Title: 5-AIQ inhibits H2O2-induced apoptosis through reactive oxygen species scavenging and Akt/GSK-3β signaling pathway in H9c2 cardiomyocytes.
Journal: Toxicology and applied pharmacology20130401
Title: Dopaminochrome induces caspase-independent apoptosis in the mesencephalic cell line, MN9D.
Journal: Journal of neurochemistry20120701
Title: 5-Aminoisoquinolinone reduces the expression of vascular endothelial growth factor-C via the nuclear factor-κB signaling pathway in CT26 cells.
Journal: Asian Pacific journal of cancer prevention : APJCP20120101
Title: Inhibition of poly(ADP-ribose) polymerase-1 attenuates the toxicity of carbon tetrachloride.
Journal: Journal of enzyme inhibition and medicinal chemistry20111201
Title: 5-Benzamidoisoquinolin-1-ones and 5-(ω-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2).
Journal: Journal of medicinal chemistry20110414
Title: Synthesis of 4-alkyl-, 4-aryl- and 4-arylamino-5-aminoisoquinolin-1-ones and identification of a new PARP-2 selective inhibitor.
Journal: Organic & biomolecular chemistry20110207
Title: Parvovirus B19 nonstructural protein-induced damage of cellular DNA and resultant apoptosis.
Journal: International journal of medical sciences20110101
Title: Low doses of 3-aminobenzamide, a poly(ADP-ribose) polymerase inhibitor, stimulate angiogenesis by regulating expression of urokinase type plasminogen activator and matrix metalloprotease 2.
Journal: Vascular cell20110101
Title: Hepatoprotective effects of select water-soluble PARP inhibitors in a carbon tetrachloride model.
Journal: International journal of critical illness and injury science20110101
Title: Oocyte numbers in the mouse increase after treatment with 5-aminoisoquinolinone: a potent inhibitor of poly(ADP-ribosyl)ation.
Journal: Biology of reproduction20100501
Title: PolyADP-ribosylation is required for pronuclear fusion during postfertilization in mice.
Journal: PloS one20100101
Title: Inhibition of matrix metalloproteinase-2 by PARP inhibitors.
Journal: Biochemical and biophysical research communications20091002
Title: Effect of poly (ADP-ribose) polymerase-1 inhibition on the proliferation of murine colon carcinoma CT26 cells.
Journal: Pathology oncology research : POR20090901
Title: Protective effects of caspase-9 and poly(ADP-ribose) polymerase inhibitors on ischemia-reperfusion-induced myocardial injury.
Journal: Archives of pharmacal research20090701
Title: Poly(ADP-ribose) polymerase inhibition down-regulates expression of metastasis-related genes in CT26 colon carcinoma cells.
Journal: Pathobiology : journal of immunopathology, molecular and cellular biology20090501
Title: Poly(ADP-ribose) polymerase 1 at the crossroad of metabolic stress and inflammation in aging.
Journal: Aging20090501
Title: Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor.
Journal: Journal of medicinal chemistry20090212
Title: Influence of 5-aminoisoquinolin-1-one (5-AIQ) on neutrophil chemiluminescence in rats with transient and prolonged focal cerebral ischemia and after reperfusion.
Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society20081201
Title: Bench-to-bedside review: latest results in hemorrhagic shock.
Journal: Critical care (London, England)20080101
Title: [Inhibitory effect of 5-aminoisoquinolinone on PARP activity in colon carcinoma cell line HT-29].
Journal: Ai zheng = Aizheng = Chinese journal of cancer20070601
Title: 5-Aminoisoquinolin-1(2H)-one, a water-soluble poly (ADP-ribose) polymerase (PARP) inhibitor reduces the evolution of experimental periodontitis in rats.
Journal: Journal of clinical periodontology20070201
Title: Therapeutic effect of a poly(ADP-ribose) polymerase-1 inhibitor on experimental arthritis by downregulating inflammation and Th1 response.
Journal: PloS one20070101
Title: Poly(ADP-ribose)polymerase inhibition decreases angiogenesis.
Journal: Biochemical and biophysical research communications20061201
Title: Possible role of poly(ADP-ribose) polymerase in pathological and physiological cardiac hypertrophy.
Journal: Methods and findings in experimental and clinical pharmacology20061201
Title: Protective effects of PARP inhibition on liver microcirculation and function after haemorrhagic shock and resuscitation in male rats.
Journal: Intensive care medicine20061001
Title: Effect of poly(ADP-ribosyl)ation inhibitors on the genotoxic effects of the boron neutron capture reaction.
Journal: Mutation research20050502
Title: Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and the development of bleomycin-induced lung injury.
Journal: The Journal of pharmacology and experimental therapeutics20050501
Title: Pathophysiological role of poly(ADP-ribose) polymerase (PARP) activation during acetaminophen-induced liver cell necrosis in mice.
Journal: Toxicological sciences : an official journal of the Society of Toxicology20050301
Title: Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and secondary damage in experimental spinal cord trauma.
Journal: The Journal of pharmacology and experimental therapeutics20050201
Title: Inhibition of poly(ADP-ribose) polymerase prevents allergen-induced asthma-like reaction in sensitized Guinea pigs.
Journal: The Journal of pharmacology and experimental therapeutics20041201
Title: 5-Aminoisoquinolinone reduces colon injury by experimental colitis.
Journal: Naunyn-Schmiedeberg's archives of pharmacology20041201
Title: Effects of inhibition of poly(adenosine diphosphate-ribose) synthase on acute cardiac allograft rejection.
Journal: Transplantation20040915
Title: Beneficial effects of 5-aminoisoquinolinone, a novel, potent, water-soluble, inhibitor of poly (ADP-ribose) polymerase, in a rat model of splanchnic artery occlusion and reperfusion.
Journal: European journal of pharmacology20040525
Title: 5-Aminoisoquinolinone reduces renal injury and dysfunction caused by experimental ischemia/reperfusion.
Journal: Kidney international20040201
Title: 5-Aminoisoquinolinone, a novel inhibitor of poly(adenosine disphosphate-ribose) polymerase, reduces microvascular liver injury but not mortality rate after hepatic ischemia-reperfusion.
Journal: Critical care medicine20040201
Title: Hepatic microcirculation in ischemia/reperfusion: is there a role for poly(adenosine 5'-diphosphate-ribose) polymerases?
Journal: Critical care medicine20040201
Title: The novel PARP inhibitor 5-aminoisoquinolinone reduces the liver injury caused by ischemia and reperfusion in the rat.
Journal: Medical science monitor : international medical journal of experimental and clinical research20021101
Title: Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase, in a rodent model of lung injury.
Journal: Biochemical pharmacology20020115
Title: 5-aminoisoquinolinone, a potent inhibitor of poly (adenosine 5'-diphosphate ribose) polymerase, reduces myocardial infarct size.
Journal: European journal of pharmacology20011026
