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944261-79-4,MFCD10574689
Catalog No.:AA005XDY

944261-79-4 | A-803467

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Purity
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1mg
98%
in stock  
$22.00   $15.00
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5mg
≥98%
in stock  
$53.00   $37.00
- +
10mg
98%
in stock  
$77.00   $54.00
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50mg
98%
in stock  
$160.00   $112.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA005XDY
Chemical Name:
A-803467
CAS Number:
944261-79-4
Molecular Formula:
C19H16ClNO4
Molecular Weight:
357.7876
MDL Number:
MFCD10574689
SMILES:
COc1cc(cc(c1)OC)NC(=O)c1ccc(o1)c1ccc(cc1)Cl
Properties
Properties
 
Form:
Solid  
MP:
128-130˚C  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
429  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
4.4  

Literature

Title: Blocking Scn10a channels in heart reduces late sodium current and is antiarrhythmic.

Journal: Circulation research 20120720

Title: A channelopathy contributes to cerebellar dysfunction in a model of multiple sclerosis.

Journal: Annals of neurology 20120201

Title: The differential effect of intrathecal Nav1.8 blockers on the induction and maintenance of capsaicin- and peripheral ischemia-induced mechanical allodynia and thermal hyperalgesia.

Journal: Anesthesia and analgesia 20120101

Title: Involvement of Nav 1.8 sodium ion channels in the transduction of mechanical pain in a rodent model of osteoarthritis.

Journal: Arthritis research & therapy 20120101

Title: Na(v)1.8 channelopathy in mutant mice deficient for myelin protein zero is detrimental to motor axons.

Journal: Brain : a journal of neurology 20110201

Title: Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives.

Journal: Bioorganic & medicinal chemistry letters 20101115

Title: Regional differences in nerve terminal Na+ channel subtype expression and Na+ channel-dependent glutamate and GABA release in rat CNS.

Journal: Journal of neurochemistry 20100601

Title: Structural determinants of drugs acting on the Nav1.8 channel.

Journal: The Journal of biological chemistry 20090417

Title: Additive antinociceptive effects of the selective Nav1.8 blocker A-803467 and selective TRPV1 antagonists in rat inflammatory and neuropathic pain models.

Journal: The journal of pain : official journal of the American Pain Society 20090301

Title: A selective Nav1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats.

Journal: The Journal of pharmacology and experimental therapeutics 20080301

Title: Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain.

Journal: Journal of medicinal chemistry 20080214

Title: Painful research: identification of a small-molecule inhibitor that selectively targets Nav1.8 sodium channels.

Journal: Molecular interventions 20070801

Title: Sodium channel blockers.

Journal: Journal of medicinal chemistry 20070531

Title: A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20070515

Title: Block of Nav1.8 by small molecules.

Journal: Channels (Austin, Tex.) 20070101

Title: Anreddy N, et al. A-803467, a tetrodotoxin-resistant sodium channel blocker, modulates ABCG2-mediated MDR in vitro and in vivo. Oncotarget. 2015;6(36):39276-39291.

Title: Jarvis MF, et al. A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. Proc Natl Acad Sci U S A. 2007;104(20):8520-8525.

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