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95635-56-6,MFCD03788770
Catalog No.:AA00H8NT

95635-56-6 | Ranolazine dihydrochloride

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Purity
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100mg
98%(HPLC)
in stock  
$42.00   $29.00
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250mg
96%
in stock  
$60.00   $42.00
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1g
96%
in stock  
$133.00   $94.00
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5g
96%
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$427.00   $299.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00H8NT
Chemical Name:
Ranolazine dihydrochloride
CAS Number:
95635-56-6
Molecular Formula:
C24H35Cl2N3O4
Molecular Weight:
500.4584
MDL Number:
MFCD03788770
SMILES:
COc1ccccc1OCC(CN1CCN(CC1)CC(=O)Nc1c(C)cccc1C)O.Cl.Cl
Properties
Properties
 
BP:
624.1°C at 760 mmHg  
Form:
Solid  
MP:
222-229.5 °C(lit.)  
Solubility:
H2O: 10 mg/mL, soluble  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
531  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
9  
Undefined Atom Stereocenter Count:
1  

Literature

Title: Differential regulation of tefluthrin and telmisartan on the gating charges of I(Na) activation and inactivation as well as on resurgent and persistent I(Na) in a pituitary cell line (GH(3)).

Journal: Toxicology letters 20180315

Title: Mechanism of As2O3-Induced Action Potential Prolongation and Using hiPS-CMs to Evaluate the Rescue Efficacy of Drugs With Different Rescue Mechanism.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20170801

Title: Discovery of triazolopyridine GS-458967, a late sodium current inhibitor (Late INai) of the cardiac NaV 1.5 channel with improved efficacy and potency relative to ranolazine.

Journal: Bioorganic & medicinal chemistry letters 20160701

Title: Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11).

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20131201

Title: Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20131201

Title: Effect of ranolazine on left ventricular dyssynchrony in patients with coronary artery disease.

Journal: The American journal of cardiology 20121115

Title: Late sodium current inhibition alone with ranolazine is sufficient to reduce ischemia- and cardiac glycoside-induced calcium overload and contractile dysfunction mediated by reverse-mode sodium/calcium exchange.

Journal: The Journal of pharmacology and experimental therapeutics 20121101

Title: Antiarrhythmic properties of ranolazine--from bench to bedside.

Journal: Expert opinion on investigational drugs 20121101

Title: Pathological role of serum- and glucocorticoid-regulated kinase 1 in adverse ventricular remodeling.

Journal: Circulation 20121030

Title: Electrophysiological characterization of sodium-activated potassium channels in NG108-15 and NSC-34 motor neuron-like cells.

Journal: Acta physiologica (Oxford, England) 20121001

Title: Effects of ranolazine on exercise tolerance and angina frequency in patients with severe chronic angina receiving maximally-tolerated background therapy: analysis from the Combination Assessment of Ranolazine In Stable Angina (CARISA) randomized trial.

Journal: European journal of preventive cardiology 20121001

Title: Carbon monoxide induces cardiac arrhythmia via induction of the late Na+ current.

Journal: American journal of respiratory and critical care medicine 20121001

Title: [New pharmacological approaches to ischemic heart disease].

Journal: Giornale italiano di cardiologia (2006) 20121001

Title: Comparison of effectiveness of ranolazine plus amiodarone versus amiodarone alone for conversion of recent-onset atrial fibrillation.

Journal: The American journal of cardiology 20120901

Title: New treatment options for late Na current, arrhythmias, and diastolic dysfunction.

Journal: Current heart failure reports 20120901

Title: Ranolazine-induced severe bladder hypotonia.

Journal: The Annals of pharmacotherapy 20120901

Title: Long-term nerve excitability changes by persistent Na+ current blocker ranolazine.

Journal: Neuroscience letters 20120830

Title: [Involvement of veratridine-induced increase of reverse Na(+)/Ca(2+) exchange current in intracellular Ca(2+) overload and extension of action potential duration in rabbit ventricular myocytes].

Journal: Sheng li xue bao : [Acta physiologica Sinica] 20120825

Title: A novel reverse phase stability indicating RP-UPLC method for the quantitative determination of fifteen related substances in Ranolazine drug substance and drug product.

Journal: Talanta 20120815

Title: Metabolic antianginal agent ranolazine offers good symptom relief in a patient with inoperable severe aortic stenosis.

Journal: Cardiovascular therapeutics 20120801

Title: ATX-II-induced pulmonary vein arrhythmogenesis related to atrial fibrillation and long QT syndrome.

Journal: European journal of clinical investigation 20120801

Title: Prospective evaluation of pregnancy-associated plasma protein-a and outcomes in patients with acute coronary syndromes.

Journal: Journal of the American College of Cardiology 20120724

Title: Development and validation of a sensitive U-HPLC-MS/MS method with electrospray ionization for quantitation of ranolazine in human plasma: application to a clinical pharmacokinetic study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120715

Title: Treating stable angina - is there a NICE way towards an international consensus?

Journal: International journal of clinical practice 20120701

Title: Changes of the peripheral nerve excitability in vivo induced by the persistent Na+ current blocker ranolazine.

Journal: Neuroscience letters 20120614

Title: Ranolazine decreases mechanosensitivity of the voltage-gated sodium ion channel Na(v)1.5: a novel mechanism of drug action.

Journal: Circulation 20120605

Title: Cardiac sodium channel Na(v)1.5 mechanosensitivity is inhibited by ranolazine.

Journal: Circulation 20120605

Title: Ranolazine stabilizes cardiac ryanodine receptors: a novel mechanism for the suppression of early afterdepolarization and torsades de pointes in long QT type 2.

Journal: Heart rhythm 20120601

Title: Block of Na+ currents and suppression of action potentials in embryonic rat dorsal root ganglion neurons by ranolazine.

Journal: Neuropharmacology 20120601

Title: Costs and clinical outcomes associated with use of ranolazine for treatment of angina.

Journal: Clinical therapeutics 20120601

Title: A pilot randomized study of ranolazine for reduction of myocardial damage during elective percutaneous coronary intervention.

Journal: American heart journal 20120601

Title: Osteoprotegerin and cardiovascular mortality in patients with non-ST elevation acute coronary syndromes.

Journal: Heart (British Cardiac Society) 20120515

Title: Effect of ranolazine on rat intrarenal arteries in vitro.

Journal: European journal of pharmacology 20120515

Title: Osteoprotegerin and outcomes in acute coronary syndromes--when the culprit is not the plaque.

Journal: Heart (British Cardiac Society) 20120501

Title: Rate-dependent effects of vernakalant in the isolated non-remodeled canine left atria are primarily due to block of the sodium channel: comparison with ranolazine and dl-sotalol.

