Home Amines 934-32-7
934-32-7,MFCD00005596
Catalog No.:AA0063AF

934-32-7 | 2-Aminobenzimidazole

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  • Technical Information
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  • Technical Information
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Technical Information
Catalog Number:
AA0063AF
Chemical Name:
2-Aminobenzimidazole
CAS Number:
934-32-7
Molecular Formula:
C7H7N3
Molecular Weight:
133.1506
MDL Number:
MFCD00005596
SMILES:
Nc1nc2c([nH]1)cccc2
Properties
Properties
 
BP:
368.9 °C at 760 mmHg  
Form:
Solid  
MP:
226-230 °C(lit.)  
Refractive Index:
1.5341 (estimate)  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
126  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
XLogP3:
0.9  

Literature

Title: Microheterogeneity in native and cation-exchanged Nafion membranes.

Journal: The journal of physical chemistry. B 20120823

Title: Bis(2-amino-1H-benzimidazol-3-ium) tetrakis(μ-but-2-enoato)-κ4O:O';κ3O,O':O;κ3O:O,O'-bis[bis(but-2-enoato-κ2O,O')holmium(III)].

Journal: Acta crystallographica. Section C, Crystal structure communications 20120701

Title: Hollow-fiber liquid-phase microextraction for the determination of pesticides and metabolites in soils and water samples using HPLC and fluorescence detection.

Journal: Electrophoresis 20120701

Title: 2-Aminobenzimidazole derivatives strongly inhibit and disperse Pseudomonas aeruginosa biofilms.

Journal: Angewandte Chemie (International ed. in English) 20120521

Title: Mixed ligand copper(II) complexes of N,N-bis(benzimidazol-2-ylmethyl)amine (BBA) with diimine co-ligands: efficient chemical nuclease and protease activities and cytotoxicity.

Journal: Inorganic chemistry 20120521

Title: Dispersive liquid-liquid microextraction of pesticides and metabolites from soils using 1,3-dipentylimidazolium hexafluorophosphate ionic liquid as an alternative extraction solvent.

Journal: Electrophoresis 20120501

Title: Evaluation of gyrase B as a drug target in Mycobacterium tuberculosis.

Journal: The Journal of antimicrobial chemotherapy 20120201

Title: Molecular structure, vibrational spectroscopic, first-order hyperpolarizability and HOMO, LUMO studies of 2-aminobenzimidazole.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20111215

Title: Discovery of cyclic guanidines as potent, orally active, human glucagon receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters 20111201

Title: 1-Prop-2-ynyl-1H-benzimidazol-2-amine.

Journal: Acta crystallographica. Section E, Structure reports online 20111201

Title: Synthesis of novel isatin-thiazoline and isatin-benzimidazole conjugates as anti-breast cancer agents.

Journal: Archives of pharmacal research 20111001

Title: Removal of nonspecific binding proteins from cell and tissue extracts using 2-aminobenzimidazole-tethered affinity resin.

Journal: Die Pharmazie 20110901

Title: Detection of benzimidazole carbamates and amino metabolites in liver by surface plasmon resonance-biosensor.

Journal: Analytica chimica acta 20110826

Title: Accurate predictions of nonpolar solvation free energies require explicit consideration of binding-site hydration.

Journal: Journal of the American Chemical Society 20110824

Title: 2-Amino-6-nitro-1,3-benzothia-zol-3-ium hydrogen sulfate.

Journal: Acta crystallographica. Section E, Structure reports online 20110801

Title: 3,3'-Dichloro-biphenyl-4,4'-diaminium sulfate.

Journal: Acta crystallographica. Section E, Structure reports online 20110801

Title: Ionic liquid-dispersive liquid-liquid microextraction for the simultaneous determination of pesticides and metabolites in soils using high-performance liquid chromatography and fluorescence detection.

Journal: Journal of chromatography. A 20110729

Title: Discovery and characterization of 2-aminobenzimidazole derivatives as selective NOD1 inhibitors.

