal of pharmacology 20050110

Title: Synthesis and biological evaluation of new phenidone analogues as potential dual cyclooxygenase (COX-1 and COX-2) and human lipoxygenase (5-LOX) inhibitors.

Journal: Farmaco (Societa chimica italiana : 1989) 20050101

Title: Micellar electrokinetic chromatography at low pH with polyelectrolyte-coated capillaries.

Journal: Journal of chromatography. A 20040709

Title: Evolutionary change from induced to constitutive expression of an indirect plant resistance.

Journal: Nature 20040708

Title: Transcriptional activation of Igl, the gene for indole formation in Zea mays: a structure-activity study with elicitor-active N-acyl glutamines from insects.

Journal: Phytochemistry 20040401

Title: Molecular mechanism of nucleotide-induced primary granule release in human neutrophils: role for the P2Y2 receptor.

Journal: American journal of physiology. Cell physiology 20040201

Title: A facile synthesis of 1-ethoxy-4-cyano-5-ethoxycarbonyl-3H-azuleno[1,2-c]pyran-3-one, a selective 15-lipoxygenase inhibitor.

Journal: Bioorganic & medicinal chemistry letters 20040105

Title: Anti-inflammatory activity of (E)-1-(3,4-dimethoxyphenyl) butadiene from Zingiber cassumunar Roxb.

Journal: Journal of ethnopharmacology 20030801

Title: Dual positional specificity and expression of non-traditional lipoxygenase induced by wounding and methyl jasmonate in maize seedlings.

Journal: Plant molecular biology 20030801

Title: 12-lipoxygenase in opioid-induced delayed cardioprotection: gene array, mass spectrometric, and pharmacological analyses.

Journal: Circulation research 20030404

Title: Toxicity of human monocytic THP-1 cells and microglia toward SH-SY5Y neuroblastoma cells is reduced by inhibitors of 5-lipoxygenase and its activating protein FLAP.

Journal: Journal of leukocyte biology 20030301

Title: [Lipoxygenase-mediated N-demethylation of pesticides in vitro].

Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20021201

Title: Antioxidant activity of the methanol fraction of Pluchea indica root extract.

Journal: Phytotherapy research : PTR 20020601

Title: Modulation by eicosanoid biosynthesis inhibitors of immune responses by the insect Manduca sexta to the pathogenic fungus Metarhizium anisopliae.

Journal: Journal of invertebrate pathology 20020201

Title: Degradation of medical x-ray film developing wastewaters by advanced oxidation processes.

Journal: Water research 20011101

Title: Eicosanoids act in nodulation reactions to bacterial infections in newly emerged adult honey bees, Apis mellifera, but not in older foragers.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20010901

Title: N-Aminoindoline derivatives as inhibitors of 5-lipoxygenase.

Journal: Bioorganic & medicinal chemistry letters 20010326

Title: Signaling pathways involved in the A and B receptor-mediated cortisol secretagogue effect of endothelins in the human adrenal cortex.

Journal: International journal of molecular medicine 20010301

Title: Ion channel-forming alamethicin is a potent elicitor of volatile biosynthesis and tendril coiling. Cross talk between jasmonate and salicylate signaling in lima bean.

Journal: Plant physiology 20010101

Title: NRH:quinone oxidoreductase2 (NQO2).

Journal: Chemico-biological interactions 20001201

Title: A useful method for differential evaluation of anti-inflammatory effects due to cyclooxygenase and 5-lipoxygenase inhibitions in mice.

Journal: Japanese journal of pharmacology 19940801

Title: Effects of some non-steroidal anti-inflammatory drugs and other agents on cyclooxygenase and lipoxygenase activities in some enzyme preparations.

Journal: Japanese journal of pharmacology 19850601

Title: Moon C, et al. Phenidone, a dual inhibitor of cyclooxygenases and lipoxygenases, ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes. Brain Res. 2005;1035(2):206-210.

Title: Stern N, et al. The lipoxygenase inhibitor phenidone is a potent hypotensive agent in the spontaneously hypertensive rat. Am J Hypertens. 1993;6(1):52-58.

Title: Petrakiev A, et al. Emission spectral analysis using photographic plates treated with a phenidone developer. Talanta. 1969;16(12):1583-1587.

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Tags:92-43-3 Molecular Formula|92-43-3 MDL|92-43-3 SMILES|92-43-3 1-Phenyl-3-pyrazolidinone |Heterocyclic_Building_Blocks |Organic_Building_Blocks