Journal: Circulation. Arrhythmia and electrophysiology 20120401

Title: Electrophysiological characteristics of canine superior vena cava sleeve preparations: effect of ranolazine.

Journal: Circulation. Arrhythmia and electrophysiology 20120401

Title: [Management of refractory symptoms in hypertrophic cardiomyopathy with restrictive pathophysiology: novel perspectives for ranolazine].

Journal: Giornale italiano di cardiologia (2006) 20120401

Title: [Update coronary artery disease: important progresses in acute and chronic therapy].

Journal: MMW Fortschritte der Medizin 20120322

Title: Ranolazine improves cardiac diastolic dysfunction through modulation of myofilament calcium sensitivity.

Journal: Circulation research 20120316

Title: Development and validation of a sensitive LC-MS/MS assay for simultaneous quantitation of ranolazine and its three metabolites in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120315

Title: Ranolazine safely decreases ventricular and atrial fibrillation in Timothy syndrome (LQT8).

Journal: Pacing and clinical electrophysiology : PACE 20120301

Title: Comparison of electrophysiological and antiarrhythmic effects of vernakalant, ranolazine, and sotalol in canine pulmonary vein sleeve preparations.

Journal: Heart rhythm 20120301

Title: Comparative pharmacophysiology of vernakalant, ranolazine, and d-sotalol in canine pulmonary vein sleeve preparations: new flavors or same old taste?

Journal: Heart rhythm 20120301

Title: Role of ranolazine in angina, heart failure, arrhythmias, and diabetes.

Journal: Pharmacology & therapeutics 20120301

Title: Damage to mitochondrial complex I during cardiac ischemia reperfusion injury is reduced indirectly by anti-anginal drug ranolazine.

Journal: Biochimica et biophysica acta 20120301

Title: The use of ranolazine to facilitate electrical cardioversion in cardioversion-resistant patients: a case series.

Journal: Pacing and clinical electrophysiology : PACE 20120301

Title: Second chance for dronedarone after recent setback?

Journal: Lancet (London, England) 20120218

Title: [Conservative therapy of patients with stable coronary heart disease].

Journal: Herz 20120201

Title: Ranolazine for the treatment of refractory angina in a veterans population.

Journal: Cardiovascular revascularization medicine : including molecular interventions 20120101

Title: Therapeutic inhibition of fatty acid oxidation in right ventricular hypertrophy: exploiting Randle's cycle.

Journal: Journal of molecular medicine (Berlin, Germany) 20120101

Title: Atrial-selective sodium channel block strategy to suppress atrial fibrillation: ranolazine versus propafenone.

Journal: The Journal of pharmacology and experimental therapeutics 20120101

Title: Role of ST2 in non-ST-elevation acute coronary syndrome in the MERLIN-TIMI 36 trial.

Journal: Clinical chemistry 20120101

Title: Clinical experience with ranolazine in a veteran population with chronic stable angina.

Journal: The Annals of pharmacotherapy 20120101

Title: Is randomization to placebo safe? Risk in placebo-controlled angina trials: angina risk meta-analysis.

Journal: Cardiology 20120101

Title: Ranolazine, tacrolimus, and diltiazem might be a hazardous combination in a transplant patient.

Journal: Renal failure 20120101

Title: [Ranolazine in the treatment of chronic stable angina].

Journal: La Clinica terapeutica 20120101

Title: Validated liquid chromatography mass spectrometry method for quantitative determination of strictosamide in dog plasma and its application to pharmacokinetic study.

Journal: Biomedical chromatography : BMC 20111201

Title: Ranolazine reduces ventricular tachycardia burden and ICD shocks in patients with drug-refractory ICD shocks.

Journal: Pacing and clinical electrophysiology : PACE 20111201

Title: Effects of ranolazine on cloned cardiac kv4.3 potassium channels.

Journal: The Journal of pharmacology and experimental therapeutics 20111201

Title: The editor's roundtable: role of percutaneous coronary intervention and drug-eluting stents in patients with stable coronary heart disease.

Journal: The American journal of cardiology 20111115

Title: Metabolic modulation: a new therapeutic target in treatment of heart failure.

Journal: American journal of therapeutics 20111101

Title: Arrhythmogenic left atrial cellular electrophysiology in a murine genetic long QT syndrome model.

Journal: Cardiovascular research 20111001

Title: Ranolazine reduces Ca2+ overload and oxidative stress and improves mitochondrial integrity to protect against ischemia reperfusion injury in isolated hearts.

Journal: Pharmacological research 20111001

Title: Mechanisms of atrial-selective block of Na⁺ channels by ranolazine: I. Experimental analysis of the use-dependent block.

Journal: American journal of physiology. Heart and circulatory physiology 20111001

Title: Mechanisms of atrial-selective block of Na⁺ channels by ranolazine: II. Insights from a mathematical model.

Journal: American journal of physiology. Heart and circulatory physiology 20111001

Title: [The late sodium current: pathophysiology and pharmacology of a new therapeutic target].

Journal: Giornale italiano di cardiologia (2006) 20111001

Title: Ranolazine injection into coronary or femoral arteries exerts marked, transient regional vasodilation without systemic hypotension in an intact porcine model.

Journal: Circulation. Cardiovascular interventions 20111001

Title: Modulation of the late sodium current by ATX-II and ranolazine affects the reverse use-dependence and proarrhythmic liability of IKr blockade.

Journal: British journal of pharmacology 20110901

Title: Nav1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S mice.

Journal: American journal of physiology. Cell physiology 20110901

Title: Estimating the risk of drug-induced proarrhythmia using human induced pluripotent stem cell-derived cardiomyocytes.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20110901

Title: Comparison of effectiveness and safety of ranolazine versus amiodarone for preventing atrial fibrillation after coronary artery bypass grafting.

Journal: The American journal of cardiology 20110901

Title: Effects of ranolazine on cardiovascular system.

Journal: Recent patents on cardiovascular drug discovery 20110901

Title: The antianginal agent ranolazine is a potent antiarrhythmic agent that reduces ventricular arrhythmias: through a mechanism favoring inhibition of late sodium channel.

Journal: Cardiovascular therapeutics 20110801

Title: Electrophysiologic basis for the antiarrhythmic actions of ranolazine.

Journal: Heart rhythm 20110801

Title: Ranolazine: Déjà vu of the amiodarone story.

Journal: Heart rhythm 20110801

Title: Medical therapy versus myocardial revascularization in chronic coronary syndrome and stable angina.

Journal: The American journal of medicine 20110801

Title: Class I/B antiarrhythmic property of ranolazine, a novel antianginal agent, in dog and human cardiac preparations.

Journal: European journal of pharmacology 20110715

Title: Ranolazine for the treatment of heart failure with preserved ejection fraction: background, aims, and design of the RALI-DHF study.

