Name: Name:Motolimod
Brand: AABLOCKS
SKU: AA003A5O
Rating: 90 (10 reviews)

Catalog No.: AA003A5O

926927-61-9 | Motolimod

Pack Size： 1mg

Purity： 98+%

in stock

$38.00 $27.00

Pack Size： 2mg

Purity： 98+%

in stock

$64.00 $45.00

Pack Size： 5mg

Purity： 98+%

in stock

$96.00 $68.00

Pack Size： 25mg

Purity： 98+%

in stock

$240.00 $168.00

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Technical Information

Catalog Number: AA003A5O

Chemical Name: Motolimod

CAS Number: 926927-61-9

Molecular Formula: C28H34N4O2

Molecular Weight: 458.5952

MDL Number: MFCD28044318

SMILES: CCCN(C(=O)C1=Cc2ccc(cc2N=C(C1)N)c1ccc(cc1)C(=O)N1CCCC1)CCC

Properties

Complexity: 771

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 34

Hydrogen Bond Acceptor Count: 3

Hydrogen Bond Donor Count: 1

Isotope Atom Count: 0

Rotatable Bond Count: 7

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 3.8

Downstream Synthesis Route

1226791-83-8

926927-61-9

[1]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO;PFIZERINC-WO2010/54215,2010,A1Locationinpatent:Page/Pagecolumn42

874302-76-8

{2-amino-8-4-(pyrrolidinylcarbonyl)phenyl-(3H-benzofazepin-4-yl)}-N,N-dipropylcarboxamide

C36H40N4O5S2

[1]Patent:WO2019/34868,2019,A1.Locationinpatent:Paragraph00580

Literature fold

Title: A phase I dose-finding study of the novel Toll-like receptor 8 agonist VTX-2337 in adult subjects with advanced solid tumors or lymphoma.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20140715

Title: VTX-2337 is a novel TLR8 agonist that activates NK cells and augments ADCC.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20120115

Title: Lu H, et al. VTX-2337 is a novel TLR8 agonist that activates NK cells and augments ADCC. Clin Cancer Res. 2012 Jan 15;18(2):499-509.

Title: Dietsch GN, et al. Coordinated Activation of Toll-Like Receptor8 (TLR8) and NLRP3 by the TLR8 Agonist, VTX-2337, Ignites Tumoricidal Natural Killer Cell Activity. PLoS One. 2016 Feb 29;11(2):e0148764.

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