Home Amines 93413-62-8
93413-62-8,MFCD00871934
Catalog No.:AA006FVB

93413-62-8 | 4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol

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5mg
>98%(HPLC)powder
in stock  
$34.00   $24.00
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1g
98%
in stock  
$54.00   $38.00
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5g
98%
in stock  
$145.00   $102.00
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25g
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100g
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA006FVB
Chemical Name:
4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol
CAS Number:
93413-62-8
Molecular Formula:
C16H25NO2
Molecular Weight:
263.3752
MDL Number:
MFCD00871934
SMILES:
CN(CC(C1(O)CCCCC1)c1ccc(cc1)O)C
Properties
Properties
 
BP:
403.8°C at 760 mmHg  
Form:
Solid  
MP:
208-213 °C  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
266  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
1  
XLogP3:
2.6  

Literature

Title: Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis.

Journal: Chemical research in toxicology 20150518

Title: Syndrome of inappropriate antidiuretic hormone secretion associated with desvenlafaxine.

Journal: International journal of clinical pharmacy 20140401

Title: Discovery of a potent, dual serotonin and norepinephrine reuptake inhibitor.

Journal: ACS medicinal chemistry letters 20130613

Title: The effect of age, sex, smoking and co-medication on serum levels of venlafaxine and O-desmethylvenlafaxine under naturalistic conditions.

Journal: Pharmacopsychiatry 20120901

Title: Metabolites: novel therapeutics or 'me-too' drugs? Using desvenlafaxine as an example.

Journal: CNS spectrums 20120901

Title: High-dose desvenlafaxine in outpatients with major depressive disorder.

Journal: CNS spectrums 20120901

Title: An indirect comparison of the efficacy and safety of desvenlafaxine and venlafaxine using placebo as the common comparator.

Journal: CNS spectrums 20120901

Title: Field and laboratory studies of the fate and enantiomeric enrichment of venlafaxine and O-desmethylvenlafaxine under aerobic and anaerobic conditions.

Journal: Chemosphere 20120601

Title: A short-term double-blind randomized controlled pilot trial with active or placebo pindolol in patients treated with venlafaxine for major depression.

Journal: Nordic journal of psychiatry 20120601

Title: Lack of a pharmacokinetic drug-drug interaction with venlafaxine extended-release/indinavir and desvenlafaxine extended-release/indinavir.

Journal: European journal of clinical pharmacology 20120501

Title: Effective and clinically meaningful non-hormonal hot flash therapies.

Journal: Maturitas 20120501

Title: Impact of wastewater treatment plant discharge of lidocaine, tramadol, venlafaxine and their metabolites on the quality of surface waters and groundwater.

Journal: Journal of environmental monitoring : JEM 20120501

Title: Occurrence of Tako-Tsubo cardiomyopathy in association with ingestion of serotonin/noradrenaline reuptake inhibitors.

Journal: Heart, lung & circulation 20120401

Title: Occurrence and removal of lidocaine, tramadol, venlafaxine, and their metabolites in German wastewater treatment plants.

Journal: Environmental science and pollution research international 20120301

Title: Species comparison of in vivo P-glycoprotein-mediated brain efflux using mdr1a-deficient rats and mice.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120301

Title: The effect of dose titration and dose tapering on the tolerability of desvenlafaxine in women with vasomotor symptoms associated with menopause.

Journal: Journal of women's health (2002) 20120201

Title: Randomized placebo- and active-controlled study of desvenlafaxine for menopausal vasomotor symptoms.

Journal: Climacteric : the journal of the International Menopause Society 20120201

Title: Influence of CYP2D6 genotype on the disposition of the enantiomers of venlafaxine and its major metabolites in postmortem femoral blood.

Journal: Forensic science international 20120110

Title: Assessing the relationship between functional impairment/recovery and depression severity: a pooled analysis.

Journal: International clinical psychopharmacology 20120101

Title: Duloxetine versus other anti-depressive agents for depression.

