Home Other Building Blocks 950912-80-8
950912-80-8,MFCD12828759
Catalog No.:AA01CC00

950912-80-8 | PF-670462

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$21.00   $15.00
- +
5mg
98%
in stock  
$50.00   $35.00
- +
10mg
98%
in stock  
$73.00   $51.00
- +
50mg
98%
in stock  
$208.00   $146.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01CC00
Chemical Name:
PF-670462
CAS Number:
950912-80-8
Molecular Formula:
C19H22Cl2FN5
Molecular Weight:
410.3159
MDL Number:
MFCD12828759
SMILES:
Nc1nccc(n1)c1n(cnc1c1ccc(cc1)F)C1CCCCC1.Cl.Cl
Properties
Computed Properties
 
Complexity:
422  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
3  

Literature

Title: Inhibition of αENaC expression and ENaC activity following blockade of the circadian clock-regulatory kinases CK1δ/ε.

Journal: American journal of physiology. Renal physiology 20121001

Title: Inhibition of the casein-kinase-1-ε/δ/ prevents relapse-like alcohol drinking.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20120801

Title: IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation.

Journal: Oncogene 20110602

Title: Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period.

Journal: The Journal of pharmacology and experimental therapeutics 20090801

Title: A role for casein kinase 1 epsilon in the locomotor stimulant response to methamphetamine.

Journal: Psychopharmacology 20090501

Title: An inhibitor of casein kinase I epsilon induces phase delays in circadian rhythms under free-running and entrained conditions.

Journal: The Journal of pharmacology and experimental therapeutics 20070801

Title: Badura L, et al. An inhibitor of casein kinase I epsilon induces phase delays in circadian rhythms under free-running and entrained conditions. J Pharmacol Exp Ther. 2007 Aug;322(2):730-8. Epub 2007 May 14.

Title: Cheong JK, et al. IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/? and Wnt/β-catenin independent inhibition of mitotic spindle formation. Oncogene. 2011 Jun 2;30(22):2558-69.

Title: Kennaway DJ, et al. Acute inhibition of casein kinase 1δ/ε rapidly delays peripheral clock gene rhythms. Mol Cell Biochem. 2015 Jan;398(1-2):195-206.

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SDS
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