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94535-50-9,MFCD00864806
Catalog No.:AA01E5WC

94535-50-9 | Levcromakalim

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10mg
≥99%
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$407.00   $285.00
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50mg
≥99%
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$1,597.00   $1,118.00
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01E5WC
Chemical Name:
Levcromakalim
CAS Number:
94535-50-9
Molecular Formula:
C16H18N2O3
Molecular Weight:
286.3257
MDL Number:
MFCD00864806
SMILES:
N#Cc1ccc2c(c1)C(N1CCCC1=O)C(C(O2)(C)C)O
Properties
Computed Properties
 
Complexity:
481  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
0.8  

Literature

Title: Pharmacological preconditioning of ATP-sensitive potassium channel openers on acute urinary retention-induced bladder dysfunction in the rat.

Journal: BJU international 20120901

Title: Synthesis and pharmacological activity of N-(2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)-4H-1,2,4-benzothiadiazine-3-carboxamides 1,1-dioxides on rat uterus, rat aorta and rat pancreatic β-cells.

Journal: European journal of medicinal chemistry 20120801

Title: CaMKII inhibition hyperpolarizes membrane and blocks nitrergic IJP by closing a Cl(-) conductance in intestinal smooth muscle.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20120715

Title: Isoflurane pretreatment preserves adenosine triphosphate-sensitive K(+) channel function in the human artery exposed to oxidative stress caused by high glucose levels.

Journal: Anesthesia and analgesia 20120701

Title: The role of K ATP channels on ischemia-reperfusion injury in the rat testis.

Journal: Life sciences 20120515

Title: Mineralocorticoids participate in the reduced vascular reactivity of pregnant rats.

Journal: American journal of physiology. Heart and circulatory physiology 20120301

Title: Role of potassium channels in the antidepressant-like effect of folic acid in the forced swimming test in mice.

Journal: Pharmacology, biochemistry, and behavior 20120301

Title: K(ATP) channel openers in the trigeminovascular system.

Journal: Cephalalgia : an international journal of headache 20120101

Title: Vasodilator effects of cromakalim and HA 1077 in diabetic rat aorta.

Journal: Swiss medical weekly 20120101

Title: The relaxant action of nicorandil in bovine tracheal smooth muscle.

Journal: Pharmacology 20120101

Title: A novel cromakalim analogue induces cell cycle arrest and apoptosis in human cervical carcinoma HeLa cells through the caspase- and mitochondria-dependent pathway.

Journal: International journal of oncology 20111201

Title: Reopening of ATP-sensitive potassium channels reduces neuropathic pain and regulates astroglial gap junctions in the rat spinal cord.

Journal: Pain 20111101

Title: Eicosapentaenoic acid reduces ischemic ventricular fibrillation via altering monophasic action potential in pigs.

Journal: Journal of molecular and cellular cardiology 20110901

Title: Interaction of morphine and potassium channel openers on experimental models of pain in mice.

Journal: Fundamental & clinical pharmacology 20110801

Title: Modulation of the 6-position of benzopyran derivatives and inhibitory effects on the insulin releasing process.

Journal: Bioorganic & medicinal chemistry 20110701

Title: Phasic activity of urinary bladder smooth muscle in the streptozotocin-induced diabetic rat: effect of potassium channel modulators.

Journal: European journal of pharmacology 20110625

Title: Impaired vascular responses of insulin-resistant rats after mild subarachnoid hemorrhage.

Journal: American journal of physiology. Heart and circulatory physiology 20110601

Title: Nicorandil ameliorates ischaemia-reperfusion injury in the rat kidney.

Journal: British journal of pharmacology 20110501

Title: Role of different types of potassium channels and peroxisome proliferator-activated receptors γ in the antidepressant-like activity of bis selenide in the mouse tail suspension test.

Journal: Neuroscience letters 20110303

Title: Potassium channel openers exhibit cross-tolerance with morphine in two experimental models of pain.

Journal: The West Indian medical journal 20101001

Title: Interspecies differences and extracellular calcium dependence in the vasorelaxing effect of cromakalim in isolated human, porcine, and canine coronary arteries.

Journal: Journal of cardiovascular pharmacology and therapeutics 20100901

Title: Evidence of the involvement of K+ channels and PPARgamma receptors in the antidepressant-like activity of diphenyl diselenide in mice.

Journal: The Journal of pharmacy and pharmacology 20100901

Title: Direct effect of mild hypothermia on the coronary vasodilation induced by an ATP-sensitive K channel opener, a nitric oxide donor and isoflurane in isolated rat hearts.

Journal: Journal of anesthesia 20100801

Title: Effects of K openers on the QT prolongation induced by HERG-blocking drugs in guinea-pigs.

Journal: The Journal of pharmacy and pharmacology 20100701

Title: The role of ATP-sensitive potassium channel on acute urinary retention and subsequent catheterization in the rat.

Journal: European journal of pharmacology 20100610

Title: K(ATP) channel openers protect mesencephalic neurons against MPP+-induced cytotoxicity via inhibition of ROS production.

Journal: Journal of neuroscience research 20100201

Title: Cellular coupling of potassium channels with beta2 adrenoceptors in mediating myometrial relaxation in buffaloes (Bubalus bubalis).

Journal: Journal of veterinary pharmacology and therapeutics 20100201

Title: ATP-sensitive potassium channels contribute to the time-dependent alteration in the pentylenetetrazole-induced seizure threshold in diabetic mice.