Journal: The Cochrane database of systematic reviews 20120101

Title: Desvenlafaxine in the treatment of major depressive disorder.

Journal: Expert opinion on pharmacotherapy 20111201

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Preclinical pharmacology of TP1, a novel potent triple reuptake inhibitor with antidepressant properties.

Journal: Neuroscience 20111124

Title: Severe acute cardiomyopathy associated with venlafaxine overdose and possible role of CYP2D6 and CYP2C19 polymorphisms.

Journal: Clinical toxicology (Philadelphia, Pa.) 20111101

Title: Inhibitory effects of desvenlafaxine on gastric slow waves, antral contractions, and gastric accommodation mediated via the sympathetic mechanism in dogs.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20111001

Title: Symptomatic and functional improvement in employed depressed patients: a double-blind clinical trial of desvenlafaxine versus placebo.

Journal: Journal of clinical psychopharmacology 20111001

Title: Clinical outcomes following switch from venlafaxine ER to desvenlafaxine in nonresponders and responders.

Journal: Current medical research and opinion 20110901

Title: A simple HPLC method for the simultaneous determination of venlafaxine and its major metabolite O-desmethylvenlafaxine in human serum.

Journal: Bioanalysis 20110801

Title: Fatal venlafaxine poisonings are associated with a high prevalence of drug interactions.

Journal: International journal of legal medicine 20110501

Title: Induction of drug efflux protein expression by venlafaxine but not desvenlafaxine.

Journal: Biopharmaceutics & drug disposition 20110501

Title: A rapid, Web-based method for obtaining patient views on effects and side-effects of antidepressants.

Journal: Journal of affective disorders 20110401

Title: Antidepressant-mediated gastroesophageal reflux disease.

Journal: The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists 20110401

Title: Tolerance to desvenlafaxine in rapid metabolizing depressed patients.

Journal: International clinical psychopharmacology 20110301

Title: Open-label treatment with desvenlafaxine in postmenopausal women with major depressive disorder not responding to acute treatment with desvenlafaxine or escitalopram.

Journal: CNS drugs 20110301

Title: Estimation of desvenlafaxine transfer into milk and infant exposure during its use in lactating women with postnatal depression.

Journal: Archives of women's mental health 20110201

Title: Quantification of antidepressants and antipsychotics in human serum by precipitation and ultra high pressure liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110101

Title: The pharmacokinetics and safety of desvenlafaxine in subjects with chronic renal impairment.

Journal: International journal of clinical pharmacology and therapeutics 20110101

Title: Pharmacokinetics of venlafaxine extended release 75  mg and desvenlafaxine 50  mg in healthy CYP2D6 extensive and poor metabolizers: a randomized, open-label, two-period, parallel-group, crossover study.

Journal: Clinical drug investigation 20110101

Title: Comments on 'Desvenlafaxine as a possible cause of acquired hemophilia'.

Journal: General hospital psychiatry 20110101

Title: Assessment of infant dose through milk in a lactating woman taking amisulpride and desvenlafaxine for treatment-resistant depression.

Journal: Therapeutic drug monitoring 20101201

Title: Desvenlafaxine for major depressive disorder: incremental clinical benefits from a second-generation serotonin-norepinephrine reuptake inhibitor.

Journal: Expert opinion on drug metabolism & toxicology 20101201

Title: Stereoselective determination of venlafaxine and its three demethylated metabolites in human plasma and whole blood by liquid chromatography with electrospray tandem mass spectrometric detection and solid phase extraction.

Journal: Journal of pharmaceutical and biomedical analysis 20101102

Title: Cytochrome P450 2D6 phenotype predicts antidepressant efficacy of venlafaxine: a secondary analysis of 4 studies in major depressive disorder.

Journal: The Journal of clinical psychiatry 20101101

Title: HAM-D17 and HAM-D6 sensitivity to change in relation to desvenlafaxine dose and baseline depression severity in major depressive disorder.

