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923359-38-0,MFCD28335199
Catalog No.:AA00GU6O

923359-38-0 | Sar407899

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$12.00   $8.00
- +
5mg
98+%
in stock  
$28.00   $20.00
- +
10mg
98+%
in stock  
$39.00   $28.00
- +
25mg
98+%
in stock  
$58.00   $41.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00GU6O
Chemical Name:
Sar407899
CAS Number:
923359-38-0
Molecular Formula:
C14H16N2O2
Molecular Weight:
244.2890
MDL Number:
MFCD28335199
SMILES:
O=c1[nH]ccc2c1ccc(c2)OC1CCNCC1
Properties
Computed Properties
 
Complexity:
337  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
2  
XLogP3:
1.4  

Literature

Title: Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20110215

Title: Pharmacological characterization of SAR407899, a novel rho-kinase inhibitor.

Journal: Hypertension (Dallas, Tex. : 1979) 20090901

Title: L?hn M, et al. Pharmacological characterization of SAR407899, a novel rho-kinase inhibitor. Hypertension. 2009 Sep;54(3):676-83.

Title: Guagnini F, et al. Erectile properties of the Rho-kinase inhibitor SAR407899 in diabetic animals and human isolated corpora cavernosa. J Transl Med. 2012 Mar 23;10:59.

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SDS
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