97322-87-7
71-43-2
[1]JournalofMedicinalChemistry,1989,vol.32,p.421-428
[1]JournalofMedicinalChemistry,1989,vol.32,p.421-428
[1]ChemicalandPharmaceuticalBulletin,1991,vol.39,p.2124-2125
[1]Arzneimittel-Forschung/DrugResearch,1997,vol.47,p.356-368
[1]JournalofMedicinalChemistry,1999,vol.42,p.3265-3278
Title: The urinary metabolites of DINCH(®) have an impact on the activities of the human nuclear receptors ERα, ERβ, AR, PPARα and PPARγ.
Journal: Toxicology letters 20180501
Title: Cell-based assay using glutathione-depleted HepaRG and HepG2 human liver cells for predicting drug-induced liver injury.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20180401
Title: Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury.
Journal: Archives of toxicology 20180101
Title: From the Cover: Fenretinide, Troglitazone, and Elmiron Add to Weight of Evidence Support for Hemangiosarcoma Mode-of-Action From Studies in Mice.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20180101
Title: Individual serum bile acid profiling in rats aids in human risk assessment of drug-induced liver injury due to BSEP inhibition.
Journal: Toxicology and applied pharmacology 20180101
Title: Increased susceptibility to troglitazone-induced mitochondrial permeability transition in type 2 diabetes mellitus model rat.
Journal: The Journal of toxicological sciences 20180101
Title: Editor's Highlight: Mechanistic Toxicity Tests Based on an Adverse Outcome Pathway Network for Hepatic Steatosis.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20170901
Title: Adipogenic Effects and Gene Expression Profiling of Firemaster® 550 Components in Human Primary Preadipocytes.
Journal: Environmental health perspectives 20170901
Title: Agonistic and antagonistic effects of phthalates and their urinary metabolites on the steroid hormone receptors ERα, ERβ, and AR.
Journal: Toxicology letters 20170805
Title: Prediction of drug-induced liver injury using keratinocytes.
Journal: Journal of applied toxicology : JAT 20170701
Title: Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.
Journal: Chemical research in toxicology 20170515
Title: Humanizing the zebrafish liver shifts drug metabolic profiles and improves pharmacokinetics of CYP3A4 substrates.
Journal: Archives of toxicology 20170301
Title: Editor's Highlight: Transgenic Zebrafish Reporter Lines as Alternative In Vivo Organ Toxicity Models.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20170301
Title: Both cholestatic and steatotic drugs trigger extensive alterations in the mRNA level of biliary transporters in rat hepatocytes: Application to develop new predictive biomarkers for early drug development.
Journal: Toxicology letters 20161130
Title: Activation of the Constitutive Androstane Receptor by Monophthalates.
Journal: Chemical research in toxicology 20161017
Title: Activation of p38 Mitogen-Activated Protein Kinase by Clotrimazole Induces Multidrug Resistance-Associated Protein 3 Activation through a Novel Transcriptional Element.
Journal: The Journal of pharmacology and experimental therapeutics 20161001
Title: Inhibition of Macrophage CD36 Expression and Cellular Oxidized Low Density Lipoprotein (oxLDL) Accumulation by Tamoxifen: A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR)γ-DEPENDENT MECHANISM.
Journal: The Journal of biological chemistry 20160812
Title: High content analysis assay for prediction of human hepatotoxicity in HepaRG and HepG2 cells.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20160601
Title: Development of an optimized cytotoxicity assay system for CYP3A4-mediated metabolic activation via modified piggyBac transposition.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20160401
Title: Bisphenol S Induces Adipogenesis in Primary Human Preadipocytes From Female Donors.
Journal: Endocrinology 20160401
Title: Pioglitazone, a PPARγ agonist, attenuates PDGF-induced vascular smooth muscle cell proliferation through AMPK-dependent and AMPK-independent inhibition of mTOR/p70S6K and ERK signaling.
Journal: Biochemical pharmacology 20160201
Title: Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20151225
Title: Transcriptomics hit the target: Monitoring of ligand-activated and stress response pathways for chemical testing.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20151225
Title: Gene expression analysis in the lung of the rasH2 transgenic mouse at week 4 prior to induction of malignant tumor formation by urethane and N-methylolacrylamide.
Journal: The Journal of toxicological sciences 20151201
Title: Transcriptional and post-transcriptional control of adipocyte differentiation by Jumonji domain-containing protein 6.
Journal: Nucleic acids research 20150918
Title: Are zebrafish larvae suitable for assessing the hepatotoxicity potential of drug candidates?
Journal: Journal of applied toxicology : JAT 20150901
Title: Stimulating basal mitochondrial respiration decreases doxorubicin apoptotic signaling in H9c2 cardiomyoblasts.
Journal: Toxicology 20150806
Title: Multiparametric assay using HepaRG cells for predicting drug-induced liver injury.
Journal: Toxicology letters 20150702
Title: EPI-001 is a selective peroxisome proliferator-activated receptor-gamma modulator with inhibitory effects on androgen receptor expression and activity in prostate cancer.
Journal: Oncotarget 20150201
Title: Novel drug candidates for the treatment of metastatic colorectal cancer through global inverse gene-expression profiling.
Journal: Cancer research 20141015
Title: Sargahydroquinoic acid inhibits TNFα-induced AP-1 and NF-κB signaling in HaCaT cells through PPARα activation.
Journal: Biochemical and biophysical research communications 20140808
Title: Manganese superoxide dismutase is a promising target for enhancing chemosensitivity of basal-like breast carcinoma.
Journal: Antioxidants & redox signaling 20140520
Title: In silico identification and in vitro validation of potential cholestatic compounds through 3D ligand-based pharmacophore modeling of BSEP inhibitors.
Journal: Chemical research in toxicology 20140519
Title: PPAR agonists reduce steatosis in oleic acid-overloaded HepaRG cells.
Journal: Toxicology and applied pharmacology 20140401
Title: Transcriptional and epigenetic mechanisms underlying enhanced in vitro adipocyte differentiation by the brominated flame retardant BDE-47.
Journal: Environmental science & technology 20140401
Title: A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20140101
Title: CDK5-induced p-PPARγ(Ser 112) downregulates GFAP via PPREs in developing rat brain: effect of metal mixture and troglitazone in astrocytes.
Journal: Cell death & disease 20140101
Title: Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11).
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20131201
Title: Mechanisms of resveratrol-induced inhibition of clonal expansion and terminal adipogenic differentiation in 3T3-L1 preadipocytes.
Journal: The journals of gerontology. Series A, Biological sciences and medical sciences 20131101
Title: A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20131101
Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.
Journal: Bioorganic & medicinal chemistry letters 20130801
Title: HepG2 cells simultaneously expressing five P450 enzymes for the screening of hepatotoxicity: identification of bioactivable drugs and the potential mechanism of toxicity involved.
Journal: Archives of toxicology 20130601
Title: In vitro toxicological characterization of perfluorinated carboxylic acids with different carbon chain lengths.
Journal: Toxicology letters 20130412
Title: Arsenic inhibits the adipogenic differentiation of mesenchymal stem cells by down-regulating peroxisome proliferator-activated receptor gamma and CCAAT enhancer-binding proteins.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20130201
Title: Differential effect of troglitazone on the human bile acid transporters, MRP2 and BSEP, in the PXB hepatic chimeric mouse.
Journal: Toxicologic pathology 20121201
Title: A nonradioisotope chemiluminescent assay for evaluation of 2-deoxyglucose uptake in 3T3-L1 adipocytes. Effect of various carbonyls species on insulin action.
Journal: Biochimie 20121201
Title: Real-time concurrent monitoring of apoptosis, cytosolic calcium, and mitochondria permeability transition for hypermulticolor high-content screening of drug-induced mitochondrial dysfunction-mediated hepatotoxicity.
Journal: Toxicology letters 20121017
Title: Chimeric mice with a humanized liver as an animal model of troglitazone-induced liver injury.
Journal: Toxicology letters 20121002
Title: Generation of proliferating human hepatocytes using Upcyte® technology: characterisation and applications in induction and cytotoxicity assays.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20121001
Title: Palmitate increases the susceptibility of cells to drug-induced toxicity: an in vitro method to identify drugs with potential contraindications in patients with metabolic disease.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20121001
Title: Mouse precision-cut liver slices as an ex vivo model to study idiosyncratic drug-induced liver injury.
Journal: Chemical research in toxicology 20120917
Title: Suppression of IL-8 production in gastric epithelial cells by MUC1 mucin and peroxisome proliferator-associated receptor-γ.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20120915
Title: A peroxisome proliferator-activated receptor ligand MCC-555 imparts anti-proliferative response in pancreatic cancer cells by PPARgamma-independent up-regulation of KLF4.
Journal: Toxicology and applied pharmacology 20120901
Title: In vitro approach to assess the potential for risk of idiosyncratic adverse reactions caused by candidate drugs.
Journal: Chemical research in toxicology 20120820
Title: Activation of adipogenesis by lipocalin-type prostaglandin D synthase-generated Δ¹²-PGJ₂ acting through PPARγ-dependent and independent pathways.
Journal: Gene 20120815
Title: Regulatory role of KEAP1 and NRF2 in PPARγ expression and chemoresistance in human non-small-cell lung carcinoma cells.
Journal: Free radical biology & medicine 20120815
Title: The endocrine disruptor diethylstilbestrol induces adipocyte differentiation and promotes obesity in mice.
Journal: Toxicology and applied pharmacology 20120815
Title: 15-Deoxy-Δ(12,14)-prostaglandin J(2) attenuates the biological activities of monocyte/macrophage cell lines.
Journal: European journal of cell biology 20120801
Title: [AMP-activated protein kinase-alpha is involved in the autophagy and apoptosis caused by troglitazone].
Journal: Wei sheng wu xue bao = Acta microbiologica Sinica 20120704
Title: The development of subcutaneous sarcomas in rodents exposed to peroxisome proliferators agonists: hypothetical mechanisms of action and de-risking attitude.
Journal: Toxicologic pathology 20120701
Title: Regulation of the human endogenous retroviral Syncytin-1 and cell-cell fusion by the nuclear hormone receptors PPARγ/RXRα in placentogenesis.
Journal: Journal of cellular biochemistry 20120701
Title: Total synthesis and dual PPARα/γ agonist effects of amorphastilbol and its synthetic derivatives.
Journal: Bioorganic & medicinal chemistry letters 20120615
Title: Ethyl 2,4,6-trihydroxybenzoate is an agonistic ligand for liver X receptor that induces cholesterol efflux from macrophages without affecting lipid accumulation in HepG2 cells.
Journal: Bioorganic & medicinal chemistry letters 20120615
Title: Evaluation of the pharmacokinetics, biotransformation and hepatic transporter effects of troglitazone in mice with humanized livers.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20120601
Title: Synthesis and cytotoxic activity of new acridine-thiazolidine derivatives.
Journal: Bioorganic & medicinal chemistry 20120601
Title: Endogenous bile acid disposition in rat and human sandwich-cultured hepatocytes.
Journal: Toxicology and applied pharmacology 20120515
Title: Development of a multiparametric cell-based protocol to screen and classify the hepatotoxicity potential of drugs.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20120501
Title: Synthesis of new troglitazone derivatives: anti-proliferative activity in breast cancer cell lines and preliminary toxicological study.
Journal: European journal of medicinal chemistry 20120501
Title: Sesquiterpene lactones from Tithonia diversifolia act as peroxisome proliferator-activated receptor agonists.
Journal: Bioorganic & medicinal chemistry letters 20120415
Title: PPARγ inhibits airway epithelial cell inflammatory response through a MUC1-dependent mechanism.
Journal: American journal of physiology. Lung cellular and molecular physiology 20120401
Title: Anti-inflammatory and PPAR transactivational effects of secondary metabolites from the roots of Asarum sieboldii.
Journal: Bioorganic & medicinal chemistry letters 20120401
Title: Synergistic effect of cyanidin and PPAR agonist against nonalcoholic steatohepatitis-mediated oxidative stress-induced cytotoxicity through MAPK and Nrf2 transduction pathways.
Journal: Journal of agricultural and food chemistry 20120321
Title: Acetylenic acid analogues from the edible mushroom Chanterelle (Cantharellus cibarius) and their effects on the gene expression of peroxisome proliferator-activated receptor-gamma target genes.
Journal: Bioorganic & medicinal chemistry letters 20120315
Title: Evaluation of drugs with specific organ toxicities in organ-specific cell lines.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20120301
Title: Interleukin-17A increases leptin production in human bone marrow mesenchymal stem cells.
Journal: Biochemical pharmacology 20120301
Title: Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity.
Journal: Journal of medicinal chemistry 20120112
Title: Molecular Insights into Human Monoamine Oxidase B Inhibition by the Glitazone Anti-Diabetes Drugs.
Journal: ACS medicinal chemistry letters 20120112
Title: The PPAR-γ agonist troglitazone antagonizes survival pathways induced by STAT-3 in recombinant interferon-β treated pancreatic cancer cells.
Journal: Biotechnology advances 20120101
Title: Regulation of lipoprotein lipase gene expression by insulin and troglitazone in rainbow trout (Oncorhynchus mykiss) adipocyte cells in culture.
Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20120101
Title: Species-specific toxicity of troglitazone on rats and human by gel entrapped hepatocytes.
Journal: Toxicology and applied pharmacology 20120101
Title: Telmisartan ameliorates lipopolysaccharide-induced innate immune response through peroxisome proliferator-activated receptor-γ activation in human monocytes.
Journal: Journal of hypertension 20120101
Title: Troglitazone induces extracellular matrix and cytoskeleton remodeling in mouse collecting duct cells.
Journal: Journal of biomedicine & biotechnology 20120101
Title: 1β-Hydroxy-2-oxopomolic acid isolated from Agrimonia pilosa extract inhibits adipogenesis in 3T3-L1 cells.
Journal: Biological & pharmaceutical bulletin 20120101
Title: Troglitazone attenuates TGF-β1-induced EMT in alveolar epithelial cells via a PPARγ-independent mechanism.
Journal: PloS one 20120101
Title: Proteome analysis identified the PPARγ ligand 15d-PGJ2 as a novel drug inhibiting melanoma progression and interfering with tumor-stroma interaction.
Journal: PloS one 20120101
Title: Cytotoxicity of troglitazone through PPARγ-independent pathway and p38 MAPK pathway in renal cell carcinoma.
Journal: Cancer letters 20111222
Title: Indomethacin induces cellular morphological change and migration via epithelial-mesenchymal transition in A549 human lung cancer cells: a novel cyclooxygenase-inhibition-independent effect.
Journal: Biochemical pharmacology 20111201
Title: Involvement of different human glutathione transferase isoforms in the glutathione conjugation of reactive metabolites of troglitazone.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20111201
Title: Evaluation of direct and indirect effects of the PPARγ agonist troglitazone on mouse endothelial cell proliferation.
Journal: Toxicologic pathology 20111201
Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Journal: PLoS computational biology 20111201
Title: [Drug-induced hepatic injury, the challenge for cause investigation].
Journal: Rinsho byori. The Japanese journal of clinical pathology 20111201
Title: 2,7-Disubstituted-pyrrolotriazine kinase inhibitors with an unusually high degree of reactive metabolite formation.
Journal: Chemical research in toxicology 20111121
Title: Troglitazone-activated PPARγ inhibits LPS-induced lung alveolar type II epithelial cells injuries via TNF-α.
Journal: Molecular biology reports 20111101
Title: Activation of Trim17 by PPARγ is involved in di(2-ethylhexyl) phthalate (DEHP)-induced apoptosis on Neuro-2a cells.