Journal: Pharmacopsychiatry 20101101

Title: Differential outcomes from metabolic ratios in the identification of CYP2D6 phenotypes--focus on venlafaxine and O-desmethylvenlafaxine.

Journal: European journal of clinical pharmacology 20100901

Title: Retrospective analysis of suicidality in patients treated with the antidepressant desvenlafaxine.

Journal: Journal of clinical psychopharmacology 20100801

Title: Pharmacological and clinical profile of newer antidepressants: implications for the treatment of elderly patients.

Journal: Drugs & aging 20100801

Title: Short-term efficacy and safety of desvenlafaxine in a randomized, placebo-controlled study of perimenopausal and postmenopausal women with major depressive disorder.

Journal: The Journal of clinical psychiatry 20100801

Title: Antidepressant 'treatment'.

Journal: Menopause (New York, N.Y.) 20100701

Title: Desvenlafaxine and escitalopram for the treatment of postmenopausal women with major depressive disorder.

Journal: Menopause (New York, N.Y.) 20100701

Title: Analysis by age and sex of efficacy data from placebo-controlled trials of desvenlafaxine in outpatients with major depressive disorder.

Journal: Journal of clinical psychopharmacology 20100601

Title: Desvenlafaxine: a therapeutic option for treatment of menopausal hot flashes.

Journal: Maturitas 20100501

Title: Simultaneous quantification of venlafaxine and O-desmethylvenlafaxine in human plasma by ultra performance liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100301

Title: Analysis of the effect of desvenlafaxine on anxiety symptoms associated with major depressive disorder: pooled data from 9 short-term, double-blind, placebo-controlled trials.

Journal: CNS spectrums 20100301

Title: Desvenlafaxine for the prevention of relapse in major depressive disorder: results of a randomized trial.

Journal: Journal of clinical psychopharmacology 20100201

Title: Clinical utility of desvenlafaxine 50 mg/d for treating MDD: a review of two randomized placebo-controlled trials for the practicing physician.

Journal: Current medical research and opinion 20100101

Title: Understanding outliers on the usual dose-response curve: venlafaxine as a way to phenotype patients in terms of their CYP 2D6 status and why it matters.

Journal: Journal of psychiatric practice 20100101

Title: Mania possibly induced by desvenlafaxine.

Journal: Journal of psychiatric practice 20100101

Title: Desvenlafaxine succinate: a newer antidepressant for the treatment of depression and somatic symptoms.

Journal: Postgraduate medicine 20100101

Title: Correction of venlafaxine- and duloxetine-induced transaminase elevations with desvenlafaxine in a patient with Gilbert's syndrome.

Journal: CNS spectrums 20100101

Title: Efficacy, safety, and tolerability of Desvenlafaxine 50 mg/d for the treatment of major depressive disorder:a systematic review of clinical trials.

Journal: Primary care companion to the Journal of clinical psychiatry 20100101

Title: Desvenlafaxine as a possible cause of acquired hemophilia.

Journal: General hospital psychiatry 20100101

Title: IFN-gamma reduction by tricyclic antidepressants.

Journal: International journal of psychiatry in medicine 20100101

Title: Rapid high-performance liquid chromatography-tandem mass spectrometry method for simultaneous measurement of venlafaxine and O-desmethylvenlafaxine in human plasma and its application in comparative bioavailability study.

Journal: Biomedical chromatography : BMC 20091201

Title: Discontinuation symptoms and taper/poststudy-emergent adverse events with desvenlafaxine treatment for major depressive disorder.

Journal: International clinical psychopharmacology 20091101

Title: Simultaneous determination of venlafaxine and its main active metabolite O-desmethyl venlafaxine in rat plasma by LC-MS/MS.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20091001

Title: Desvenlafaxine: application withdrawal. Desvenlafaxine: withdrawal of marketing application for depression also.