Journal: Chemistry & biology 20110729

Title: Aggregation of 2-aminobenzimidazole--a combined experimental and theoretical investigation.

Journal: Chemphyschem : a European journal of chemical physics and physical chemistry 20110620

Title: Chromogenic and fluorescent recognition of iodide with a benzimidazole-based tripodal receptor.

Journal: Organic letters 20110617

Title: Biodegradation kinetics of the benzimidazole fungicide thiophanate-methyl by bacteria isolated from loamy sand soil.

Journal: Biodegradation 20110601

Title: A protocol to 2-aminobenzimidazoles via copper-catalyzed cascade addition and cyclization of o-haloanilines and carbodiimides.

Journal: The Journal of organic chemistry 20110506

Title: Design, synthesis and biological evaluation of novel inhibitors of Trypanosoma brucei pteridine reductase 1.

Journal: ChemMedChem 20110207

Title: One-pot microwave assisted synthesis under green chemistry conditions, antioxidant screening, and cytotoxicity assessments of benzimidazole Schiff bases and pyrimido[1,2-a]benzimidazol-3(4H)-ones.

Journal: European journal of medicinal chemistry 20110101

Title: Synthesis of benzothiophene carboxamide derivatives and their pharmacological evaluation as potent antihypertriglyceridemic agents in rats.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20110101

Title: A facile and convenient synthesis of some novel hydrazones, Schiff's base and pyrazoles incorporating thieno[2,3-b]thiophenes.

Journal: International journal of molecular sciences 20110101

Title: Discovery, characterization, and structure-activity relationships of an inhibitor of inward rectifier potassium (Kir) channels with preference for Kir2.3, Kir3.x, and Kir7.1.

Journal: Frontiers in pharmacology 20110101

Title: Isolation and characterization of Pseudomonas sp. CBW capable of degrading carbendazim.

Journal: Biodegradation 20101101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Biodegradation of carbendazim by a novel actinobacterium Rhodococcus jialingiae djl-6-2.

Journal: Chemosphere 20101001

Title: Experimental and theoretical studies on the mechanism of photochemical hydrogen transfer from 2-aminobenzimidazole to nπ* and ππ* aromatic ketones.

Journal: The journal of physical chemistry. B 20100916

Title: Fragment-based discovery and optimization of BACE1 inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20100901

Title: Inhibition of protein kinase C-driven nuclear factor-kappaB activation: synthesis, structure-activity relationship, and pharmacological profiling of pathway specific benzimidazole probe molecules.

Journal: Journal of medicinal chemistry 20100624

Title: Experimental and theoretical (DFT) characterization of the excited states and N-centered radical species derived from 2-aminobenzimidazole, the core substructure of a family of bioactive compounds.

Journal: The journal of physical chemistry. B 20100520

Title: The discovery and structure-activity relationships of 2-(piperidin-3-yl)-1H-benzimidazoles as selective, CNS penetrating H1-antihistamines for insomnia.

Journal: Bioorganic & medicinal chemistry letters 20100501

Title: 3,4-Dimethyl-1H-1,2,4-triazepino[2,3-a]benzimidazol-2(3H)-one.

Journal: Acta crystallographica. Section E, Structure reports online 20100501

Title: Zinc fingered: new compounds that thwart gram-positive biofilm formation by sequestering zinc.

Journal: Chembiochem : a European journal of chemical biology 20100412

Title: Design, synthesis, and in vitro antiproliferative activity of benzimidazole analogues for radiopharmaceutical efficacy.

Journal: Cancer biotherapy & radiopharmaceuticals 20100401

Title: Chemical biology strategy reveals pathway-selective inhibitor of NF-kappaB activation induced by protein kinase C.

Journal: ACS chemical biology 20100319

Title: Concise synthesis of 2, 3-diarylpyrimido[1,2-a]benzimidazole based on isoflavones.