Journal: Toxicology letters 20111030
Title: Mitochondrial amplification selectively increases doxorubicin sensitivity in breast cancer cells with acquired antiestrogen resistance.
Journal: Breast cancer research and treatment 20111001
Title: Association of the SLC30A8 missense polymorphism R325W with proinsulin levels at baseline and after lifestyle, metformin or troglitazone intervention in the Diabetes Prevention Program.
Journal: Diabetologia 20111001
Title: Pro-bone and antifat effects of green tea and its polyphenol, epigallocatechin, in rat mesenchymal stem cells in vitro.
Journal: Journal of agricultural and food chemistry 20110928
Title: Evaluation of PPARγ agonists on rodent endothelial cell proliferation.
Journal: Toxicology 20110905
Title: Peroxisome proliferator-activated receptor γ agonist troglitazone inhibits high mobility group box 1 expression in endothelial cells via suppressing transcriptional activity of nuclear factor κB and activator protein 1.
Journal: Shock (Augusta, Ga.) 20110901
Title: Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro.
Journal: Journal of natural products 20110826
Title: Troglitazone, a PPAR agonist, inhibits human prostate cancer cell growth through inactivation of NFκB via suppression of GSK-3β expression.
Journal: Cancer biology & therapy 20110815
Title: Application of CYP102A1M11H as a tool for the generation of protein adducts of reactive drug metabolites.
Journal: Chemical research in toxicology 20110815
Title: Development of a highly sensitive cytotoxicity assay system for CYP3A4-mediated metabolic activation.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110801
Title: Chemical genomics profiling of environmental chemical modulation of human nuclear receptors.
Journal: Environmental health perspectives 20110801
Title: 15-Deoxy-Δ(12,14)-prostaglandin J(2) interferes inducible synthesis of prostaglandins E(2) and F(2α) that suppress subsequent adipogenesis program in cultured preadipocytes.
Journal: Prostaglandins & other lipid mediators 20110801
Title: Effects of impressic acid from Acanthopanax koreanum on NF-κB and PPARγ activities.
Journal: Archives of pharmacal research 20110801
Title: Troglitazone induced apoptosis via PPARγ activated POX-induced ROS formation in HT29 cells.
Journal: Biomedical and environmental sciences : BES 20110801
Title: Toxic metabolite formation from Troglitazone (TGZ): new insights from a DFT study.
Journal: Chemical research in toxicology 20110718
Title: Anti-inflammatory effects of thiazolidinediones in human airway smooth muscle cells.
Journal: American journal of respiratory cell and molecular biology 20110701
Title: Stable reporter cell lines for peroxisome proliferator-activated receptor γ (PPARγ)-mediated modulation of gene expression.
Journal: Analytical biochemistry 20110701
Title: In vitro investigation of the glutathione transferase M1 and T1 null genotypes as risk factors for troglitazone-induced liver injury.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110701
Title: Comparative gene expression profiles induced by PPARγ and PPARα/γ agonists in rat hepatocytes.
Journal: Toxicology and applied pharmacology 20110701
Title: Troglitazone suppresses c-Myc levels in human prostate cancer cells via a PPARγ-independent mechanism.
Journal: Cancer biology & therapy 20110615
Title: Synergistic interactions between heregulin and peroxisome proliferator-activated receptor-gamma (PPARgamma) agonist in breast cancer cells.
Journal: The Journal of biological chemistry 20110603
Title: Combined treatment with TRAIL and PPARγ ligands overcomes chemoresistance of ovarian cancer cell lines.
Journal: Journal of cancer research and clinical oncology 20110501
Title: Suppression of endothelin-1-induced cardiac myocyte hypertrophy by PPAR agonists: role of diacylglycerol kinase zeta.
Journal: Cardiovascular research 20110501
Title: Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells.
Journal: Bioorganic & medicinal chemistry 20110501
Title: A comparative integrated transcript analysis and functional characterization of differential mechanisms for induction of liver hypertrophy in the rat.
Journal: Toxicology and applied pharmacology 20110415
Title: Differential disposition of chenodeoxycholic acid versus taurocholic acid in response to acute troglitazone exposure in rat hepatocytes.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20110401
Title: Regulation of dectin-1-mediated dendritic cell activation by peroxisome proliferator-activated receptor-gamma ligand troglitazone.
Journal: Blood 20110331
Title: Beta-3 agonist-induced lipolysis and nitric oxide production: relationship to PPARgamma agonist/antagonist and AMP kinase modulation.
Journal: General physiology and biophysics 20110301
Title: Differential effects of PPARgamma ligands on oxidative stress-induced death of retinal pigmented epithelial cells.
Journal: Investigative ophthalmology & visual science 20110222
Title: Peroxisome proliferator-activated receptor gamma negatively regulates IFN-beta production in Toll-like receptor (TLR) 3- and TLR4-stimulated macrophages by preventing interferon regulatory factor 3 binding to the IFN-beta promoter.
Journal: The Journal of biological chemistry 20110218
Title: Glutaminolysis and glycolysis regulation by troglitazone in breast cancer cells: Relationship to mitochondrial membrane potential.
Journal: Journal of cellular physiology 20110201
Title: Thiazolidinediones/PPARγ agonists and fatty acid synthase inhibitors as an experimental combination therapy for prostate cancer.
Journal: International journal of oncology 20110201
Title: 17β-Estradiol inhibition of PPARγ-induced adipogenesis and adipocyte-specific gene expression.
Journal: Acta pharmacologica Sinica 20110201
Title: Tanshinone IIA attenuates atherosclerosis in ApoE(-/-) mice through down-regulation of scavenger receptor expression.
Journal: European journal of pharmacology 20110110
Title: Pioglitazone modulates tumor cell metabolism and proliferation in multicellular tumor spheroids.
Journal: Cancer chemotherapy and pharmacology 20110101
Title: Identification of clinically used drugs that activate pregnane X receptors.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110101
Title: Therapy: The second time as farce: rosiglitazone and the regulators.
Journal: Nature reviews. Endocrinology 20110101
Title: Troglitazone attenuates epidermal growth factor receptor signaling independently of peroxisome proliferator-activated receptor in PC-3 cells.
Journal: Oncology reports 20110101
Title: Duration and magnitude of extracellular signal-regulated protein kinase phosphorylation determine adipogenesis or osteogenesis in human bone marrow-derived stem cells.
Journal: Yonsei medical journal 20110101
Title: Drug-induced idiosyncratic hepatotoxicity: prevention strategy developed after the troglitazone case.
Journal: Drug metabolism and pharmacokinetics 20110101
Title: Specific thiazolidinediones inhibit ovarian cancer cell line proliferation and cause cell cycle arrest in a PPARγ independent manner.
Journal: PloS one 20110101
Title: Label-free detection with surface plasmon resonance imaging.
Journal: Methods in molecular biology (Clifton, N.J.) 20110101
Title: Current topics in drug metabolism and drug toxicity. Preface.
Journal: Drug metabolism and pharmacokinetics 20110101
Title: Troglitazone induces apoptosis in gastric cancer cells through the NAG-1 pathway.
Journal: Molecular medicine reports 20110101
Title: Do amorphous troglitazones prepared from two diastereomer-pairs have the same molecular mobility and crystallization rate at the surface?
Journal: Chemical & pharmaceutical bulletin 20110101
Title: Inhibition of monoacylglycerol lipase by troglitazone, N-arachidonoyl dopamine and the irreversible inhibitor JZL184: comparison of two different assays.
Journal: British journal of pharmacology 20101201
Title: A novel xenobiotic responsive element regulated by aryl hydrocarbon receptor is involved in the induction of BCRP/ABCG2 in LS174T cells.
Journal: Biochemical pharmacology 20101201
Title: Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20101201
Title: A predictive ligand-based Bayesian model for human drug-induced liver injury.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20101201
Title: SorLA modulates atheroprotective properties of CLA by regulating monocyte migration.
Journal: Atherosclerosis 20101201
Title: N,N-Bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines (HQNBA): peroxisome proliferator-activated receptor (PPAR-γ) agonists with neuroprotective properties.
Journal: Bioorganic & medicinal chemistry letters 20101201
Title: Palmitate-induced down-regulation of sortilin and impaired GLUT4 trafficking in C2C12 myotubes.
Journal: The Journal of biological chemistry 20101105
Title: New troglitazone derivatives devoid of PPARγ agonist activity display an increased antiproliferative effect in both hormone-dependent and hormone-independent breast cancer cell lines.
Journal: Breast cancer research and treatment 20101101
Title: Multiple mechanisms underlying troglitazone-induced mitochondrial permeability transition.
Journal: Toxicology and applied pharmacology 20101101
Title: Suppression of NF-kappaB and GSK-3beta is involved in colon cancer cell growth inhibition by the PPAR agonist troglitazone.
Journal: Chemico-biological interactions 20101006
Title: Troglitazone induces cytotoxicity in part by promoting the degradation of peroxisome proliferator-activated receptor γ co-activator-1α protein.
Journal: British journal of pharmacology 20101001
Title: In vitro and in vivo therapeutic efficacy of the PPAR-γ agonist troglitazone in combination with cisplatin against malignant pleural mesothelioma cell growth.
Journal: Cancer science 20100901
Title: Identification of novel monoamine oxidase B inhibitors by structure-based virtual screening.
Journal: Bioorganic & medicinal chemistry letters 20100901
Title: Identification of troglitazone responsive genes: induction of RTP801 during troglitazone-induced apoptosis in Hep 3B cells.
Journal: BMB reports 20100901
Title: Peroxisome proliferator-activated receptors gamma and alpha agonists stimulate cardiac glucose uptake via activation of AMP-activated protein kinase.
Journal: The Journal of nutritional biochemistry 20100701
Title: Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist inhibits transforming growth factor-beta1 and matrix production in human dermal fibroblasts.
Journal: Journal of plastic, reconstructive & aesthetic surgery : JPRAS 20100701
Title: Conjugated linoleic acid suppresses the migratory and inflammatory phenotype of the monocyte/macrophage cell.
Journal: Atherosclerosis 20100701
Title: Troglitazone is an estrogen-related receptor alpha and gamma inverse agonist.
Journal: Biochemical pharmacology 20100701
Title: Functional characterization of five CYP2C8 variants and prediction of CYP2C8 genotype-dependent effects on in vitro and in vivo drug-drug interactions.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20100701
Title: Troglitazone stimulates beta-arrestin-dependent cardiomyocyte contractility via the angiotensin II type 1A receptor.
Journal: Biochemical and biophysical research communications 20100611
Title: Direct toxicity effects of sulfo-conjugated troglitazone on human hepatocytes.
Journal: Toxicology letters 20100602
Title: Factors influencing the differentiation of bovine preadipocytes in vitro.
Journal: Journal of animal science 20100601
Title: PPARgamma agonists upregulate the barrier function of tight junctions via a PKC pathway in human nasal epithelial cells.
Journal: Pharmacological research 20100601
Title: Physiologic and pharmacologic modulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta-cells by peroxisome proliferator-activated receptor (PPAR)-gamma signaling: possible mechanism for the GIP resistance in type 2 diabetes.
Journal: Diabetes 20100601
Title: Stimulators of AMP-activated kinase (AMPK) inhibit seawater- but not cAMP-induced oocyte maturation in a marine worm: Implications for interactions between cAMP and AMPK signaling.
Journal: Molecular reproduction and development 20100601
Title: Negative regulation of the oncogenic transcription factor FoxM1 by thiazolidinediones and mithramycin.
Journal: Cancer biology & therapy 20100601
Title: Troglitazone, a ligand of peroxisome proliferator-activated receptor-{gamma}, stabilizes NUCB2 (Nesfatin) mRNA by activating the ERK1/2 pathway: isolation and characterization of the human NUCB2 gene.
Journal: Endocrinology 20100601
Title: Reversal of P-glycoprotein-mediated multidrug resistance in SGC7901/VCR cells by PPARgamma activation by troglitazone.
Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20100601
Title: High endoplasmic reticulum activity renders multiple myeloma cells hypersensitive to mitochondrial inhibitors.
Journal: Cancer chemotherapy and pharmacology 20100501
Title: Troglitazone ameliorates high glucose-induced EMT and dysfunction of SGLTs through PI3K/Akt, GSK-3β, Snail1, and β-catenin in renal proximal tubule cells.
Journal: American journal of physiology. Renal physiology 20100501
Title: Contribution of high basolateral bile salt efflux to the lack of hepatotoxicity in rat in response to drugs inducing cholestasis in human.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20100501
Title: Thiazolidinediones alter growth and epithelial cell integrity, independent of PPAR-γ and MAPK activation, in mouse M1 cortical collecting duct cells.
Journal: American journal of physiology. Renal physiology 20100501
Title: An in vitro drug-induced hepatotoxicity screening system using CYP3A4-expressing and gamma-glutamylcysteine synthetase knockdown cells.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20100401
Title: Mechanisms of membrane transport of poorly soluble drugs: role of micelles in oral absorption processes.
Journal: Journal of pharmaceutical sciences 20100301
Title: Biliary efflux transporters involved in the clearance of rosuvastatin in sandwich culture of primary rat hepatocytes.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20100301
Title: The synergistic anticancer effect of troglitazone combined with aspirin causes cell cycle arrest and apoptosis in human lung cancer cells.
Journal: Molecular carcinogenesis 20100301
Title: Troglitazone inhibits histone deacetylase activity in breast cancer cells.
Journal: Cancer letters 20100227
Title: High glucose enhances angiotensin-II-mediated peroxisome proliferation-activated receptor-gamma inactivation in human coronary artery endothelial cells.
Journal: Experimental and molecular pathology 20100201
Title: Investigation of the role of the thiazolidinedione ring of troglitazone in inducing hepatotoxicity.
Journal: Toxicology letters 20100201
Title: 3T3-L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-gamma-dependent and mediated by the caspase-3-dependent apoptotic pathway.
Journal: The FEBS journal 20100201
Title: Opposite effects of two thiazolidinediones, ciglitazone and troglitazone, on proteinase-activated receptor-1-triggered prostaglandin E(2) release.
Journal: Toxicology 20100131
Title: DC-SCRIPT: nuclear receptor modulation and prognostic significance in primary breast cancer.
Journal: Journal of the National Cancer Institute 20100106
Title: Prediction of recrystallization behavior of troglitazone/polyvinylpyrrolidone solid dispersion by solid-state NMR.
Journal: International journal of pharmaceutics 20100104
Title: PPARgamma activation extinguishes smoking carcinogen by inhibiting NNK-mediated proliferation.
Journal: American journal of respiratory cell and molecular biology 20100101
Title: Hepatobiliary disposition of troglitazone and metabolites in rat and human sandwich-cultured hepatocytes: use of Monte Carlo simulations to assess the impact of changes in biliary excretion on troglitazone sulfate accumulation.
Journal: The Journal of pharmacology and experimental therapeutics 20100101
Title: Autophagy augmented by troglitazone is independent of EGFR transactivation and correlated with AMP-activated protein kinase signaling.
Journal: Autophagy 20100101
Title: Troglitazone.
Journal: Handbook of experimental pharmacology 20100101
Title: PPARgamma agonists inhibit TGF-beta-PKA signaling in glomerulosclerosis.
Journal: Acta pharmacologica Sinica 20100101
Title: A fraction of unripe kiwi fruit extract regulates adipocyte differentiation and function in 3T3-L1 cells.