Journal: Prescrire international 20091001

Title: [Non-hormonal treatment for vasomotor symptoms during menopause: role of desvenlafaxine].

Journal: Ginecologia y obstetricia de Mexico 20091001

Title: Assessing the efficacy of desvenlafaxine for improving functioning and well-being outcome measures in patients with major depressive disorder: a pooled analysis of 9 double-blind, placebo-controlled, 8-week clinical trials.

Journal: The Journal of clinical psychiatry 20091001

Title: Venlafaxine in human breast milk and nursing infant plasma: determination of exposure.

Journal: The Journal of clinical psychiatry 20090901

Title: Venlafaxine metabolism as a marker of cytochrome P450 enzyme 2D6 metabolizer status.

Journal: Journal of clinical psychopharmacology 20090801

Title: Desvenlafaxine: a new serotonin-norepinephrine reuptake inhibitor for the treatment of adults with major depressive disorder.

Journal: Clinical therapeutics 20090601

Title: Desvenlafaxine 50 and 100 mg/d in the treatment of major depressive disorder: an 8-week, phase III, multicenter, randomized, double-blind, placebo-controlled, parallel-group trial and a post hoc pooled analysis of three studies.

Journal: Clinical therapeutics 20090601

Title: Desvenlafaxine: a new antidepressant or just another one?

Journal: Expert opinion on pharmacotherapy 20090401

Title: New drug update: 2008.

Journal: The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists 20090401

Title: Desvenlafaxine for the treatment of vasomotor symptoms associated with menopause: a double-blind, randomized, placebo-controlled trial of efficacy and safety.

Journal: American journal of obstetrics and gynecology 20090301

Title: The effects of desvenlafaxine and paroxetine on the pharmacokinetics of the cytochrome P450 2D6 substrate desipramine in healthy adults.

Journal: Journal of clinical pharmacology 20090201

Title: A double-blind, randomly assigned, placebo-controlled study of desvenlafaxine efficacy and safety for the treatment of vasomotor symptoms associated with menopause.

Journal: American journal of obstetrics and gynecology 20090201

Title: Comparison of the pharmacokinetics of venlafaxine extended release and desvenlafaxine in extensive and poor cytochrome P450 2D6 metabolizers.

Journal: Journal of clinical psychopharmacology 20090201

Title: Drug approvals: '08 in review. Desvenlafaxine (Pristiq).

Journal: The Nurse practitioner 20090201

Title: Desvenlafaxine, a serotonin-norepinephrine uptake inhibitor for major depressive disorder, neuropathic pain and the vasomotor symptoms associated with menopause.

Journal: Current opinion in investigational drugs (London, England : 2000) 20090101

Title: A placebo-controlled study evaluating the efficacy and safety of flexible-dose desvenlafaxine treatment in outpatients with major depressive disorder.

Journal: CNS spectrums 20090101

Title: Desvenlafaxine and venlafaxine exert minimal in vitro inhibition of human cytochrome P450 and P-glycoprotein activities.

Journal: Psychopharmacology bulletin 20090101

Title: Analysis of depressive symptoms in patients with major depressive disorder treated with desvenlafaxine or placebo.

Journal: Psychopharmacology bulletin 20090101

Title: An assessment of drug-drug interactions: the effect of desvenlafaxine and duloxetine on the pharmacokinetics of the CYP2D6 probe desipramine in healthy subjects.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20081201

Title: Desvenlafaxine succinate for major depressive disorder: a critical review of the evidence.

Journal: Expert review of neurotherapeutics 20081201

Title: Effect of desvenlafaxine on the cytochrome P450 2D6 enzyme system.

Journal: Journal of psychiatric practice 20081101

Title: Desvenlafaxine: another 'me too' drug?

Journal: The Annals of pharmacotherapy 20081001

Title: Desvenlafaxine succinate for the treatment of major depressive disorder.

