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939981-39-2,MFCD29905459
Catalog No.:AA00GU3B

939981-39-2 | RG7112

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$21.00   $15.00
- +
5mg
98+%
in stock  
$50.00   $35.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00GU3B
Chemical Name:
RG7112
CAS Number:
939981-39-2
Molecular Formula:
C38H48Cl2N4O4S
Molecular Weight:
727.7831
MDL Number:
MFCD29905459
SMILES:
CCOc1cc(ccc1C1=NC(C(N1C(=O)N1CCN(CC1)CCCS(=O)(=O)C)(C)c1ccc(cc1)Cl)(C)c1ccc(cc1)Cl)C(C)(C)C
Properties
Computed Properties
 
Complexity:
1260  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
49  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
0  
Isotope Atom Count:
0  
Rotatable Bond Count:
10  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
7.3  

Downstream Synthesis Route
CASUnavailable 
  939981-39-2 

[1]Locationinpatent:bodytextBarriosSosa,AnaC.;Conway,Ryan;Williamson,R.Thomas;Suchy,JamesP.;Edwards,William;Cleary,Thomas[OrganicProcessResearchandDevelopment,2011,vol.15,#6,p.1458-1463]

[1]Fry,DavidC.;Wartchow,Charles;Graves,Bradford;Janson,Cheryl;Lukacs,Christine;Kammlott,Ursula;Belunis,Charles;Palme,Stefan;Klein,Christian;Vu,Binh[ACSMedicinalChemistryLetters,2013,vol.4,#7,p.660-665]

939983-66-1   
CASUnavailable 
  939981-39-2    1313611-27-6 

[1]Fry,DavidC.;Wartchow,Charles;Graves,Bradford;Janson,Cheryl;Lukacs,Christine;Kammlott,Ursula;Belunis,Charles;Palme,Stefan;Klein,Christian;Vu,Binh[ACSMedicinalChemistryLetters,2013,vol.4,#7,p.660-665]

Literature

Title: Potent effect of the MDM2 inhibitor AMG232 on suppression of glioblastoma stem cells.

Journal: Cell death & disease 20180801

Title: p53 and NF-κB coregulate proinflammatory gene responses in human macrophages.

Journal: Cancer research 20140415

Title: Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development.

Journal: ACS medicinal chemistry letters 20130509

Quotation Request
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SDS
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Tags:939981-39-2 Molecular Formula|939981-39-2 MDL|939981-39-2 SMILES|939981-39-2 RG7112
Catalog No.: AA00GU3B
939981-39-2,MFCD29905459
939981-39-2 | RG7112
Pack Size： 1mg
Purity： 98+%
in stock
$21.00 $15.00
Pack Size： 5mg
Purity： 98+%
in stock
$50.00 $35.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00GU3B
Chemical Name: RG7112
CAS Number: 939981-39-2
Molecular Formula: C38H48Cl2N4O4S
Molecular Weight: 727.7831
MDL Number: MFCD29905459
SMILES: CCOc1cc(ccc1C1=NC(C(N1C(=O)N1CCN(CC1)CCCS(=O)(=O)C)(C)c1ccc(cc1)Cl)(C)c1ccc(cc1)Cl)C(C)(C)C
Properties
Complexity: 1260  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 2  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 49  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 0  
Isotope Atom Count: 0  
Rotatable Bond Count: 10  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 7.3  
Downstream Synthesis Route
CASUnavailable 
  939981-39-2 

[1]Locationinpatent:bodytextBarriosSosa,AnaC.;Conway,Ryan;Williamson,R.Thomas;Suchy,JamesP.;Edwards,William;Cleary,Thomas[OrganicProcessResearchandDevelopment,2011,vol.15,#6,p.1458-1463]

1313703-90-0    939981-39-2    1313611-27-6 

[1]Fry,DavidC.;Wartchow,Charles;Graves,Bradford;Janson,Cheryl;Lukacs,Christine;Kammlott,Ursula;Belunis,Charles;Palme,Stefan;Klein,Christian;Vu,Binh[ACSMedicinalChemistryLetters,2013,vol.4,#7,p.660-665]

939983-66-1   
CASUnavailable 
  939981-39-2    1313611-27-6 

[1]Fry,DavidC.;Wartchow,Charles;Graves,Bradford;Janson,Cheryl;Lukacs,Christine;Kammlott,Ursula;Belunis,Charles;Palme,Stefan;Klein,Christian;Vu,Binh[ACSMedicinalChemistryLetters,2013,vol.4,#7,p.660-665]

Literature fold

Title: Potent effect of the MDM2 inhibitor AMG232 on suppression of glioblastoma stem cells.

Journal: Cell death & disease20180801

Title: p53 and NF-κB coregulate proinflammatory gene responses in human macrophages.

Journal: Cancer research20140415

Title: Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development.

Journal: ACS medicinal chemistry letters20130509

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