Journal: Journal of combinatorial chemistry 20100308

Title: Novel small molecule bradykinin B1 receptor antagonists. Part 2: 5-membered diaminoheterocycles.

Journal: Bioorganic & medicinal chemistry letters 20100201

Title: The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii.

Journal: Bioorganic & medicinal chemistry 20100115

Title: The leucine zipper domains of the transcription factors GCN4 and c-Jun have ribonuclease activity.

Journal: PloS one 20100101

Title: 2-Aminobenzimidazoles as potent Aurora kinase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20090901

Title: Simultaneous analysis of thiabendazole, carbendazim and 2-aminobenzimidazole in concentrated fruit juices by liquid chromatography after a single mix-mode solid-phase extraction cleanup.

Journal: Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20090801

Title: 2-Amino-6-nitro-1H-benzoimidazol-3-ium chloride.

Journal: Acta crystallographica. Section E, Structure reports online 20090801

Title: Ethyl 5-[(1H-benzoimidazol-2-yl)amino-carbon-yl]-4-hydr-oxy-2-methyl-6-oxo-1-propyl-1,6-dihydro-pyridine-3-carboxyl-ate-ethanol-methanol (4/2/1).

Journal: Acta crystallographica. Section E, Structure reports online 20090801

Title: A 2-aminobenzimidazole that inhibits and disperses gram-positive biofilms through a zinc-dependent mechanism.

Journal: Journal of the American Chemical Society 20090729

Title: One scaffold, three binding modes: novel and selective pteridine reductase 1 inhibitors derived from fragment hits discovered by virtual screening.

Journal: Journal of medicinal chemistry 20090723

Title: Identification of 2-aminobenzimidazoles as potent melanin-concentrating hormone 1-receptor (MCH1R) antagonists.

Journal: Bioorganic & medicinal chemistry letters 20090701

Title: [Characterization of a carbendazim-degrading Trichoderma sp. T2-2 and its application in bioremediation].

Journal: Wei sheng wu xue bao = Acta microbiologica Sinica 20090701

Title: IRAK-4 inhibitors for inflammation.

Journal: Current topics in medicinal chemistry 20090501

Title: QSAR analysis of 2-amino or 2-methyl-1-substituted benzimidazoles against Pseudomonas aeruginosa.

Journal: International journal of molecular sciences 20090401

Title: New sensitive kinetic spectrophotometric methods for determination of omeprazole in dosage forms.

Journal: International journal of analytical chemistry 20090101

Title: 2-Amino-benzimidazolium hydrogen sulfate.

Journal: Acta crystallographica. Section E, Structure reports online 20090101

Title: 2-Aminobenzimidazoles as potent ITK antagonists: trans-stilbene-like moieties targeting the kinase specificity pocket.

Journal: Bioorganic & medicinal chemistry letters 20081201

Title: 2-Amino-1H-benzoimidazol-3-ium 4,4,4-trifluoro-1,3-dioxo-1-phenyl-butan-2-ide.

Journal: Acta crystallographica. Section E, Structure reports online 20081201

Title: Discovery of potent, orally active benzimidazole glucagon receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters 20080701

Title: Lead identification of 2-iminobenzimidazole antagonists of the chemokine receptor CXCR3.

Journal: Bioorganic & medicinal chemistry letters 20080401

Title: Reaction of nitrilimines with 2-substituted aza-heterocycles. Synthesis of pyrrolo[1,2-a]pyridine and pyrimido[2,1-d]1,2,3,5- tetrazine.

Journal: Molecules (Basel, Switzerland) 20080128

Title: Synthesis, structure and biological activities of cobalt(II) and zinc(II) coordination compounds with 2-benzimidazole derivatives.

Journal: Journal of inorganic biochemistry 20080101

Title: A three component one-pot procedure for the synthesis of [1,2,4]triazolo/benzimidazolo-quinazolinone derivatives in the presence of H6P2W18O(62).18H2O as a green and reusable catalyst.

