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951650-22-9,MFCD14635200
Catalog No.:AA01DOK9

951650-22-9 | NS 11394

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1mg
≥98%
in stock  
$46.00   $32.00
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5mg
≥98%
in stock  
$199.00   $139.00
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10mg
≥98%
in stock  
$348.00   $243.00
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100mg
95%
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$662.00   $463.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01DOK9
Chemical Name:
NS 11394
CAS Number:
951650-22-9
Molecular Formula:
C23H19N3O
Molecular Weight:
353.4165
MDL Number:
MFCD14635200
SMILES:
N#Cc1ccccc1c1cccc(c1)n1cnc2c1ccc(c2)C(O)(C)C
Properties
Computed Properties
 
Complexity:
567  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
4.1  

Literature

Title: Positive allosteric modulation of GABA-A receptors reduces capsaicin-induced primary and secondary hypersensitivity in rats.

Journal: Neuropharmacology 20121201

Title: Comparison of the novel subtype-selective GABAA receptor-positive allosteric modulator NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with diazepam, zolpidem, bretazenil, and gaboxadol in rat models of inflammatory and neuropathic pain.

Journal: The Journal of pharmacology and experimental therapeutics 20081201

Title: NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile], a unique subtype-selective GABAA receptor positive allosteric modulator: in vitro actions, pharmacokinetic properties and in vivo anxiolytic efficacy.

Journal: The Journal of pharmacology and experimental therapeutics 20081201

Title: N. R. Mirza, et al. NS11394 --(1-Hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl-biphenyl-2-carbonitrile, a Unique Subtype-Selective GABAA Receptor Positive Allosteric Modulator: In Vitro Actions, Pharmacokinetic Properties and in Vivo Anxiolytic Efficacy. THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2008 Jul.

Title: G. Munro, J. A., et al. Comparison of the Novel Subtype-Selective GABAA Receptor-Positive Allosteric Modulator NS11394 ′--(1-Hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl-biphenyl-2-carbonitrile with Diazepam, Zolpidem, Bretazenil, and Gaboxadol in Rat Models of Inflammatory and Neuropathic Pain. Journal of Pharmacology and Experimental Therapeutics December 2008, 327 (3) 969-981.

Title: Martine Hofmann, et al. Assessment of the effects of NS11394 and L-838417, a2/3 subunit-selective GABAA receptor-positive allosteric modulators, in tests for pain, anxiety, memory and motor function. Behavioural Pharmacology 2012, 23:790–801.

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