Journal: BioFactors (Oxford, England) 20100101
Title: Effect of troglitazone on tumor growth and pulmonary metastasis development of the mouse osteosarcoma cell line LM8.
Journal: BMC cancer 20100101
Title: PPARgamma2 expression in growth plate chondrocytes is regulated by p38 and GSK-3.
Journal: Journal of cellular and molecular medicine 20100101
Title: Troglitazone suppresses telomerase activity independently of PPARgamma in estrogen-receptor negative breast cancer cells.
Journal: BMC cancer 20100101
Title: Troglitazone regulates anaplerosis via a pull/push affect on glutamate dehydrogenase mediated glutamate deamination in kidney-derived epithelial cells; implications for the Warburg effect.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101
Title: Influence of troglitazone, sodium butyrate, 5-aminosalicylic acid and BAY 11-7082 on the chemokine ENA-78/CXCL5 secretion in the intestinal subepithelial myofibroblasts.
Journal: Acta poloniae pharmaceutica 20100101
Title: Rapid LC-MS drug metabolite profiling using microsomal enzyme bioreactors in a parallel processing format.
Journal: Analytical chemistry 20091215
Title: Production of a reactive metabolite of troglitazone by electrochemical oxidation performed in nonaqueous medium.
Journal: Journal of pharmaceutical and biomedical analysis 20091205
Title: Carbon monoxide (from CORM-2) inhibits high glucose-induced ICAM-1 expression via AMP-activated protein kinase and PPAR-gamma activations in endothelial cells.
Journal: Atherosclerosis 20091201
Title: Peroxisome proliferator-activated receptor gamma antagonists decrease Na+ transport via the epithelial Na+ channel.
Journal: Molecular pharmacology 20091201
Title: PPARgamma activation induces autophagy in breast cancer cells.
Journal: The international journal of biochemistry & cell biology 20091101
Title: Role of peroxisome proliferator-activated receptor beta/delta in chicken adipogenesis.
Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20091101
Title: Troglitazone, but not rosiglitazone, damages mitochondrial DNA and induces mitochondrial dysfunction and cell death in human hepatocytes.
Journal: Toxicology and applied pharmacology 20091101
Title: Thiazolidinedione derivatives as PTP1B inhibitors with antihyperglycemic and antiobesity effects.
Journal: Bioorganic & medicinal chemistry letters 20091101
Title: Osthole, a potential antidiabetic agent, alleviates hyperglycemia in db/db mice.
Journal: Chemico-biological interactions 20091030
Title: Mouse carnitine-acylcarnitine translocase (CACT) is transcriptionally regulated by PPARalpha and PPARdelta in liver cells.
Journal: Biochimica et biophysica acta 20091001
Title: Structurally diverse peroxisome proliferator-activated receptor agonists induce apoptosis in human uro-epithelial cells by a receptor-independent mechanism involving store-operated calcium channels.
Journal: Cell proliferation 20091001
Title: Construction of triple-transfected cells [organic anion-transporting polypeptide (OATP) 1B1/multidrug resistance-associated protein (MRP) 2/MRP3 and OATP1B1/MRP2/MRP4] for analysis of the sinusoidal function of MRP3 and MRP4.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20091001
Title: Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20091001
Title: Signal transducer and activator of transcription 3 (STAT3) regulates adipocyte differentiation via peroxisome-proliferator-activated receptor gamma (PPARgamma).
Journal: Biology of the cell 20090923
Title: Establishment of knockdown of superoxide dismutase 2 and expression of CYP3A4 cell system to evaluate drug-induced cytotoxicity.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20090901
Title: Effect of membrane cholesterol on BSEP/Bsep activity: species specificity studies for substrates and inhibitors.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20090901
Title: Technical pitfalls and improvements for high-speed screening and QSAR analysis to predict inhibitors of the human bile salt export pump (ABCB11/BSEP).
Journal: The AAPS journal 20090901
Title: Troglitazone inhibits vascular endothelial growth factor-induced angiogenic signaling via suppression of reactive oxygen species production and extracellular signal-regulated kinase phosphorylation in endothelial cells.
Journal: Journal of pharmacological sciences 20090901
Title: Stearic acid-induced cardiac lipotoxicity is independent of cellular lipid and is mitigated by the fatty acids oleic and capric acid but not by the PPAR agonist troglitazone.
Journal: Experimental physiology 20090801
Title: Protective effect of peroxisome proliferator-activated receptor-gamma agonists on activated renal proximal tubular epithelial cells in IgA nephropathy.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20090701
Title: Thiazolidinediones for the treatment in NASH: sustained benefit after drug discontinuation?
Journal: Journal of clinical gastroenterology 20090701
Title: Differential modulation of farnesoid X receptor signaling pathway by the thiazolidinediones.
Journal: The Journal of pharmacology and experimental therapeutics 20090701
Title: Thiazolidinediones in NASH. An odd couple meant to be?
Journal: Journal of clinical gastroenterology 20090701
Title: Towards an extended functional hepatocyte in vitro culture.
Journal: Tissue engineering. Part C, Methods 20090601
Title: An integrated approach to improved toxicity prediction for the safety assessment during preclinical drug development using Hep G2 cells.
Journal: Toxicology and applied pharmacology 20090601
Title: Thiazolidinediones induce proliferation of human bronchial epithelial cells through the GPR40 receptor.
Journal: American journal of physiology. Lung cellular and molecular physiology 20090601
Title: Troglitazone inhibits cell proliferation by attenuation of epidermal growth factor receptor signaling independent of peroxisome proliferator-activated receptor gamma.
Journal: Cell research 20090601
Title: Moving away from PPARs - EGFR signaling and the anti-cancer effects of thiazolinedinediones.
Journal: Cell research 20090601
Title: 15-deoxy-Delta(12,14)-prostaglandin J(2) inhibits fibrogenic response in human hepatoma cells.
Journal: Toxicology letters 20090522
Title: Effects of the PPARgamma agonist troglitazone on endothelial cells in vivo and in vitro: differences between human and mouse.
Journal: Toxicology and applied pharmacology 20090515
Title: Caspase-mediated cleavage of beta-catenin precedes drug-induced apoptosis in resistant cancer cells.
Journal: The Journal of biological chemistry 20090515
Title: Insulin resistance directly contributes to androgenic potential within ovarian theca cells.
Journal: Fertility and sterility 20090501
Title: PPARgamma-independent antitumor effects of thiazolidinediones.
Journal: Cancer letters 20090418
Title: Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes.
Journal: Chemico-biological interactions 20090415
Title: PPARgamma agonists attenuate proliferation and modulate Wnt/beta-catenin signalling in melanoma cells.
Journal: The international journal of biochemistry & cell biology 20090401
Title: Type 2 deiodinase expression is induced by peroxisomal proliferator-activated receptor-gamma agonists in skeletal myocytes.
Journal: Endocrinology 20090401
Title: Troglitazone suppresses transforming growth factor-beta1-induced collagen type I expression in keloid fibroblasts.
Journal: The British journal of dermatology 20090401
Title: Proteasome inhibition overcomes the resistance of renal cell carcinoma cells against the PPARgamma ligand troglitazone.
Journal: Cellular and molecular life sciences : CMLS 20090401
Title: Identification of nobiletin, a polymethoxyflavonoid, as an enhancer of adiponectin secretion.
Journal: Bioorganic & medicinal chemistry letters 20090401
Title: Troglitazone increases expression of E-cadherin and claudin 4 in human pancreatic cancer cells.
Journal: Biochemical and biophysical research communications 20090313
Title: Gene expression profile in colon cancer cells with respect to XIAP expression status.
Journal: International journal of colorectal disease 20090301
Title: Inhibition of colorectal cancer by targeting hepatocyte nuclear factor-4alpha.
Journal: International journal of cancer 20090301
Title: Fluorescent benzofurazan-cholic acid conjugates for in vitro assessment of bile acid uptake and its modulation by drugs.
Journal: ChemMedChem 20090301
Title: Activation of PPARalpha and PPARgamma reduces triacylglycerol synthesis in rat hepatoma cells by reduction of nuclear SREBP-1.
Journal: European journal of pharmacology 20090301
Title: Skp2 promotes adipocyte differentiation via a p27Kip1-independent mechanism in primary mouse embryonic fibroblasts.
Journal: Biochemical and biophysical research communications 20090206
Title: Hepatocarcinogenic susceptibility of rasH2 mice to troglitazone in a two-stage hepatocarcinogenesis model.
Journal: Archives of toxicology 20090201
Title: Topical peroxisome proliferator activated receptor activators accelerate postnatal stratum corneum acidification.
Journal: The Journal of investigative dermatology 20090201
Title: The association of ENPP1 K121Q with diabetes incidence is abolished by lifestyle modification in the diabetes prevention program.
Journal: The Journal of clinical endocrinology and metabolism 20090201
Title: Sensitivity of liver injury in heterozygous Sod2 knockout mice treated with troglitazone or acetaminophen.
Journal: Toxicologic pathology 20090201
Title: Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells.
Journal: World journal of gastroenterology 20090121
Title: Combination of melatonin and a peroxisome proliferator-activated receptor-gamma agonist induces apoptosis in a breast cancer cell line.
Journal: Journal of pineal research 20090101
Title: PPAR-gamma agonist attenuates renal interstitial fibrosis and inflammation through reduction of TGF-beta.
Journal: Laboratory investigation; a journal of technical methods and pathology 20090101
Title: PPAR-gamma agonists inhibit TGF-beta1-induced chemokine expression in human tubular epithelial cells.
Journal: Acta pharmacologica Sinica 20090101
Title: Effect of bone morphogenetic protein-2 (BMP-2) or troglitazone, as an inducer of osteogenic cells or adipocytes, on differentiation of a bone marrow mesenchymal progenitor cell line established from temperature-sensitive (ts) simian virus (SV) 40 T-antigen gene transgenic mice.
Journal: Biological & pharmaceutical bulletin 20090101
Title: A trapping method for semi-quantitative assessment of reactive metabolite formation using [35S]cysteine and [14C]cyanide.
Journal: Drug metabolism and pharmacokinetics 20090101
Title: Estrogen-dependent regulation of PPAR-gamma signaling on collagen biosynthesis in adenocarcinoma endometrial cells.
Journal: Neoplasma 20090101
Title: Rosiglitazone prevents high glucose-induced vascular endothelial growth factor and collagen IV expression in cultured mesangial cells.
Journal: Experimental diabetes research 20090101
Title: [Cytotoxicity of troglitazone, structural analogue of alpha-tocopherol is mediated by inhibition of NAD(P)H:quinone oxidoreductase].
Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20090101
Title: Metformin and troglitazone in the treatment of female infertility associated with polycystic ovarian syndrome.
Journal: JNMA; journal of the Nepal Medical Association 20090101
Title: CD36 signaling inhibits the translation of heat shock protein 70 induced by oxidized low density lipoprotein through activation of peroxisome proliferators-activated receptor gamma.
Journal: Experimental & molecular medicine 20081231
Title: Troglitazone enhances tamoxifen-induced growth inhibitory activity of MCF-7 cells.
Journal: Biochemical and biophysical research communications 20081205
Title: Disruption of ERalpha signalling pathway by PPARgamma agonists: evidences of PPARgamma-independent events in two hormone-dependent breast cancer cell lines.
Journal: Breast cancer research and treatment 20081201
Title: Troglitazone inhibits cell migration, adhesion, and spreading by modulating cytoskeletal rearrangement in human breast cancer cells.
Journal: Molecular carcinogenesis 20081201
Title: 15-deoxy-Delta12,14-prostaglandin J2 inhibits INF-gamma-induced JAK/STAT1 signalling pathway activation and IP-10/CXCL10 expression in mesangial cells.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20081201
Title: Troglitazone-mediated sensitization to TRAIL-induced apoptosis is regulated by proteasome-dependent degradation of FLIP and ERK1/2-dependent phosphorylation of BAD.
Journal: Cancer biology & therapy 20081201
Title: FLIPing the apoptosis switch on in brain tumors using Troglitazone and TRAIL.
Journal: Cancer biology & therapy 20081201
Title: Sepsis-induced inhibition of neutrophil chemotaxis is mediated by activation of peroxisome proliferator-activated receptor-{gamma}.
Journal: Blood 20081115
Title: Adiponectin and its response to thiazolidinediones are associated with insulin-mediated glucose metabolism in type 2 diabetic patients and their first-degree relatives.
Journal: Diabetes, obesity & metabolism 20081101
Title: Mitochondrial dysfunction and delayed hepatotoxicity: another lesson from troglitazone.
Journal: Diabetologia 20081101
Title: Suppression of cytokine responses by indomethacin in podocytes: a mechanism through induction of unfolded protein response.
Journal: American journal of physiology. Renal physiology 20081101
Title: Adipose tissue fat accumulation is reduced by a single intraperitoneal injection of peroxisome proliferator-activated receptor gamma agonist when given to newly hatched chicks.
Journal: Poultry science 20081101
Title: Cloning of the dog bile salt export pump (BSEP; ABCB11) and functional comparison with the human and rat proteins.
Journal: Biopharmaceutics & drug disposition 20081101
Title: Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Journal: Journal of medicinal chemistry 20081009
Title: The effect of plasminogen activator inhibitor-1 -675 4G/5G polymorphism on PAI-1 gene expression and adipocyte differentiation.
Journal: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20081001
Title: Extremely weak tumor-promoting effect of troglitazone on splenic hemangiosarcomas in rasH2 mice induced by urethane.
Journal: Archives of toxicology 20081001
Title: Differentiation of bovine intramuscular and subcutaneous stromal-vascular cells exposed to dexamethasone and troglitazone.
Journal: Journal of animal science 20081001
Title: Keratinocyte-derived vascular endothelial growth factor biosynthesis represents a pleiotropic side effect of peroxisome proliferator-activated receptor-gamma agonist troglitazone but not rosiglitazone and involves activation of p38 mitogen-activated protein kinase: implications for diabetes-impaired skin repair.
Journal: Molecular pharmacology 20081001
Title: First versus repeat treatment with a lifestyle intervention program: attendance and weight loss outcomes.
Journal: International journal of obesity (2005) 20081001
Title: Electrochemical oxidation of troglitazone: identification and characterization of the major reactive metabolite in liver microsomes.
Journal: Chemical research in toxicology 20081001
Title: Troglitazone increases IL-1beta induced cyclooxygenase-2 and inducible nitric oxide synthase expression via enhanced phosphorylation of IkappaBalpha in vascular smooth muscle cells from Wistar-Kyoto rats and spontaneously hypertensive rats.
Journal: Biological & pharmaceutical bulletin 20081001
Title: Loss of XIAP sensitizes colon cancer cells to PPARgamma independent antitumor effects of troglitazone and 15-PGJ2.
Journal: Cancer letters 20080918
Title: Troglitazone but not conjugated linoleic acid reduces gene expression and activity of matrix-metalloproteinases-2 and -9 in PMA-differentiated THP-1 macrophages.
Journal: The Journal of nutritional biochemistry 20080901
Title: An algorithm for thorough background subtraction from high-resolution LC/MS data: application to the detection of troglitazone metabolites in rat plasma, bile, and urine.
Journal: Journal of mass spectrometry : JMS 20080901
Title: Cellular imaging predictions of clinical drug-induced liver injury.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20080901
Title: Evaluation of solid dispersions on a molecular level by the Raman mapping technique.
Journal: International journal of pharmaceutics 20080901
Title: Circulating free fatty acids are increased independently of PPARgamma activity after administration of poloxamer 407 to mice.