Journal: Clinical cardiology 20110701

Title: [New agents for the therapy of angina pectoris].

Journal: Der Internist 20110701

Title: Ranolazine: an antianginal drug with antiarrhythmic properties.

Journal: Expert review of cardiovascular therapy 20110701

Title: Improvement in left ventricular systolic and diastolic performance during ranolazine treatment in patients with stable angina.

Journal: Journal of cardiovascular pharmacology and therapeutics 20110601

Title: First direct comparison of the late sodium current blocker ranolazine to established antiarrhythmic agents in an ischemia/reperfusion model.

Journal: Journal of cardiovascular pharmacology and therapeutics 20110601

Title: Antiadrenergic and hemodynamic effects of ranolazine in conscious dogs.

Journal: Journal of cardiovascular pharmacology 20110601

Title: Reducing the late sodium current improves cardiac function during sodium pump inhibition by ouabain.

Journal: The Journal of pharmacology and experimental therapeutics 20110501

Title: The effect of ranolazine on the vasodilator-induced myocardial perfusion abnormality.

Journal: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 20110501

Title: Ranolazine improves angina in women with evidence of myocardial ischemia but no obstructive coronary artery disease.

Journal: JACC. Cardiovascular imaging 20110501

Title: Late sodium current contributes to the reverse rate-dependent effect of IKr inhibition on ventricular repolarization.

Journal: Circulation 20110426

Title: Letter by Madias regarding article, 'Relationship between nonsustained ventricular tachycardia after non-ST-elevation acute coronary syndrome and sudden cardiac death: observations from the Metabolic Efficiency with Ranolazine for Less Ischemia in Non-ST-Elevation Acute Coronary Syndrome-Thrombolysis in Myocardial Infarction 36 (MERLIN-TIMI 36) randomized controlled trial'.

Journal: Circulation 20110412

Title: Letter by Ayalloore and LeLorier regarding article, 'Relationship between nonsustained ventricular tachycardia after non-ST-elevation acute coronary syndrome and sudden cardiac death: observations from the Metabolic Efficiency with Ranolazine for Less Ischemia in Non-ST-Elevation Acute Coronary Syndrome-Thrombolysis in Myocardial Infarction 36 (MERLIN-TIMI 36) randomized controlled trial'.

Journal: Circulation 20110412

Title: Antifibrillatory effect of ranolazine during severe coronary stenosis in the intact porcine model.

Journal: Heart rhythm 20110401

Title: Ranolazine increases β-cell survival and improves glucose homeostasis in low-dose streptozotocin-induced diabetes in mice.

Journal: The Journal of pharmacology and experimental therapeutics 20110401

Title: Suppression of re-entrant and multifocal ventricular fibrillation by the late sodium current blocker ranolazine.

Journal: Journal of the American College of Cardiology 20110118

Title: Electrophysiological properties of HBI-3000: a new antiarrhythmic agent with multiple-channel blocking properties in human ventricular myocytes.

Journal: Journal of cardiovascular pharmacology 20110101

Title: Angiotensin II induces afterdepolarizations via reactive oxygen species and calmodulin kinase II signaling.

Journal: Journal of molecular and cellular cardiology 20110101

Title: Y1767C, a novel SCN5A mutation, induces a persistent Na+ current and potentiates ranolazine inhibition of Nav1.5 channels.

Journal: American journal of physiology. Heart and circulatory physiology 20110101

Title: Ranolazine block of human Na v 1.4 sodium channels and paramyotonia congenita mutants.

Journal: Channels (Austin, Tex.) 20110101

Title: Extended-release ranolazine: critical evaluation of its use in stable angina.

Journal: Vascular health and risk management 20110101

Title: The electrophysiological properties of ranolazine: a metabolic anti-ischemic drug or an energy-efficient antiarrhythmic agent?

Journal: Reviews in cardiovascular medicine 20110101

Title: Ranolazine--treatment of ventricular tachycardia and symptomatic ventricular premature beats in ischemic cardiomyopathy.

Journal: Pacing and clinical electrophysiology : PACE 20101201

Title: Effects of ranolazine on fatty acid transformation in the isolated perfused rat liver.

Journal: Molecular and cellular biochemistry 20101201

Title: Perspective: does ranolazine have potential for the treatment of atrial fibrillation?

Journal: Expert opinion on investigational drugs 20101201

Title: [New developments in the antiarrhythmic therapy of atrial fibrillation].

Journal: Herzschrittmachertherapie & Elektrophysiologie 20101201

Title: Ranolazine selectively blocks persistent current evoked by epilepsy-associated Naν1.1 mutations.

Journal: British journal of pharmacology 20101101

Title: Ranolazine-tacrolimus interaction.

Journal: The Annals of pharmacotherapy 20101101

Title: Rhabdomyolysis in a patient receiving ranolazine and simvastatin.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20101101

Title: Synergistic effect of the combination of ranolazine and dronedarone to suppress atrial fibrillation.

Journal: Journal of the American College of Cardiology 20101005

Title: [Ranolazine--an additional anti-anginal drug].

Journal: Deutsche medizinische Wochenschrift (1946) 20101001

Title: The anti-ischemic mechanism of action of ranolazine in stable ischemic heart disease.

Journal: Journal of the American College of Cardiology 20100914

Title: Ranolazine and its anti-ischemic effects: revisiting an old mechanistic paradigm anew?

Journal: Journal of the American College of Cardiology 20100914

Title: [Optimization of the formulation of ranolazine hydrochloride sustained-release tablet and its pharmacokinetics in dogs].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100901

Title: Ranolazine is effective for acute or chronic ischemic dysfunction with heart failure.

Journal: Journal of the American College of Cardiology 20100831

Title: The riddle of nonsustained ventricular tachycardia and sudden cardiac death: are we approaching a solution?

Journal: Circulation 20100803

Title: Relationship between nonsustained ventricular tachycardia after non-ST-elevation acute coronary syndrome and sudden cardiac death: observations from the metabolic efficiency with ranolazine for less ischemia in non-ST-elevation acute coronary syndrome-thrombolysis in myocardial infarction 36 (MERLIN-TIMI 36) randomized controlled trial.

Journal: Circulation 20100803

Title: Autophagy induced by ischemic preconditioning is essential for cardioprotection.

Journal: Journal of cardiovascular translational research 20100801

Title: Conventional and novel drug therapeutics to relief myocardial ischemia.

Journal: Cardiovascular drugs and therapy 20100801

Title: Late sodium current contributes to diastolic cell Ca2+ accumulation in chronic heart failure.

Journal: The journal of physiological sciences : JPS 20100701

Title: Modulation of myocardial metabolism: an emerging therapeutic principle.

Journal: Current opinion in cardiology 20100701

Title: Ask the doctor. A year ago, I had an orchiectomy for prostate cancer; my PSA is now 0.74. Not long afterward, I had two cardiac stents implanted. I still have some angina and shortness of breath. I started Ranexa a couple of weeks ago, which helps my angina. Do you have any suggestions for my heart since I no longer make testosterone, which I understand helps protect men's hearts and arteries.

Journal: Harvard heart letter : from Harvard Medical School 20100701

Title: Effect of ranolazine on A1C and glucose levels in hyperglycemic patients with non-ST elevation acute coronary syndrome.

Journal: Diabetes care 20100601

Title: Altered Na(+) currents in atrial fibrillation effects of ranolazine on arrhythmias and contractility in human atrial myocardium.

Journal: Journal of the American College of Cardiology 20100525

Title: Enhanced late na(+) currents in atrial fibrillation new drug target or just an epiphenomenon?

Journal: Journal of the American College of Cardiology 20100525

Title: Prospective evaluation of the prognostic implications of improved assay performance with a sensitive assay for cardiac troponin I.

Journal: Journal of the American College of Cardiology 20100511

Title: Clinical features and outcomes of women with unstable ischemic heart disease: observations from metabolic efficiency with ranolazine for less ischemia in non-ST-elevation acute coronary syndromes-thrombolysis in myocardial infarction 36 (MERLIN-TIMI 36).

Journal: Circulation 20100427

Title: New antiarrhythmic drugs for treatment of atrial fibrillation.

Journal: Lancet (London, England) 20100403

Title: Ranolazine (Ranexa) in the treatment of chronic stable angina.

Journal: Advances in therapy 20100401

Title: B-type natriuretic peptide and the effect of ranolazine in patients with non-ST-segment elevation acute coronary syndromes: observations from the MERLIN-TIMI 36 (Metabolic Efficiency With Ranolazine for Less Ischemia in Non-ST Elevation Acute Coronary-Thrombolysis In Myocardial Infarction 36) trial.

Journal: Journal of the American College of Cardiology 20100323

Title: Biomarker bonanza?

Journal: Journal of the American College of Cardiology 20100323

Title: Intrapericardial ranolazine prolongs atrial refractory period and markedly reduces atrial fibrillation inducibility in the intact porcine heart.

Journal: Journal of cardiovascular pharmacology 20100301

Title: Ranolazine: an anti-anginal drug with further therapeutic potential.

Journal: Expert review of cardiovascular therapy 20100301

Title: Late na(+) current inhibition by ranolazine reduces torsades de pointes in the chronic atrioventricular block dog model.

Journal: Journal of the American College of Cardiology 20100223

Title: Synergistic electrophysiologic and antiarrhythmic effects of the combination of ranolazine and chronic amiodarone in canine atria.

Journal: Circulation. Arrhythmia and electrophysiology 20100201

Title: Ranolazine-related dyspnea on exertion.

Journal: The American journal of geriatric pharmacotherapy 20100201

Title: Ranolazine attenuation of CFA-induced mechanical hyperalgesia.

Journal: Pain medicine (Malden, Mass.) 20100101

Title: Chick embryo partial ischemia model: a new approach to study ischemia ex vivo.

Journal: PloS one 20100101

Title: Effects of ranolazine on wild-type and mutant hNav1.7 channels and on DRG neuron excitability.

Journal: Molecular pain 20100101

Title: Ranolazine: a new approach to treating an old problem.

Journal: Texas Heart Institute journal 20100101

Title: At the dawn of a new era in treating angina pectoris, or just another antianginal drug? Some considerations about ranolazine.

Journal: Romanian journal of internal medicine = Revue roumaine de medecine interne 20100101

Title: [Ranolazine--new treatment of chronic stable angina pectoris].

Journal: Ugeskrift for laeger 20091207

Title: Ranolazine attenuates behavioral signs of neuropathic pain.

Journal: Behavioural pharmacology 20091201

Title: Ranolazine antagonizes the effects of increased late sodium current on intracellular calcium cycling in rat isolated intact heart.

Journal: The Journal of pharmacology and experimental therapeutics 20091101

Title: Ranolazine, an antianginal agent, markedly reduces ventricular arrhythmias induced by ischemia and ischemia-reperfusion.

Journal: American journal of physiology. Heart and circulatory physiology 20091101

Title: Use-dependent block of cardiac late Na(+) current by ranolazine.

Journal: Heart rhythm 20091101

Title: Synthesis of ranolazine metabolites and their anti-myocardial ischemia activities.

Journal: Chemical & pharmaceutical bulletin 20091101

Title: A study of the effects of ranolazine using automated quantitative analysis of serial myocardial perfusion images.

Journal: JACC. Cardiovascular imaging 20091101

Title: Ranolazine and the myocardial demand-supply balance.

Journal: JACC. Cardiovascular imaging 20091101

Title: A novel mechanism for the treatment of angina, arrhythmias, and diastolic dysfunction: inhibition of late I(Na) using ranolazine.

Journal: Journal of cardiovascular pharmacology 20091001

Title: A slowly inactivating sodium current contributes to spontaneous diastolic depolarization of atrial myocytes.

Journal: American journal of physiology. Heart and circulatory physiology 20091001

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: New pharmacological agents for arrhythmias.

Journal: Circulation. Arrhythmia and electrophysiology 20091001

Title: Suppression of non-sustained ventricular tachycardia with ranolazine: a case report.

Journal: WMJ : official publication of the State Medical Society of Wisconsin 20091001

Title: Ranolazine as a cardioplegia additive improves recovery of diastolic function in isolated rat hearts.

Journal: Circulation 20090915

Title: Reduction of repolarization reserve unmasks the proarrhythmic role of endogenous late Na(+) current in the heart.

Journal: American journal of physiology. Heart and circulatory physiology 20090901

Title: Chronic angina and the treatment with ranolazine: facts and recommendations.

Journal: Progress in cardiovascular nursing 20090901

Title: Analytical studies of rapidly inactivating and noninactivating sodium currents in differentiated NG108-15 neuronal cells.

Journal: Journal of theoretical biology 20090821

Title: Diastolic transient inward current in long QT syndrome type 3 is caused by Ca2+ overload and inhibited by ranolazine.

Journal: Journal of molecular and cellular cardiology 20090801

Title: The late Na+ current (INa) inhibitor ranolazine attenuates effects of palmitoyl-L-carnitine to increase late INa and cause ventricular diastolic dysfunction.

Journal: The Journal of pharmacology and experimental therapeutics 20090801

Title: Ranolazine improves endothelial function in patients with stable coronary artery disease.

Journal: Coronary artery disease 20090801

Title: Ranolazine: new drug. Stable angina: not worth the risk.

Journal: Prescrire international 20090801

Title: Ranolazine exerts potent effects on atrial electrical properties and abbreviates atrial fibrillation duration in the intact porcine heart.

Journal: Journal of cardiovascular electrophysiology 20090701

Title: Effects of ranolazine, a novel anti-anginal drug, on ion currents and membrane potential in pituitary tumor GH(3) cells and NG108-15 neuronal cells.

Journal: Journal of pharmacological sciences 20090701

Title: Economic impact of angina after an acute coronary syndrome: insights from the MERLIN-TIMI 36 trial.

Journal: Circulation. Cardiovascular quality and outcomes 20090701

Title: Ranolazine as an adjunct to cardioplegia: a potential new therapeutic application.

Journal: Journal of cardiovascular pharmacology and therapeutics 20090601

Title: Efficacy of ranolazine in patients with chronic angina observations from the randomized, double-blind, placebo-controlled MERLIN-TIMI (Metabolic Efficiency With Ranolazine for Less Ischemia in Non-ST-Segment Elevation Acute Coronary Syndromes) 36 Trial.

Journal: Journal of the American College of Cardiology 20090428

Title: Evaluation of the glycometabolic effects of ranolazine in patients with and without diabetes mellitus in the MERLIN-TIMI 36 randomized controlled trial.

Journal: Circulation 20090421

Title: Ischemia detected on continuous electrocardiography after acute coronary syndrome: observations from the MERLIN-TIMI 36 (Metabolic Efficiency With Ranolazine for Less Ischemia in Non-ST-Elevation Acute Coronary Syndrome-Thrombolysis In Myocardial Infarction 36) trial.

Journal: Journal of the American College of Cardiology 20090421

Title: Direct toxic effects of aqueous extract of cigarette smoke on cardiac myocytes at clinically relevant concentrations.

Journal: Toxicology and applied pharmacology 20090401

Title: Cardiomyocytes from postinfarction failing rat hearts have improved ischemia tolerance.

Journal: American journal of physiology. Heart and circulatory physiology 20090301

Title: The metabolic treatment of patients with coronary artery disease: effects on quality of life and effort angina.

Journal: Current pharmaceutical design 20090101

Title: [Mechanisms of myocardial cell protection from ischemia/reperfusion injury and potential clinical implications].

Journal: Giornale italiano di cardiologia (2006) 20090101

Title: Atrial-selective sodium channel block as a novel strategy for the management of atrial fibrillation.

Journal: Journal of electrocardiology 20090101

Title: The antiarrhythmic effects of ranolazine.

Journal: Reviews in cardiovascular medicine 20090101

Title: Potential application of late sodium current blockade in the treatment of heart failure and atrial fibrillation.

Journal: Reviews in cardiovascular medicine 20090101

Title: Determination of ranolazine in human plasma by LC-MS/MS and its application in bioequivalence study.

Journal: Journal of pharmaceutical and biomedical analysis 20081215

Title: Use of ranolazine in long-QT syndrome type 3.

Journal: Journal of cardiovascular electrophysiology 20081201

Title: Ranolazine shortens repolarization in patients with sustained inward sodium current due to type-3 long-QT syndrome.

Journal: Journal of cardiovascular electrophysiology 20081201

Title: Ranolazine combined with enalapril or metoprolol prevents progressive LV dysfunction and remodeling in dogs with moderate heart failure.

Journal: American journal of physiology. Heart and circulatory physiology 20081101

Title: Ranolazine: new paradigm for management of myocardial ischemia, myocardial dysfunction, and arrhythmias.

Journal: Cardiology clinics 20081101

Title: Effects of ranolazine on disease-specific health status and quality of life among patients with acute coronary syndromes: results from the MERLIN-TIMI 36 randomized trial.

Journal: Circulation. Cardiovascular quality and outcomes 20081101

Title: Ranolazine for chronic stable angina.

Journal: Lancet (London, England) 20081011

Title: Effect of ranolazine on ventricular vulnerability and defibrillation threshold in the intact porcine heart.

Journal: Journal of cardiovascular electrophysiology 20081001

Title: The antianginal agent, ranolazine, reduces myocardial infarct size but does not alter anatomic no-reflow or regional myocardial blood flow in ischemia/reperfusion in the rabbit.

Journal: Journal of cardiovascular pharmacology and therapeutics 20080901

Title: Pathophysiology and pharmacology of the cardiac 'late sodium current.'.

Journal: Pharmacology & therapeutics 20080901

Title: Chronic stable angina pectoris.

Journal: Disease-a-month : DM 20080901

Title: Determination of ranolazine in human plasma by liquid chromatographic-tandem mass spectrometric assay.

Journal: Journal of chromatographic science 20080901

Title: Utility of ranolazine in chronic stable angina patients.

Journal: Vascular health and risk management 20080801

Title: Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts--role of late sodium current and intracellular ion accumulation.

Journal: Journal of molecular and cellular cardiology 20080701

Title: Another calcium paradox in heart failure.

Journal: Journal of molecular and cellular cardiology 20080701

Title: Antiarrhythmic effects of ranolazine in canine pulmonary vein sleeve preparations.

Journal: Heart rhythm 20080701

Title: Chasing with ranolazine pulmonary vein afterpotentials before it's too late.

Journal: Heart rhythm 20080701

Title: The evolving role of medical therapy for chronic stable angina.

Journal: Current cardiology reports 20080701

Title: Expanding the understanding of the treatment of chronic angina: a 21st century approach-part II.

Journal: Clinical cardiology 20080701

Title: Metabolic agents in the management of diabetic coronary patients: a new era.

Journal: International journal of cardiology 20080623

Title: Antitorsadogenic effects of ({+/-})-N-(2,6-dimethyl-phenyl)-(4[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazine (ranolazine) in anesthetized rabbits.

Journal: The Journal of pharmacology and experimental therapeutics 20080601

Title: Late sodium current inhibition as a new cardioprotective approach.

Journal: Journal of molecular and cellular cardiology 20080601

Title: Ranolozine-induced suppression of ventricular tachycardia in a patient with nonischemic cardiomyopathy: a case report.

Journal: Pacing and clinical electrophysiology : PACE 20080601

Title: Rapid kinetic interactions of ranolazine with HERG K+ current.

Journal: Journal of cardiovascular pharmacology 20080601

Title: Expanding the understanding of the treatment of chronic angina: a 21st century approach--part 1.

Journal: Clinical cardiology 20080601

Title: An increase of late sodium current induces delayed afterdepolarizations and sustained triggered activity in atrial myocytes.

Journal: American journal of physiology. Heart and circulatory physiology 20080501

Title: Is ranolazine an antiarrhythmic drug?

Journal: American journal of physiology. Heart and circulatory physiology 20080501

Title: Ranolazine inhibits an oxidative stress-induced increase in myocyte sodium and calcium loading during simulated-demand ischemia.

Journal: Journal of cardiovascular pharmacology 20080501

Title: Mechanism of action of the new anti-ischemia drug ranolazine.

Journal: Clinical research in cardiology : official journal of the German Cardiac Society 20080401

Title: What's new in clinical pharmacology and therapeutics.

Journal: WMJ : official publication of the State Medical Society of Wisconsin 20080401

Title: Inhibition of late sodium current to reduce electrical and mechanical dysfunction of ischaemic myocardium.

Journal: British journal of pharmacology 20080301

Title: The cardiac persistent sodium current: an appealing therapeutic target?

Journal: British journal of pharmacology 20080301

Title: State- and use-dependent block of muscle Nav1.4 and neuronal Nav1.7 voltage-gated Na+ channel isoforms by ranolazine.

Journal: Molecular pharmacology 20080301

Title: Atrial-selective sodium channel block as a strategy for suppression of atrial fibrillation.

Journal: Annals of the New York Academy of Sciences 20080301

Title: Metabolic efficiency with ranolazine for less ischemia in non-ST elevation acute coronary syndromes (MERLIN TIMI-36) study.

Journal: Expert review of cardiovascular therapy 20080101

Title: [Determination of residual solvents in ranolazine by headspace gas chromatography].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20080101

Title: Ranolazine: a review of its use in chronic stable angina pectoris.

Journal: Drugs 20080101

Title: Block of tetrodotoxin-sensitive, Na(V)1.7 and tetrodotoxin-resistant, Na(V)1.8, Na+ channels by ranolazine.

Journal: Channels (Austin, Tex.) 20080101

Title: Multiple drug interactions in a renal transplant patient leading to simvastatin-induced rhabdomyolysis: a case report.

Journal: Medscape journal of medicine 20080101

Title: Sinus node dysfunction in ATX-II-induced in-vitro murine model of long QT3 syndrome and rescue effect of ranolazine.

Journal: Progress in biophysics and molecular biology 20080101

Title: Management of chronic stable angina pectoris.

Journal: Boletin de la Asociacion Medica de Puerto Rico 20080101

Title: Ranolazine: a new option in the management of chronic stable angina.

Journal: Pharmacotherapy 20071201

Title: Effect of ranolazine, an antianginal agent with novel electrophysiological properties, on the incidence of arrhythmias in patients with non ST-segment elevation acute coronary syndrome: results from the Metabolic Efficiency With Ranolazine for Less Ischemia in Non ST-Elevation Acute Coronary Syndrome Thrombolysis in Myocardial Infarction 36 (MERLIN-TIMI 36) randomized controlled trial.

Journal: Circulation 20071009

Title: The year in non-ST-segment elevation acute coronary syndrome.

Journal: Journal of the American College of Cardiology 20071002

Title: Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation: differences in sodium channel inactivation between atria and ventricles and the role of ranolazine.

Journal: Circulation 20070925

Title: Ranolazine in patients with coronary artery disease.

Journal: Expert opinion on pharmacotherapy 20070901

Title: Ranolazine--a nicely timed new medical therapy for stable angina.

Journal: International journal of clinical practice 20070701

Title: Ranolazine in patients with angina and coronary artery disease.

Journal: Current cardiology reports 20070701

Title: Cellular basis for the electrocardiographic and arrhythmic manifestations of Timothy syndrome: effects of ranolazine.

Journal: Heart rhythm 20070501

Title: Ranolazine: a novel agent that improves dysfunctional sodium channels.

Journal: International journal of clinical practice 20070501

Title: Effects of ranolazine on recurrent cardiovascular events in patients with non-ST-elevation acute coronary syndromes: the MERLIN-TIMI 36 randomized trial.

Journal: JAMA 20070425

Title: Does ranolazine have a place in the treatment of acute coronary syndromes?

Journal: JAMA 20070425

Title: A comparison between ranolazine and CVT-4325, a novel inhibitor of fatty acid oxidation, on cardiac metabolism and left ventricular function in rat isolated perfused heart during ischemia and reperfusion.

Journal: The Journal of pharmacology and experimental therapeutics 20070401

Title: New options help angina patients live more active lives. Treating the underlying disease may help you live longer, too.

Journal: Heart advisor 20070401

Title: Long-term safety of a novel antianginal agent in patients with severe chronic stable angina: the Ranolazine Open Label Experience (ROLE).

Journal: Journal of the American College of Cardiology 20070313

Title: Sensitive quantification of ranolazine in human plasma by liquid chromatography--tandem mass spectrometry with positive electrospray ionization.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070201

Title: Drug approvals.

Journal: The Nurse practitioner 20070201

Title: New drugs 07, part I.

Journal: Nursing 20070201

Title: Trials and tribulations associated with angina and traditional therapeutic approaches.

Journal: Clinical cardiology 20070201

Title: Novel therapeutic approaches to treating chronic angina in the setting of chronic ischemic heart disease.

Journal: Clinical cardiology 20070201

Title: Gender comparison of efficacy and safety of ranolazine for chronic angina pectoris in four randomized clinical trials.

Journal: The American journal of cardiology 20070101

Title: Safety and efficacy of extended-release ranolazine in patients aged 70 years or older with chronic stable angina pectoris.

Journal: The American journal of geriatric cardiology 20070101

Title: Ranolazine, a partial fatty acid oxidation inhibitor, its potential benefit in angina and other cardiovascular disorders.

Journal: Recent patents on cardiovascular drug discovery 20070101

Title: Ranolazine: a novel therapeutic option in chronic stable angina.

Journal: Kathmandu University medical journal (KUMJ) 20070101

Title: Ranolazine decreases diastolic calcium accumulation caused by ATX-II or ischemia in rat hearts.

Journal: Journal of molecular and cellular cardiology 20061201

Title: Ranolazine in the management of chronic stable angina.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20061201

Title: A pilot study of ranolazine in patients with intermittent claudication.

Journal: International angiology : a journal of the International Union of Angiology 20061201

Title: Ranolazine, an inhibitor of the late sodium channel current, reduces postischemic myocardial dysfunction in the rabbit.

Journal: Journal of cardiovascular pharmacology and therapeutics 20061201

Title: Ranolazine for the management of coronary artery disease.

Journal: Clinical therapeutics 20061201

Title: Inherited long QT syndrome: phenotype and therapy to use and avoid.

Journal: Clinical cardiology 20061001

Title: Modification of myocardial substrate use as a therapy for heart failure.

Journal: Nature clinical practice. Cardiovascular medicine 20060901

Title: Antianginal efficacy of ranolazine when added to treatment with amlodipine: the ERICA (Efficacy of Ranolazine in Chronic Angina) trial.

Journal: Journal of the American College of Cardiology 20060801

Title: Ranolazine: augmenting the antianginal armamentarium.

Journal: Journal of the American College of Cardiology 20060801

Title: Ranolazine, a novel anti-anginal agent, does not alter isosorbide dinitrate- or sildenafil-induced changes in blood pressure in conscious dogs.

Journal: European journal of pharmacology 20060717

Title: Improved left ventricular function and reduced necrosis after myocardial ischemia/reperfusion in rabbits treated with ranolazine, an inhibitor of the late sodium channel.

Journal: The Journal of pharmacology and experimental therapeutics 20060701

Title: Inhibition of the late sodium current as a potential cardioprotective principle: effects of the late sodium current inhibitor ranolazine.

Journal: Heart (British Cardiac Society) 20060701

Title: Treatment options for refractory angina in patients who are not candidates for revascularization.

Journal: Current cardiology reports 20060701

Title: Mechanism of action of ranolazine.

Journal: Archives of internal medicine 20060626

Title: Ranolazine (ranexa) for chronic angina.

Journal: The Medical letter on drugs and therapeutics 20060605

Title: Metabolic therapeutics in angina pectoris: history revisited with perhexiline.

Journal: European journal of cardiovascular nursing : journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology 20060601

Title: Evaluation of a novel anti-ischemic agent in acute coronary syndromes: design and rationale for the Metabolic Efficiency with Ranolazine for Less Ischemia in Non-ST-elevation acute coronary syndromes (MERLIN)-TIMI 36 trial.

Journal: American heart journal 20060601

Title: Ranolazine.

Journal: Nature reviews. Drug discovery 20060601

Title: New angina medication approved.

Journal: Health news (Waltham, Mass.) 20060601

Title: Ranolazine for the treatment of chronic angina and potential use in other cardiovascular conditions.

Journal: Circulation 20060523

Title: Ranolazine and late cardiac sodium current--a therapeutic target for angina, arrhythmia and more?

Journal: British journal of pharmacology 20060501

Title: Molecular basis of ranolazine block of LQT-3 mutant sodium channels: evidence for site of action.

Journal: British journal of pharmacology 20060501

Title: Ranolazine improves abnormal repolarization and contraction in left ventricular myocytes of dogs with heart failure by inhibiting late sodium current.

Journal: Journal of cardiovascular electrophysiology 20060501

Title: Applying science to drug discovery.

Journal: Biochemical Society transactions 20060401

Title: Ranolazine: a new approach to management of patients with angina.

Journal: The Annals of pharmacotherapy 20060401

Title: Inhibition of sodium-dependent calcium overload to treat myocardial ischemia.

Journal: Clinical cardiology 20060401

Title: FDA okays new drug for tough-to-treat chest pain.

Journal: Harvard heart letter : from Harvard Medical School 20060401

Title: Ranolazine: focusing on angina pectoris.

Journal: Drugs of today (Barcelona, Spain : 1998) 20060301

Title: Evolving treatment strategies for chronic refractory angina.

Journal: Expert opinion on pharmacotherapy 20060201

Title: Effects of ranolazine on exercise tolerance and HbA1c in patients with chronic angina and diabetes.

Journal: European heart journal 20060101

Title: Ranolazine is associated with cardiovascular and metabolic improvement: a win-win for patients with diabetes.

Journal: European heart journal 20060101

Title: Simple, sensitive and rapid liquid chromatography/atmospheric pressure chemical ionization mass spectrometric method for the quantitation of Ranolazine in rat plasma.

Journal: Rapid communications in mass spectrometry : RCM 20060101

Title: Analytical and semipreparative resolution of ranolazine enantiomers by liquid chromatography using polysaccharide chiral stationary phases.

Journal: Journal of separation science 20060101

Title: Ranolazine, a novel agent for chronic stable angina.

Journal: Pharmacotherapy 20060101

Title: Ranolazine: a review of its use in chronic stable angina pectoris.

Journal: Drugs 20060101

Title: Clinical pharmacokinetics of ranolazine.

Journal: Clinical pharmacokinetics 20060101

Title: New drugs: lubiprostone, ranolazine, and anidulafungin.

Journal: Journal of the American Pharmacists Association : JAPhA 20060101

Title: New treatment for chest pain.

Journal: FDA consumer 20060101

Title: Spotlight on ranolazine in chronic stable angina pectoris.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20060101

Title: Metabolic modulators for chronic cardiac ischemia.

Journal: Journal of cardiovascular pharmacology and therapeutics 20051201

Title: Chronic stable angina.

Journal: The New England journal of medicine 20051006

Title: New drugs for prevention, relief. How you might benefit if 3 medications win FDA approval.

Journal: Heart advisor 20051001

Title: Effect of renal impairment on multiple-dose pharmacokinetics of extended-release ranolazine.

Journal: Clinical pharmacology and therapeutics 20050901

Title: Ranolazine: new approach for the treatment of stable angina pectoris.

Journal: Expert review of cardiovascular therapy 20050901

Title: Combination pharmacologic therapies for heart failure: what next after angiotensin-converting enzyme inhibitors and beta-blockers?

Journal: Current heart failure reports 20050801

Title: Effect of hepatic impairment on the multiple-dose pharmacokinetics of ranolazine sustained-release tablets.

Journal: Journal of clinical pharmacology 20050701

Title: Studies to investigate the pharmacokinetic interactions between ranolazine and ketoconazole, diltiazem, or simvastatin during combined administration in healthy subjects.

Journal: Journal of clinical pharmacology 20050401

Title: The degree of potassium channel blockade and the risk of torsade de pointes: the truth, nothing but the truth, but not the whole truth.

Journal: European heart journal 20050301

Title: Ranolazine CV Therapeutics.

Journal: Current opinion in investigational drugs (London, England : 2000) 20050301

Title: Comparative efficacy of ranolazine versus atenolol for chronic angina pectoris.

Journal: The American journal of cardiology 20050201

Title: Ranolazine. A metabolic modulator for the treatment of chronic stable angina.

Journal: Cardiology in review 20050101

Title: Medical management of myocardial ischemia.

Journal: The American journal of geriatric cardiology 20050101

Title: Chronic angina: new medical options for treatment.

Journal: Reviews in cardiovascular medicine 20050101

Title: Myocardial metabolism: a new target for the treatment of heart disease?

Journal: Current hypertension reports 20041201

Title: Efficacy and safety of a metabolic modulator drug in chronic stable angina: review of evidence from clinical trials.

Journal: Journal of cardiovascular pharmacology and therapeutics 20040901

Title: Electrophysiologic properties and antiarrhythmic actions of a novel antianginal agent.

Journal: Journal of cardiovascular pharmacology and therapeutics 20040901

Title: Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties.

Journal: Circulation 20040824

Title: Cardiac metabolism as a target for the treatment of heart failure.

Journal: Circulation 20040824

Title: Antiarrhythmic effects of ranolazine in a guinea pig in vitro model of long-QT syndrome.

Journal: The Journal of pharmacology and experimental therapeutics 20040801

Title: Antagonism by ranolazine of the pro-arrhythmic effects of increasing late INa in guinea pig ventricular myocytes.

Journal: Journal of cardiovascular pharmacology 20040801

Title: Ranolazine: ion-channel-blocking actions and in vivo electrophysiological effects.

Journal: British journal of pharmacology 20040801

Title: Ischemic heart disease: metabolic approaches to management.

Journal: Clinical cardiology 20040801

Title: The anti-ischemia agent ranolazine promotes the development of intestinal tumors in APC(Min/+) mice.

Journal: Cancer letters 20040625

Title: Ranolazine as add-on therapy for patients with severe chronic angina.

Journal: JAMA 20040428

Title: Ranolazine as add-on therapy for patients with severe chronic angina.

Journal: JAMA 20040428

Title: Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe angina.

Journal: Journal of the American College of Cardiology 20040421

Title: Metabolic manipulation in ischaemic heart disease, a novel approach to treatment.

Journal: European heart journal 20040401

Title: Companies facing ethical issue as drugs are tested overseas.

Journal: The New York times on the Web 20040305

Title: FDA evaluating new angina drug.

Journal: Health news (Waltham, Mass.) 20040301

Title: Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trial.

Journal: JAMA 20040121

Title: Ranolazine and other antianginal therapies in the era of the drug-eluting stent.

Journal: JAMA 20040121

Title: Report from the 100th Cardiovascular and Renal Drugs Advisory Committee meeting: US Food and Drug Administration: December 8-9, 2003 Gaithersburg, MD.

Journal: Circulation 20040120

Title: A shift in myocardial substrate, improved endothelial function, and diminished sympathetic activity may contribute to the anti-anginal impact of very-low-fat diets.

Journal: Medical hypotheses 20040101

Title: Effects of very low-fat diets on anginal symptoms.

Journal: Medical hypotheses 20040101

Title: Common cardiac conditions in the elderly are still not well understood.

Journal: The American journal of geriatric cardiology 20040101

Title: [Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina. Results of CARISA].

Journal: Kardiologiia 20040101

Title: [Regulation of myocardial metabolism: possibilities and application in cardiac surgery].

Journal: Kardiologia polska 20031201

Title: The antianginal agent trimetazidine does not exert its functional benefit via inhibition of mitochondrial long-chain 3-ketoacyl coenzyme A thiolase.

Journal: Circulation research 20030808

Title: Partial fatty acid oxidation (pFOX) inhibition: a new therapy for chronic stable angina.

Journal: Clinical cardiology 20030401

Title: Metabolic modulation and optimization of energy consumption in heart failure.

Journal: The Medical clinics of North America 20030301

Title: Gender difference in ranolazine pharmacokinetics in rats.

Journal: European journal of drug metabolism and pharmacokinetics 20030101

Title: Molecule of the month: ranolazine.

Journal: Drug news & perspectives 20030101

Title: Measuring antianginal drug efficacy using exercise testing for chronic angina: improved exercise performance with ranolazine, a pFOX inhibitor.

Journal: Current problems in cardiology 20021201

Title: Ranolazine, a partial fatty acid oxidation (pFOX) inhibitor, improves left ventricular function in dogs with chronic heart failure.

Journal: Journal of cardiac failure 20021201

Title: The use of partial fatty acid oxidation inhibitors for metabolic therapy of angina pectoris and heart failure.

Journal: Herz 20021101

Title: Short-term treatment with ranolazine improves mechanical efficiency in dogs with chronic heart failure.

Journal: Circulation research 20020823

Title: Partial fatty acid oxidation inhibitors for stable angina.

Journal: Expert opinion on investigational drugs 20020501

Title: Anti-angina drug shifts heart muscle's fuel use. Compelling the heart to burn more blood sugar and less fat appears to boost cardiac efficiency.

Journal: Heart advisor 20020401

Title: New angina drugs on the horizon?

Journal: Harvard heart letter : from Harvard Medical School 20020201

Title: The use of ranolazine in cardiovascular disease.

Journal: Expert opinion on investigational drugs 20020101

Title: Clinical trials update: The Heart Protection Study, IONA, CARISA, ENRICHD, ACUTE, ALIVE, MADIT II and REMATCH. Impact Of Nicorandil on Angina. Combination Assessment of Ranolazine In Stable Angina. ENhancing Recovery In Coronary Heart Disease patients. Assessment of Cardioversion Using Transoesophageal Echocardiography. AzimiLide post-Infarct surVival Evaluation. Randomised Evaluation of Mechanical Assistance for Treatment of Chronic Heart failure.

Journal: European journal of heart failure 20020101

Title: Cardiovascular news.

Journal: Circulation 20011127

Title: Mitochondria as target for antiischemic drugs.

Journal: Advanced drug delivery reviews 20010702

Title: Ranolazine, a partial fatty acid oxidation inhibitor, reduces myocardial infarct size and cardiac troponin T release in the rat.

Journal: European journal of pharmacology 20010420

Title: Evidence that ranolazine behaves as a weak beta1- and beta2-adrenoceptor antagonist in the rat [correction of cat] cardiovascular system.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20010401

Title: Ranolazine: a potential new treatment for chronic stable angina.

Journal: Heart disease (Hagerstown, Md.) 20010101

Title: Role of metabolically active drugs in the management of ischemic heart disease.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20010101

Title: Keating GM. Ranolazine: A Review of Its Use as Add-On Therapy in Patients with Chronic Stable Angina Pectoris. Drugs. 2013 Jan;73(1):55-73.

Title: Wang WQ, Robertson C, Dhalla AK, Belardinelli L. Antitorsadogenic effects of ({+/-})-N-(2,6-dimethyl-phenyl)-(4-hydroxy-3-(2-methoxyphenoxy)propyl-1-piperazine (ranolazine) in anesthetized rabbits. J Pharmacol Exp Ther. 2008 Jun;325(3):875-81. doi: 10.1124/jpet.108.137729. Epub 2008 Mar 5.

Title: Zacharowski K, Blackburn B, Thiemermann C. Ranolazine, a partial fatty acid oxidation inhibitor, reduces myocardial infarct size and cardiac troponin T release in the rat. Eur J Pharmacol. 2001 Apr 20;418(1-2):105-10.

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Tags:95635-56-6 Molecular Formula|95635-56-6 MDL|95635-56-6 SMILES|95635-56-6 Ranolazine dihydrochloride