Journal: Molecular diversity 20080101

Title: Synthesis and antitrichinellosis activity of some bis(benzimidazol-2-yl)amines.

Journal: Bioorganic & medicinal chemistry 20070915

Title: Synthesis and biological evaluation of new 3-substituted indole derivatives as potential anti-inflammatory and analgesic agents.

Journal: Bioorganic & medicinal chemistry 20070601

Title: Benzimidazole condensed ring systems: new synthesis and antineoplastic activity of substituted 3,4-dihydro- and 1,2,3,4-tetrahydro-benzo[4,5]imidazo[1,2-a]pyrimidine derivatives.

Journal: Archives of pharmacal research 20070601

Title: Urearetics: a small molecule screen yields nanomolar potency inhibitors of urea transporter UT-B.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070201

Title: Molecular modeling of some 1H-benzimidazole derivatives with biological activity against Entamoeba histolytica: a comparative molecular field analysis study.

Journal: Bioorganic & medicinal chemistry 20070115

Title: Benzimidazole nitrogen-directed, regiocontrolled, lithiation of ferrocenyl- and phenyl-N-n-butylbenzimidazoles.

Journal: The Journal of organic chemistry 20070105

Title: Microwave assisted synthesis of triazoloquinazolinones and benzimidazoquinazolinones.

Journal: Beilstein journal of organic chemistry 20070101

Title: Synthesis of tetrahydrobenzimidazo[1,2-b]quinazolin-1(2H)-one and tetrahydro-1,2,4-triazolo[5,1-b]quinazolin-8(4H)-one ring systems under solvent-free conditions.

Journal: Combinatorial chemistry & high throughput screening 20061201

Title: An in vitro investigation on acid catalyzed reactions of proton pump inhibitors in the absence of an electrophile.

Journal: International journal of pharmaceutics 20061012

Title: Toward bifunctional antibody catalysis.

Journal: Bioorganic & medicinal chemistry 20060915

Title: Synthesis and QSAR studies of novel 1-substituted-2-aminobenzimidazoles derivatives.

Journal: European journal of medicinal chemistry 20060901

Title: Isolation and characterization of a carbendazim-degrading Rhodococcus sp. djl-6.

Journal: Current microbiology 20060701

Title: Site-specific cleavage of RNA by a metal-free artificial nuclease attached to antisense oligonucleotides.

Journal: Journal of the American Chemical Society 20060621

Title: Structure-guided design of peptide-based tryptase inhibitors.

Journal: Biochemistry 20060516

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Synthesis and biological evaluation of new non-imidazole H3-receptor antagonists of the 2-aminobenzimidazole series.

Journal: Bioorganic & medicinal chemistry 20060301

Title: A novel one-pot three-component reaction: synthesis of triheterocyclic 4H-pyrimido[2,1-b]benzazoles ring systems.

Journal: Bioorganic & medicinal chemistry letters 20051215

Title: In silico fragment-based discovery of indolin-2-one analogues as potent DNA gyrase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20051201

Title: Validation of a histamine H3 receptor model through structure-activity relationships for classical H3 antagonists.

Journal: Bioorganic & medicinal chemistry 20051001

Title: Convenient synthesis of fused heterocyclic 1,3,5-triazines from some N-acyl imidates and heterocyclic amines as anticancer and antioxidant agents.

Journal: Archiv der Pharmazie 20050801

Title: Prediction of genotoxicity of chemical compounds by statistical learning methods.

Journal: Chemical research in toxicology 20050601

Title: Determination of azolic fungicides in wine by solid-phase extraction and high-performance liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry.

Journal: Journal of chromatography. A 20050527

Title: Substituted aminobenzimidazole pyrimidines as cyclin-dependent kinase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20050415

Title: Influence of solvent properties on separation and detection performance in non-aqueous capillary electrophoresis-mass spectrometry of basic analytes.