Journal: Canadian journal of physiology and pharmacology 20080901
Title: Sulindac derivatives that activate the peroxisome proliferator-activated receptor gamma but lack cyclooxygenase inhibition.
Journal: Journal of medicinal chemistry 20080828
Title: Troglitazone-induced hepatic mitochondrial proteome expression dynamics in heterozygous Sod2(+/-) mice: two-stage oxidative injury.
Journal: Toxicology and applied pharmacology 20080815
Title: Induction of G1 phase arrest and apoptosis in MDA-MB-231 breast cancer cells by troglitazone, a synthetic peroxisome proliferator-activated receptor gamma (PPARgamma) ligand.
Journal: Cell biology international 20080801
Title: [Stimulating autophagosome formation and inducing mixed cell death in HeLa cells by troglitazone].
Journal: Wei sheng wu xue bao = Acta microbiologica Sinica 20080801
Title: Troglitazone thiol adduct formation in human liver microsomes: enzyme kinetics and reaction phenotyping.
Journal: Drug metabolism letters 20080801
Title: Cytoprotective effect of tauroursodeoxycholate on hepatocyte apoptosis induced by peroxisome proliferator-activated receptor gamma ligand.
Journal: Journal of gastroenterology and hepatology 20080701
Title: Effect of pioglitazone on progression of subclinical atherosclerosis in non-diabetic premenopausal Hispanic women with prior gestational diabetes.
Journal: Atherosclerosis 20080701
Title: The effect of PPAR ligands to modulate glucose metabolism alters the incorporation of metabolic precursors into proteoglycans synthesized by human vascular smooth muscle cells.
Journal: Archives of physiology and biochemistry 20080701
Title: Down-regulation of X-linked inhibitor of apoptosis synergistically enhanced peroxisome proliferator-activated receptor gamma ligand-induced growth inhibition in colon cancer.
Journal: Molecular cancer therapeutics 20080701
Title: In vivo and in vitro regulation of syndecan 1 in prostate cells by n-3 polyunsaturated fatty acids.
Journal: The Journal of biological chemistry 20080627
Title: Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid.
Journal: The Journal of biological chemistry 20080620
Title: Regulation of EP4 expression via the Sp-1 transcription factor: inhibition of expression by anti-cancer agents.
Journal: Biochimica et biophysica acta 20080601
Title: Effects of amide constituents from pepper on adipogenesis in 3T3-L1 cells.
Journal: Bioorganic & medicinal chemistry letters 20080601
Title: Chemotherapeutic drugs induce PPAR-gamma expression and show sequence-specific synergy with PPAR-gamma ligands in inhibition of non-small cell lung cancer.
Journal: Neoplasia (New York, N.Y.) 20080601
Title: [The protective effects and mechanisms of peroxisome proliferator-activated receptor-gamma agonist in rats with acute lung injury].
Journal: Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20080601
Title: Troglitazone up-regulates vascular endothelial argininosuccinate synthase.
Journal: Biochemical and biophysical research communications 20080530
Title: PPARgamma ligands suppress the feedback loop between E2F2 and cyclin-E1.
Journal: Biochemical and biophysical research communications 20080523
Title: Activation of AMP-activated protein kinase, inhibition of pyruvate dehydrogenase activity, and redistribution of substrate partitioning mediate the acute insulin-sensitizing effects of troglitazone in skeletal muscle cells.
Journal: Journal of cellular physiology 20080501
Title: PPAR-gamma agonists inhibit profibrotic phenotypes in human lung fibroblasts and bleomycin-induced pulmonary fibrosis.
Journal: American journal of physiology. Lung cellular and molecular physiology 20080501
Title: Effect of troglitazone on CYP1A1 induction.
Journal: Toxicology 20080418
Title: Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3.
Journal: European journal of pharmacology 20080414
Title: Troglitazone, a peroxisome proliferator-activated receptor gamma ligand, induces growth inhibition and apoptosis of HepG2 human liver cancer cells.
Journal: World journal of gastroenterology 20080414
Title: Pharmacological exploitation of the peroxisome proliferator-activated receptor gamma agonist ciglitazone to develop a novel class of androgen receptor-ablative agents.
Journal: Journal of medicinal chemistry 20080410
Title: Is the metabolic syndrome an intracellular Cushing state? Effects of multiple humoral factors on the transcriptional activity of the hepatic glucocorticoid-activating enzyme (11beta-hydroxysteroid dehydrogenase type 1) gene.
Journal: Molecular and cellular endocrinology 20080326
Title: Ciglitazone induces caspase-independent apoptosis through down-regulation of XIAP and survivin in human glioma cells.
Journal: Neurochemical research 20080301
Title: Phosphorylated troglitazone activates PPARgamma and inhibits vascular smooth muscle cell proliferation and proteoglycan synthesis.
Journal: Journal of cardiovascular pharmacology 20080301
Title: Ciglitazone induces caspase-independent apoptosis via p38-dependent AIF nuclear translocation in renal epithelial cells.
Journal: Toxicology 20080203
Title: The mitochondrial superoxide/thioredoxin-2/Ask1 signaling pathway is critically involved in troglitazone-induced cell injury to human hepatocytes.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20080201
Title: A novel peroxisome proliferator-activated receptor alpha/gamma agonist, BPR1H0101, inhibits topoisomerase II catalytic activity in human cancer cells.
Journal: Anti-cancer drugs 20080201
Title: Optimization of in vitro conditions for bovine subcutaneous and intramuscular preadipocyte differentiation.
Journal: Journal of animal science 20080101
Title: HepaRG cells as an in vitro model for evaluation of cytochrome P450 induction in humans.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20080101
Title: SOCS 3 and PPAR-gamma ligands inhibit the expression of IL-6 and TGF-beta1 by regulating JAK2/STAT3 signaling in pancreas.
Journal: The international journal of biochemistry & cell biology 20080101
Title: Troglitazone suppresses transforming growth factor beta-mediated fibrogenesis in retinal pigment epithelial cells.
Journal: Molecular vision 20080101
Title: Pigment epithelium-derived factor is an angiogenesis and lipid regulator that activates peroxisome proliferator-activated receptor alpha.
Journal: Advances in experimental medicine and biology 20080101
Title: The synthetic PPARgamma agonist troglitazone inhibits eotaxin-enhanced eosinophil adhesion to ICAM-1-coated plates.
Journal: International archives of allergy and immunology 20080101
Title: Peroxisome proliferator-activated receptor-gamma and growth inhibition by its ligands in prostate cancer.
Journal: Cancer detection and prevention 20080101
Title: Mechanisms of pancreatic fibrosis and applications to the treatment of chronic pancreatitis.
Journal: Journal of gastroenterology 20080101
Title: Troglitazone induced cytosolic acidification via extracellular signal-response kinase activation and mitochondrial depolarization: complex I proton pumping regulates ammoniagenesis in proximal tubule-like LLC-PK1 cells.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20080101
Title: [Pathophysiological relevance of peroxisome proliferators activated receptors (PPAR) to joint diseases - the pro and con of agonists].
Journal: Journal de la Societe de biologie 20080101
Title: Inhibition of adhesive interaction between multiple myeloma and bone marrow stromal cells by PPARgamma cross talk with NF-kappaB and C/EBP.
Journal: Blood 20071215
Title: Anti-inflammatory lipid mediator 15d-PGJ2 inhibits translation through inactivation of eIF4A.
Journal: The EMBO journal 20071212
Title: Carcinogenic susceptibility of rasH2 mice to troglitazone.
Journal: Archives of toxicology 20071201
Title: The Pro12Ala variant at the peroxisome proliferator-activated receptor gamma gene and change in obesity-related traits in the Diabetes Prevention Program.
Journal: Diabetologia 20071201
Title: Use of insulin sensitizers in NASH.
Journal: Endocrinology and metabolism clinics of North America 20071201
Title: Effect of Troglitazone on expression of adhesion molecules and eNOS in human saphenous vein graft.
Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20071201
Title: Capacitative calcium entry contributes to the differential transactivation of the epidermal growth factor receptor in response to thiazolidinediones.
Journal: Molecular pharmacology 20071101
Title: [Adverse effects of insulin sensitisers and biguanides].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20071028
Title: [Abnormality of liver functional test in patients with drug-induced liver injury].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20071028
Title: NR4A orphan nuclear receptors modulate insulin action and the glucose transport system: potential role in insulin resistance.
Journal: The Journal of biological chemistry 20071026
Title: Comparison of vascular relaxation, lipolysis and glucose uptake by peroxisome proliferator-activated receptor-gamma activation in +db/+m and +db/+db mice.
Journal: European journal of pharmacology 20071015
Title: Structural basis for activation of fatty acid-binding protein 4.
Journal: Journal of molecular biology 20071005
Title: Mechanism of TNFalpha-induced IL-1alpha, IL-1beta and IL-6 expression in human cardiac fibroblasts: effects of statins and thiazolidinediones.
Journal: Cardiovascular research 20071001
Title: Investigation of the lipophilic behaviour of some thiazolidinediones. Relationships with PPAR-gamma activity.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071001
Title: Regulation of retinol binding protein 4 production in primary human adipocytes by adiponectin, troglitazone and TNF-alpha.
Journal: Diabetologia 20071001
Title: Activation of adenosine monophosphate activated protein kinase inhibits growth of multiple myeloma cells.
Journal: Experimental cell research 20071001
Title: A peroxisome proliferator-activated receptor gamma antagonist induces vimentin cleavage and inhibits invasion in high-grade hepatocellular carcinoma.
Journal: Oncology reports 20071001
Title: Capsaicin, a spicy component of hot peppers, modulates adipokine gene expression and protein release from obese-mouse adipose tissues and isolated adipocytes, and suppresses the inflammatory responses of adipose tissue macrophages.
Journal: FEBS letters 20070918
Title: Peroxisome proliferator-activated receptor gamma interacts with CIITA x RFX5 complex to repress type I collagen gene expression.
Journal: The Journal of biological chemistry 20070907
Title: Conditioned medium obtained from in vitro differentiated adipocytes and resistin induce insulin resistance in human hepatocytes.
Journal: FEBS letters 20070904
Title: Apoptotic action of peroxisome proliferator-activated receptor-gamma activation in human non small-cell lung cancer is mediated via proline oxidase-induced reactive oxygen species formation.
Journal: Molecular pharmacology 20070901
Title: New type of anti-diabetic compounds from the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium).
Journal: Bioorganic & medicinal chemistry letters 20070901
Title: Bioactive constituents from chinese natural medicines. XXIV. Hypoglycemic effects of Sinocrassula indica in sugar-loaded rats and genetically diabetic KK-A(y) mice and structures of new acylated flavonol glycosides, sinocrassosides A(1), A(2), B(1), and B(2).
Journal: Chemical & pharmaceutical bulletin 20070901
Title: Differentiation of human circulating fibrocytes as mediated by transforming growth factor-beta and peroxisome proliferator-activated receptor gamma.
Journal: The Journal of biological chemistry 20070803
Title: Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20070801
Title: Successful preparation of metabolite of troglitazone by in-flow electrochemical reaction on coulometric electrode.
Journal: Chemical & pharmaceutical bulletin 20070801
Title: Treatment update: thiazolidinediones in combination with metformin for the treatment of type 2 diabetes.
Journal: Vascular health and risk management 20070801
Title: [Effect of peroxisome proliferators-activated receptor gamma ligands on cytotrophoblast invasion in first trimester pregnancy].
Journal: Zhonghua fu chan ke za zhi 20070801
Title: Protective effects of peroxisome proliferator-activated receptor gamma ligand on apoptosis and hepatocyte growth factor induction in renal ischemia-reperfusion injury.
Journal: Transplantation 20070727
Title: Hypoglycemic action of thiazolidinediones/peroxisome proliferator-activated receptor gamma by inhibition of the c-Jun NH2-terminal kinase pathway.
Journal: Diabetes 20070701
Title: Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-L alpha.
Journal: Molecular and cellular biology 20070701
Title: Evaluation of a basic physiologically based pharmacokinetic model for simulating the first-time-in-animal study.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20070701
Title: [Peroxisome proliferator-activated receptor activator troglitazone inhibits angiotensin II-stimulated secretion of vasoactive factors by endothelial cells].
Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20070701
Title: Troglitazone acutely activates AMP-activated protein kinase and inhibits insulin secretion from beta cells.
Journal: Life sciences 20070620
Title: Mechanism of thiazolidinedione-dependent cell death in Jurkat T cells.
Journal: Molecular pharmacology 20070601
Title: Laminar shear stress up-regulates the expression of stearoyl-CoA desaturase-1 in vascular endothelial cells.
Journal: Cardiovascular research 20070601
Title: Expression of heme oxygenase-1 in human vascular cells is regulated by peroxisome proliferator-activated receptors.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20070601
Title: The peroxisome proliferator-activated receptor-gamma agonist troglitazone inhibits transforming growth factor-beta-mediated glioma cell migration and brain invasion.
Journal: Molecular cancer therapeutics 20070601
Title: [Inhibitive effect of troglitazone on TGF-beta(1) and fibronectin expression in human peritoneal mesothelial cells].
Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20070601
Title: Troglitazone induces differentiation in Trypanosoma brucei.
Journal: Experimental cell research 20070515
Title: Role of mitogen-activated protein kinase (MAPK) in troglitazone-induced osteoblastic cell death.
Journal: Toxicology 20070505
Title: Effect of physical properties of troglitazone crystal on the molecular interaction with PVP during heating.
Journal: International journal of pharmaceutics 20070504
Title: Beta-cell preservation with thiazolidinediones.
Journal: Diabetes research and clinical practice 20070501
Title: Troglitazone-induced hepatic necrosis in an animal model of silent genetic mitochondrial abnormalities.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20070501
Title: Peroxisome proliferator-activated receptor-gamma agonists inhibit respiratory syncytial virus-induced expression of intercellular adhesion molecule-1 in human lung epithelial cells.
Journal: Immunology 20070501
Title: Glutathione-S-transferase (GST) M1 null genotype and combined GSTM1 and GSTT1 null genotypes as a risk factor for alcoholic mild liver dysfunction.
Journal: Clinical pharmacology and therapeutics 20070501
Title: ALK-mediated Na+/H+ exchanger-dependent intracellular alkalinization: does it matter for oncogenesis?
Journal: Haematologica 20070501
Title: Troglitazone hepatotoxicity: are we getting closer to understanding idiosyncratic liver injury?
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20070501
Title: Differential effects of PPARgamma agonists on the metabolic properties of gliomas and astrocytes.
Journal: Neuroscience letters 20070424
Title: Diabetes drugs tied to fractures in women.
Journal: JAMA 20070418
Title: Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone.
Journal: The Journal of clinical endocrinology and metabolism 20070401
Title: PPAR-gamma agonists induce the expression of VEGF and its receptors in cultured cardiac myofibroblasts.
Journal: Cardiovascular research 20070401
Title: Effect of antihypertensive therapy on progression of carotid intima-media thickness in patients with type 2 diabetes mellitus.
Journal: The American journal of cardiology 20070401
Title: Peroxisome proliferator-activated receptor gamma-independent suppression of androgen receptor expression by troglitazone mechanism and pharmacologic exploitation.
Journal: Cancer research 20070401
Title: New oral agents for type 2 diabetes.
Journal: Clinical medicine (London, England) 20070401
Title: SNP communications: coalition of toxicology and drug metabolism and pharmacokinetics.
Journal: Drug metabolism and pharmacokinetics 20070401
Title: Troglitazone inhibits oxidized low-density lipoprotein-induced macrophage proliferation: impact of the suppression of nuclear translocation of ERK1/2.