Journal: Seizure 20100101

Title: Assessment of ECG interval and restitution parameters in the canine model of short QT syndrome.

Journal: Journal of pharmacological and toxicological methods 20100101

Title: New R/S-3,4-dihydro-2,2-dimethyl-2H-1-benzopyrans as K(ATP) channel openers: modulation of the 4-position.

Journal: Bioorganic & medicinal chemistry 20091115

Title: The effect of progesterone on myometrial contractility, potassium channels, and tocolytic efficacy.

Journal: Reproductive sciences (Thousand Oaks, Calif.) 20091101

Title: Beneficial effect of propofol on arterial adenosine triphosphate-sensitive K+ channel function impaired by thromboxane.

Journal: Anesthesiology 20090801

Title: Prevention of cerebral vasospasm by local delivery of cromakalim with a biodegradable controlled-release system in a rat model of subarachnoid hemorrhage.

Journal: Journal of neurosurgery 20090501

Title: Positive inotropic effects of Tityus cambridgei and T. serrulatus scorpion venoms on skeletal muscle.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20090401

Title: ATP-sensitive K+ channels in pig urethral smooth muscle cells are heteromultimers of Kir6.1 and Kir6.2.

Journal: American journal of physiology. Renal physiology 20090101

Title: Vascular effects of estrone and diethylstilbestrol in porcine coronary arteries.

Journal: Menopause (New York, N.Y.) 20090101

Title: Role of potassium channels in the relaxant effect of levosimendan in guinea pig tracheal preparations.

Journal: Pharmacological reports : PR 20090101

Title: Syntaxin-1A inhibition of P-1075, cromakalim, and diazoxide actions on mouse cardiac ATP-sensitive potassium channel.

Journal: Cardiovascular research 20081201

Title: QSAR study about ATP-sensitive potassium channel activation of cromakalim analogues using CP-MLR approach.

Journal: European journal of medicinal chemistry 20081101

Title: Spontaneous contractions of the pig urinary bladder: the effect of ATP-sensitive potassium channels and the role of the mucosa.

Journal: BJU international 20081101

Title: Levcromakalim and MgGDP activate small conductance ATP-sensitive K+ channels of K+ channel pore 6.1/sulfonylurea receptor 2A in pig detrusor smooth muscle cells: uncoupling of cAMP signal pathways.

Journal: The Journal of pharmacology and experimental therapeutics 20081001

Title: K+ channel inhibition modulates the biochemical and morphological differentiation of human placental cytotrophoblast cells in vitro.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20081001

Title: Roles of phosphatidylinositol 3-kinase-Akt and NADPH oxidase in adenosine 5'-triphosphate-sensitive K+ channel function impaired by high glucose in the human artery.

Journal: Hypertension (Dallas, Tex. : 1979) 20080901

Title: K(ATP)-mediated vasodilation is impaired in obese Zucker rats.

Journal: Microcirculation (New York, N.Y. : 1994) 20080801

Title: Molecular determinants for the activating/blocking actions of the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the skeletal muscle KATP channels.

Journal: Molecular pharmacology 20080701

Title: Decreased expression of aortic KIR6.1 and SUR2B in hypertension does not correlate with changes in the functional role of K(ATP) channels.

Journal: European journal of pharmacology 20080610

Title: Nutritional level and energetic source are determinants of elevated circulatory lipohydroperoxide concentration.

Journal: The British journal of nutrition 20080601

Title: Synthesis and activity on rat aorta rings and rat pancreatic beta-cells of ring-opened analogues of benzopyran-type potassium channel activators.

Journal: Bioorganic & medicinal chemistry 20080601

Title: [Effects of potassium channel activators on transient inward current in guinea pig ventricular myocytes].

Journal: Zhonghua er ke za zhi = Chinese journal of pediatrics 20080601

Title: New R/S-3,4-dihydro-2,2-dimethyl-6-halo-4-(phenylaminothiocarbonylamino)-2H-1-benzopyrans structurally related to (+/-)-cromakalim as tissue-selective pancreatic beta-cell K(ATP) channel openers.

Journal: Bioorganic & medicinal chemistry 20080515

Title: K(ATP) channel expression and pharmacological in vivo and in vitro studies of the K(ATP) channel blocker PNU-37883A in rat middle meningeal arteries.

Journal: British journal of pharmacology 20080501

Title: Cromakalim activates the K(ATP) and enhances spontaneous transient outward potassium currents in rat saphenous arterial myocytes.

Journal: Pharmacological research 20080501

Title: Mitochondrial ATP-sensitive K+ channels regulate NMDAR activity in the cortex of the anoxic western painted turtle.

Journal: The Journal of physiology 20080215

Title: The synthesis and biological evaluation of a range of novel functionalized benzopyrans as potential potassium channel activators.

Journal: Bioorganic & medicinal chemistry letters 20080201

Title: Inhibitory effects of different ATP-sensitive potassium channel openers on electrically generated and carbachol-induced contractions of porcine and human detrusor muscle.

Journal: Fundamental & clinical pharmacology 20080201

Title: Reduced expression of Kir6.2/SUR2A subunits explains KATP deficiency in K+-depleted rats.

Journal: Neuromuscular disorders : NMD 20080101

Title: Role of different types of potassium channels in the antidepressant-like effect of agmatine in the mouse forced swimming test.

Journal: European journal of pharmacology 20071201

Title: Acute antihypertensive action of Tempol in the spontaneously hypertensive rat.

