Home Other Building Blocks 937263-43-9
937263-43-9,MFCD22380467
Catalog No.:AA00GTX3

937263-43-9 | Irbinitinib

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$7.00   $5.00
- +
100mg
98%
in stock  
$89.00   $62.00
- +
250mg
98%
in stock  
$150.00   $105.00
- +
1g
98%
in stock  
$403.00   $282.00
- +
5g
98%
in stock  
$1,696.00   $1,187.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00GTX3
Chemical Name:
Irbinitinib
CAS Number:
937263-43-9
Molecular Formula:
C26H24N8O2
Molecular Weight:
480.5212
MDL Number:
MFCD22380467
SMILES:
Cc1cc(ccc1Oc1ccn2c(c1)ncn2)Nc1ncnc2c1cc(cc2)NC1=NC(CO1)(C)C
Properties
Computed Properties
 
Complexity:
796  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
4  

Downstream Synthesis Route

[1]CurrentPatentAssignee:PFIZERINC-WO2013/142875,2013,A1Locationinpatent:Paragraph00154

[1]CurrentPatentAssignee:PFIZERINC-WO2013/142875,2013,A1Locationinpatent:Paragraph00153

[2]CurrentPatentAssignee:PFIZERINC-US9457093,2016,B2Locationinpatent:Page/Pagecolumn21;22

[3]DeVries,Peter;Forero-Torres,Andres;Kulukian,Anita;Lee,Patrice;Peterson,Scott;Rosler,Robert;Taylor,Janelle;Watson,Daniel[MolecularCancerTherapeutics,2020,vol.19,#4,p.976-987]

[4]Lyu,Yaodong;Huang,Liliang;Zhu,Xiaolei;Lu,Sheng;Mao,Yongjun[OrganicPreparationsandProceduresInternational,2021,vol.53,#6,p.554-561]

[5]CurrentPatentAssignee:PFIZERINC-WO2013/56108,2013,A2Locationinpatent:Paragraph000141

[6]Müller,Marius;Shalgunov,Vladimir;Hvass,Lars;Jørgensen,JesperT.;Kramer,Vasko;Staudt,Markus;Battisti,UmbertoMaria;Kjaer,Andreas;Herth,MatthiasM.[BioorganicandMedicinalChemistryLetters,2023,vol.80]

[7]Müller,Marius;Shalgunov,Vladimir;Hvass,Lars;Jørgensen,JesperT.;Kramer,Vasko;Staudt,Markus;Battisti,UmbertoMaria;Kjaer,Andreas;Herth,MatthiasM.[BioorganicandMedicinalChemistryLetters,2023,vol.80]

[8]CurrentPatentAssignee:GUANGDONGRUNXINGBIOLOGICALTECH-CN115650977,2023,ALocationinpatent:Paragraph0044-0047

[1]CurrentPatentAssignee:SHANGHAIUNIVERSITYOFENGINEERINGSCIENCES-CN109942576,2019,A

[2]Bu,Lehao;Chen,Wenxin;Liu,Yaowei;Mao,Yongjun;Yin,Lingfeng;Zhang,Long[Synthesis,2019,vol.51,#13,p.2660-2664]

[3]Bu,Lehao;Chen,Wenxin;Liu,Yaowei;Mao,Yongjun;Yin,Lingfeng;Zhang,Long[Synthesis,2019,vol.51,#13,p.2660-2664]

[4]CurrentPatentAssignee:WUHANNINEZHOULUSTUMEDICINESCIENCEANDTECHLIMITEDCOMPANY-CN114230568,2022,A

[1]Patent:CN109942576,2019,A

[1]CurrentPatentAssignee:SHANGHAIUNIVERSITYOFENGINEERINGSCIENCES-CN109942576,2019,A

[2]Bu,Lehao;Chen,Wenxin;Liu,Yaowei;Mao,Yongjun;Yin,Lingfeng;Zhang,Long[Synthesis,2019,vol.51,#13,p.2660-2664]

[3]Bu,Lehao;Chen,Wenxin;Liu,Yaowei;Mao,Yongjun;Yin,Lingfeng;Zhang,Long[Synthesis,2019,vol.51,#13,p.2660-2664]

Literature

Title: Phase I Study of ONT-380, a HER2 Inhibitor, in Patients with HER2(+)-Advanced Solid Tumors, with an Expansion Cohort in HER2(+) Metastatic Breast Cancer (MBC).

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20170715

Title: Moulder-Thompson S, et al. Phase 1 Study of ONT-380, a HER2 Inhibitor, in Patients with HER2+ Advanced Solid Tumors, with an Expansion Cohort in HER2+ Metastatic Breast Cancer (MBC). Clin Cancer Res. 2017 Jan 4. pii: clincanres.1496.2016.

Title: Abstract: In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 852. doi:1538-7445.AM2012-852

Title: P. Lee, et al. In Vivo Activity of ARRY-380, a Potent, Small Molecule Inhibitor of ErbB2 in Combination with RP-56976. Cancer Research

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