Journal: Atherosclerosis 20070301
Title: Troglitazone and pioglitazone interactions via PPAR-gamma-independent and -dependent pathways in regulating physiological responses in renal tubule-derived cell lines.
Journal: American journal of physiology. Cell physiology 20070301
Title: Downregulation of cyclooxygenase-2 expression and activation of caspase-3 are involved in peroxisome proliferator-activated receptor-gamma agonists induced apoptosis in human monocyte leukemia cells in vitro.
Journal: Annals of hematology 20070301
Title: Peroxisome proliferator-activated receptor alpha-independent effects of peroxisome proliferators on cysteinyl leukotriene production in mast cells.
Journal: European journal of pharmacology 20070205
Title: Involvement of breast cancer resistance protein (BCRP/ABCG2) in the biliary excretion and intestinal efflux of troglitazone sulfate, the major metabolite of troglitazone with a cholestatic effect.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20070201
Title: Regulation and function of collagenous repeat containing sequence of 26-kDa protein gene product 'cartonectin'.
Journal: Obesity (Silver Spring, Md.) 20070201
Title: Effect of thiazolidinediones on bile acid transport in rat liver.
Journal: Life sciences 20070130
Title: [Effects of peroxisome proliferator-activated receptor gamma and its ligands on cytotrophoblast invasion in first trimester of pregnancy and mechanism thereof].
Journal: Zhonghua yi xue za zhi 20070116
Title: Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers.
Journal: The Journal of pharmacology and experimental therapeutics 20070101
Title: Connective tissue growth factor and fibronectin secretion in renal tubular epithelial cells induced by TGF-beta1: suppressive effects of troglitazone.
Journal: Cell biology international 20070101
Title: Open channel block of Kv1.3 by rosiglitazone and troglitazone: Kv1.3 as the pharmacological target for rosiglitazone.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20070101
Title: Upregulation of MIP-2 (CXCL2) expression by 15-deoxy-Delta(12,14)-prostaglandin J(2) in mouse peritoneal macrophages.
Journal: Immunology and cell biology 20070101
Title: Pharmacokinetic study of intraperitoneally administered troglitazone in mice using ultra-performance liquid chromatography/tandem mass spectrometry.
Journal: Rapid communications in mass spectrometry : RCM 20070101
Title: Peroxisome proliferator-activated receptor-gamma agonists cause growth arrest and apoptosis in human ovarian carcinoma cell lines.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20070101
Title: A pathogenic mechanism leading to partial lipodistrophy and prospects for pharmacological treatment of insulin resistance syndrome.
Journal: Acta bio-medica : Atenei Parmensis 20070101
Title: Activation of peroxisome proliferator-activated receptor-gamma protects pancreatic beta-cells from cytokine-induced cytotoxicity via NF kappaB pathway.
Journal: The international journal of biochemistry & cell biology 20070101
Title: Exacerbation of acidosis during ischemia and reperfusion arrhythmia in hearts from type 2 Diabetic Otsuka Long-Evans Tokushima Fatty rats.
Journal: Cardiovascular diabetology 20070101
Title: Tort law: Desiano and the Second Circuit's repudiation of de jure tort reform.
Journal: The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics 20070101
Title: Use of sandwich-cultured hepatocytes to evaluate impaired bile acid transport as a mechanism of drug-induced hepatotoxicity.
Journal: Molecular pharmaceutics 20070101
Title: Role of epidermal growth factor receptor (EGFR)-signaling versus cellular acidosis via Na+/H+ exchanger1(NHE1)-inhibition in troglitazone-induced growth arrest of breast cancer-derived cells MCF-7.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101
Title: Metabolic flux profiling of reaction modules in liver drug transformation.
Journal: Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 20070101
Title: Inhibition of cell motility by troglitazone in human ovarian carcinoma cell line.
Journal: BMC cancer 20070101
Title: Activating effect of benzbromarone, a uricosuric drug, on peroxisome proliferator-activated receptors.
Journal: PPAR research 20070101
Title: [The anti-diabetic drug troglitazone sensitizes colon cancer cells to TRAIL-induced apoptosis by down-regulating FLIP].
Journal: Verhandlungen der Deutschen Gesellschaft fur Pathologie 20070101
Title: Tetrahydroisoquinoline PPARgamma agonists: design of novel, highly selective non-TZD antihyperglycemic agents.
Journal: Bioorganic & medicinal chemistry letters 20061215
Title: Effect of ligand troglitazone on peroxisome proliferator-activated receptor gamma expression and cellular growth in human colon cancer cells.
Journal: World journal of gastroenterology 20061207
Title: Rosiglitazone inhibits mouse liver regeneration.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20061201
Title: Genetic analysis of peroxisome proliferator-activated receptor gamma1 splice variants in human colorectal cell lines.
Journal: International journal of oncology 20061201
Title: Troglitazone inhibits synthesis of transforming growth factor-beta1 and reduces matrix production in human peritoneal mesothelial cells.
Journal: Nephrology (Carlton, Vic.) 20061201
Title: Synergistic effects of troglitazone in combination with cytotoxic agents in acute myelogenous leukaemia cells.
Journal: Leukemia research 20061101
Title: Tissue-specific expression and regulation of GSK-3 in human skeletal muscle and adipose tissue.
Journal: American journal of physiology. Endocrinology and metabolism 20061101
Title: Modulation of early human preadipocyte differentiation by glucocorticoids.
Journal: Endocrinology 20061101
Title: Apoptosis induced by troglitazone is both peroxisome proliferator-activated receptor-gamma- and ERK-dependent in human non-small lung cancer cells.
Journal: Journal of cellular physiology 20061101
Title: Dephosphorylation of ribosomal protein P0 in response to troglitazone-induced cytotoxicity.
Journal: Toxicology letters 20061025
Title: Phorbol ester potentiates the growth inhibitory effects of troglitazone via up-regulation of PPARgamma in A549 cells.
Journal: Biochemical and biophysical research communications 20061020
Title: AMPK regulation of the growth of cultured human keratinocytes.
Journal: Biochemical and biophysical research communications 20061020
Title: Use of immortalized human hepatocytes to predict the magnitude of clinical drug-drug interactions caused by CYP3A4 induction.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20061001
Title: Protection of the kidney by thiazolidinediones: an assessment from bench to bedside.
Journal: Kidney international 20061001
Title: Metabolism of troglitazone in hepatocytes isolated from experimentally induced diabetic rats.
Journal: The Journal of pharmacy and pharmacology 20061001
Title: Metabolic and non-metabolic factors determining troglitazone hepatotoxicity: a review.
Journal: Drug metabolism and pharmacokinetics 20061001
Title: Activation of peroxisome proliferator-activated receptor-gamma (PPARgamma) induces cell death through MAPK-dependent mechanism in osteoblastic cells.
Journal: Toxicology and applied pharmacology 20060901
Title: Troglitazone sensitizes tumor cells to TRAIL-induced apoptosis via down-regulation of FLIP and Survivin.
Journal: Apoptosis : an international journal on programmed cell death 20060901
Title: Insulin sensitivity during oral glucose tolerance test and its relations to parameters of glucose metabolism and endothelial function in type 2 diabetic subjects under metformin and thiazolidinedione.
Journal: Diabetes, obesity & metabolism 20060901
Title: A Ligand for peroxisome proliferator-activated receptor gamma inhibits human cholangiocarcinoma cell growth: potential molecular targeting strategy for cholangioma.
Journal: Digestive diseases and sciences 20060901
Title: 15-Deoxy-12,14-prostaglandin J2 inhibits interferon gamma induced MHC class II but not class I expression on ARPE cells through a PPAR gamma independent mechanism.
Journal: Prostaglandins & other lipid mediators 20060901
Title: PPARgamma activation induces CD36 expression and stimulates foam cell like changes in rVSMCs.
Journal: Prostaglandins & other lipid mediators 20060901
Title: PPAR gamma ligand troglitazone lowers cholesterol synthesis in HepG2 and Caco-2 cells via a reduced concentration of nuclear SREBP-2.
Journal: Experimental biology and medicine (Maywood, N.J.) 20060901
Title: Enhancement of sodium/iodide symporter expression in thyroid and breast cancer.
Journal: Endocrine-related cancer 20060901
Title: The PPAR gamma agonist troglitazone induces musclin mRNA expression in human myotubes.
Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20060901
Title: [Effects of peroxisome proliferator-activated receptor-gamma ligand troglitazone on colon cancer cell growth].
Journal: Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20060818
Title: Rosiglitazone ameliorates cisplatin-induced renal injury in mice.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20060801
Title: Troglitazone, a peroxisome proliferator-activated receptor-gamma agonist, decreases tau phosphorylation in CHOtau4R cells.
Journal: Journal of neurochemistry 20060801
Title: Troglitazone acutely inhibits protein synthesis in endothelial cells via a novel mechanism involving protein phosphatase 2A-dependent p70 S6 kinase inhibition.
Journal: American journal of physiology. Cell physiology 20060801
Title: The use of hepatotoxic signals to predict the safety of peroxisome proliferator-activated receptor agonists.
Journal: Expert opinion on drug metabolism & toxicology 20060801
Title: Thiazolidinedione bioactivation: a comparison of the bioactivation potentials of troglitazone, rosiglitazone, and pioglitazone using stable isotope-labeled analogues and liquid chromatography tandem mass spectrometry.
Journal: Chemical research in toxicology 20060801
Title: [Troglitazone sensitizes effect of epirubicin on breast cancer cells].
Journal: Ai zheng = Aizheng = Chinese journal of cancer 20060801
Title: Differences in hepatotoxicity and gene expression profiles by anti-diabetic PPAR gamma agonists on rat primary hepatocytes and human HepG2 cells.
Journal: Molecular diversity 20060801
Title: Development of small-molecule cyclin D1-ablative agents.
Journal: Journal of medicinal chemistry 20060727
Title: Troglitazone inhibits endothelial cell proliferation through suppression of casein kinase 2 activity.
Journal: Biochemical and biophysical research communications 20060721
Title: Peroxisome proliferator-activated receptor-gamma agonists inhibit the replication of respiratory syncytial virus (RSV) in human lung epithelial cells.
Journal: Virology 20060705
Title: Thiazolidinediones can rapidly activate AMP-activated protein kinase in mammalian tissues.
Journal: American journal of physiology. Endocrinology and metabolism 20060701
Title: Effect of peroxisome proliferator-activated receptor gamma agonist treatment on subclinical atherosclerosis in patients with insulin-requiring type 2 diabetes.
Journal: Diabetes care 20060701
Title: Activation of Sirt1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells.
Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20060701
Title: Thiazolidinediones and rexinoids induce peroxisome proliferator-activated receptor-coactivator (PGC)-1alpha gene transcription: an autoregulatory loop controls PGC-1alpha expression in adipocytes via peroxisome proliferator-activated receptor-gamma coactivation.
Journal: Endocrinology 20060601
Title: Risks of troglitazone apparent before approval in USA.
Journal: Diabetologia 20060601
Title: [Drug-induced liver injury].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20060601
Title: Effects of eicosapentaenoic acid (EPA) on adiponectin gene expression and secretion in primary cultured rat adipocytes.
Journal: Journal of physiology and biochemistry 20060601
Title: Cytokine secretion by human adipocytes is differentially regulated by adiponectin, AICAR, and troglitazone.
Journal: Biochemical and biophysical research communications 20060512
Title: Molecular mechanism of 1,25-dihydroxyvitamin D3 inhibition of adipogenesis in 3T3-L1 cells.
Journal: American journal of physiology. Endocrinology and metabolism 20060501
Title: Peroxisome proliferator-activated receptor gamma regulates expression of signal transducer and activator of transcription 5A.
Journal: Experimental cell research 20060501
Title: A comparison of thiazolidinedione-induced adipogenesis and myogenesis in stromal-vascular cells from subcutaneous adipose tissue or semitendinosus muscle of postnatal pigs.
Journal: Journal of animal science 20060501
Title: Regulators for blood glucose level affect gene expression of aquaporin 3.
Journal: Biological & pharmaceutical bulletin 20060501
Title: [PPARgamma1 overexpression on caveolin-1 expression of Raw264.7 cells].
Journal: Zhonghua xin xue guan bing za zhi 20060501
Title: Synthetic peroxisome proliferator-activated receptor gamma agonists rosiglitazone and troglitazone suppress transcription by promoter 3 of the human thromboxane A2 receptor gene in human erythroleukemia cells.
Journal: Biochemical pharmacology 20060428
Title: Novel high-affinity PPARgamma agonist alone and in combination with paclitaxel inhibits human anaplastic thyroid carcinoma tumor growth via p21WAF1/CIP1.
Journal: Oncogene 20060413
Title: Urinary excretions of lipocalin-type prostaglandin D2 synthase predict the development of proteinuria and renal injury in OLETF rats.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20060401
Title: 'Hy's law,' the 'Rezulin Rule,' and other predictors of severe drug-induced hepatotoxicity: putting risk-benefit into perspective.
Journal: Pharmacoepidemiology and drug safety 20060401
Title: Peroxisome proliferator-activated receptors-gamma activator, ciglitazone, inhibits human melanocyte growth through induction of apoptosis.
Journal: Archives of dermatological research 20060401
Title: Effects of PPAR and RXR ligands in semaphorin 6B gene expression of human MCF-7 breast cancer cells.
Journal: International journal of oncology 20060401
Title: Hy's law: predicting serious hepatotoxicity.
Journal: Pharmacoepidemiology and drug safety 20060401
Title: Rules and laws of drug hepatotoxicity.
Journal: Pharmacoepidemiology and drug safety 20060401
Title: How can 'Hy's law' help the clinician?
Journal: Pharmacoepidemiology and drug safety 20060401
Title: [Effects of peroxisome proliferators-activated receptor gamma agonists on transforming growth factor-beta1 and Smads signal pathway: experiment with rat renal fibroblasts].
Journal: Zhonghua yi xue za zhi 20060321
Title: Peroxisome-proliferator-activated receptor-gamma agonists inhibit the release of proinflammatory cytokines from RSV-infected epithelial cells.
Journal: Virology 20060315
Title: A peroxisome proliferator-activated receptor-gamma agonist, troglitazone, facilitates caspase-8 and -9 activities by increasing the enzymatic activity of protein-tyrosine phosphatase-1B on human glioma cells.
Journal: The Journal of biological chemistry 20060310
Title: Antagonistic effects of oxidized low density lipoprotein and alpha-tocopherol on CD36 scavenger receptor expression in monocytes: involvement of protein kinase B and peroxisome proliferator-activated receptor-gamma.
Journal: The Journal of biological chemistry 20060310
Title: Troglitazone induction of COX-2 expression is dependent on ERK activation in keratinocytes.
Journal: Prostaglandins, leukotrienes, and essential fatty acids 20060301
Title: Effect of troglitazone on tumor necrosis factor alpha and transforming growth factor beta expression and action in human adipocyte precursor cells in primary culture.
Journal: Metabolism: clinical and experimental 20060301
Title: Effects of conjugated linoleic acid and troglitazone on lipid accumulation and composition in lean and Zucker diabetic fatty (fa/fa) rats.
Journal: Lipids 20060301
Title: Effect of ecdysterone on glucose metabolism in vitro.
Journal: Life sciences 20060202
Title: Dramatic synergistic anticancer effect of clinically achievable doses of lovastatin and troglitazone.
Journal: International journal of cancer 20060201
Title: CLA isomers inhibit TNFalpha-induced eicosanoid release from human vascular smooth muscle cells via a PPARgamma ligand-like action.