Journal: American journal of physiology. Heart and circulatory physiology 20071201

Title: The endogenous cannabinoid anandamide inhibits cromakalim-activated K+ currents in follicle-enclosed Xenopus oocytes.

Journal: The Journal of pharmacology and experimental therapeutics 20071101

Title: Vasorelaxant effect of levcromakalim on isolated umbilical arteries of preeclamptic women.

Journal: European journal of obstetrics, gynecology, and reproductive biology 20071001

Title: Time-dependent alteration in cromakalim-induced relaxation of corpus cavernosum from streptozocin-induced diabetic rats.

Journal: Life sciences 20070901

Title: Store-refilling involves both L-type calcium channels and reverse-mode sodium-calcium exchange in airway smooth muscle.

Journal: The European respiratory journal 20070801

Title: K+ channel modulation of slow wave activity in the guinea-pig prostate.

Journal: British journal of pharmacology 20070701

Title: Inhibition of KATP channels in the rat tail artery by neurally released noradrenaline acting on postjunctional alpha2-adrenoceptors.

Journal: The Journal of physiology 20070601

Title: Role of ATP-sensitive potassium channels in the biphasic effects of morphine on pentylenetetrazole-induced seizure threshold in mice.

Journal: Epilepsy research 20070601

Title: Inhibitory effect of tramadol on vasorelaxation mediated by ATP-sensitive K+ channels in rat aorta.

Journal: Canadian journal of anaesthesia = Journal canadien d'anesthesie 20070601

Title: The inhibition of different types of potassium channels underlies the antidepressant-like effect of adenosine in the mouse forced swimming test.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20070413

Title: Smooth muscle mediates circumferential conduction of hyperpolarization and relaxation to focal endothelial cell activation in large coronary arteries.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20070401

Title: Vardenafil increases coronary flow response to hypercapnic acidosis in isolated guinea pig heart.

Journal: Basic research in cardiology 20070301

Title: Differential effects of etomidate and midazolam on vascular adenosine triphosphate-sensitive potassium channels: isometric tension and patch clamp studies.

Journal: Anesthesiology 20070301

Title: Electrophysiological and pharmacological characterization of the K(ATP) channel involved in the K+-current responses to FSH and adenosine in the follicular cells of Xenopus oocyte.

Journal: The journal of physiological sciences : JPS 20070201

Title: Matrix metalloproteinase 2-induced venous dilation via hyperpolarization and activation of K+ channels: relevance to varicose vein formation.

Journal: Journal of vascular surgery 20070201

Title: Effect of KATP channel openers on myogenic and neurogenic responses in goat urinary bladder.

Journal: Indian journal of experimental biology 20070201

Title: Alteration of vascular reactivity in diabetic human mammary artery and the effects of thiazolidinediones.

Journal: The Journal of pharmacy and pharmacology 20061201

Title: Opening mitoKATP increases superoxide generation from complex I of the electron transport chain.

Journal: American journal of physiology. Heart and circulatory physiology 20061101

Title: Mechanism of reactive oxygen species generation after opening of mitochondrial KATP channels.

Journal: American journal of physiology. Heart and circulatory physiology 20061101

Title: Propofol and thiopental attenuate adenosine triphosphate-sensitive potassium channel relaxation in pulmonary veins.

Journal: American journal of physiology. Lung cellular and molecular physiology 20061001

Title: Impairment of the vascular relaxation and differential expression of caveolin-1 of the aorta of diabetic +db/+db mice.

Journal: European journal of pharmacology 20060928

Title: Activation of the iberiotoxin-sensitive BKCa channels by salvianolic acid B of the porcine coronary artery smooth muscle cells.

Journal: European journal of pharmacology 20060928

Title: Beat-to-Beat variability of repolarization determines proarrhythmic outcome in dogs susceptible to drug-induced torsades de pointes.

Journal: Journal of the American College of Cardiology 20060919

Title: The role of potassium channels in the vasodilatory effect of levosimendan in human internal thoracic arteries.

Journal: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20060801

Title: Design, synthesis, and pharmacological evaluation of R/S-3,4-dihydro-2,2-dimethyl- 6-halo-4-(phenylaminocarbonylamino)-2H-1-benzopyrans: toward tissue-selective pancreatic beta-cell KATP channel openers structurally related to (+/-)-cromakalim.

Journal: Journal of medicinal chemistry 20060727

Title: Efficacy of different vasodilators on human umbilical arterial smooth muscle under normal and reduced oxygen conditions.

Journal: Early human development 20060701

Title: Synthetic peroxisome proliferator-activated receptor-gamma agonists restore impaired vasorelaxation via ATP-sensitive K+ channels by high glucose.

Journal: The Journal of pharmacology and experimental therapeutics 20060701

Title: The potassium channel opener levcromakalim causes expansive remodelling of experimental vein grafts.

Journal: Journal of vascular surgery 20060701

Title: Synthesis and pharmacological evaluation of some N-arylsulfonyl-N-methyl-N'-(2,2-dimethyl-2H-1-benzopyran-4-yl)ureas structurally related to cromakalim.

Journal: Bioorganic & medicinal chemistry 20060515

Title: L-beta,beta-dimethylcysteine attenuates the haemodynamic responses elicited by systemic injections of peroxynitrite in anaesthetized rats.

Journal: British journal of pharmacology 20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: The role of potassium channels in relaxant effect of levosimendan in rat small mesenteric arteries.

Journal: Cardiovascular drugs and therapy 20060401

Title: Augmented activity of adenosine triphosphate-sensitive K+ channels induced by droperidol in the rat aorta.

