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Journal: The Lancet. Haematology 20180201
Title: Differences in gene expression and alterations in cell cycle of acute myeloid leukemia cell lines after treatment with JAK inhibitors.
Journal: European journal of pharmacology 20151015
Title: The novel Janus kinase inhibitor ruxolitinib confers protection against carbon tetrachloride-induced hepatotoxicity via multiple mechanisms.
Journal: Chemico-biological interactions 20140905
Title: Ruxolitinib and tofacitinib are potent and selective inhibitors of HIV-1 replication and virus reactivation in vitro.
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Title: Regulation of inflammatory responses in tumor necrosis factor-activated and rheumatoid arthritis synovial macrophages by JAK inhibitors.
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Title: Ruxolitinib, an oral JAK1 and JAK2 inhibitor, in myelofibrosis.
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Title: Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia.
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Title: Advances in the management of myelofibrosis.
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Journal: Deutsche medizinische Wochenschrift (1946) 20121001
Title: Therapeutic effects of ruxolitinib in patients with myelofibrosis without clinically significant splenomegaly.
Journal: Blood 20120927
Title: Inhibition of JAKs in macrophages increases lipopolysaccharide-induced cytokine production by blocking IL-10-mediated feedback.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20120915
Title: Allogeneic hematopoietic cell transplantation for myelofibrosis in the era of JAK inhibitors.
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Title: Ruxolitinib inhibits transforming JAK2 fusion proteins in vitro and induces complete cytogenetic remission in t(8;9)(p22;p24)/PCM1-JAK2-positive chronic eosinophilic leukemia.
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Title: Long-term outcomes of 107 patients with myelofibrosis receiving JAK1/JAK2 inhibitor ruxolitinib: survival advantage in comparison to matched historical controls.
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Title: U.S. Food and Drug Administration approval: ruxolitinib for the treatment of patients with intermediate and high-risk myelofibrosis.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20120615
Title: The effect of CYP3A4 inhibition or induction on the pharmacokinetics and pharmacodynamics of orally administered ruxolitinib (INCB018424 phosphate) in healthy volunteers.
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Title: Ruxolitinib: the first FDA approved therapy for the treatment of myelofibrosis.
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Title: Ruxolitinib for myelofibrosis.
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Title: Ruxolitinib for myelofibrosis.
Journal: The New England journal of medicine 20120524
Title: Phase 2 study of the JAK kinase inhibitor ruxolitinib in patients with refractory leukemias, including postmyeloproliferative neoplasm acute myeloid leukemia.
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Title: Kinase domain mutations confer resistance to novel inhibitors targeting JAK2V617F in myeloproliferative neoplasms.
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Title: Management of myeloproliferative neoplasms: from academic guidelines to clinical practice.
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Title: JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis.
Journal: The New England journal of medicine 20120301
Title: A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis.
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Title: STAT3 is activated by JAK2 independent of key oncogenic driver mutations in non-small cell lung carcinoma.
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