Journal: Biochimica et biophysica acta 20060201
Title: Thiazolidinediones inhibit insulin-like growth factor-i-induced activation of p70S6 kinase and suppress insulin-like growth factor-I tumor-promoting activity.
Journal: Cancer research 20060201
Title: Proline oxidase, a proapoptotic gene, is induced by troglitazone: evidence for both peroxisome proliferator-activated receptor gamma-dependent and -independent mechanisms.
Journal: The Journal of biological chemistry 20060127
Title: Troglitazone regulates peroxisome proliferator-activated receptors and inducible nitric oxide synthase in murine ovarian macrophages.
Journal: Biology of reproduction 20060101
Title: Troglitazone: the lesson that nobody learned?
Journal: Diabetologia 20060101
Title: Troglitazone inhibits tumor growth in hepatocellular carcinoma in vitro and in vivo.
Journal: Hepatology (Baltimore, Md.) 20060101
Title: 15-Deoxy-Delta(12,14)-prostaglandin J(2) and troglitazone regulation of the release of phospholipid metabolites, inflammatory cytokines and proteases from human gestational tissues.
Journal: Placenta 20060101
Title: Editorial overview: safety of drugs can never be absolute.
Journal: Current opinion in drug discovery & development 20060101
Title: Computational toxicology: heading toward more relevance in drug discovery and development.
Journal: Current opinion in drug discovery & development 20060101
Title: Insulin-lowering agents inhibit synthesis of testosterone in ovaries of DHEA-induced PCOS rats.
Journal: Gynecologic and obstetric investigation 20060101
Title: Thiazolidinediones inhibit albumin uptake by proximal tubular cells through a mechanism independent of peroxisome proliferator activated receptor gamma.
Journal: American journal of nephrology 20060101
Title: PPARgamma-independent induction of growth arrest and apoptosis in prostate and bladder carcinoma.
Journal: BMC cancer 20060101
Title: Regulatory effects of synthetic liver X receptor- and peroxisome-proliferator activated receptor agonists on sterol transport pathways in polarized cerebrovascular endothelial cells.
Journal: The international journal of biochemistry & cell biology 20060101
Title: Gene expression analysis of troglitazone reveals its impact on multiple pathways in cell culture: a case for in vitro platforms combined with gene expression analysis for early (idiosyncratic) toxicity screening.
Journal: International journal of toxicology 20060101
Title: An update on the Diabetes Prevention Program.
Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20060101
Title: Can glycemic targets be achieved-- in particular with two daily injections of a mix of intermediate- and short-acting insulin?
Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20060101
Title: Effect of troglitazone on serum gamma-glutamyltransferase activity and plasma t-PA/PAI-1 complex in type 2 diabetic patients.
Journal: Arzneimittel-Forschung 20060101
Title: Troglitazone inhibits cell growth and induces apoptosis of B-cell acute lymphoblastic leukemia cells with t(14;18).
Journal: Acta haematologica 20060101
Title: The effects of thiazolidinediones on blood pressure levels - a systematic review.
Journal: Blood pressure 20060101
Title: Troglitazone and 9cis,11trans,13trans-conjugated linolenic acid: comparison of their antiproliferative and apoptosis-inducing effects on different colon cancer cell lines.
Journal: Chemotherapy 20060101
Title: The thiazolidinedione drug troglitazone up-regulates nitric oxide synthase expression in vascular endothelial cells.
Journal: Journal of diabetes and its complications 20060101
Title: Different roles of protein kinase C-betaI and -delta in the regulation of adipocyte differentiation.
Journal: The international journal of biochemistry & cell biology 20060101
Title: Anti-inflammatory effects of PPAR-gamma agonists directly correlate with PPAR-gamma expression during acute pancreatitis.
Journal: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20060101
Title: An in vitro approach to detect metabolite toxicity due to CYP3A4-dependent bioactivation of xenobiotics.
Journal: Toxicology 20051215
Title: PPAR-gamma agonists inhibit toll-like receptor-mediated activation of dendritic cells via the MAP kinase and NF-kappaB pathways.
Journal: Blood 20051201
Title: Detection of autoantibody to aldolase B in sera from patients with troglitazone-induced liver dysfunction.
Journal: Toxicology 20051201
Title: PPAR-gamma-agonists' renal effects.
Journal: Minerva urologica e nefrologica = The Italian journal of urology and nephrology 20051201
Title: Management of the metabolic syndrome.
Journal: Panminerva medica 20051201
Title: Proinflammatory adipocytokines induce TIMP-1 expression in 3T3-L1 adipocytes.
Journal: FEBS letters 20051121
Title: Distinct mechanisms of glucose lowering by specific agonists for peroxisomal proliferator activated receptor gamma and retinoic acid X receptors.
Journal: The Journal of biological chemistry 20051118
Title: Inhibition of nuclear translocation of nuclear factor-kappaB despite lack of functional IkappaBalpha protein overcomes multiple defects in apoptosis signaling in human B-cell malignancies.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20051115
Title: Transcriptional regulation of activating transcription factor 3 involves the early growth response-1 gene.
Journal: The Journal of pharmacology and experimental therapeutics 20051101
Title: Rating the severity of the medical consequences of drug-induced liver injury.
Journal: Regulatory toxicology and pharmacology : RTP 20051101
Title: Activation of peroxisome proliferator-activated receptor-gamma by troglitazone (TGZ) inhibits human lung cell growth.
Journal: Journal of cellular biochemistry 20051101
Title: Troglitazone inhibits long-term glycation and oxidation of low-density lipoprotein.
Journal: Journal of cardiovascular pharmacology 20051101
Title: Sequence variation in PPARG may underlie differential response to troglitazone.
Journal: Diabetes 20051101
Title: The metabolic effects of troglitazone in patients with diabetes and end-stage renal disease.
Journal: Endocrine 20051101
Title: Adiponectin is expressed in the brown adipose tissue and surrounding immature tissues in mouse embryos.
Journal: Biochimica et biophysica acta 20051015
Title: Peroxisome proliferator activated receptor-gamma ligands induced cell growth inhibition and its influence on matrix metalloproteinase activity in human myeloid leukemia cells.
Journal: Cancer chemotherapy and pharmacology 20051001
Title: Risk of hospitalization for heart failure associated with thiazolidinedione therapy: a medicaid claims-based case-control study.
Journal: Pharmacotherapy 20051001
Title: Inhibitory effect of PPAR-gamma activator on IL-6 and mPGES protein expression in PBMC induced by homocysteine.
Journal: Hemodialysis international. International Symposium on Home Hemodialysis 20051001
Title: Prooxidant and antioxidant activity of vitamin E analogues and troglitazone.
Journal: Chemical research in toxicology 20051001
Title: Effects of water content in physical mixture and heating temperature on crystallinity of troglitazone-PVP K30 solid dispersions prepared by closed melting method.
Journal: International journal of pharmaceutics 20050930
Title: Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism.
Journal: Bioorganic & medicinal chemistry letters 20050915
Title: Peroxisome proliferator-activated receptor gamma agonist troglitazone induces colon tumors in normal C57BL/6J mice and enhances colonic carcinogenesis in Apc1638 N/+ Mlh1+/- double mutant mice.
Journal: International journal of cancer 20050910
Title: Regulation of adiponectin receptor 1 in human hepatocytes by agonists of nuclear receptors.
Journal: Biochemical and biophysical research communications 20050902
Title: Modulation of cytokine-induced cyclooxygenase 2 expression by PPARG ligands through NFkappaB signal disruption in human WISH and amnion cells.
Journal: Biology of reproduction 20050901
Title: Peroxisome proliferator-activated receptor-gamma ligands suppress fibronectin gene expression in human lung carcinoma cells: involvement of both CRE and Sp1.
Journal: American journal of physiology. Lung cellular and molecular physiology 20050901
Title: Agonists of peroxisome proliferator-activated receptor-gamma attenuate the Abeta-mediated impairment of LTP in the hippocampus in vitro.
Journal: Neuropharmacology 20050901
Title: Differential modulation of COX-2 expression in A549 airway epithelial cells by structurally distinct PPAR(gamma) agonists: evidence for disparate functional effects which are independent of NF-(kappa)B and PPAR(gamma).
Journal: Cellular signalling 20050901
Title: Peroxisome proliferator activated receptor-gamma (PPARgamma) represses thyroid hormone signaling in growth plate chondrocytes.
Journal: Bone 20050901
Title: Metformin reduces adiponectin protein expression and release in 3T3-L1 adipocytes involving activation of AMP activated protein kinase.
Journal: European journal of pharmacology 20050822
Title: Automated screening with confirmation of mechanism-based inactivation of CYP3A4, CYP2C9, CYP2C19, CYP2D6, and CYP1A2 in pooled human liver microsomes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050801
Title: The effect of PPARgamma ligands on UV- or chemically-induced carcinogenesis in mouse skin.
Journal: Molecular carcinogenesis 20050801
Title: Drugs for diabetes.
Journal: Treatment guidelines from the Medical Letter 20050801
Title: Pivotal role of peroxisome proliferator-activated receptor gamma (PPARgamma) in regulation of erythroid progenitor cell proliferation and differentiation.
Journal: Experimental hematology 20050801
Title: Troglitazone overcomes doxorubicin-resistance in resistant K562 leukemia cells.
Journal: Leukemia & lymphoma 20050801
Title: Effect of troglitazone on the excess testosterone and LH secretion in thyroidectomized, insulin-resistant, type 2 diabetic Goto-Kakizaki rats.
Journal: Endocrine 20050801
Title: A novel peroxisome proliferator-activated receptor gamma isoform with dominant negative activity generated by alternative splicing.
Journal: The Journal of biological chemistry 20050715
Title: Anandamide induced PPARgamma transcriptional activation and 3T3-L1 preadipocyte differentiation.
Journal: European journal of pharmacology 20050711
Title: Impaired fatty acid metabolism in type 2 diabetic skeletal muscle cells is reversed by PPARgamma agonists.
Journal: American journal of physiology. Endocrinology and metabolism 20050701
Title: The synthetic PPARgamma agonist troglitazone inhibits IL-5-induced CD69 upregulation and eosinophil-derived neurotoxin release from eosinophils.
Journal: Pharmacology 20050701
Title: Adiponectin receptor gene expression in human skeletal muscle cells is not regulated by fibrates and thiazolidinediones.
Journal: International journal of obesity (2005) 20050701
Title: Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
Journal: Journal of pharmaceutical sciences 20050701
Title: Troglitazone and 15-deoxy-delta(12,14)-prostaglandin J2 inhibit shear-induced coupling factor 6 release in endothelial cells.
Journal: Cardiovascular research 20050701
Title: Troglitazone reverses the inhibition of nitric oxide production by high glucose in cultured bovine retinal pericytes.
Journal: Experimental eye research 20050701
Title: Troglitazone-induced changes in adiponectin do not affect endothelial function in diabetes.
Journal: Obesity research 20050701
Title: 15-Deoxy-delta12,14-PGJ2 inhibits IL-6-induced Stat3 phosphorylation in lymphocytes.
Journal: Experimental & molecular medicine 20050630
Title: Involvement of MEK-ERK signaling pathway in the inhibition of cell growth by troglitazone in human pancreatic cancer cells.
Journal: Biochemical and biophysical research communications 20050624
Title: [Medical management of primary nonalcoholic fatty liver disease].
Journal: Medicina clinica 20050618
Title: The PPAR(gamma) K422Q mutation does not contribute to troglitazone inefficiency in colon cancer treatment.
Journal: Cancer letters 20050616
Title: PPARgamma2 regulates lipogenesis and lipid accumulation in steatotic hepatocytes.
Journal: American journal of physiology. Endocrinology and metabolism 20050601
Title: Troglitazone's rapid and sustained activation of ERK1/2 induces cellular acidosis in LLC-PK1-F+ cells: physiological responses.
Journal: American journal of physiology. Renal physiology 20050601
Title: Determination of troglitazone stereoisomers in rat plasma using semi-micro HPLC with electrochemical detection.
Journal: Journal of pharmaceutical and biomedical analysis 20050601
Title: Peroxisome proliferator-activated receptor gamma ligands induce cell cycle arrest and apoptosis in human renal carcinoma cell lines.
Journal: Acta pharmacologica Sinica 20050601
Title: Chemopreventive effect of peroxisome proliferator-activated receptor gamma on gastric carcinogenesis in mice.
Journal: Cancer research 20050601
Title: Action of thiazolidinediones on differentiation, proliferation and apoptosis of normal and transformed thyrocytes in culture.
Journal: Endocrine-related cancer 20050601
Title: Angiotensin II promotes leptin production in cultured human fat cells by an ERK1/2-dependent pathway.
Journal: Obesity research 20050601
Title: Insulin resistance contributes to obesity-related proteinuria.
Journal: Internal medicine (Tokyo, Japan) 20050601
Title: Glycolaldehyde-modified bovine serum albumin downregulates leptin expression in mouse adipocytes via a CD36-mediated pathway.
Journal: Annals of the New York Academy of Sciences 20050601
Title: Role of insulin secretagogues and insulin sensitizing agents in the prevention of cardiovascular disease in patients who have diabetes.
Journal: Cardiology clinics 20050501
Title: Troglitazone causes acute mitochondrial membrane depolarisation and an AMPK-mediated increase in glucose phosphorylation in muscle cells.
Journal: Diabetologia 20050501
Title: Thiazolidinediones inhibit apoptosis and heat shock protein 60 expression in human vascular endothelial cells.
Journal: Thrombosis and haemostasis 20050501
Title: Prevention of type 2 diabetes.
Journal: Current molecular medicine 20050501
Title: The anti-invasive activity of cyclooxygenase inhibitors is regulated by the transcription factor ATF3 (activating transcription factor 3).
Journal: Molecular cancer therapeutics 20050501
Title: The peroxisome proliferator-activated receptor gamma ligand troglitazone induces apoptosis and p53 in rat granulosa cells.
Journal: Molecular and cellular endocrinology 20050415
Title: Increased Akt protein expression is associated with decreased ceramide content in skeletal muscle of troglitazone-treated mice.
Journal: Biochemical pharmacology 20050415
Title: Effect of thiazolidinedione treatment on progression of subclinical atherosclerosis in premenopausal women at high risk for type 2 diabetes.
Journal: The Journal of clinical endocrinology and metabolism 20050401
Title: Peroxisome proliferator-activated receptor gamma-independent ablation of cyclin D1 by thiazolidinediones and their derivatives in breast cancer cells.
Journal: Molecular pharmacology 20050401
Title: Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): implication of macrophages resident in the AT.
Journal: The Journal of clinical endocrinology and metabolism 20050401
Title: Relationship between peroxisome proliferator-activated receptor-gamma expression and differentiation of human esophageal squamous cell carcinoma.
Journal: Oncology reports 20050401
Title: Drug-induced hepatotoxicity: 2005.
Journal: Journal of clinical gastroenterology 20050401
Title: Effect of troglitazone on the desaturases in a rat model of insulin-resistance induced by a sucrose-rich diet.
Journal: Prostaglandins, leukotrienes, and essential fatty acids 20050401
Title: Importance of chroman ring and tyrosine phosphorylation in the subtype-specific translocation and activation of diacylglycerol kinase alpha by D-alpha-tocopherol.
Journal: Genes to cells : devoted to molecular & cellular mechanisms 20050401
Title: UDP-glucuronosyltransferases and clinical drug-drug interactions.