Journal: Anesthesia and analgesia 20060301

Title: Pharmacological characterization of urinary bladder smooth muscle contractility following partial bladder outlet obstruction in pigs.

Journal: European journal of pharmacology 20060217

Title: Different glibenclamide-sensitivity of ATP-sensitive K+ currents using different patch-clamp recording methods.

Journal: European journal of pharmacology 20060215

Title: Effects of mitiglinide and sulfonylureas in isolated canine coronary arteries and perfused rat hearts.

Journal: European journal of pharmacology 20060215

Title: Evidence that inward rectifier K+ channels mediate relaxation by the PGI2 receptor agonist cicaprost via a cyclic AMP-independent mechanism.

Journal: Cardiovascular research 20060101

Title: Investigation of the relaxant effects of pinacidil and cromakalim on the sheep sphincter of Oddi.

Journal: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20060101

Title: From cromakalim to different structural classes of K(ATP) channel openers.

Journal: Current topics in medicinal chemistry 20060101

Title: Activation of endothelial NADPH oxidase during normoxic lung ischemia is KATP channel dependent.

Journal: American journal of physiology. Lung cellular and molecular physiology 20051201

Title: Multiple actions of U-37883A, an ATP-sensitive K+ channel blocker, on membrane currents in pig urethra.

Journal: European journal of pharmacology 20051107

Title: Role of SHP-1, Kv.1.2, and cGMP in nitric oxide-induced ERK1/2 MAP kinase dephosphorylation in rat vascular smooth muscle cells.

Journal: Cardiovascular research 20051101

Title: Loss of K+ATP-channel-mediated vasodilation after induction of tachyphylaxis to peroxynitrite.

Journal: Journal of cardiovascular pharmacology 20051101

Title: Role of ATP-sensitive K+ -channels in hemodynamic effects of peroxynitrite in anesthetized rats.

Journal: Journal of cardiovascular pharmacology 20051101

Title: Sulphonylurea receptors differently modulate ICC pacemaker Ca2+ activity and smooth muscle contractility.

Journal: Journal of cell science 20050915

Title: Antispasmodic and blood pressure lowering effects of Valeriana wallichii are mediated through K+ channel activation.

Journal: Journal of ethnopharmacology 20050914

Title: Role of nitric oxide scavenging in vascular response to cell-free hemoglobin transfusion.

Journal: American journal of physiology. Heart and circulatory physiology 20050901

Title: Heat shock protein modulation of KATP and KCa channel cerebrovasodilation after brain injury.

Journal: American journal of physiology. Heart and circulatory physiology 20050901

Title: The diacylglycerol lipase inhibitor RHC-80267 potentiates the relaxation to acetylcholine in rat mesenteric artery by anti-cholinesterase action.

Journal: European journal of pharmacology 20050704

Title: SUR, ABC proteins targeted by KATP channel openers.

Journal: Journal of molecular and cellular cardiology 20050601

Title: Doxapram stimulates the carotid body via a different mechanism than hypoxic chemotransduction.

Journal: Respiratory physiology & neurobiology 20050512

Title: 150-kD oxygen-regulated protein is an essential factor for insulin release.

Journal: Pancreas 20050501

Title: Endogenous hydrogen peroxide regulates the excitability of midbrain dopamine neurons via ATP-sensitive potassium channels.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050427

Title: Role of KATP channels in the regulation of rat dura and pia artery diameter.

Journal: Cephalalgia : an international journal of headache 20050401

Title: Alteration of cyclopiazonic acid-mediated contracture of mouse diaphragm after denervation.

Journal: Pharmacology 20050301

Title: Inhibitory effects of lidocaine and mexiletine on vasorelaxation mediated by adenosine triphosphate-sensitive K+ channels and the role of kinases in the porcine coronary artery.

Journal: Anesthesiology 20050301

Title: Changes in pH increase perfusion pressure of coronary arteries in the rat.

Journal: Journal of pharmacological sciences 20050301

Title: Involvement of adenosine triphosphate-sensitive potassium channels in the response of membrane potential to hyperosmolality in cultured human aorta endothelial cells.

Journal: Anesthesia and analgesia 20050201

Title: 4,6-Disubstituted 2,2-dimethylchromans structurally related to the K(ATP) channel opener cromakalim: design, synthesis, and effect on insulin release and vascular tone.

Journal: Journal of medicinal chemistry 20050127

Title: KATP-channel-induced vasodilation is modulated by the Na,K-pump activity in rabbit coronary small arteries.

Journal: British journal of pharmacology 20041201

Title: Effect of two amino acids in TM17 of Sulfonylurea receptor SUR1 on the binding of ATP-sensitive K+ channel modulators.

Journal: Diabetes 20041201

Title: Effect of chronic insulin on cromakalim-induced relaxation in established streptozotocin-diabetic rat basilar artery.

Journal: European journal of pharmacology 20041103

Title: Altered vascular reactivity and KATP channel currents in vascular smooth muscle cells from deoxycorticosterone acetate (DOCA)-salt hypertensive rats.

Journal: Journal of cardiovascular pharmacology 20041101

Title: Pathophysiological plasma ET-1 levels antagonize beta-adrenergic dilation of coronary resistance vessels in conscious dogs.

Journal: American journal of physiology. Heart and circulatory physiology 20041001

Title: Lys-[Leu8,des-Arg9]-bradykinin blocks lipopolysaccharide-induced SHR aorta hyperpolarization by inhibition of Ca(++)- and ATP-dependent K+ channels.

