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93379-54-5,MFCD00074918
Catalog No.:AA003CK3

93379-54-5 | (S)-Atenolol

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10mg
≥98%
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$202.00   $142.00
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50mg
≥98%
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$602.00   $422.00
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003CK3
Chemical Name:
(S)-Atenolol
CAS Number:
93379-54-5
Molecular Formula:
C15H24N2O2
Molecular Weight:
264.3633
MDL Number:
MFCD00074918
SMILES:
O[C@@H](CNC(C)C)CCc1ccc(cc1)CC(=O)N
Properties
Properties
 
MP:
150 - 153°C  
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
263  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
8  
XLogP3:
0.2  

Literature

Title: 3-[4-(2-Amino-2-oxoeth-yl)phen-oxy]-2-hy-droxy-N-isopropyl-propanaminium 1,1'-binaphthyl-2,2'-diyl phosphate.

Journal: Acta crystallographica. Section E, Structure reports online 20110101

Title: Determination of enantiomers of atenolol and propranolol in pharmaceutical formulations by HPLC.

Journal: Journal of AOAC International 20110101

Title: Label-free integrative pharmacology on-target of drugs at the β(2)-adrenergic receptor.

Journal: Scientific reports 20110101

Title: A comparative study of nebivolol and (S) atenolol on blood pressure and heart rate on essential hypertensive patients.

Journal: Indian journal of pharmacology 20101201

Title: Spectrophotometric method for simultaneous estimation of atenolol in combination with losartan potassium and hydrochlorothiazide in bulk and tablet formulation.

Journal: Journal of pharmacy & bioallied sciences 20100101

Title: Influence of plasma protein binding on pharmacodynamics: Estimation of in vivo receptor affinities of beta blockers using a new mechanism-based PK-PD modelling approach.

Journal: Journal of pharmaceutical sciences 20091001

Title: Clinical pharmacology.

Journal: Indian journal of pharmacology 20081001

Title: Mechanism-based pharmacodynamic modeling of S(-)-atenolol: estimation of in vivo affinity for the beta1-adrenoceptor with an agonist-antagonist interaction model.

Journal: The Journal of pharmacology and experimental therapeutics 20080301

Title: Infrared spectroscopy of racemic and enantiomeric forms of atenolol.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20070801

Title: Pharmacokinetic-pharmacodynamic modelling of S(-)-atenolol in rats: reduction of isoprenaline-induced tachycardia as a continuous pharmacodynamic endpoint.

Journal: British journal of pharmacology 20070601

Title: The future lies in chiral purity: a perspective.

Journal: Journal of the Indian Medical Association 20070401

Title: Enantioanalysis of bisoprolol in human plasma with a macrocyclic antibiotic HPLC chiral column using fluorescence detection and solid phase extraction.

Journal: Chemical & pharmaceutical bulletin 20070201

Title: Development of safer molecules through chirality.

Journal: Indian journal of medical sciences 20061001

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Direct enantiomeric resolution of betaxolol with application to analysis of pharmaceutical products.

Journal: Analytical chemistry insights 20060101

Title: Insights into cyclodextrin interactions during sample stacking using capillary isotachophoresis with on-line microcoil NMR detection.

Journal: Magnetic resonance in chemistry : MRC 20050901

Title: An efficient asymmetric synthesis of (S)-atenolol: using hydrolytic kinetic resolution.

Journal: Bioorganic & medicinal chemistry 20050201

Title: Binding of (-)-[3H]-CGP12177 at two sites in recombinant human beta 1-adrenoceptors and interaction with beta-blockers.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20040501

Title: Enantioselective determination of (R)- and (S)-sotalol in human plasma by on-line coupling of a restricted-access material precolumn to a cellobiohydrolase I-based chiral stationary phase.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020805

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Low-molecular-weight chiral cation exchangers: novel chiral stationary phases and their application for enantioseparation of chiral bases by nonaqueous capillary electrochromatography.

Journal: Electrophoresis 20020201

Title: An improved HPLC-fluorescence stereoselective method for analysis of (+)-S- and (-)-R-sotalol enantiomers in plasma sample.

Journal: Bollettino chimico farmaceutico 20010101

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