Title: Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury.
Journal: Archives of toxicology 20180101
Title: Effects of dextran sulfate sodium induced experimental colitis on cytochrome P450 activities in rat liver, kidney and intestine.
Journal: Chemico-biological interactions 20170601
Title: A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen.
Journal: Toxicology and applied pharmacology 20160201
Title: Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class.
Journal: Toxicology letters 20160122
Title: Hepato-protective effect of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1-p53 signaling pathways.
Journal: Toxicology letters 20150716
Title: Metabolic characterization of cell systems used in in vitro toxicology testing: lung cell system BEAS-2B as a working example.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20130901
Title: The inhibition of major human hepatic cytochrome P450 enzymes by 18 pesticides: comparison of the N-in-one and single substrate approaches.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20130801
Title: Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata.
Journal: Journal of neurophysiology 20130515
Title: Direct and metabolism-dependent cytochrome P450 inhibition assays for evaluating drug-drug interactions.
Journal: Journal of applied toxicology : JAT 20130201
Title: Induction of brain CYP2E1 by chronic ethanol treatment and related oxidative stress in hippocampus, cerebellum, and brainstem.
Journal: Toxicology 20121216
Title: Application of an innovative design space optimization strategy to the development of liquid chromatographic methods to combat potentially counterfeit nonsteroidal anti-inflammatory drugs.
Journal: Journal of chromatography. A 20121109
Title: Cerebellar ataxia by enhanced Ca(V)2.1 currents is alleviated by Ca2+-dependent K+-channel activators in Cacna1a(S218L) mutant mice.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20121031
Title: Development and validation of packed column supercritical fluid chromatographic technique for quantification of chlorzoxazone, paracetamol and aceclofenac in their individual and combined dosage forms.
Journal: Journal of chromatographic science 20121001
Title: In-vitro metabolism of glycyrrhetinic acid by human and rat liver microsomes and its interactions with six CYP substrates.
Journal: The Journal of pharmacy and pharmacology 20121001
Title: Synthesis and biological activities of some 1,3-benzoxazol-2(3H)-one derivatives as anti-quorum sensing agents.
Journal: Arzneimittel-Forschung 20120701
Title: Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Journal: Journal of medicinal chemistry 20120524
Title: CYP2E1 phenotype in Mexican workers occupationally exposed to low levels of toluene.
Journal: Toxicology letters 20120425
Title: Diffusion of counterfeit drugs in developing countries and stability of galenics stored for months under different conditions of temperature and relative humidity.
Journal: Croatian medical journal 20120401
Title: Polysaccharide peptides from Coriolus versicolor competitively inhibit model cytochrome P450 enzyme probe substrates metabolism in human liver microsomes.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20120315
Title: Spectrofluorimetric assessment of chlorzoxazone and ibuprofen in pharmaceutical formulations by using Eu-tetracycline HCl optical sensor doped in sol-gel matrix.
Journal: Journal of fluorescence 20120301
Title: Molecular dynamics simulations of CYP2E1.
Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20120301
Title: Fluorescence detection of ligand binding to labeled cytochrome P450 BM3.
Journal: Dalton transactions (Cambridge, England : 2003) 20120221
Title: Metabolic capabilities of cytochrome P450 enzymes in Chinese liver microsomes compared with those in Caucasian liver microsomes.
Journal: British journal of clinical pharmacology 20120201
Title: Muscle relaxants for pain management in rheumatoid arthritis.
Journal: The Cochrane database of systematic reviews 20120118
Title: Evaluation of impact of Herba Erigerontis injection, a Chinese herbal prescription, on rat hepatic cytochrome P450 enzymes by cocktail probe drugs.
Journal: Journal of ethnopharmacology 20120106
Title: CYP2E1 Sensitizes the Liver to LPS- and TNF α-Induced Toxicity via Elevated Oxidative and Nitrosative Stress and Activation of ASK-1 and JNK Mitogen-Activated Kinases.
Journal: International journal of hepatology 20120101
Title: Immunological response as a source to variability in drug metabolism and transport.
Journal: Frontiers in pharmacology 20120101
Title: Effects of capsaicin and dihydrocapsaicin on human and rat liver microsomal CYP450 enzyme activities in vitro and in vivo.
Journal: Journal of Asian natural products research 20120101
Title: Investigation of indazole unbinding pathways in CYP2E1 by molecular dynamics simulations.
Journal: PloS one 20120101
Title: Plastics and carcinogenesis: The example of vinyl chloride.
Journal: Journal of carcinogenesis 20120101
Title: An overview of the evidence and mechanisms of herb-drug interactions.
Journal: Frontiers in pharmacology 20120101
Title: Genetic polymorphisms in CYP2E1: association with schizophrenia susceptibility and risperidone response in the Chinese Han population.
Journal: PloS one 20120101
Title: K(Ca)2 and k(ca)3 channels in learning and memory processes, and neurodegeneration.
Journal: Frontiers in pharmacology 20120101
Title: [Inhibitory effects of astragaloside IV on cytochrome P450 enzyme of rat liver microsomes].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120101
Title: Inhibitory effects of kale ingestion on metabolism by cytochrome P450 enzymes in rats.
Journal: Biomedical research (Tokyo, Japan) 20120101
Title: Effects of normothermic hepatic ischemia-reperfusion injury on the in vivo, isolated perfused liver, and microsomal disposition of chlorzoxazone, a cytochrome P450 2E1 probe, in rats.
Journal: Journal of pharmaceutical sciences 20111201
Title: Independent and combined effects of ethanol self-administration and nicotine treatment on hepatic CYP2E1 in African green monkeys.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20111201
Title: Cardiac arrest and therapeutic hypothermia decrease isoform-specific cytochrome P450 drug metabolism.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20111201
Title: Application of a systems approach to the bottom-up assessment of pharmacokinetics in obese patients: expected variations in clearance.
Journal: Clinical pharmacokinetics 20111201
Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Journal: PLoS computational biology 20111201
Title: Characterization of inhibitory effects of perfluorooctane sulfonate on human hepatic cytochrome P450 isoenzymes: focusing on CYP2A6.
Journal: Chemico-biological interactions 20111115
Title: Identification of the human liver cytochrome P450 isoenzymes responsible for the 5-methylhydroxylation of the novel anti-fibrotic drug AKF-PD.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20111001
Title: Benefit of using muscle relaxants in the routine treatment protocol of oral submucosal fibrosis: a pilot study.
Journal: Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India 20111001
Title: The effects of nitrogen-heme-iron coordination on substrate affinities for cytochrome P450 2E1.
Journal: Chemico-biological interactions 20110815
Title: In vitro inhibitory effects of Wen-pi-tang-Hab-Wu-ling-san on human cytochrome P450 isoforms.
Journal: Journal of clinical pharmacy and therapeutics 20110801
Title: Significantly reduced cytochrome P450 3A4 expression and activity in liver from humans with diabetes mellitus.
Journal: British journal of pharmacology 20110701
Title: Regional distribution of drug-metabolizing enzyme activities in the liver and small intestine of cynomolgus monkeys.