Journal: European journal of pharmacology 20040913

Title: Visceral periadventitial adipose tissue regulates arterial tone of mesenteric arteries.

Journal: Hypertension (Dallas, Tex. : 1979) 20040901

Title: Lidocaine impairs vasodilation mediated by adenosine triphosphate-sensitive K+ channels but not by inward rectifier K+ channels in rat cerebral microvessels.

Journal: Anesthesia and analgesia 20040901

Title: Role of adenosine triphosphate-dependent potassium channels in canine penile erection.

Journal: Urology 20040901

Title: Ca2+ flux through voltage-gated channels with flow cessation in pulmonary microvascular endothelial cells.

Journal: Microcirculation (New York, N.Y. : 1994) 20040901

Title: The synergistic effect of adenosine A2A receptors agonist, type IV phosphodiestease inhibitor and ATP-sensitive K channels activation on free radicals production and aggregation of human polymorphoneuclear leukocytes.

Journal: Pharmacological research 20040801

Title: The protective effect of protein kinase C and adenosine triphosphate-sensitive potassium channel agonists against inflammation in rat endothelium and vascular smooth muscle in vitro and in vivo.

Journal: Anesthesia and analgesia 20040801

Title: Altered gene expression and increased bursting activity of colonic smooth muscle ATP-sensitive K+ channels in experimental colitis.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20040701

Title: Effects of bupivacaine enantiomers and ropivacaine on vasorelaxation mediated by adenosine triphosphate-sensitive K(+) channels in the rat aorta.

Journal: Anesthesiology 20040701

Title: Spreading dilatation in rat mesenteric arteries associated with calcium-independent endothelial cell hyperpolarization.

Journal: The Journal of physiology 20040501

Title: Recent developments in the chemistry of potassium channel activators: the cromakalim analogs.

Journal: Current medicinal chemistry 20040501

Title: Endothelial cell proliferation associated with abrupt reduction in shear stress is dependent on reactive oxygen species.

Journal: Antioxidants & redox signaling 20040401

Title: Role of ATP-sensitive K+ channels in relaxation of penile resistance arteries.

Journal: Urology 20040401

Title: Amplification by hyperoxia of coronary vasodilation induced by propofol.

Journal: Anesthesia and analgesia 20040301

Title: Blocking actions of glibenclamide on ATP-sensitive K+ channels in pig urethral myocytes.

Journal: The Journal of pharmacy and pharmacology 20040301

Title: Cocaine inhibits cromakalim-activated K+ currents in follicle-enclosed Xenopus oocytes.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20040201

Title: [High throughput screening method of potassium channel regulators].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20040201

Title: Correlation between spontaneous electrical, calcium and mechanical activity in detrusor smooth muscle of the guinea-pig bladder.

Journal: British journal of pharmacology 20040101

Title: 1-(2-pyrimidinyl)-piperazine, a buspirone metabolite, modulates bladder function in the anesthetized rat.

Journal: Neurourology and urodynamics 20040101

Title: Effects of ouabain on human bronchial muscle in vitro.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20031101

Title: Diazoxide induces delayed pre-conditioning in cultured rat cortical neurons.

Journal: Journal of neurochemistry 20031101

Title: ATP-dependent K+ channels in renal ischemia reperfusion injury.

Journal: Renal failure 20031101

Title: Shear stress increases expression of a KATP channel in rat and bovine pulmonary vascular endothelial cells.

Journal: American journal of physiology. Cell physiology 20031001

Title: Cromakalim inhibits transmitter acetylcholine release in rat trachea by an action on epithelial cells and a diffusible factor.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20031001

Title: Highly potent 1,4-benzothiazine derivatives as K(ATP)-channel openers.

Journal: Journal of medicinal chemistry 20030814

Title: Effect of acute hypoxia on ATP-sensitive potassium currents in substantia gelatinosa neurons of juvenile rats.

Journal: Pflugers Archiv : European journal of physiology 20030801

Title: The role of K+ channels in vasorelaxation induced by hypoxia and the modulator effects of lidocaine in the rat carotid artery.

Journal: Anesthesia and analgesia 20030801

Title: Melatonin inhibits nitrate tolerance in isolated coronary arteries.

Journal: British journal of pharmacology 20030801

Title: Differential role of PTK and ERK MAPK in superoxide impairment of K(ATP) and K(Ca) channel cerebrovasodilation.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20030701

Title: Role of cyclooxygenase-1 and -2, phospholipase C, and protein kinase C in prostaglandin-mediated gastroprotection.

Journal: The Journal of pharmacology and experimental therapeutics 20030601

Title: Mitochondrial K ATP channel activation is important in the antiarrhythmic and cardioprotective effects of non-hypotensive doses of nicorandil and cromakalim during ischemia/reperfusion: a study in an intact anesthetized rabbit model.

Journal: Pharmacological research 20030601

Title: Defibrillatory action of glibenclamide is independent from ATP-sensitive K+ channels and free radicals.

Journal: Journal of cardiovascular pharmacology 20030601

Title: Differential antivasoconstrictor effects of levcromakalim and rilmakalim on the isolated human mammary artery and saphenous vein.

Journal: Journal of pharmacological sciences 20030601

Title: Effect of hypoxia on vasodilator responses to S-nitroso-N-acetylpenicillamine and levcromakalim in guinea pig basilar artery.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20030501

Title: Dualistic actions of cromakalim and new potent 2H-1,4-benzoxazine derivatives on the native skeletal muscle K ATP channel.