Journal: Pharmacology & therapeutics 20050401
Title: Prevention of type 2 diabetes with troglitazone in the Diabetes Prevention Program.
Journal: Diabetes 20050401
Title: Improvement of liver function parameters in patients with type 2 diabetes treated with thiazolidinediones.
Journal: Metabolism: clinical and experimental 20050401
Title: Negative ion tandem mass spectrometry for the detection of glutathione conjugates.
Journal: Chemical research in toxicology 20050401
Title: Polycystic ovary syndrome.
Journal: The New England journal of medicine 20050324
Title: Peroxisome proliferator-activated receptor gamma-independent activation of p38 MAPK by thiazolidinediones involves calcium/calmodulin-dependent protein kinase II and protein kinase R: correlation with endoplasmic reticulum stress.
Journal: The Journal of biological chemistry 20050318
Title: Peroxisome proliferator-activated receptor gamma inhibition prevents adhesion to the extracellular matrix and induces anoikis in hepatocellular carcinoma cells.
Journal: Cancer research 20050315
Title: Inhibition of beta-oxidative respiration is a therapeutic window associated with the cancer chemo-preventive activity of PPARgamma agonists.
Journal: FEBS letters 20050314
Title: Peroxisome proliferator-activated receptor gamma is expressed in hippocampal neurons and its activation prevents beta-amyloid neurodegeneration: role of Wnt signaling.
Journal: Experimental cell research 20050310
Title: PPAR-gamma activation fails to provide myocardial protection in ischemia and reperfusion in pigs.
Journal: American journal of physiology. Heart and circulatory physiology 20050301
Title: Expression of survivin and bax/bcl-2 in peroxisome proliferator activated receptor-gamma ligands induces apoptosis on human myeloid leukemia cells in vitro.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20050301
Title: Modelling cell signalling and differentiation in the urothelium.
Journal: Bulletin of mathematical biology 20050301
Title: Development of a complex scintillation proximity assay for high-throughput screening of PPARgamma modulators.
Journal: Acta pharmacologica Sinica 20050301
Title: Thiazolidinediones inhibit proliferation of microvascular and macrovascular cells by a PPARgamma-independent mechanism.
Journal: Diabetologia 20050301
Title: Thiazolidinediones upregulate fatty acid uptake and oxidation in adipose tissue of diabetic patients.
Journal: Diabetes 20050301
Title: Therapeutic effects of troglitazone in experimental chronic pancreatitis in mice.
Journal: The American journal of pathology 20050301
Title: Troglitazone, the peroxisome proliferator-activated receptor-gamma agonist, induces antiproliferation and redifferentiation in human thyroid cancer cell lines.
Journal: Thyroid : official journal of the American Thyroid Association 20050301
Title: PPAR-gamma activation inhibits angiogenesis by blocking ELR+CXC chemokine production in non-small cell lung cancer.
Journal: Neoplasia (New York, N.Y.) 20050301
Title: Troglitazone reduces leptinemia during experimental dexamethasone-induced stress.
Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20050301
Title: A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line.
Journal: The AAPS journal 20050301
Title: Thiazolidenediones mediate apoptosis in prostate cancer cells in part through inhibition of Bcl-xL/Bcl-2 functions independently of PPARgamma.
Journal: Cancer research 20050215
Title: Evaluation of solid state form of troglitazone by solid state NMR spectroscopy.
Journal: Journal of pharmaceutical and biomedical analysis 20050207
Title: Liposarcoma subtypes: identification with computed tomography and ultrasound-guided percutaneous needle biopsy.
Journal: European radiology 20050201
Title: Xenobiotics inhibit hepatic uptake and biliary excretion of taurocholate in rat hepatocytes.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20050201
Title: Chaperone proteins involved in troglitazone-induced toxicity in human hepatoma cell lines.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20050201
Title: Troglitazone and liver injury: in search of answers.
Journal: Hepatology (Baltimore, Md.) 20050201
Title: Insight into hepatotoxicity: The troglitazone experience.
Journal: Hepatology (Baltimore, Md.) 20050201
Title: Growth stimulation of COX-2-negative pancreatic cancer by a selective COX-2 inhibitor.
Journal: Cancer research 20050201
Title: Preventing the progression of diabetes mellitus.
Journal: American family physician 20050201
Title: [Pexoxisome proliferator-activated receptor gamma ligands suppress liver carcinogenesis induced by diethylnitrosamine in rats].
Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20050201
Title: Thiazolidinediones for treatment of polycystic ovary syndrome.
Journal: Pharmacotherapy 20050201
Title: Therapeutic potential of thiazolidinediones in activation of peroxisome proliferator-activated receptor gamma for monocyte recruitment and endothelial regeneration.
Journal: European journal of pharmacology 20050131
Title: Differential regulation of chemokine expression by peroxisome proliferator-activated receptor gamma agonists: interactions with glucocorticoids and beta2-agonists.
Journal: The Journal of biological chemistry 20050128
Title: Troglitazone induces a rapid drop of mitochondrial membrane potential in liver HepG2 cells.
Journal: Toxicology letters 20050115
Title: Pro-inflammatory properties for thiazolidinediones.
Journal: Biochemical pharmacology 20050115
Title: Effects of PPAR-gamma ligands on vascular smooth muscle marker expression in hypertensive and normal arteries.
Journal: American journal of physiology. Heart and circulatory physiology 20050101
Title: Role of PP2C in cardiac lipid accumulation in obese rodents and its prevention by troglitazone.
Journal: American journal of physiology. Endocrinology and metabolism 20050101
Title: Activation of peroxisome proliferator-activated receptor-gamma and retinoid X receptor inhibits aromatase transcription via nuclear factor-kappaB.
Journal: Endocrinology 20050101
Title: High volume bioassays to assess CYP3A4-mediated drug interactions: induction and inhibition in a single cell line.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050101
Title: Impact of regulatory labeling for troglitazone and rosiglitazone on hepatic enzyme monitoring compliance: findings from the state of Ohio medicaid program.
Journal: Pharmacoepidemiology and drug safety 20050101
Title: Pharmacologic prevention or delay of type 2 diabetes mellitus.
Journal: The Annals of pharmacotherapy 20050101
Title: Peroxisome proliferator-activated receptor-gamma ligands reduce inflammation and infarction size in transient focal ischemia.
Journal: Neuroscience 20050101
Title: Inhibition of interleukin-1beta-induced cyclooxygenase 2 expression in human synovial fibroblasts by 15-deoxy-Delta12,14-prostaglandin J2 through a histone deacetylase-independent mechanism.
Journal: Arthritis and rheumatism 20050101
Title: Influence of physiological conditions on laser damage thresholds for blood, heart, and liver cells.
Journal: Lasers in surgery and medicine 20050101
Title: Troglitazone, a PPAR-gamma activator prevents endothelial cell adhesion molecule expression and lymphocyte adhesion mediated by TNF-alpha.
Journal: BMC physiology 20050101
Title: Idiosyncratic liver injury: challenges and approaches.
Journal: Toxicologic pathology 20050101
Title: Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands.
Journal: BMC cancer 20050101
Title: Regulatory paternalism in the market for drugs: lessons from Vioxx and Celebrex.
Journal: Yale journal of health policy, law, and ethics 20050101
Title: Anti-inflammatory effects of troglitazone in nondiabetic obese subjects independent of changes in insulin sensitivity.
Journal: The Netherlands journal of medicine 20050101
Title: Rapid detection and characterization of minor reactive metabolites using stable-isotope trapping in combination with tandem mass spectrometry.
Journal: Rapid communications in mass spectrometry : RCM 20050101
Title: Peroxisome proliferator-activated receptor gamma ligand prevents the development of chronic pancreatitis through modulating NF-kappaB-dependent proinflammatory cytokine production and pancreatic stellate cell activation.
Journal: Roczniki Akademii Medycznej w Bialymstoku (1995) 20050101
Title: Unliganded RXR acts as an inhibitory factor on troglitazone-induced activation.
Journal: Life sciences 20041231
Title: Ox-LDL suppresses PMA-induced MMP-9 expression and activity through CD36-mediated activation of PPAR-g.
Journal: Experimental & molecular medicine 20041231
Title: A yeast two-hybrid technology-based system for the discovery of PPARgamma agonist and antagonist.
Journal: Analytical biochemistry 20041215
Title: Analysis of human cytochrome P450 2C8 substrate specificity using a substrate pharmacophore and site-directed mutants.
Journal: Biochemistry 20041214
Title: Peroxisome proliferator-activated receptor gamma-dependent activation of p21 in Panc-28 pancreatic cancer cells involves Sp1 and Sp4 proteins.
Journal: Endocrinology 20041201
Title: Viability assessment in sandwich-cultured rat hepatocytes after xenobiotic exposure.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20041201
Title: Peroxisome proliferator-activated receptor gamma ligands suppress liver carcinogenesis induced by diethylnitrosamine in rats.
Journal: World journal of gastroenterology 20041201
Title: Peroxisome-proliferator-activated receptor gamma induces a clearance mechanism for the amyloid-beta peptide.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20041201
Title: Troglitazone attenuates hypoxia-induced injury in cultured term human trophoblasts.
Journal: American journal of obstetrics and gynecology 20041201
Title: Troglitazone inhibits cyclin D1 expression and cell cycling independently of PPARgamma in normal mouse skin keratinocytes.
Journal: The Journal of investigative dermatology 20041201
Title: Health-related quality of life in women with polycystic ovary syndrome, a self-administered questionnaire, was validated.
Journal: Journal of clinical epidemiology 20041201
Title: Effects of troglitazone and insulin on glucose production in cultured hepatocytes isolated from rats on high fat diet.
Journal: Collegium antropologicum 20041201
Title: Fucoxanthin induces apoptosis and enhances the antiproliferative effect of the PPARgamma ligand, troglitazone, on colon cancer cells.
Journal: Biochimica et biophysica acta 20041118
Title: Ontology-based knowledge management of troglitazone-induced hepatotoxicity.
Journal: Drug discovery today 20041115
Title: Synthesis and biological evaluation of thiazolidine-2,4-dione and 2,4-thione derivatives as inhibitors of translation initiation.
Journal: Bioorganic & medicinal chemistry letters 20041101
Title: Regulating the balance between peroxisome proliferator-activated receptor gamma and beta-catenin signaling during adipogenesis. A glycogen synthase kinase 3beta phosphorylation-defective mutant of beta-catenin inhibits expression of a subset of adipogenic genes.
Journal: The Journal of biological chemistry 20041022
Title: Lack of efficacy of troglitazone at clinically achievable concentrations, with or without 9-cis retinoic acid or cytotoxic agents, for hepatocellular carcinoma cell lines.
Journal: British journal of cancer 20041018
Title: Troglitazone acts on cellular pH and DNA synthesis through a peroxisome proliferator-activated receptor gamma-independent mechanism in breast cancer-derived cell lines.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20041015
Title: The forkhead transcription factor FoxC2 inhibits white adipocyte differentiation.
Journal: The Journal of biological chemistry 20041008
Title: Peroxisome proliferator-activated receptor gamma ligands improve the antitumor efficacy of thrombospondin peptide ABT510.
Journal: Molecular cancer research : MCR 20041001
Title: Simultaneous, bidirectional inhibitory crosstalk between PPAR and STAT5b.
Journal: Toxicology and applied pharmacology 20040915
Title: Peroxisome proliferator-activated receptor gamma ligands inhibit Rho/Rho kinase pathway by inducing protein tyrosine phosphatase SHP-2.
Journal: Circulation research 20040903
Title: Modulation of carbohydrate response element-binding protein gene expression in 3T3-L1 adipocytes and rat adipose tissue.
Journal: American journal of physiology. Endocrinology and metabolism 20040901
Title: Fenofibrate, troglitazone, and 15-deoxy-Delta12,14-prostaglandin J2 close KATP channels and induce insulin secretion.
Journal: The Journal of pharmacology and experimental therapeutics 20040901
Title: Cardiovascular and sympathetic effects of reversing insulin resistance in hypertension.
Journal: Journal of hypertension 20040901
Title: PPARgamma agonists: killing two birds with one stone?
Journal: Journal of hypertension 20040901
Title: Improvement of insulin resistance by troglitazone ameliorates cardiac sympathetic nervous dysfunction in patients with essential hypertension.
Journal: Journal of hypertension 20040901
Title: Activators of PPARgamma antagonize protection of cardiac myocytes by endothelin-1.
Journal: Biochemical and biophysical research communications 20040820
Title: Uniformity and physical states of troglitazone in solid dispersions determined by electron probe microanalysis and microthermal analysis.
Journal: International journal of pharmaceutics 20040806
Title: Beneficial effects of troglitazone on neutrophil dysfunction in multiple low-dose streptozotocin-induced diabetic mice.
Journal: Clinical and experimental immunology 20040801
Title: Impact of safety warnings on drug utilization: marketplace life span of cisapride and troglitazone.
Journal: Pharmacotherapy 20040801
Title: Attenuated inhibition of L-type calcium currents by troglitazone in fructose-fed rat cardiac ventricular myocytes.
Journal: Journal of cardiovascular pharmacology 20040701
Title: Troglitazone inhibits the progression of chronic pancreatitis and the profibrogenic activity of pancreatic stellate cells via a PPARgamma-independent mechanism.
Journal: Pancreas 20040701
Title: Peroxisome proliferator activated receptors alpha and gamma require zinc for their anti-inflammatory properties in porcine vascular endothelial cells.
Journal: The Journal of nutrition 20040701
Title: PPARgamma agonists ameliorate endothelial cell activation via inhibition of diacylglycerol-protein kinase C signaling pathway: role of diacylglycerol kinase.
Journal: Circulation research 20040611
Title: Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells.
Journal: Oncogene 20040603
Title: Inverse gene expression patterns for macrophage activating hepatotoxicants and peroxisome proliferators in rat liver.
Journal: Biochemical pharmacology 20040601
Title: Differential effects of peroxisome proliferator activated receptor-gamma (PPAR gamma) ligands in proximal tubular cells: thiazolidinediones are partial PPAR gamma agonists.
Journal: Kidney international 20040601
Title: Metabolic activation of troglitazone: identification of a reactive metabolite and mechanisms involved.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20040601
Title: Changes in insulin sensitivity in response to troglitazone do not differ between subjects with and without the common, functional Pro12Ala peroxisome proliferator-activated receptor-gamma2 gene variant: results from the Troglitazone in Prevention of Diabetes (TRIPOD) study.
Journal: Diabetes care 20040601
Title: Evidence of systematic expressed sequence tag IMAGE clone cross-hybridization on cDNA microarrays.
Journal: Genomics 20040601
Title: Pharmacological treatment of insulin resistance at two different stages in the evolution of type 2 diabetes: impact on glucose tolerance and beta-cell function.
Journal: The Journal of clinical endocrinology and metabolism 20040601
Title: Novel medical approaches for the treatment of Cushing's disease.
Journal: Journal of endocrinological investigation 20040601
Title: [Depression of mPges expression by troglitazone in human renal glomerulus induced by high glucose and LPS].
Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20040601
Title: Activation of peroxisome proliferator-activated receptor gamma inhibits interleukin-1beta-induced membrane-associated prostaglandin E2 synthase-1 expression in human synovial fibroblasts by interfering with Egr-1.
Journal: The Journal of biological chemistry 20040521
Title: Small interfering RNA knockdown of calcium-independent phospholipases A2 beta or gamma inhibits the hormone-induced differentiation of 3T3-L1 preadipocytes.