Journal: Drug metabolism and pharmacokinetics 20110601
Title: In vitro inhibition of porcine cytochrome P450 by 17β -estradiol and 17α-estradiol.
Journal: Interdisciplinary toxicology 20110601
Title: Chlorzoxazone, an SK-type potassium channel activator used in humans, reduces excessive alcohol intake in rats.
Journal: Biological psychiatry 20110401
Title: KCa2 channels activation prevents [Ca2+]i deregulation and reduces neuronal death following glutamate toxicity and cerebral ischemia.
Journal: Cell death & disease 20110401
Title: A UPLC-MS/MS assay of the 'Pittsburgh cocktail': six CYP probe-drug/metabolites from human plasma and urine using stable isotope dilution.
Journal: The Analyst 20110207
Title: Determination of brain cytochrome P450 2E1 activity in rat with the probe of chlorzoxazone by liquid chromatography-mass spectrometry.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110201
Title: Screening of conditions controlling spectrophotometric sequential injection analysis.
Journal: Chemistry Central journal 20110101
Title: Fluorescence Spectrometric Determination of Drugs Containing α-Methylene Sulfone/Sulfonamide Functional Groups Using N-Methylnicotinamide Chloride as a Fluorogenic Agent.
Journal: International journal of analytical chemistry 20110101
Title: The SK channel as a novel target for treating alcohol use disorders.
Journal: Channels (Austin, Tex.) 20110101
Title: Network neighbors of drug targets contribute to drug side-effect similarity.
Journal: PloS one 20110101
Title: Drug use in elderly patients: Are we there yet?
Journal: Journal of pharmacology & pharmacotherapeutics 20110101
Title: Spectrophotometric determination of tizanidine and orphenadrine via ion pair complex formation using eosin Y.
Journal: Chemistry Central journal 20110101
Title: Protective effects of goldenseal (Hydrastis canadensis L.) on acetaminophen-induced hepatotoxicity through inhibition of CYP2E1 in rats.
Journal: Pharmacognosy research 20110101
Title: Development and validation of simultaneous spectrophotometric methods for drotaverine hydrochloride and aceclofenac from tablet dosage form.
Journal: Indian journal of pharmaceutical sciences 20110101
Title: A predictive ligand-based Bayesian model for human drug-induced liver injury.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20101201
Title: Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.
Journal: Healthcare informatics research 20101201
Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Journal: Bioorganic & medicinal chemistry letters 20101101
Title: Screening and quantitative determination of twelve acidic and neutral pharmaceuticals in whole blood by liquid-liquid extraction and liquid chromatography-tandem mass spectrometry.
Journal: Journal of analytical toxicology 20100901
Title: Human blood concentrations of cotinine, a biomonitoring marker for tobacco smoke, extrapolated from nicotine metabolism in rats and humans and physiologically based pharmacokinetic modeling.
Journal: International journal of environmental research and public health 20100901
Title: Small scale screening to determine the ability of different polymers to inhibit drug crystallization upon rapid solvent evaporation.
Journal: Molecular pharmaceutics 20100802
Title: Basolateral Cl- uptake mechanisms in Xenopus laevis lung epithelium.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20100701
Title: Pharmacologic management of chronic pain.
Journal: The Korean journal of pain 20100601
Title: KCa channels as therapeutic targets in episodic ataxia type-2.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100526
Title: The therapeutic mode of action of 4-aminopyridine in cerebellar ataxia.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100526
Title: Engineering bacterial cytochrome P450 (P450) BM3 into a prototype with human P450 enzyme activity using indigo formation.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20100501
Title: Chlorzoxazone metabolism by porcine cytochrome P450 enzymes and the effect of cytochrome b5.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20100501
Title: Effect of buagafuran on liver microsomal cytochrome P450 in rats.
Journal: Journal of Asian natural products research 20100501
Title: Inhibition of human liver microsomal CYP by nateglinide.
Journal: The Journal of pharmacy and pharmacology 20100501
Title: Human CYP2E1 is regulated by miR-378.
Journal: Biochemical pharmacology 20100401
Title: Herb-drug interactions: in vivo and in vitro effect of Shenmai injection, a herbal preparation, on the metabolic activities of hepatic cytochrome P450 3A1/2, 2C6, 1A2, and 2E1 in rats.
Journal: Planta medica 20100201
Title: Effects of cytochrome P450 inhibitors on the biotransformation of fluorogenic substrates by adult male rat liver microsomes and cDNA-expressed rat cytochrome P450 isoforms.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20100201
Title: Exposure of the U.S. population to acrylamide in the National Health and Nutrition Examination Survey 2003-2004.
Journal: Environmental health perspectives 20100201
Title: Effects of nicotine on cytochrome P450 2A6 and 2E1 activities.
Journal: British journal of clinical pharmacology 20100201
Title: In vivo CYP2E1 phenotyping as a new potential biomarker of occupational and experimental exposure to benzene.
Journal: Toxicology letters 20100115
Title: Inappropriate prescribing in the hospitalized elderly patient: defining the problem, evaluation tools, and possible solutions.
Journal: Clinical interventions in aging 20100101
Title: Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish.
Journal: BMC genomics 20100101
Title: Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20091201
Title: [Role of physical therapy in the treatment of gonarthrosis].
Journal: La Revue du praticien 20091120
Title: Time-dependent effects of Klebsiella pneumoniae endotoxin on the pharmacokinetics of chlorzoxazone and its main metabolite, 6-hydroxychlorzoxazone, in rats: restoration of the parameters in 96 hour in KPLPS rats to control levels.
Journal: Biopharmaceutics & drug disposition 20091101
Title: Protective effects of thiopronin against isoniazid-induced hepatotoxicity in rats.
Journal: Toxicology 20091029
Title: Effects of Angelicae tenuissima radix, Angelicae dahuricae radix and Scutellariae radix extracts on cytochrome P450 activities in healthy volunteers.
Journal: Basic & clinical pharmacology & toxicology 20091001
Title: Malaria downmodulates mRNA expression and catalytic activities of CYP1A2, 2E1 and 3A11 in mouse liver.
Journal: European journal of pharmacology 20090815
Title: [Experimental study on cytochrome P450 enzymes after receiving ferment powder caterpillar fungus].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090801
Title: The mechanism of the rat liver cytochrome P4502E1 inhibition by the synthetic prostanoids of A-type.
Journal: Prostaglandins & other lipid mediators 20090601
Title: Evidence that humans metabolize benzene via two pathways.
Journal: Environmental health perspectives 20090601
Title: Chlorzoxazone esters of some non-steroidal anti-inflammatory (NSAI) carboxylic acids as mutual prodrugs: design, synthesis, pharmacological investigations and docking studies.
Journal: Bioorganic & medicinal chemistry 20090515
Title: Ion channel modulators mediated alterations in NO-induced free radical generation and neutrophil membrane potential.
Journal: Free radical research 20090501
Title: Bax inhibitor 1 regulates ER-stress-induced ROS accumulation through the regulation of cytochrome P450 2E1.
Journal: Journal of cell science 20090415
Title: A simplified method to determine five cytochrome p450 probe drugs by HPLC in a single run.
Journal: Biological & pharmaceutical bulletin 20090401
Title: Effects of rifampin on CYP2E1-dependent hepatotoxicity of isoniazid in rats.
Journal: Pharmacological research 20090201
Title: In vivo role of cytochrome P450 2E1 and glutathione-S-transferase activity for acrylamide toxicokinetics in humans.
Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20090201
Title: Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway.
Journal: The Biochemical journal 20090101
Title: Interactions between herbal medicines and prescribed drugs: an updated systematic review.
Journal: Drugs 20090101
Title: Chlorzoxazone hydroxylation in microsomes and hepatocytes from cytochrome P450 oxidoreductase-null mice.
Journal: Journal of biochemical and molecular toxicology 20090101
Title: Analysis of nine drugs and their cytochrome P450-specific probe metabolites from urine by liquid chromatography-tandem mass spectrometry utilizing sub 2 microm particle size column.
Journal: Journal of chromatography. A 20081226
Title: K(+)-channel openers suppress epileptiform activities induced by 4-aminopyridine in cultured rat hippocampal neurons.
Journal: Journal of pharmacological sciences 20081201
Title: Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5.
Journal: The Journal of biological chemistry 20081114
Title: Effect of berberine on hepatocyte proliferation, inducible nitric oxide synthase expression, cytochrome P450 2E1 and 1A2 activities in diethylnitrosamine- and phenobarbital-treated rats.
Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20081101
Title: Deleterious effects induced by oxidative stress in liver nuclei from rats receiving an alcohol-containing liquid diet.
Journal: Toxicology and industrial health 20081101
Title: Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Journal: Journal of medicinal chemistry 20081009
Title: Human CYP2E1 mediates the formation of glycidamide from acrylamide.
Journal: Archives of toxicology 20081001
Title: Molecular and cellular basis of small--and intermediate-conductance, calcium-activated potassium channel function in the brain.
Journal: Cellular and molecular life sciences : CMLS 20081001
Title: Cellular imaging predictions of clinical drug-induced liver injury.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20080901
Title: Simultaneous determination of aceclofenac, paracetamol, and chlorzoxazone by RP-HPLC in pharmaceutical dosage form.
Journal: Journal of chromatographic science 20080801
Title: [HPLC for determination of activity of serum CYP2E1].
Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20080801
Title: Pharmacokinetic parameters of chlorzoxazone and its main metabolite, 6-hydroxychlorzoxazone, after intravenous and oral administration of chlorzoxazone to liver cirrhotic rats with diabetes mellitus.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20080701
Title: Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Journal: Journal of medicinal chemistry 20080612
Title: Current industrial practices in assessing CYP450 enzyme induction: preclinical and clinical.
Journal: The AAPS journal 20080601
Title: Evaluation of protective effects of Chi-Zhi-Huang decoction on Phase I drug metabolism of liver injured rats by cocktail probe drugs.
Journal: Journal of ethnopharmacology 20080522
Title: Hepatic cytochrome P450 2E1 activity in nonalcoholic fatty liver disease.
Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20080501
Title: High-performance liquid chromatographic analysis of resveratrol analog 3,5,4'-trimethoxystilbene in rat plasma.
Journal: Methods and findings in experimental and clinical pharmacology 20080401
Title: Modulation of P450 enzymes by Cuban natural products rich in polyphenolic compounds in rat hepatocytes.
Journal: Chemico-biological interactions 20080310
Title: Human cytochrome P450 2A13 efficiently metabolizes chemicals in air pollutants: naphthalene, styrene, and toluene.
Journal: Chemical research in toxicology 20080301
Title: [Expression of human CYP2E1 in insect cells using bac-to-bac expression system].
Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20080301
Title: The inhibitory effect of tannic acid on cytochrome P450 enzymes and NADPH-CYP reductase in rat and human liver microsomes.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080201
Title: Association of potentially inappropriate medication use with adverse outcomes in ambulatory elderly patients with chronic diseases: experience in a Taiwanese medical setting.
Journal: Drugs & aging 20080101
Title: Exogenous and endogenous determinants of blood trihalomethane levels after showering.
Journal: Environmental health perspectives 20080101
Title: The influence of a newly developed quinolone: antofloxacin, on CYP activity in rats.
Journal: European journal of drug metabolism and pharmacokinetics 20080101
Title: Study of cytochrome P450 2E1 and its allele variants in liver injury of nondiabetic, nonalcoholic steatohepatitis obese women.
Journal: Biological research 20080101
Title: Soft occlusal splint therapy in the management of myofascial pain dysfunction syndrome: a follow-up study.
Journal: Indian journal of dental research : official publication of Indian Society for Dental Research 20080101
Title: Role of cytochrome P450 in drug interactions.
Journal: Nutrition & metabolism 20080101
Title: Clinical review: Drug metabolism and nonrenal clearance in acute kidney injury.
Journal: Critical care (London, England) 20080101
Title: Influence of diosmin pretreatment on the pharmacokinetics of chlorzoxazone in healthy male volunteers.
Journal: Drug metabolism and drug interactions 20080101
Title: Chlorzoxazone as a cause of acute liver failure requiring liver transplantation.
Journal: Digestive diseases and sciences 20071201
Title: Evaluation of the assumptions of an ontogeny model of rat hepatic cytochrome P450 activity.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20071201
Title: Circadian rhythm of cytochrome P4502E1 and its effect on disposition kinetics of chlorzoxazone in rats.
Journal: European journal of pharmacology 20071121
Title: Functional characterization of human and cynomolgus monkey cytochrome P450 2E1 enzymes.
Journal: Life sciences 20071027
Title: Induction of hepatic CYP2E1 by a subtoxic dose of acetaminophen in rats: increase in dichloromethane metabolism and carboxyhemoglobin elevation.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20071001
Title: Is bupropion a more specific substrate for porcine CYP2E than chlorzoxazone and p-nitrophenol?
Journal: Basic & clinical pharmacology & toxicology 20070901
Title: Effects of Ganoderma lucidum polysaccharide on CYP2E1, CYP1A2 and CYP3A activities in BCG-immune hepatic injury in rats.
Journal: Biological & pharmaceutical bulletin 20070901
Title: Effects of hypothermia on drug disposition, metabolism, and response: A focus of hypothermia-mediated alterations on the cytochrome P450 enzyme system.
Journal: Critical care medicine 20070901
Title: CFTR-dependent Cl- secretion in Xenopus laevis lung epithelium.
Journal: Respiratory physiology & neurobiology 20070815
Title: Expression and activity of the cytochrome P450 2E1 in patients with nonalcoholic steatosis and steatohepatitis.
Journal: Liver international : official journal of the International Association for the Study of the Liver 20070801
Title: In vitro interaction cocktail assay for nine major cytochrome P450 enzymes with 13 probe reactions and a single LC/MSMS run: analytical validation and testing with monoclonal anti-CYP antibodies.
Journal: Journal of mass spectrometry : JMS 20070701
Title: Modulation of hepatic and renal metabolism and toxicity of trichloroethylene and perchloroethylene by alterations in status of cytochrome P450 and glutathione.
Journal: Toxicology 20070603
Title: Artemisinin antimalarials moderately affect cytochrome P450 enzyme activity in healthy subjects.
Journal: Fundamental & clinical pharmacology 20070601
Title: Phenotyping of cytochrome P450 2E1 in vitro and in vivo.
Journal: Current drug metabolism 20070601
Title: Expression of CYP2E1 in human nasopharynx and its metabolic effect in vitro.
Journal: Molecular and cellular biochemistry 20070401
Title: Wild-type CYP102A1 as a biocatalyst: turnover of drugs usually metabolised by human liver enzymes.
Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20070301
Title: Induction of CYP2B and CYP2E1 in precision-cut rat liver slices cultured in defined medium.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20070201
Title: Obesity-induced increase of CYP2E1 activity and its effect on disposition kinetics of chlorzoxazone in Zucker rats.
Journal: Biochemical pharmacology 20070101
Title: Modification of CYP2E1 and CYP3A4 activities in haemoglobin E-beta thalassemia patients.
Journal: European journal of clinical pharmacology 20070101
Title: Simultaneous determination of paracetamol, chlorzoxazone, and related impurities 4-aminophenol, 4'-chloroacetanilide, and p-chlorophenol in pharmaceutical preparations by high-performance liquid chromatography.
Journal: Journal of AOAC International 20070101
Title: The effect of acetaminophen (four grams a day for three consecutive days) on hepatic tests in alcoholic patients--a multicenter randomized study.
Journal: BMC medicine 20070101
Title: Simultaneous determination of chlorzoxazone and ketoprofen in binary mixtures and in ternary mixtures containing the chlorzoxazone degradation product by reversed-phase liquid chromatography.
Journal: Journal of AOAC International 20070101
Title: A study on the pharmacokinetics of chlorzoxazone in healthy Thai volunteers.
Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20070101
Title: Pharmacokinetics of etoposide in rats with uranyl nitrate (UN)-induced acute renal failure (ARF): optimization of the duration of UN dosing.
Journal: European journal of drug metabolism and pharmacokinetics 20070101
Title: Phenobarbital induces monkey brain CYP2E1 protein but not hepatic CYP2E1, in vitro or in vivo chlorzoxazone metabolism.
Journal: European journal of pharmacology 20061215
Title: The inhibitory effect of polyunsaturated fatty acids on human CYP enzymes.
Journal: Life sciences 20061125
Title: Effects of glucose supplementation on the pharmacokinetics of intravenous chlorzoxazone in rats with water deprivation for 72 h.
Journal: Life sciences 20061102
Title: Pharmacokinetics of chlorzoxazone in rats with diabetes: Induction of CYP2E1 on 6-hydroxychlorzoxazone formation.
Journal: Journal of pharmaceutical sciences 20061101
Title: Effect of conjugated equine estrogens on oxidative metabolism in middle-aged and elderly postmenopausal women.
Journal: Journal of clinical pharmacology 20061101
Title: OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice.
Journal: PLoS medicine 20061101
Title: Comparison of basal level metabolic enzyme activities of freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss) and rat.
Journal: Aquatic toxicology (Amsterdam, Netherlands) 20061025
Title: Ageing is associated with increased expression but decreased activity of CYP2E1 in male Wistar rats.
Journal: Life sciences 20061012
Title: Chlorzoxazone inhibits contraction of rat thoracic aorta.
Journal: European journal of pharmacology 20060918
Title: Characteristics and trends of 3,4-methylenedioxymethamphetamine (MDMA) tablets found in Taiwan from 2002 to February 2005.
Journal: Forensic science international 20060912
Title: In vivo and in vitro characterization of chlorzoxazone metabolism and hepatic CYP2E1 levels in African Green monkeys: induction by chronic nicotine treatment.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20060901
Title: Liver disease selectively modulates cytochrome P450--mediated metabolism.
Journal: Clinical pharmacology and therapeutics 20060901
Title: Validation of incorporating flurbiprofen into the Pittsburgh cocktail.
Journal: Clinical pharmacology and therapeutics 20060901
Title: Development of dosage design of hepatic metabolizing drugs using serum albumin level in chronic hepatic failure.
Journal: Biological & pharmaceutical bulletin 20060801
Title: Characterization of hepatic drug-metabolizing activities of Bama miniature pigs (Sus scrofa domestica): comparison with human enzyme analogs.
Journal: Comparative medicine 20060801
Title: Selective effects of nitric oxide on the disposition of chlorzoxazone and dextromethorphan in isolated perfused rat livers.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20060701
Title: Hepatic disposition of the cytochrome P450 2E1 marker chlorzoxazone and its hydroxylated metabolite in isolated perfused rat livers.
Journal: Journal of pharmaceutical sciences 20060701
Title: Clearance of unusual muscular uptake of F-18 FDG in the lower lumbar region on a repeat FDG-PET scan after oral chlorzoxazone intervention.
Journal: Clinical nuclear medicine 20060701
Title: Inhibitory effects of cytostatically active 6-aminobenzo[c]phenanthridines on cytochrome P450 enzymes in human hepatic microsomes.
Journal: Basic & clinical pharmacology & toxicology 20060701
Title: Enzymatic properties of human CYP2W1 expressed in Escherichia coli.
Journal: Biochemical and biophysical research communications 20060623
Title: Prediction of in vivo drug clearance from in vitro data. II: potential inter-ethnic differences.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20060601
Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Title: Regional and cellular distribution of CYP2E1 in monkey brain and its induction by chronic nicotine.
Journal: Neuropharmacology 20060401
Title: Induction and recovery time course of rat brain CYP2E1 after nicotine treatment.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20060401
Title: Occupational toluene exposure induces cytochrome P450 2E1 mRNA expression in peripheral lymphocytes.
Journal: Environmental health perspectives 20060401
Title: High-performance liquid chromatography spectrometric analysis of trans-resveratrol in rat plasma.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060307
Title: Therapeutic hypothermia-induced pharmacokinetic alterations on CYP2E1 chlorzoxazone-mediated metabolism in a cardiac arrest rat model.
Journal: Critical care medicine 20060301
Title: Inhibition of human cytochrome P450 isoforms and NADPH-CYP reductase in vitro by 15 herbal medicines, including Epimedii herba.
Journal: Journal of clinical pharmacy and therapeutics 20060201
Title: CYP2A5-mediated activation and early ultrastructural changes in the olfactory mucosa: studies on 2,6-dichlorophenyl methylsulfone.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20060101
Title: Relationship between in vivo chlorzoxazone hydroxylation, hepatic cytochrome P450 2E1 content and liver injury in obese non-alcoholic fatty liver disease patients.
Journal: Hepatology research : the official journal of the Japan Society of Hepatology 20060101
Title: Effects of steady-state lasofoxifene on CYP2D6- and CYP2E1-mediated metabolism.
Journal: The Annals of pharmacotherapy 20060101
Title: Chlorzoxazone metabolism is increased in fasted Sprague-Dawley rats.
Journal: The Journal of pharmacy and pharmacology 20060101
Title: Serum aminotransferase activity as a predictor for estimation of total clearance of hepatically metabolized drugs in rats with acute hepatic failure.
Journal: Biological & pharmaceutical bulletin 20060101
Title: Effect of high-dose aspirin on CYP2E1 activity in healthy subjects measured using chlorzoxazone as a probe.
Journal: Journal of clinical pharmacology 20060101
Title: Effects of irsogladine on P450-isoform specific activities in human hepatic microsomes.
Journal: Arzneimittel-Forschung 20060101
Title: Methemoglobinemia: life-threatening hazard of multiple drug ingestions.
Journal: Boletin de la Asociacion Medica de Puerto Rico 20060101
Title: Functional characterisation of an engineered multidomain human P450 2E1 by molecular Lego.
Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20051201
Title: Antitumor drug ellipticine inhibits the activities of rat hepatic cytochromes P450.
Journal: Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 20051201
Title: Cytochrome P450 2E polymorphism in feline liver.
Journal: Biochimica et biophysica acta 20051115
Title: In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations in human liver microsomes: a comparison with SKF-525A.
Journal: Drug metabolism and pharmacokinetics 20051001
Title: Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism.
Journal: Bioorganic & medicinal chemistry letters 20050915
Title: Characterization of microsomal cytochrome P450-dependent monooxygenases in the rat olfactory mucosa.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050801
Title: Effect of 1-aminobenzotriazole on the in vitro metabolism and single-dose pharmacokinetics of chlorzoxazone, a selective CYP2E1 substrate in Wistar rats.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20050801
Title: Expression and induction potential of cytochromes P450 in human cryopreserved hepatocytes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050701
Title: Enzyme-selective effects of nitric oxide on affinity and maximum velocity of various rat cytochromes P450.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050601
Title: Minipig cytochrome P450 2E1: comparison with human enzyme.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050601
Title: Effect of age and postoperative time on cytochrome p450 enzyme activity following liver transplantation.
Journal: Journal of clinical pharmacology 20050601
Title: Inhibition of human cytochrome P450 enzymes by the natural hepatotoxin safrole.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20050501
Title: Activity of CYP2E1 and CYP3A enzymes in adults with moderate alcohol consumption: a comparison with nonalcoholics.
Journal: Hepatology (Baltimore, Md.) 20050501
Title: In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes.
Journal: Clinical pharmacology and therapeutics 20050501
Title: [Ratio spectrophotometry and its application to assay of compound pharmacy preparations].
Journal: Guang pu xue yu guang pu fen xi = Guang pu 20050401
Title: The cyp2e1-humanized transgenic mouse: role of cyp2e1 in acetaminophen hepatotoxicity.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050301
Title: The stimulatory role of human cytochrome b5 in the bioactivation activities of human CYP1A2, 2A6 and 2E1: a new cell expression system to study cytochrome P450 mediated biotransformation.
Journal: Mutagenesis 20050301
Title: Cytochrome P-450 activity is differentially altered in severely injured patients.
Journal: Critical care medicine 20050301
Title: Comparison of cytochrome P4502E1 (CYP2E1) activity and hepatic and lymphocyte mRNA expression in patients with chronic hepatitis C.
Journal: Toxicology letters 20050115
Title: Multiple P450 substrates in a single run: rapid and comprehensive in vitro interaction assay.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20050101
Title: Validation of a simple bioanalytical method for the determination of DRF-6196, a novel oxazolidinone, in mouse plasma: application to a single-dose pharmacokinetic study.
Journal: Arzneimittel-Forschung 20050101
Title: Clinical assessment of effects of botanical supplementation on cytochrome P450 phenotypes in the elderly: St John's wort, garlic oil, Panax ginseng and Ginkgo biloba.
Journal: Drugs & aging 20050101
Title: High-throughput screening of inhibitory potential of nine cytochrome P450 enzymes in vitro using liquid chromatography/tandem mass spectrometry.
Journal: Rapid communications in mass spectrometry : RCM 20050101
Title: Effects of etodolac on P450 isoform-specific activities in human hepatic microsomes.
Journal: Arzneimittel-Forschung 20050101
Title: The effect of isoniazid containing regimen on CYP2E1 during antituberculosis therapy.
Journal: Research communications in molecular pathology and pharmacology 20050101
Title: Bioequivalence revisited: influence of age and sex on CYP enzymes.
Journal: Clinical pharmacology and therapeutics 20041201
Title: Comparative studies of the effects of two novel sugar drug candidates on the CYP 1A2 and CYP 2E1 enzymes in different sexed rats using a 'cocktail' approach.
Journal: Molecules (Basel, Switzerland) 20041130
Title: Inhibitory effect of antituberculosis drugs on human cytochrome P450-mediated activities.
Journal: Journal of pharmacological sciences 20041101
Title: In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto.
Journal: Clinical pharmacology and therapeutics 20041101
Title: Bioactivation of 1,1-dichloroethylene by CYP2E1 and CYP2F2 in murine lung.
Journal: The Journal of pharmacology and experimental therapeutics 20040901
Title: A convenient five-drug cocktail for the assessment of major drug metabolizing enzymes: a pilot study.
Journal: British journal of clinical pharmacology 20040901
Title: Different mechanisms of handling ingested polycyclic aromatic hydrocarbons in mammalian species: organ-specific response patterns of CYP1A1-induction after oral intake of PAH-contaminated soils.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20040901
Title: Metabolism of human cytochrome P450 marker substrates in mouse: a strain and gender comparison.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20040901
Title: Robustness of chlorzoxazone as an in vivo measure of cytochrome P450 2E1 activity.
Journal: British journal of clinical pharmacology 20040801
Title: Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: a systematic review.
Journal: Journal of pain and symptom management 20040801
Title: Identification of the main human cytochrome P450 enzymes involved in safrole 1'-hydroxylation.
Journal: Chemical research in toxicology 20040801
Title: Functional and molecular identification of intermediate-conductance Ca(2+)-activated K(+) channels in breast cancer cells: association with cell cycle progression.
Journal: American journal of physiology. Cell physiology 20040701
Title: The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20040701
Title: Validated assays for human cytochrome P450 activities.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20040601
Title: Assessment of drug-drug interaction potential of enfuvirtide in human immunodeficiency virus type 1-infected patients.
Journal: Clinical pharmacology and therapeutics 20040601
Title: Phenacetin and chlorzoxazone biotransformation in aging male Fischer 344 rats.
Journal: The Journal of pharmacy and pharmacology 20040601
Title: Presence of cytochrome P450 enzymes in human CD34+ haematopoietic progenitor cells.
Journal: General physiology and biophysics 20040601
Title: Potential of pranlukast and zafirlukast in the inhibition of human liver cytochrome P450 enzymes.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20040501
Title: Effect of posaconazole on cytochrome P450 enzymes: a randomized, open-label, two-way crossover study.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20040401
Title: ATP release triggered by activation of the Ca2+-activated K+ channel in human airway Calu-3 cells.
Journal: American journal of respiratory cell and molecular biology 20040301
Title: Age-related changes in the protein and mRNA levels of CYP2E1 and CYP3A isoforms as well as in their hepatic activities in Wistar rats. What role for oxidative stress?
Journal: Archives of toxicology 20040301
Title: Phase I and II enzyme characterization of two sources of HepG2 cell lines.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20040301
Title: Pharmacokinetic and pharmacodynamic assessment of a five-probe metabolic cocktail for CYPs 1A2, 3A4, 2C9, 2D6 and 2E1.
Journal: British journal of clinical pharmacology 20040201
Title: Serum aminotransferase activity as a predictor of clearance of drugs metabolized by CYP isoforms in rats with acute hepatic failure induced by carbon tetrachloride.
Journal: International journal of pharmaceutics 20040128
Title: Characteristics and a functional implication of Ca(2+)-activated K(+) current in mouse aortic endothelial cells.
Journal: Pflugers Archiv : European journal of physiology 20040101
Title: The olivacine derivative s 16020 (9-hydroxy-5,6-dimethyl-N-[2-(dimethylamino)ethyl)-6H-pyrido(4,3-B)-carbazole-1-carboxamide) induces CYP1A and its own metabolism in human hepatocytes in primary culture.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20040101
Title: Annular leucocytoclastic vasculitis induced by chlorzoxazone.
Journal: The British journal of dermatology 20040101
Title: Cytochrome P450 1A2 (CYP1A2) activity, mammographic density, and oxidative stress: a cross-sectional study.
Journal: Breast cancer research : BCR 20040101
Title: Identification of sequences responsible for intracellular targeting and membrane binding of rat CYP2E1 in yeast.
Journal: Biochemistry 20031216
Title: Comparison of chlorzoxazone one-sample methods to estimate CYP2E1 activity in humans.
Journal: European journal of clinical pharmacology 20031201
Title: Impaired 6-hydroxychlorzoxazone elimination in patients with kidney disease: Implication for cytochrome P450 2E1 pharmacogenetic studies.
Journal: Clinical pharmacology and therapeutics 20031201
Title: 'Open access' generic method for continuous determination of major human CYP450 probe substrates/metabolites and its application in drug metabolism studies.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20031201
Title: GYKI-47261, a new AMPA [2-amino-3-(3-hydroxymethylisoxazole-4-yl)propionic acid] antagonist, is a CYP2E1 inducer.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20031101
Title: Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20031101
Title: Effects of cigarette smoking and carbon monoxide on chlorzoxazone and caffeine metabolism.
Journal: Clinical pharmacology and therapeutics 20031101
Title: CYP2E1 regulation by benzene and other small organic chemicals in rat liver and peripheral lymphocytes.
Journal: Toxicology letters 20030915
Title: Simultaneous determination of aspirin and isosorbide 5-mononitrate in formulation by reversed phase high pressure liquid chromatography.
Journal: Journal of pharmaceutical and biomedical analysis 20030821
Title: Characterization of vectorial chloride transport pathways in the human pancreatic duct adenocarcinoma cell line HPAF.
Journal: American journal of physiology. Cell physiology 20030801
Title: Rates of metabolism of chlorzoxazone, dextromethorphan, 7-ethoxycoumarin, imipramine, quinidine, testosterone and verapamil by fresh and cryopreserved rat liver slices, and some comparisons with microsomes.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20030801
Title: CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease.
Journal: Hepatology (Baltimore, Md.) 20030801
Title: Effects of glucose on the pharmacokinetics of intravenous chlorzoxazone in rats with acute renal failure induced by uranyl nitrate.
Journal: Journal of pharmaceutical sciences 20030801
Title: Phorbol ester induces CYP2E1 in astrocytes, through a protein kinase C- and tyrosine kinase-dependent mechanism.
Journal: Journal of neurochemistry 20030801
Title: Differential inhibition of human cytochrome P450 enzymes by epsilon-viniferin, the dimer of resveratrol: comparison with resveratrol and polyphenols from alcoholized beverages.
Journal: Life sciences 20030718
Title: Effects of recombinant human growth hormone on the pharmacokinetics of intravenous chlorzoxazone in rats with acute renal failure induced by uranyl nitrate.
Journal: Life sciences 20030606
Title: Effects of acute renal failure on the pharmacokinetics of chlorzoxazone in rats.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20030601
Title: How useful is the 'cocktail approach' for evaluating human hepatic drug metabolizing capacity using cytochrome P450 phenotyping probes in vivo?
Journal: Journal of clinical pharmacy and therapeutics 20030601
Title: Functional characterization of three human cytochrome p450 2E1 variants with amino acid substitutions.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20030601
Title: Diterpene quinone tanshinone IIA selectively inhibits mouse and human cytochrome p4501A2.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20030601
Title: Cytochrome P450 expression and testosterone metabolism in the liver of deer.
Journal: Toxicology 20030501
Title: Construction and assessment of models of CYP2E1: predictions of metabolism from docking, molecular dynamics, and density functional theoretical calculations.
Journal: Journal of medicinal chemistry 20030424
Title: Lipopolysaccharide-mediated modulation of cytochromes P450 in Stat1 null mice.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20030401
Title: Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis.
Journal: Hepatology (Baltimore, Md.) 20030401
Title: The cytochrome P-450 isoenzyme CYP2E1 in the biological processing of industrial chemicals: consequences for occupational and environmental medicine.
Journal: International archives of occupational and environmental health 20030401
Title: Kinetic study of alkaline induced hydrolysis of the skeletal muscle relaxant chlorzoxazone using ratio spectra first derivative spectrophotometry.
Journal: Farmaco (Societa chimica italiana : 1989) 20030401
Title: Metabolism of chloroform in the human liver and identification of the competent P450s.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20030301
Title: Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis.
Journal: Hepatology (Baltimore, Md.) 20030301
Title: Pharmacokinetics of intravenous chlorzoxazone in rats with dehydration and rehydration: effects of food intakes.
Journal: Biopharmaceutics & drug disposition 20030301
Title: Isozyme-specific induction of low-dose aspirin on cytochrome P450 in healthy subjects.
Journal: Clinical pharmacology and therapeutics 20030301
Title: Study of the fragmentation mechanism of protonated 6-hydroxychlorzoxazone: application in simultaneous analysis of CYP2E1 activity with major human cytochrome P450s.
Journal: Analytical chemistry 20030201
Title: Unexpected down-regulation of the hIK1 Ca2+-activated K+ channel by its opener 1-ethyl-2-benzimidazolinone in HaCaT keratinocytes. Inverse effects on cell growth and proliferation.
Journal: The Journal of biological chemistry 20030131
Title: Determination of 6-hydroxychlorzoxazone and chlorzoxazone in porcine microsome samples.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030125
Title: Stimulatory effects of chlorzoxazone, a centrally acting muscle relaxant, on large conductance calcium-activated potassium channels in pituitary GH3 cells.
Journal: Brain research 20030103
Title: Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes.
Journal: Archives of biochemistry and biophysics 20030101
Title: Diabetes mellitus increases the in vivo activity of cytochrome P450 2E1 in humans.
Journal: British journal of clinical pharmacology 20030101
Title: Maintenance of liver functions in rat hepatocytes cultured as spheroids in a rotating wall vessel.
Journal: In vitro cellular & developmental biology. Animal 20030101
Title: In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations catalyzed by human cytochrome P450 enzymes: a comparison with SKF-525A and ketoconazole.
Journal: Drug metabolism and pharmacokinetics 20030101
Title: Heterologous expression of mouse cytochrome P450 2e1 in V79 cells: construction and characterisation of the cell line and comparison with V79 cell lines stably expressing rat P450 2E1 and human P450 2E1.
Journal: Alternatives to laboratory animals : ATLA 20030101
Title: Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20021201
Title: Potentiation of 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123)-induced liver toxicity by ethanol in guinea-pigs.
Journal: Archives of toxicology 20021201
Title: Validated HPLC method for determination of chlorzoxazone in human serum and its application in a clinical pharmacokinetic study.
Journal: Die Pharmazie 20021201
Title: Conformational changes in nitric oxide synthases induced by chlorzoxazone and nitroindazoles: crystallographic and computational analyses of inhibitor potency.
Journal: Biochemistry 20021126
Title: Monolithic silica rod liquid chromatography with ultraviolet or fluorescence detection for metabolite analysis of cytochrome P450 marker reactions.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021125
Title: Phenotype distribution and gender-related differences of CYP2E1 activity in a Chinese population.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20021101
Title: [Simultaneous determination of three probe drugs by reversed-phase high performance liquid chromatography].
Journal: Se pu = Chinese journal of chromatography 20021101
Title: Inhibition of cytochrome P450 2E1 by propofol in human and porcine liver microsomes.
Journal: Biochemical pharmacology 20021001
Title: Metabolizing enzyme localization and activities in the first trimester human placenta: the effect of maternal and gestational age, smoking and alcohol consumption.
Journal: Human reproduction (Oxford, England) 20021001
Title: Plasma levels of TNF-alpha and IL-6 are inversely related to cytochrome P450-dependent drug metabolism in patients with congestive heart failure.
Journal: Journal of cardiac failure 20021001
Title: Cytochrome P450 2E1 expression induces hepatocyte resistance to cell death from oxidative stress.
Journal: Antioxidants & redox signaling 20021001
Title: Cytochrome P4502E1 phenotyping by the measurement of the chlorzoxazone metabolic ratio: assessment of its usefulness in workers exposed to styrene.
Journal: International archives of occupational and environmental health 20020901
Title: Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans.
Journal: Clinical pharmacology and therapeutics 20020901
Title: Cytochrome P450 2E1 and 3A activities do not differ between Mexicans and European Americans.
Journal: Clinical pharmacology and therapeutics 20020901
Title: Watercress has no Importance for the elimination of ethanol by CYP2E1 inhibition.
Journal: Pharmacology & toxicology 20020901
Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
Journal: The Journal of biological chemistry 20020419
Title: Effect of methacrylonitrile on cytochrome P-450 2E1 (CYP2E1) expression in male F344 rats.
Journal: Journal of toxicology and environmental health. Part A 20020412
Title: Effects of cysteine on the pharmacokinetics of intravenous chlorzoxazone in rats with protein-calorie malnutrition.
Journal: Biopharmaceutics & drug disposition 20020401
Title: Inhibition of cytochromes P450 by antifungal imidazole derivatives.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20020301
Title: The alkaloid rutaecarpine is a selective inhibitor of cytochrome P450 1A in mouse and human liver microsomes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20020301
Title: Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat.
Journal: Biochemical pharmacology 20020301
Title: Effects of flavonoids isolated from Scutellariae radix on cytochrome P-450 activities in human liver microsomes.
Journal: Journal of toxicology and environmental health. Part A 20020301
Title: Cytochrome P450 enzymes contributing to demethylation of maprotiline in man.
Journal: Pharmacology & toxicology 20020301
Title: Effect of chronic disulfiram administration on the activities of CYP1A2, CYP2C19, CYP2D6, CYP2E1, and N-acetyltransferase in healthy human subjects.
Journal: British journal of clinical pharmacology 20020201
Title: Dynamics of cytochrome P4502E1 activity in man: induction by ethanol and disappearance during withdrawal phase.
Journal: Journal of hepatology 20020101
Title: Fondaparinux sodium is not metabolised in mammalian liver fractions and does not inhibit cytochrome P450-mediated metabolism of concomitant drugs.
Journal: Clinical pharmacokinetics 20020101
Title: Mechanism of aerobic transformation of carbon tetrachloride by poplar cells.
Journal: Biodegradation 20020101
Title: Stability of cytochrome P450 enzymes in human liver samples stored in different tissue preservation buffers.
Journal: Research communications in molecular pathology and pharmacology 20020101
Title: Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components.
Journal: Toxicology letters 20011215
Title: Chlorzoxazone or 1-EBIO increases Na(+) absorption across cystic fibrosis airway epithelial cells.
Journal: American journal of physiology. Lung cellular and molecular physiology 20011101
Title: Low doses of nicotine and ethanol induce CYP2E1 and chlorzoxazone metabolism in rat liver.
Journal: The Journal of pharmacology and experimental therapeutics 20011101
Title: Contribution of CYP1A2 in the hepatic metabolism of melatonin: studies with isolated microsomal preparations and liver slices.
Journal: Journal of pineal research 20011101
Title: Assessment of cytochrome P450 activity by a five-drug cocktail approach.
Journal: Clinical pharmacology and therapeutics 20011101
Title: In vitro evaluation of valproic acid as an inhibitor of human cytochrome P450 isoforms: preferential inhibition of cytochrome P450 2C9 (CYP2C9).
Journal: British journal of clinical pharmacology 20011101
Title: An interaction between the cytochrome P450 probe substrates chlorzoxazone (CYP2E1) and midazolam (CYP3A).
Journal: British journal of clinical pharmacology 20011101
Title: Toxicity and effects of 2,6-di-tert-butyl-4-methylphenyl N-methylcarbamate (terbutol) on hepatic cytochrome P450 in F344 rats.
Journal: Archives of toxicology 20011101
Title: Cytochrome CYP2E1 phenotyping and genotyping in the evaluation of health risks from exposure to polluted environments.
Journal: Toxicology letters 20011015
Title: The effect of endotoxin on hepatocyte nuclear factor 1 nuclear protein binding: potential implications on CYP2E1 expression in the rat.
Journal: The Journal of pharmacy and pharmacology 20011001
Title: Metabolism of vanoxerine, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine, by human cytochrome P450 enzymes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20010901
Title: Effect of ivermectin on activities of cytochrome P450 isoenzymes in mouflon (Ovis musimon) and fallow deer (Dama dama).