Journal: Expert opinion on pharmacotherapy 20080801

Title: Liquid chromatography tandem mass spectrometry assay for the simultaneous determination of venlafaxine and O-desmethylvenlafaxine in human plasma and its application to a bioequivalence study.

Journal: Journal of pharmaceutical and biomedical analysis 20080715

Title: Efficacy, safety, and tolerability of desvenlafaxine 50 mg/day and 100 mg/day in outpatients with major depressive disorder.

Journal: Current medical research and opinion 20080701

Title: A pooled analysis of two placebo-controlled trials of desvenlafaxine in major depressive disorder.

Journal: International clinical psychopharmacology 20080701

Title: Flat dose-response curves for efficacy: what do they mean to the clinician?

Journal: Journal of psychiatric practice 20080701

Title: Desvenlafaxine succinate for major depressive disorder.

Journal: Drugs of today (Barcelona, Spain : 1998) 20080701

Title: Desvenlafaxine for depression.

Journal: The Medical letter on drugs and therapeutics 20080519

Title: Serum concentrations of venlafaxine and its metabolites O-desmethylvenlafaxine and N-desmethylvenlafaxine in heterozygous carriers of the CYP2D6*3, *4 or *5 allele.

Journal: European journal of clinical pharmacology 20080501

Title: Desvenlafaxine succinate monohydrate.

Journal: Acta crystallographica. Section C, Crystal structure communications 20080501

Title: Effect of terbinafine and voriconazole on the pharmacokinetics of the antidepressant venlafaxine.

Journal: Clinical pharmacology and therapeutics 20080201

Title: Efficacy and tolerability of desvenlafaxine succinate treatment for menopausal vasomotor symptoms: a randomized controlled trial.

Journal: Obstetrics and gynecology 20080101

Title: Identifying meaningful differences in vasomotor symptoms among menopausal women.

Journal: Menopause (New York, N.Y.) 20080101

Title: New drugs: Etravirine, sinecatechins, and desvenlafaxine succinate.

Journal: Journal of the American Pharmacists Association : JAPhA 20080101

Title: Desvenlafaxine extended release.

Journal: CNS drugs 20080101

Title: Desvenlafaxine succinate identifies novel antagonist binding determinants in the human norepinephrine transporter.

Journal: The Journal of pharmacology and experimental therapeutics 20071101

Title: A randomized, double-blind, placebo-controlled trial of desvenlafaxine succinate in the treatment of major depressive disorder.

Journal: International clinical psychopharmacology 20071101

Title: A randomized, double-blind, placebo-controlled trial of desvenlafaxine succinate in adult outpatients with major depressive disorder.

Journal: The Journal of clinical psychiatry 20071101

Title: New products and regimens (since 2003).

Journal: Climacteric : the journal of the International Menopause Society 20071001

Title: Analysis of the second generation antidepressant venlafaxine and its main active metabolite O-desmethylvenlafaxine in human plasma by HPLC with spectrofluorimetric detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070901

Title: Venlafaxine in the treatment of children and adolescents with attention-deficit/hyperactivity disorder.

Journal: Journal of child and adolescent psychopharmacology 20070801

Title: Simultaneous stereoselective analysis of venlafaxine and O-desmethylvenlafaxine enantiomers in human plasma by HPLC-ESI/MS using a vancomycin chiral column.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070501

Title: A double-blind, placebo-controlled study of the efficacy and safety of desvenlafaxine succinate in the treatment of major depressive disorder.

Journal: The Journal of clinical psychiatry 20070501

Title: Alleviation of thermoregulatory dysfunction with the new serotonin and norepinephrine reuptake inhibitor desvenlafaxine succinate in ovariectomized rodent models.

Journal: Endocrinology 20070301

Title: Employing atmospheric pressure photoionization in liquid chromatography/tandem mass spectrometry to minimize ion suppression and matrix effects for the quantification of venlafaxine and O-desmethylvenlafaxine.

