Home Other Building Blocks 92340-57-3
92340-57-3,MFCD00869771
Catalog No.:AA00GUNT

92340-57-3 | 5-HYDROXY OMEPRAZOLE

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$695.00   $486.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00GUNT
Chemical Name:
5-HYDROXY OMEPRAZOLE
CAS Number:
92340-57-3
Molecular Formula:
C17H19N3O4S
Molecular Weight:
361.4155
MDL Number:
MFCD00869771
SMILES:
COc1c(CO)cnc(c1C)CS(=O)c1nc2c([nH]1)ccc(c2)OC
Properties
Computed Properties
 
Complexity:
469  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
1  
XLogP3:
1  

Downstream Synthesis Route

[1]CurrentPatentAssignee:NANJINGUNIVERSITY-CN103724325,2016,BLocationinpatent:Paragraph0032;0033;0070;0071

[1]Shon,JongCheol;Phuc,NguyenMinh;Kim,WonCheol;Heo,JaeKyung;Wu,Zhexue;Lee,Hyunyoung;Liu,Kwang-Hyeon[BiopharmaceuticsandDrugDisposition,2017,vol.38,#9,p.553-556]

[2]Qin,Yan;Dong,Haijun;Sun,Jiayin;Zhang,Yilong;Li,Jun;Zhang,Tianci;Chen,Guanjun;Wang,Sheng;Song,Shuai;Wang,Wei;Fan,Yuru;Wang,Jie;Huang,Xiaohui;Shen,Chenlin[Xenobiotica,2021,vol.51,#12,p.1389-1399]

Literature

Title: Variation in omeprazole pharmacokinetics in a random Iranian population: a pilot study.

Journal: Biopharmaceutics & drug disposition 20120901

Title: Evaluation of lansoprazole as a probe for assessing cytochrome P450 2C19 activity and genotype-phenotype correlation in childhood.

Journal: European journal of clinical pharmacology 20120501

Title: High-sensitivity liquid chromatography-tandem mass spectrometry for the simultaneous determination of five drugs and their cytochrome P450-specific probe metabolites in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120501

Title: Omeprazole limited sampling strategies to predict area under the concentration-time curve ratios: implications for cytochrome P450 2C19 and 3A phenotyping.

Journal: European journal of clinical pharmacology 20120401

Title: [Effect of high altitude hypoxia on the activity and protein expression of CYP2C9 and CYP2C19].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20120201

Title: Prediction of relative in vivo metabolite exposure from in vitro data using two model drugs: dextromethorphan and omeprazole.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120101

Title: Chiral assay of omeprazole and metabolites and its application to a pharmacokinetics related to CYP2C19 genotypes.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110815

Title: Clinically significant CYP2C inhibition by noscapine but not by glucosamine.

Journal: Clinical pharmacology and therapeutics 20100901

Title: CYP2C19 haplotypes in Koreans as a marker of enzyme activity evaluated with omeprazole.

Journal: Journal of clinical pharmacy and therapeutics 20090801

Title: Clopidogrel inhibits CYP2C19-dependent hydroxylation of omeprazole related to CYP2C19 genetic polymorphisms.

Journal: Journal of clinical pharmacology 20090501

Title: Enantioseparation of omeprazole and its metabolite 5-hydroxyomeprazole using open tubular capillary electrochromatography with immobilized avidin as chiral selector.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20081101

Title: Estimation of CYP2C19 activity by the omeprazole hydroxylation index at a single point in time after intravenous and oral administration.

Journal: European journal of clinical pharmacology 20071101

Title: Herbal medicine yin zhi huang induces CYP3A4-mediated sulfoxidation and CYP2C19-dependent hydroxylation of omeprazole.

Journal: Acta pharmacologica Sinica 20071001

Title: Validation of chromatographic methods: evaluation of detection and quantification limits in the determination of impurities in omeprazole.

Journal: Journal of chromatography. A 20070713

Title: Cyp2c19 genotype and omeprazole hydroxylation phenotype in Chinese Li population.

Journal: Clinical and experimental pharmacology & physiology 20070101

Title: Phenotype-genotype analysis of CYP2C19 in Colombian mestizo individuals.

Journal: BMC clinical pharmacology 20070101

Title: Enantiomeric separation of omeprazole and its metabolite 5-hydroxyomeprazole using non-aqueous capillary electrophoresis.

Journal: Journal of chromatography. A 20061006

Title: Determination of omeprazole, hydroxyomeprazole and omeprazole sulfone using automated solid phase extraction and micellar electrokinetic capillary chromatography.

Journal: Journal of pharmaceutical and biomedical analysis 20060911

Title: Analysis of omeprazole and 5-OH omeprazole in human plasma using hydrophilic interaction chromatography with tandem mass spectrometry (HILIC-MS/MS)--eliminating evaporation and reconstitution steps in 96-well liquid/liquid extraction.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060102

Title: Esomeprazole-induced healing of gastroesophageal reflux disease is unrelated to the genotype of CYP2C19: evidence from clinical and pharmacokinetic data.

Journal: Clinical pharmacology and therapeutics 20051201

Title: Analysis of omeprazole, midazolam and hydroxy-metabolites in plasma using liquid chromatography coupled to tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050925

Title: The effect of aging on the relationship between the cytochrome P450 2C19 genotype and omeprazole pharmacokinetics.

Journal: Clinical pharmacokinetics 20050101

Title: Metabolism of omeprazole after two oral doses in children 1 to 9 months old.

Journal: Proceedings of the Western Pharmacology Society 20050101

Title: Genetic polymorphism of cytochrome P450 2C19 in healthy Malaysian subjects.

Journal: British journal of clinical pharmacology 20040901

Title: Omeprazole treatment of Korean patients: effects on gastric pH and gastrin release in relation to CYP2C19 geno- and phenotypes.

Journal: Basic & clinical pharmacology & toxicology 20040901

Title: Omeprazole as a CYP2C19 marker in Chinese subjects: assessment of its gene-dose effect and intrasubject variability.

Journal: Journal of clinical pharmacology 20040601

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:92340-57-3 Molecular Formula|92340-57-3 MDL|92340-57-3 SMILES|92340-57-3 5-HYDROXY OMEPRAZOLE