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965-52-6,MFCD00079482
Catalog No.:AA003T11

965-52-6 | Nifuroxazide

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50mg
98%
in stock  
$7.00   $5.00
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1g
98%
in stock  
$14.00   $10.00
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5g
98%
in stock  
$27.00   $19.00
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25g
98%
in stock  
$57.00   $40.00
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100g
98%
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$184.00   $129.00
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003T11
Chemical Name:
Nifuroxazide
CAS Number:
965-52-6
Molecular Formula:
C12H9N3O5
Molecular Weight:
275.2170
MDL Number:
MFCD00079482
SMILES:
Oc1ccc(cc1)C(=O)N/N=C/c1ccc(o1)[N+](=O)[O-]
NSC Number:
759261
Properties
Properties
 
BP:
418.17°C (rough estimate)  
Form:
Solid  
MP:
281-283°C  
Refractive Index:
1.5700 (estimate)  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
387  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
2.1  

Upstream Synthesis Route

[1]BioorganicandMedicinalChemistry,2008,vol.16,#14,p.6724-6731

Downstream Synthesis Route

[1]TetrahedronLetters,1991,vol.32,p.631-634

[2]TetrahedronLetters,1991,vol.32,p.631-634

[1]BollettinoChimicoFarmaceutico,1997,vol.136,p.244-249

[1]BioorganicandMedicinalChemistry,2008,vol.16,p.6724-6731

[2]ToxicologyandAppliedPharmacology,2020,vol.401

965-52-6    7732-18-5    13454-96-1   
Pt(nifuroxazide)2Cl2Cl2·2H2O 

[1]RussianJournalofGeneralChemistry,2018,vol.88,p.573-579    Zh.Obshch.Khim.,2018,vol.88,p.573-579,7

Literature

Title: Nifuroxazide, a STAT3 inhibitor, mitigates inflammatory burden and protects against diabetes-induced nephropathy in rats.

Journal: Chemico-biological interactions 20180201

Title: Caco-2 cells cytotoxicity of nifuroxazide derivatives with potential activity against Methicillin-resistant Staphylococcus aureus (MRSA).

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20120401

Title: Synthesis, molecular modeling and preliminary biological evaluation of a set of 3-acetyl-2,5-disubstituted-2,3-dihydro-1,3,4-oxadiazole as potential antibacterial, anti-Trypanosoma cruzi and antifungal agents.

Journal: Bioorganic & medicinal chemistry 20111101

Title: [Enterofuril eradication therapy in chronic inflammatory diseases of the upper digestive tract].

Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Assessment of isorhamnetin 3-O-neohesperidoside from Acacia salicina: protective effects toward oxidation damage and genotoxicity induced by aflatoxin B1 and nifuroxazide.

Journal: Journal of applied toxicology : JAT 20100801

Title: Polyamine reduced diet (PRD) nutrition therapy in hormone refractory prostate cancer patients.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20100501

Title: [Eradication therapy of antibiotic-resistant strains of Helicobacter pylori].

Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20100101

Title: Design, synthesis, antimicrobial activity and molecular modeling studies of novel benzofuroxan derivatives against Staphylococcus aureus.

Journal: Bioorganic & medicinal chemistry 20090415

Title: Molecular modeling studies and in vitro bioactivity evaluation of a set of novel 5-nitro-heterocyclic derivatives as anti-T. cruzi agents.

Journal: Bioorganic & medicinal chemistry 20090401

Title: Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3.

Journal: Blood 20081215

Title: A simple and sensitive spectrofluorimetric method for analysis of some nitrofuran drugs in pharmaceutical preparations.

Journal: Journal of fluorescence 20080901

Title: Antileishmanial activity screening of 5-nitro-2-heterocyclic benzylidene hydrazides.

Journal: Bioorganic & medicinal chemistry 20080715

Title: Antioxidant activity and inhibition of aflatoxin B1-, nifuroxazide-, and sodium azide-induced mutagenicity by extracts from Rhamnus alaternus L.

Journal: Chemico-biological interactions 20080710

Title: Simultaneous determination of nifuroxazide and drotaverine hydrochloride in pharmaceutical preparations by bivariate and multivariate spectral analysis.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080201

Title: Mutagenic, antimutagenic, cytotoxic, and apoptotic activities of extracts from Pituranthos tortuosus.

Journal: Drug and chemical toxicology 20080101

Title: [Topical issues of paediatric gastroenterology].

Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20080101

Title: Polyamine contents in current foods: a basis for polyamine reduced diet and a study of its long term observance and tolerance in prostate carcinoma patients.

Journal: Amino acids 20070801

Title: A new class of nifuroxazide analogues: synthesis of 5-nitrothiophene derivatives with antimicrobial activity against multidrug-resistant Staphylococcus aureus.

Journal: Bioorganic & medicinal chemistry 20070615

Title: Synthesis and antigenotoxic activity of some naphtho[2,1-b]pyrano[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives.

Journal: European journal of medicinal chemistry 20070501

Title: Determination of nitrofurans in animal feeds by liquid chromatography-UV photodiode array detection and liquid chromatography-ionspray tandem mass spectrometry.

Journal: Analytica chimica acta 20070314

Title: Study of antimutagenic and antioxidant activities of gallic acid and 1,2,3,4,6-pentagalloylglucose from Pistacia lentiscus. Confirmation by microarray expression profiling.

Journal: Chemico-biological interactions 20070105

Title: Antigenotoxic activities of crude extracts from Acacia salicina leaves.

Journal: Environmental and molecular mutagenesis 20070101

Title: Nifuroxazide-induced acute pancreatitis: a new side-effect for an old drug?

Journal: Acta gastro-enterologica Belgica 20070101

Title: Organ-targeted mutagenicity of nitrofurantoin in Big Blue transgenic mice.

Journal: Mutagenesis 20060901

Title: A comparative study on various spectrometries with thin layer chromatography for simultaneous analysis of drotaverine and nifuroxazide in capsules.

Journal: Chemical & pharmaceutical bulletin 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Determination of nifuroxazide and drotaverine hydrochloride in pharmaceutical preparations by three independent analytical methods.

Journal: Journal of AOAC International 20060101

Title: Fly agaric (Amanita muscaria) poisoning, case report and review.

Journal: Toxicon : official journal of the International Society on Toxinology 20050601

Title: Anti-genotoxic and free-radical scavenging activities of extracts from (Tunisian) Myrtus communis.

Journal: Mutation research 20041114

Title: Determination of attapulgite and nifuroxazide in pharmaceutical formulations by sequential digital derivative spectrophotometry.

Journal: Journal of AOAC International 20040101

Title: Genotoxicity of 2-nitro-7-methoxy-naphtho[2,1-b]furan (R7000): a case study with some considerations on nitrofurantoin and nifuroxazide.

Journal: Research in microbiology 20020901

Title: Potential tuberculostatic agents. Topliss application on benzoic acid [(5-nitro-thiophen-2-yl)-methylene]-hydrazide series.

Journal: Bioorganic & medicinal chemistry 20020301

Title: Efficacy of prophylactic anti-diarrhoeal treatment in patients receiving Campto for advanced colorectal cancer.

Journal: Anticancer research 20020101

Title: Nelson EA, et al. Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3. Blood. 2008 Dec 15;112(13):5095-102.

Title: Zhu Y, et al. Nifuroxazide exerts potent anti-tumor and anti-metastasis activity in melanoma. Sci Rep. 2016 Feb 2;6:20253.

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