Journal: Rapid communications in mass spectrometry : RCM 20070101

Title: CYP2D6 polymorphism and clinical effect of the antidepressant venlafaxine.

Journal: Journal of clinical pharmacy and therapeutics 20061001

Title: Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor.

Journal: The Journal of pharmacology and experimental therapeutics 20060801

Title: Pharmacokinetic and pharmacodynamic profiles of the novel serotonin and norepinephrine reuptake inhibitor desvenlafaxine succinate in ovariectomized Sprague-Dawley rats.

Journal: Brain research 20060707

Title: CYP2D6 genotype and venlafaxine-XR concentrations in depressed elderly.

Journal: International journal of geriatric psychiatry 20060601

Title: [Trazodone for the treatment of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease: a retrospective study focused on the aggression and negativism in caregiving situations].

Journal: No to shinkei = Brain and nerve 20060601

Title: Anesthesiologist suicide with atracurium.

Journal: Journal of analytical toxicology 20060301

Title: Liquid chromatography-tandem mass spectrometry (LC-MS-MS) method for simultaneous determination of venlafaxine and its active metabolite O-desmethyl venlafaxine in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20051227

Title: Development of a solid phase extraction for 13 'new' generation antidepressants and their active metabolites for gas chromatographic-mass spectrometric analysis.

Journal: Journal of chromatography. A 20051209

Title: Metabolic ratios of psychotropics as indication of cytochrome P450 2D6/2C19 genotype.

Journal: Therapeutic drug monitoring 20050801

Title: Efficacy and tolerability of venlafaxine in geriatric outpatients with major depression: a double-blind, randomised 6-month comparative trial with citalopram.

Journal: International journal of geriatric psychiatry 20041201

Title: Quantification of venlafaxine and O-desmethylvenlafaxine in human serum using HPLC analysis.

Journal: International journal of clinical pharmacology and therapeutics 20041201

Title: Time course of clinical response to venlafaxine: relevance of plasma level and chirality.

Journal: European journal of clinical pharmacology 20040201

Title: A double blind comparison of venlafaxine and paroxetine in obsessive-compulsive disorder.

Journal: Journal of clinical psychopharmacology 20031201

Title: Inhibition of P-glycoprotein by newer antidepressants.

Journal: The Journal of pharmacology and experimental therapeutics 20030401

Title: Therapeutic drug monitoring of racemic venlafaxine and its main metabolites in an everyday clinical setting.

Journal: Therapeutic drug monitoring 20020801

Title: Steady-state concentration of venlafaxine enantiomers: model-based analysis of between-patient variability.

Journal: European journal of clinical pharmacology 20020801

Title: Distribution of venlafaxine and its O-desmethyl metabolite in human milk and their effects in breastfed infants.

Journal: British journal of clinical pharmacology 20020101

Title: Venlafaxine in neuropathic pain following treatment of breast cancer.

Journal: European journal of pain (London, England) 20020101

Title: False-positive phencyclidine immunoassay results caused by venlafaxine and O-desmethylvenlafaxine.

Journal: Clinical chemistry 20020101

Title: Venlafaxine and breast-feeding.

Journal: The American journal of psychiatry 20011201

Title: Rapid high-performance liquid chromatographic measurement of venlafaxine and O-desmethylvenlafaxine in human plasma. Application to management of acute intoxications.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20010905

Title: Use of vancomycin silica stationary phase in packed capillary electrochromatography. II. Enantiomer separation of venlafaxine and O-desmethylvenlafaxine in human plasma.

Journal: Journal of chromatography. A 20010601

Title: Nonaqueous capillary electrophoresis-mass spectrometry for separation of venlafaxine and its phase I metabolites.

Journal: Electrophoresis 20010201

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Tags:93413-62-8 Molecular Formula|93413-62-8 MDL|93413-62-8 SMILES|93413-62-8 4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol