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2-Phenylindole is a versatile compound widely employed in various chemical reactions and applications. It serves as a crucial reactant for synthesizing oxopyrrolidine analogs via iodine-catalyzed Markovnikov addition and tryptophan dioxygenase inhibitors, which are potential anticancer immunomodulators. Furthermore, it is utilized in the production of organic light-emitting diodes (OLEDs) and as a precursor for the synthesis of anti-inflammatory agents, potential cyclooxygenase-1 (COX-1)/cyclooxygenase-2 (COX-2) inhibitors, agents for cancer and malaria therapy, as well as antifungal and antibacterial agents. Additionally, 2-Phenylindole acts as a reactant in difluorohydroxylation reactions and Mannich-type reactions.