Journal: British journal of pharmacology 20030501

Title: Increased superoxide dismutase and Na+, K+-ATPase activities in aortic strips from potassium-adapted rats: implication for altered vascular reactivity.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20030501

Title: Potassium channel activators based on the benzopyran substructure: synthesis and activity of the C-8 substituent.

Journal: Bioorganic & medicinal chemistry 20030417

Title: Coronary myogenic constriction antagonizes EDHF-mediated dilation: role of KCa channels.

Journal: Hypertension (Dallas, Tex. : 1979) 20030401

Title: Mexiletine differentially modulates vasorelaxation mediated by adenosine triphosphate-sensitive K+ channels in aortas from normotensive and hypertensive rats.

Journal: Anesthesia and analgesia 20030301

Title: [Analyses of Ca-related ion channel currents and their involvement in Ca mobilization in smooth muscle and endothelial cells].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20030301

Title: Differential effects of ascorbate on endothelium-derived hyperpolarizing factor (EDHF)-mediated vasodilatation in the bovine ciliary vascular bed and coronary artery.

Journal: British journal of pharmacology 20030301

Title: Functional role of potassium channels in the vasodilating mechanism of levosimendan in porcine isolated coronary artery.

Journal: Cardiovascular drugs and therapy 20030301

Title: Contractile responses of the human umbilical artery to KCl and serotonin in Ca-free medium and the effects of levcromakalim.

Journal: Life sciences 20030207

Title: In vivo evaluation of the potency and bladder-vascular selectivity of the ATP-sensitive potassium channel openers (-)-cromakalim, ZD6169 and WAY-133537 in rats.

Journal: BJU international 20030201

Title: Differential effects of sulphonylureas on the vasodilatory response evoked by K(ATP) channel openers.

Journal: Fundamental & clinical pharmacology 20030201

Title: [Effect of levcromakalim and cromakalim on ATP-sensitive K+ channel of pulmonary arterial smooth muscle cells in pulmonary hypertensive rats].

Journal: Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20030201

Title: Inhibitory effects of etomidate and ketamine on adenosine triphosphate-sensitive potassium channel relaxation in canine pulmonary artery.

Journal: Anesthesiology 20030101

Title: Effects of ATP-sensitive K+ channel openers and tolterodine on involuntary bladder contractions in a pig model of partial bladder outlet obstruction.

Journal: Neurourology and urodynamics 20030101

Title: Inhibition of cromakalim-activated K+ current by ethanol in follicle-enclosed Xenopus oocytes.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20030101

Title: Antiulcer activity of levcromakalim and nicorandil in albino rats: a comparative study.

Journal: Polish journal of pharmacology 20030101

Title: Alterations in KATP and KCa channel function in cerebral arteries of insulin-resistant rats.

Journal: American journal of physiology. Heart and circulatory physiology 20021201

Title: Ketamine stereoselectively affects vasorelaxation mediated by ATP-sensitive K(+) channels in the rat aorta.

Journal: Anesthesiology 20021001

Title: Synthesis and vasorelaxant activity of new 1,4-benzoxazine derivatives potassium channel openers.

Journal: Bioorganic & medicinal chemistry 20020801

Title: Effects of chronic treatment with cromakalim and glibenclamide in alloxan-induced diabetic rats.

Journal: Pharmacological research 20020801

Title: Molecular modeling and QSAR studies on K(ATP) channel openers of the benzopyran type.

Journal: Journal of molecular graphics & modelling 20020801

Title: Protein tyrosine kinase and mitogen-activated protein kinase activation contribute to K(ATP) and K(ca) channel impairment after brain injury.

Journal: Brain research 20020712

Title: Potassium channels and human corporeal smooth muscle cell tone: diabetes and relaxation of human corpus cavernosum smooth muscle by adenosine triphosphate sensitive potassium channel openers.

Journal: The Journal of urology 20020701

Title: Modified ionic models of cardiac tissue for efficient large scale computations.

Journal: Physics in medicine and biology 20020607

Title: Structure-Activity studies for a novel series of tricyclic dihydropyrimidines as K(ATP) channel openers (KCOs).

Journal: Bioorganic & medicinal chemistry letters 20020603

Title: The JT-area indicates dispersion of repolarization in dogs with atrioventricular block.

Journal: Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 20020601

Title: Effect of 17beta-estradiol exposure on vasorelaxation induced by K(+) channel openers and Ca(2+) channel blockers.

Journal: Pharmacology 20020501

Title: Gene transfer of Cu/Zn SOD to cerebral vessels prevents FPI-induced CBF autoregulatory dysfunction.

Journal: American journal of physiology. Heart and circulatory physiology 20020501

Title: Opening of mitochondrial ATP-sensitive potassium channels evokes oxygen radical generation in rabbit heart slices.

Journal: Journal of biochemistry 20020501

Title: Effects of K(ATP) channel modulators on acetylcholine release from guinea-pig isolated atria and small intestine.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20020501

Title: Effects of cromakalim and glibenclamide on arteriolar and venular diameters and macromolecular leakage in the microcirculation during ischemia/reperfusion.

Journal: Journal of cardiovascular pharmacology 20020301

Title: Characterisation of the effects of potassium channel modulating agents on mouse intestinal smooth muscle.

Journal: The Journal of pharmacy and pharmacology 20020301

Title: Vasorelaxant properties of isolated human radial arteries: comparison with internal mammary arteries.

Journal: Atherosclerosis 20020201

Title: Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in human mesenteric arteries.