Journal: Journal of chromatography. A 20050311

Title: Metal-free catalysts for the hydrolysis of RNA derived from guanidines, 2-aminopyridines, and 2-aminobenzimidazoles.

Journal: Journal of the American Chemical Society 20050223

Title: Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA).

Journal: Journal of molecular biology 20041119

Title: Simultaneous separation and on-line concentration of amitrole and benzimidazole pesticides by capillary electrophoresis with a volatile migration buffer applicable to mass spectrometric detection.

Journal: Journal of chromatography. A 20041008

Title: Inhibition of human immunodeficiency virus type I integrase by naphthamidines and 2-aminobenzimidazoles.

Journal: Antiviral research 20041001

Title: Heterocyclic bis-cations as starting hits for design of inhibitors of the bifunctional enzyme histidine-containing protein kinase/phosphatase from Bacillus subtilis.

Journal: Journal of medicinal chemistry 20040422

Title: Synthesis, biological activity, QSAR and QSPR study of 2-aminobenzimidazole derivatives as potent H3-antagonists.

Journal: Bioorganic & medicinal chemistry 20040215

Title: Synthesis and antiproliferative activity in vitro of 2-aminobenzimidazole derivatives.

Journal: Farmaco (Societa chimica italiana : 1989) 20040201

Title: Generation of bis-cationic heterocyclic inhibitors of Bacillus subtilis HPr kinase/phosphatase from a ditopic dynamic combinatorial library.

Journal: Journal of medicinal chemistry 20031218

Title: The role of HB-donor groups in the heterocyclic polar fragment of H3-antagonists. I. Synthesis and biological assays.

Journal: Farmaco (Societa chimica italiana : 1989) 20030901

Title: Identification of 2-aminobenzimidazole dimers as antibacterial agents.

Journal: Bioorganic & medicinal chemistry letters 20030519

Title: Photochemical behaviour of carbendazim in aqueous solution.

Journal: Chemosphere 20030201

Title: Copper- and palladium-catalyzed intramolecular aryl guanidinylation: an efficient method for the synthesis of 2-aminobenzimidazoles.

Journal: Organic letters 20030123

Title: Carbendazim: disposition, cellular permeability, metabolite identification, and pharmacokinetic comparison with its nanoparticle.

Journal: Journal of pharmaceutical sciences 20030101

Title: On-line automated sample preparation for liquid chromatography using parallel supported liquid membrane extraction and microporous membrane liquid-liquid extraction.

Journal: Journal of chromatography. A 20021025

Title: Synthesis and antiparasitic activity of 1H-benzimidazole derivatives.

Journal: Bioorganic & medicinal chemistry letters 20020819

Title: Kinetic study of catalytic CO(2) hydration by water-soluble model compound of carbonic anhydrase and anion inhibition effect on CO(2) hydration.

Journal: Journal of inorganic biochemistry 20020428

Title: Preparation, physicochemical characterization and pharmacological study of novel ruthenium(III) complexes with imidazole and benzimidazole derivatives.

Journal: Arzneimittel-Forschung 20010901

Title: Trigonal planar copper(I) complex: synthesis, structure, and spectra of a redox pair of novel copper(II/I) complexes of tridentate bis(benzimidazol-2'-yl) ligand framework as models for electron-transfer copper proteins.

Journal: Inorganic chemistry 20010507

Title: Potential transition state phosphoramidate inhibitors of beta-tubulin as antifilarial agents.

Journal: The Journal of pharmacy and pharmacology 20010101

Title: Thermodynamic and multinuclear magnetic resonance study of dimethyltin (IV) complexes with some imidazoles in aqueous solutions.

Journal: Annali di chimica 20010101

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Tags:934-32-7 Molecular Formula|934-32-7 MDL|934-32-7 SMILES|934-32-7 2-Aminobenzimidazole |Organic_Building_Blocks