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928659-70-5,MFCD22665712
Catalog No.:AA00GU83

928659-70-5 | Eliglustat (Tartrate)

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Purity
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1mg
≥98%
in stock  
$46.00   $32.00
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5mg
≥98%
in stock  
$199.00   $139.00
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10mg
≥98%
in stock  
$348.00   $243.00
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25mg
≥98%
in stock  
$762.00   $533.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00GU83
Chemical Name:
Eliglustat (Tartrate)
CAS Number:
928659-70-5
Molecular Formula:
C50H78N4O14
Molecular Weight:
959.1727
MDL Number:
MFCD22665712
SMILES:
OC(=O)C(C(C(=O)O)O)O.CCCCCCCC(=O)NC(C(c1ccc2c(c1)OCCO2)O)CN1CCCC1.CCCCCCCC(=O)NC(C(c1ccc2c(c1)OCCO2)O)CN1CCCC1
Properties
Computed Properties
 
Complexity:
617  
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
6  
Heavy Atom Count:
68  
Hydrogen Bond Acceptor Count:
16  
Hydrogen Bond Donor Count:
8  
Rotatable Bond Count:
25  

Downstream Synthesis Route
87-69-4    491833-29-5   
eliglustathemitartrate 

[1]Patent:WO2011/66352,2011,A1.Locationinpatent:Page/Pagecolumn26

[2]Patent:CN106349210,2017,A.Locationinpatent:Paragraph0107;0108;0109

[3]Patent:WO2017/68496,2017,A1.Locationinpatent:Page/Pagecolumn28;36;37

[4]Patent:CN107445938,2017,A.Locationinpatent:Paragraph0032;0033;0034

[5]Patent:WO2019/82209,2019,A1.Locationinpatent:Page/Pagecolumn30

Literature

Title: Eliglustat, an investigational oral therapy for Gaucher disease type 1: Phase 2 trial results after 4 years of treatment.

Journal: Blood cells, molecules & diseases 20141201

Title: Eliglustat: first global approval.

Journal: Drugs 20141001

Title: Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity.

Journal: Journal of medicinal chemistry 20110224

Title: Improvement in hematological, visceral, and skeletal manifestations of Gaucher disease type 1 with oral eliglustat tartrate (Genz-112638) treatment: 2-year results of a phase 2 study.

Journal: Blood 20101118

Title: Eliglustat tartrate, an orally active glucocerebroside synthase inhibitor for the potential treatment of Gaucher disease and other lysosomal storage diseases.

Journal: Current opinion in investigational drugs (London, England : 2000) 20101001

Title: A phase 2 study of eliglustat tartrate (Genz-112638), an oral substrate reduction therapy for Gaucher disease type 1.

Journal: Blood 20100812

Title: Improved management of lysosomal glucosylceramide levels in a mouse model of type 1 Gaucher disease using enzyme and substrate reduction therapy.

Journal: Journal of inherited metabolic disease 20100601

Title: Increased hepatic insulin action in diet-induced obese mice following inhibition of glucosylceramide synthase.

Journal: PloS one 20100101

Title: Substrate reduction augments the efficacy of enzyme therapy in a mouse model of Fabry disease.

Journal: PloS one 20100101

Title: A specific and potent inhibitor of glucosylceramide synthase for substrate inhibition therapy of Gaucher disease.

Journal: Molecular genetics and metabolism 20070701

Title: McEachern KA, et al. A specific and potent inhibitor of glucosylceramide synthase for substrate inhibition therapy ofGaucher disease. Mol Genet Metab. 2007 Jul;91(3):259-67.

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SDS
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