Journal: Biochemical and biophysical research communications 20020125

Title: Circumferential stretching of saphenous vein smooth muscle enhances vasoconstrictor responses by Rho kinase-dependent pathways.

Journal: Cardiovascular research 20020101

Title: The molecular composition of K(ATP) channels in human pulmonary artery smooth muscle cells and their modulation by growth.

Journal: American journal of respiratory cell and molecular biology 20020101

Title: Evidence for the possible involvement of Ca2+ entry blockade in the relaxation by class I antiarrhythmic drugs in the isolated pig coronary smooth muscle.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20020101

Title: Active relaxation of human gallbladder muscle is mediated by ATP-sensitive potassium channels.

Journal: Digestion 20020101

Title: Effect of mild hypothermia on nicorandil-induced vasodilation of pial arterioles in cats.

Journal: Critical care medicine 20011101

Title: Effects of different types of K+ channel modulators on the spontaneous myogenic contraction of guinea-pig urinary bladder smooth muscle.

Journal: Acta physiologica Scandinavica 20011101

Title: Dimethylsulfoxide and ethanol, commonly used diluents, prevent dilation of pial arterioles by openers of K(ATP) ion channels.

Journal: European journal of pharmacology 20011026

Title: Endothelin-Induced cyclooxygenase-dependent superoxide generation contributes to K+ channel functional impairment after brain injury.

Journal: Journal of neurotrauma 20011001

Title: Identification and properties of a novel intracellular (mitochondrial) ATP-sensitive potassium channel in brain.

Journal: The Journal of biological chemistry 20010907

Title: K(ATP) channel opening during ischemia: effects on myocardial noradrenaline release and ventricular arrhythmias.

Journal: Journal of cardiovascular pharmacology 20010901

Title: Protein kinase A-dependent and -independent effects of isoproterenol in rat isolated mesenteric artery: interactions with levcromakalim.

Journal: The Journal of pharmacology and experimental therapeutics 20010901

Title: Analysis of responses to hAmylin, hCGRP, and hADM in isolated resistance arteries from the mesenteric vascular bed of the rat.

Journal: Peptides 20010901

Title: A xanthine-based KMUP-1 with cyclic GMP enhancing and K(+) channels opening activities in rat aortic smooth muscle.

Journal: British journal of pharmacology 20010901

Title: Vasopressin induced cyclooxygenase dependent superoxide generation contributes to K(+) channel function impairment after brain injury.

Journal: Brain research 20010810

Title: Cibenzoline has an inhibitory effect on vasorelaxation mediated by adenosine triphosphate-sensitive K(+) channels in the rat carotid artery.

Journal: Anesthesia and analgesia 20010801

Title: An ATP-sensitive K(+) conductance in dissociated neurones from adult rat intracardiac ganglia.

Journal: The Journal of physiology 20010801

Title: Further investigations into the endothelium-dependent hyperpolarizing effects of bradykinin and substance P in porcine coronary artery.

Journal: British journal of pharmacology 20010801

Title: Comparison of the inhibitory effects of cromakalim and pinacidil (potassium channel openers) with those of oxybutynin on stimulated guinea pig and rabbit detrusor muscle strips.

Journal: Archives of gynecology and obstetrics 20010801

Title: Influence of ATP-sensitive K+ channel modulation on the mechanical properties of diabetic myocardium.

Journal: Endocrine research 20010801

Title: Restoration of vasodilation and CBF autoregulation by genistein in rat pial artery after brain injury.

Journal: American journal of physiology. Heart and circulatory physiology 20010701

Title: The effects of flecainide on ATP-sensitive K(+) channels in pig urethral myocytes.

Journal: British journal of pharmacology 20010701

Title: Mild alkalinization and acidification differentially modify the effects of lidocaine or mexiletine on vasorelaxation mediated by ATP-sensitive K+ channels.

Journal: Anesthesiology 20010701

Title: Hemodynamic effects of levcromakalim in neonatal porcine pulmonary hypertension.

Journal: Biology of the neonate 20010701

Title: K(ATP) channels predominantly regulate conduit vessel tone in normoxic cat pulmonary arteries in vivo.

Journal: European journal of pharmacology 20010622

Title: Pharmacologic characterization of BMS-191095, a mitochondrial K(ATP) opener with no peripheral vasodilator or cardiac action potential shortening activity.

Journal: The Journal of pharmacology and experimental therapeutics 20010601

Title: Vasopressin-induced protein kinase C-dependent superoxide generation contributes to atp-sensitive potassium channel but not calcium-sensitive potassium channel function impairment after brain injury.

Journal: Stroke 20010601

Title: Endothelium-dependent desensitization to angiotensin II in rabbit aorta: the mechanisms involved.

Journal: Canadian journal of physiology and pharmacology 20010601

Title: The effect of pretreatment with ischaemic preconditioning or cromakalim on perfusion in skeletal muscle during ischaemia-reperfusion injury.

Journal: International angiology : a journal of the International Union of Angiology 20010601

Title: Low levels of K(ATP) channel activation decrease excitability and contractility of urinary bladder.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20010501

Title: Dual action of ZD6169, a novel K(+) channel opener, on ATP-sensitive K(+) channels in pig urethral myocytes.

Journal: British journal of pharmacology 20010501

Title: Evidence for a K(ATP) ion channel link in the inhibition of hypercapnic dilation of pial arterioles by 7-nitroindazole and tetrodotoxin.

Journal: European journal of pharmacology 20010413

Title: [Role of salbutamol in inducing apoptosis of cultured human airway smooth muscle cells].