Journal: Chemico-biological interactions 20010831
Title: Cytochrome P4502E1 induction increases thioacetamide liver injury in diet-restricted rats.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20010801
Title: Inhibition and inactivation of human cytochrome P450 isoforms by phenethyl isothiocyanate.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20010801
Title: Expression of cytochrome P450 2E1 in normal human bronchial epithelial cells and activation by ethanol in culture.
Journal: Archives of toxicology 20010801
Title: Chlorzoxazone: a probe drug the metabolism of which can be used to monitor one-point blood sampling in the carbon tetrachloride-intoxicated rat.
Journal: Human & experimental toxicology 20010801
Title: Synthetic chloride channel restores glutathione secretion in cystic fibrosis airway epithelia.
Journal: American journal of physiology. Lung cellular and molecular physiology 20010701
Title: The effects of alcohol and diallyl sulphide on CYP2E1 activity in humans: a phenotyping study using chlorzoxazone.
Journal: Human & experimental toxicology 20010701
Title: Identification of multiple constitutive and inducible hepatic cytochrome P450 enzymes in market weight swine.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20010601
Title: Spectrofluorometric determination of ibuprofen in pharmaceutical formulations.
Journal: Journal of pharmaceutical and biomedical analysis 20010601
Title: Genetic and dietary factors affecting human metabolism of 1,3-butadiene.
Journal: Chemico-biological interactions 20010601
Title: Genetic repeat polymorphism in the regulating region of CYP2E1: frequency and relationship with enzymatic activity in alcoholics.
Journal: Alcoholism, clinical and experimental research 20010601
Title: A comparison of aroclor 1254-induced and uninduced rat liver microsomes to human liver microsomes in phenytoin O-deethylation, coumarin 7-hydroxylation, tolbutamide 4-hydroxylation, S-mephenytoin 4'-hydroxylation, chloroxazone 6-hydroxylation and testosterone 6beta-hydroxylation.
Journal: Chemico-biological interactions 20010516
Title: Metabolic capacity and interindividual variation in toxicokinetics of styrene in volunteers.
Journal: Human & experimental toxicology 20010501
Title: Mitochondrial dysfunction by gamma-irradiation accompanies the induction of cytochrome P450 2E1 (CYP2E1) in rat liver.
Journal: Toxicology 20010321
Title: In vitro inhibition of cytochrome P450 enzymes in human liver microsomes by a potent CYP2A6 inhibitor, trans-2-phenylcyclopropylamine (tranylcypromine), and its nonamine analog, cyclopropylbenzene.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20010301
Title: Tissue-specific alterations in the 6-hydroxylation of chlorzoxazone following traumatic brain injury in the rat.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20010301
Title: Modulation of recombinant small-conductance Ca(2+)-activated K(+) channels by the muscle relaxant chlorzoxazone and structurally related compounds.
Journal: The Journal of pharmacology and experimental therapeutics 20010301
Title: Cytochrome p450-dependent metabolism of trichloroethylene in rat kidney.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20010301
Title: Cytochrome P450 expression and related metabolism in human buccal mucosa.
Journal: Carcinogenesis 20010301
Title: Inhibition of human CYP1A2 activity in vitro by methylxanthines: potent competitive inhibition by 8-phenyltheophylline.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20010301
Title: Assessment of CFTR chloride channel openers in intact normal and cystic fibrosis murine epithelia.
Journal: British journal of pharmacology 20010201
Title: Effects of organic solvents on the activities of cytochrome P450 isoforms, UDP-dependent glucuronyl transferase, and phenol sulfotransferase in human hepatocytes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20010201
Title: One hundred percent online identity check of pharmaceutical products by near-infrared spectroscopy on the packaging line.
Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20010101
Title: Characterization of xenobiotic-metabolizing cytochrome P450 (CYP) forms in ringed and grey seals from the Baltic Sea and reference sites.
Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20010101
Title: High-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing strategy. VI. Simultaneous evaluation of inhibition potential of drugs on human hepatic isozymes CYP2A6, 3A4, 2C9, 2D6 and 2E1.
Journal: Rapid communications in mass spectrometry : RCM 20010101
Title: EBIO, an agent causing maintained epithelial chloride secretion by co-ordinate actions at both apical and basolateral membranes.
Journal: Pflugers Archiv : European journal of physiology 20010101
Title: In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6.
Journal: British journal of clinical pharmacology 20000401
Title: Pharmacological activation of cloned intermediate- and small-conductance Ca(2+)-activated K(+) channels.
Journal: American journal of physiology. Cell physiology 20000301
Title: [Rhabdomyolysis and cholestatic hepatitis under treatment with simvastatin and chlorzoxazone].
Journal: Schweizerische medizinische Wochenschrift 19990403
Title: Metabolism of benzene in human liver microsomes: individual variations in relation to CYP2E1 expression.
Journal: Archives of toxicology 19990201
Title: CYP2E1-dependent benzene toxicity: the role of extrahepatic benzene metabolism.
Journal: Archives of toxicology 19990101
Title: [Severe hepatocellular damage after administration of paracetamol and chlorzoxazone in therapeutic dosage].
Journal: Praxis 19981007
Title: Expression of cytochrome P4502E1 in human liver: assessment by mRNA, genotype and phenotype.
Journal: Pharmacogenetics 19981001
Title: Cytochrome P450 catalyzed oxidation of monochlorobenzene, 1,2- and 1,4-dichlorobenzene in rat, mouse, and human liver microsomes.
Journal: Chemico-biological interactions 19980814
Title: Identification of CYP2E1 in marmoset monkey.
Journal: Biochimica et biophysica acta 19980217
Title: Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes.
Journal: The Journal of pharmacology and experimental therapeutics 19980201
Title: Benzene poisoning, a risk factor for hematological malignancy, is associated with the NQO1 609C-->T mutation and rapid fractional excretion of chlorzoxazone.
Journal: Cancer research 19970715
Title: In vivo and in vitro characterization of CYP2E1 activity in Japanese and Caucasians.
Journal: The Journal of pharmacology and experimental therapeutics 19961001
Title: Human cytochrome P450 isoform specificity in the regioselective metabolism of toluene and o-, m- and p-xylene.
Journal: The Journal of pharmacology and experimental therapeutics 19960101
Title: Human cytochrome P450 enzyme selectivities in the oxidation of chlorinated benzenes.
Journal: Toxicology and applied pharmacology 19950501
Title: Renal tumorigenicity of 1,1-dichloroethene in mice: the role of male-specific expression of cytochrome P450 2E1 in the renal bioactivation of 1,1-dichloroethene.
Journal: Toxicology and applied pharmacology 19950101
Title: Metabolic oxidation and toxification of N-methylformamide catalyzed by the cytochrome P450 isoenzyme CYP2E1.
Journal: Molecular pharmacology 19920201
Title: Chlorzoxazone-induced spasmotic torticollis.
Journal: JAMA 19811204
Title: Yamamura Y, et al. Comprehensive kinetic analysis and influence of reaction components for chlorzoxazone 6-hydroxylation in human liver microsomes with CYP antibodies. Xenobiotica. 2015 Apr;45(4):353-360.