Journal: Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20010401

Title: The role of K+ATP channels in the control of pre- and post-ischemic left ventricular developed pressure in septic rat hearts.

Journal: Canadian journal of physiology and pharmacology 20010301

Title: Peroxynitrite reduces vasodilatory responses to reduced intravascular pressure, calcitonin gene-related peptide, and cromakalim in isolated middle cerebral arteries.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20010301

Title: Salt-induced hypertension in rats alters the response of isolated aortic rings to cromakalim.

Journal: The West Indian medical journal 20010301

Title: Effects of K+ channel openers on I K(ATP) of human atrial myocytes at physiological temperatures.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20010201

Title: Impaired beta-adrenergic hyperpolarization in arteries from prehypertensive spontaneously hypertensive rats.

Journal: Hypertension (Dallas, Tex. : 1979) 20010201

Title: N-Acyl-1,2,3,4a,5,10b-hexahydro-[1]benzopyrano-[3,4-b][1,4]oxazine-9-carbonitriles as bladder-selective potassium channel openers.

Journal: Bioorganic & medicinal chemistry 20010201

Title: Intrahippocampal infusions of k-atp channel modulators influence spontaneous alternation performance: relationships to acetylcholine release in the hippocampus.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20010115

Title: Role of mitochondrial and sarcolemmal K(ATP) channels in ischemic preconditioning of the canine heart.

Journal: American journal of physiology. Heart and circulatory physiology 20010101

Title: The role of oxygen-derived free radicals in augmented relaxations to levcromakalim in the aorta from hypertensive rats.

Journal: Japanese journal of pharmacology 20010101

Title: Role of NO pathway, calcium and potassium channels in the peripheral pulmonary vascular tone in dogs.

Journal: The European respiratory journal 20010101

Title: A simple method to investigate the inhibitory effects of drugs on gastric emptying in the mouse in vivo.

Journal: Journal of pharmacological and toxicological methods 20010101

Title: Fluorescence-based functional assay for sarcolemmal ATP-sensitive potassium channel activation in cultured neonatal rat ventricular myocytes.

Journal: Journal of pharmacological and toxicological methods 20010101

Title: Role of inwardly rectifying K(+) channels in K(+)-induced cerebral vasodilatation in vivo.

Journal: American journal of physiology. Heart and circulatory physiology 20001201

Title: Involvement of ATP-sensitive potassium channels in a model of a delayed vascular hyporeactivity induced by lipopolysaccharide in rats.

Journal: British journal of pharmacology 19990701

Title: Arterial function in nitric oxide-deficient hypertension: influence of long-term angiotensin II receptor antagonism.

Journal: Cardiovascular research 19990601

Title: Glibenclamide-sensitive hypotension produced by helodermin assessed in the rat.

Journal: Biological & pharmaceutical bulletin 19981201

Title: Role of potassium channels in halothane-epinephrine arrhythmias.

Journal: Research communications in molecular pathology and pharmacology 19980601

Title: Analysis of relaxation and repolarization mechanisms of nicorandil in rat mesenteric artery.

Journal: British journal of pharmacology 19961201

Title: K+ channel openers delay intestinal transit and have antidiarrheal activity.

Journal: European journal of pharmacology 19951212

Title: Cellular localization of the inhibitory action of relaxin against uterine spasm.

Journal: British journal of pharmacology 19951201

Title: Effect of four potassium channel agonists on bupivacaine-induced toxicity in mice.

Journal: Life sciences 19950101

Title: Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.

Journal: Molecular pharmacology 19940601

Title: Effects of potassium channel modulation during global ischaemia in isolated rat heart with and without cardioplegia.

Journal: Cardiovascular research 19921101

Title: Molecular mechanism of action of nicorandil.

Journal: Journal of cardiovascular pharmacology 19920101

Title: Effects of NG-nitro-L-arginine methyl ester on vasodilator responses to adrenaline or BRL 38227 in conscious rats.

Journal: British journal of pharmacology 19911101

Title: Effects of cromakalim and pinacidil on large epicardial and small coronary arteries in conscious dogs.

Journal: The Journal of pharmacology and experimental therapeutics 19901101

Title: Suppression of repolarization-related arrhythmias in vitro and in vivo by low-dose potassium channel activators.

Journal: Circulation 19901001

Title: Preclinical pharmacology of Ro 31-6930, a new potassium channel opener.

Journal: Journal of cardiovascular pharmacology 19900201

Title: Effects of pinacidil and cromakalim (BRL 34915) on bladder function in rats with detrusor instability.

Journal: The Journal of urology 19891001

Title: The relaxant action of BRL 34915 in rat uterus.

Journal: British journal of pharmacology 19870801

Title: Matsumoto T, et al. Tunicamycin-Induced Alterations in the Vasorelaxant Response in Organ-Cultured Superior Mesenteric Arteries of Rats. Biol Pharm Bull. 2016;39(9):1475-81.

Title: Hong SH, et al. Regulation of myometrial contraction by ATP-sensitive potassium (KATP) channel via activation of SUR2B and Kir 6.2 in mouse. J Vet Med Sci. 2016 Aug 1;78(7):1153-9.

Title: Whidden MA, Altered potassium ATP channel signaling in mesenteric arteries of old high salt-fed rats. J Exerc Nutrition Biochem. 2016 Jun;20(2):58-64.

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Tags:94535-50-9 Molecular Formula|94535-50-9 MDL|94535-50-9 SMILES|94535-50-9 Levcromakalim