Journal: The Journal of biological chemistry 20040521
Title: 15-deoxy-delta 12,14-prostaglandin J2 induces heme oxygenase-1 gene expression in a reactive oxygen species-dependent manner in human lymphocytes.
Journal: The Journal of biological chemistry 20040521
Title: Structure-activity requirements for the antiproliferative effect of troglitazone derivatives mediated by depletion of intracellular calcium.
Journal: Bioorganic & medicinal chemistry letters 20040517
Title: Transactivation of the PPAR-responsive enhancer module in chemopreventive glutathione S-transferase gene by the peroxisome proliferator-activated receptor-gamma and retinoid X receptor heterodimer.
Journal: Cancer research 20040515
Title: Thiazolidinediones reduce the LDL binding affinity of non-human primate vascular cell proteoglycans.
Journal: Diabetologia 20040501
Title: Activation of peroxisome proliferator-activated receptor-gamma reverses squamous metaplasia and induces transitional differentiation in normal human urothelial cells.
Journal: The American journal of pathology 20040501
Title: Ligands of peroxisome proliferator-activated receptor gamma inhibit lung cancer cell growth and induce apoptosis by stimulation of P21 expression.
Journal: Chest 20040501
Title: Thiazolidinediones: a new class of drugs for the therapy of ischemia-reperfusion injury.
Journal: Drugs of today (Barcelona, Spain : 1998) 20040501
Title: Peroxisome proliferator-activated receptor gamma activation modulates cyclin D1 transcription via beta-catenin-independent and cAMP-response element-binding protein-dependent pathways in mouse hepatocytes.
Journal: The Journal of biological chemistry 20040423
Title: Role of PPARgamma and EGFR signalling in the urothelial terminal differentiation programme.
Journal: Journal of cell science 20040415
Title: Annexin II is a thiazolidinedione-responsive gene involved in insulin-induced glucose transporter isoform 4 translocation in 3T3-L1 adipocytes.
Journal: Endocrinology 20040401
Title: Cytokines regulate fibroblast-like synovial cell differentiation to adipocyte-like cells.
Journal: Rheumatology (Oxford, England) 20040401
Title: Incorporation of an oxygen from water into troglitazone quinone by cytochrome P450 and myeloperoxidase.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20040401
Title: Direct attenuation of plasminogen activator inhibitor type-1 expression in human adipose tissue by thiazolidinediones.
Journal: Thrombosis and haemostasis 20040401
Title: Cinnamic acid based thiazolidinediones inhibit human P450c17 and 3beta-hydroxysteroid dehydrogenase and improve insulin sensitivity independent of PPARgamma agonist activity.
Journal: Journal of molecular endocrinology 20040401
Title: [Peroxisome proliferator-actived receptor-gamma ligand troglitazone induces apoptosis in renal cell carcinoma].
Journal: Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20040401
Title: Expression and function of PPARgamma in rat placental development.
Journal: Biochemical and biophysical research communications 20040305
Title: Involvement of organic anion transporting polypeptides in the transport of troglitazone sulfate: implications for understanding troglitazone hepatotoxicity.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20040301
Title: Drug-induced liver injury.
Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040301
Title: Expression of NAG-1, a transforming growth factor-beta superfamily member, by troglitazone requires the early growth response gene EGR-1.
Journal: The Journal of biological chemistry 20040220
Title: RWJ-241947 (MCC-555), a unique peroxisome proliferator-activated receptor-gamma ligand with antitumor activity against human prostate cancer in vitro and in beige/nude/ X-linked immunodeficient mice and enhancement of apoptosis in myeloma cells induced by arsenic trioxide.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040215
Title: Causation of type 2 diabetes -- the Gordian knot unravels.
Journal: The New England journal of medicine 20040212
Title: Induction of differentiation and peroxisome proliferator-activated receptor gamma expression in colon cancer cell lines by troglitazone.
Journal: Journal of cancer research and clinical oncology 20040201
Title: Interferon regulatory factor-1 mediates PPARgamma-induced apoptosis in vascular smooth muscle cells.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20040201
Title: Liver glucokinase can be activated by peroxisome proliferator-activated receptor-gamma.
Journal: Diabetes 20040201
Title: Attenuation by 4-aminopyridine of delayed vasorelaxation by troglitazone.
Journal: Metabolism: clinical and experimental 20040201
Title: Transcriptional inactivation of STAT3 by PPARgamma suppresses IL-6-responsive multiple myeloma cells.
Journal: Immunity 20040201
Title: Nitric oxide production and regulation of endothelial nitric-oxide synthase phosphorylation by prolonged treatment with troglitazone: evidence for involvement of peroxisome proliferator-activated receptor (PPAR) gamma-dependent and PPARgamma-independent signaling pathways.
Journal: The Journal of biological chemistry 20040123
Title: Increased expression and activity of 11beta-HSD-1 in diabetic islets and prevention with troglitazone.
Journal: Biochemical and biophysical research communications 20040116
Title: Antiinflammatory roles of peroxisome proliferator-activated receptor gamma in human alveolar macrophages.
Journal: American journal of respiratory and critical care medicine 20040115
Title: Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes.
Journal: Cell 20040109
Title: Troglitazone acts by PPARgamma and PPARgamma-independent pathways on LLC-PK1-F+ acid-base metabolism.
Journal: American journal of physiology. Renal physiology 20040101
Title: Impaired expression of NADH dehydrogenase subunit 1 and PPARgamma coactivator-1 in skeletal muscle of ZDF rats: restoration by troglitazone.
Journal: Journal of lipid research 20040101
Title: Growth arrest by troglitazone is mediated by p27Kip1 accumulation, which results from dual inhibition of proteasome activity and Skp2 expression in human hepatocellular carcinoma cells.
Journal: International journal of cancer 20040101
Title: Decrease in serum C-reactive protein levels by troglitazone is associated with pretreatment insulin resistance, but independent of its effect on glycemia, in type 2 diabetic subjects.
Journal: Diabetes research and clinical practice 20040101
Title: Effects of troglitazone in young first-degree relatives of patients with type 2 diabetes.
Journal: Diabetes care 20040101
Title: Promotion of colon tumors in C57BL/6J-APC(min)/+ mice by thiazolidinedione PPARgamma agonists and a structurally unrelated PPARgamma agonist.
Journal: Toxicologic pathology 20040101
Title: The metabolic syndrome: an emerging health epidemic in women.
Journal: Progress in cardiovascular diseases 20040101
Title: Metabolic effects of Troglitazone in patients with diet-controlled type 2 diabetes.
Journal: European journal of clinical investigation 20040101
Title: Inhibition of cell invasion and morphological change by troglitazone in human pancreatic cancer cells.
Journal: Journal of gastroenterology 20040101
Title: Substitution of pioglitazone for troglitazone in patients with type 2 diabetes.
Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20040101
Title: The ligands of peroxisome proliferator-activated receptor (PPAR) gamma inhibit growth of human esophageal carcinoma cells through induction of apoptosis and cell cycle arrest.
Journal: Anticancer research 20040101
Title: Capsaicin, a spicy component of hot pepper, induces apoptosis by activation of the peroxisome proliferator-activated receptor gamma in HT-29 human colon cancer cells.
Journal: Journal of medicinal food 20040101
Title: Effect of nuclear factor-kappa B inhibitors and peroxisome proliferator-activated receptor-gamma ligands on PTHrP release from human fetal membranes.
Journal: Placenta 20040101
Title: Effects of PPARgamma ligands and C/EBPbeta enhancer on expression of extracellular-superoxide dismutase.
Journal: Redox report : communications in free radical research 20040101
Title: [Insulin resistance in polycystic ovary syndrome].
Journal: Wiener klinische Wochenschrift 20031215
Title: Thiazolidinediones inhibit cell growth of human oral squamous cell carcinoma in vitro independent of peroxisome proliferator-activated receptor gamma.
Journal: Oral oncology 20031201
Title: Tumor necrosis factor-alpha and troglitazone regulate plasminogen activator inhibitor type 1 production through extracellular signal-regulated kinase- and nuclear factor-kappaB-dependent pathways in cultured human umbilical vein endothelial cells.
Journal: The Journal of pharmacology and experimental therapeutics 20031201
Title: The effect of peroxisome proliferator-activated receptor-gamma ligand on urological cancer cells.
Journal: International journal of molecular medicine 20031201
Title: Novel PPARgamma-dependent and independent effects for thiazolidinediones.
Journal: Current opinion in lipidology 20031201
Title: A novel peroxisome proliferator-activated receptor (PPAR)gamma agonist, NIP-222, reduces urinary albumin excretion in streptozotocin-diabetic mice independent of PPARgamma activation.
Journal: Metabolism: clinical and experimental 20031201
Title: The lipid droplet-associated protein adipophilin is expressed in human trophoblasts and is regulated by peroxisomal proliferator-activated receptor-gamma/retinoid X receptor.
Journal: The Journal of clinical endocrinology and metabolism 20031201
Title: [The effect of peroxisome proliferator-activated receptor alpha and gamma ligands on free fatty acid-induced INS-1 cell impairment].
Journal: Zhonghua nei ke za zhi 20031201
Title: Peroxisome proliferator-activated receptor agonists inhibit interleukin-1beta-mediated nitric oxide production in cultured lacrimal gland acinar cells.
Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20031201
Title: Modulation of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by chemotherapy in thyroid cancer cell lines.
Journal: Thyroid : official journal of the American Thyroid Association 20031201
Title: [Progress in the prevention of type 2 diabetes].
Journal: Wiener klinische Wochenschrift 20031128
Title: Risk of unexplained acute liver failure in diabetes mellitus.
Journal: Archives of internal medicine 20031124
Title: Minimal response of circulating lipids in women with polycystic ovary syndrome to improvement in insulin sensitivity with troglitazone.
Journal: The Journal of clinical endocrinology and metabolism 20031101
Title: Contrasting effects of nateglinide and rosiglitazone on insulin secretion and phospholipase C activation.
Journal: Metabolism: clinical and experimental 20031101
Title: [Should type 2 diabetes prevention pharmacological studies prompt us to change our prescription habits?].
Journal: Diabetes & metabolism 20031101
Title: PPARgamma inhibition of cyclooxygenase-2, PGE2 synthase, and inducible nitric oxide synthase in cardiac myocytes.
Journal: Hypertension (Dallas, Tex. : 1979) 20031001
Title: Establishment of a human preadipose cell line, HPB-AML-I: refractory to PPARgamma-mediated adipogenic stimulation.
Journal: Journal of cellular physiology 20031001
Title: Troglitazone administration limits infarct size by reduced phosphorylation of canine myocardial connexin43 proteins.
Journal: American journal of physiology. Heart and circulatory physiology 20031001
Title: Apoptosis in human oral squamous cell carcinomas is induced by 15-deoxy-delta 12,14-prostaglandin J2 but not by troglitazone.
Journal: Journal of dental research 20031001
Title: Growth inhibition through activation of peroxisome proliferator-activated receptor gamma in human oesophageal squamous cell carcinoma.
Journal: European journal of cancer (Oxford, England : 1990) 20031001
Title: Selective ovary resistance to insulin signaling in women with polycystic ovary syndrome.
Journal: Fertility and sterility 20031001
Title: Peroxisome proliferator-activated receptor gamma mediated inhibition of plasminogen activator inhibitor type 1 production and proliferation of human umbilical vein endothelial cells.
Journal: Diabetes research and clinical practice 20031001
Title: Expression of NPM-RARalpha fusion gene in hematopoietic cells confers sensitivity to troglitazone-induced apoptosis.
Journal: Oncogene 20030925
Title: Alpha-lipoic acid inhibits adipocyte differentiation by regulating pro-adipogenic transcription factors via mitogen-activated protein kinase pathways.
Journal: The Journal of biological chemistry 20030912
Title: Thiazolidinediones inhibit growth of gastrointestinal, biliary, and pancreatic adenocarcinoma cells through activation of the peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha pathway.
Journal: Experimental cell research 20030910
Title: Down-regulation of acyl-CoA oxidase gene expression in heart of troglitazone-treated mice through a mechanism involving chicken ovalbumin upstream promoter transcription factor II.
Journal: Molecular pharmacology 20030901
Title: The impact of an insulin sensitizer, troglitazone, on glucose metabolism in African Americans at risk for type 2 diabetes mellitus: a placebo-controlled, 24-month randomized study.
Journal: Metabolism: clinical and experimental 20030901
Title: Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes.
Journal: Circulation research 20030822
Title: Regulation of the growth arrest and DNA damage-inducible gene 45 (GADD45) by peroxisome proliferator-activated receptor gamma in vascular smooth muscle cells.
Journal: Circulation research 20030822
Title: Thiazolidinediones upregulate impaired fatty acid uptake in skeletal muscle of type 2 diabetic subjects.
Journal: American journal of physiology. Endocrinology and metabolism 20030801
Title: Growth inhibition of pancreatic cancer cells through activation of peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha pathway.
Journal: International journal of oncology 20030801
Title: Effect of BMI and age on adipose tissue cellularity and differentiation capacity in women.
Journal: International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 20030801
Title: Effect of troglitazone on vascular and glucose metabolic actions of insulin in high-sucrose-fed rats.
Journal: Metabolism: clinical and experimental 20030801
Title: Solid-state variation of troglitazone drug substance by using a different recrystallization method.
Journal: Drug development and industrial pharmacy 20030801
Title: HER2 regulation of peroxisome proliferator-activated receptor gamma (PPARgamma) expression and sensitivity of breast cancer cells to PPARgamma ligand therapy.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030801
Title: Insulin-sparing effects of troglitazone in rat pancreatic islets.
Journal: Journal of molecular endocrinology 20030801
Title: Regulation of MMP-1 expression in vascular endothelial cells by insulin sensitizing thiazolidinediones.
Journal: Atherosclerosis 20030801
Title: Selective activation of PPARgamma inhibits pancreatic cancer invasion and decreases expression of tissue plasminogen activator.
Journal: Surgery 20030801
Title: Adiponutrin gene expression in 3T3-L1 adipocytes is downregulated by troglitazone.
Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20030801
Title: Association of troglitazone-induced liver injury with mutation of the cytochrome P450 2C19 gene.
Journal: Hepatology research : the official journal of the Japan Society of Hepatology 20030801
Title: Drug-induced hepatotoxicity.
Journal: The New England journal of medicine 20030731
Title: Troglitazone antagonizes tumor necrosis factor-alpha-induced reprogramming of adipocyte gene expression by inhibiting the transcriptional regulatory functions of NF-kappaB.
Journal: The Journal of biological chemistry 20030725
Title: Effects of troglitazone on intracellular cholesterol distribution and cholesterol-dependent cell functions in MA-10 Leydig tumor cells.
Journal: Biochemical pharmacology 20030715
Title: Neuroprotective effects of PPARgamma agonists against oxidative insults in HT-22 cells.
Journal: European journal of pharmacology 20030704
Title: 15-deoxy-delta 12,14-prostaglandin J2 and laminar fluid shear stress stabilize c-IAP1 in vascular endothelial cells.
Journal: American journal of physiology. Heart and circulatory physiology 20030701
Title: Activation of peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of curcumin on rat hepatic stellate cell growth.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20030701
Title: Troglitazone reduces heat shock protein 70 content in primary rat hepatocytes by a ubiquitin proteasome independent mechanism.
Journal: Pharmacological research 20030701
Title: Peroxisome proliferator-activated receptor-gamma agonists modulate macrophage activation by gram-negative and gram-positive bacterial stimuli.
Journal: Shock (Augusta, Ga.) 20030701
Title: Role of PPAR-gamma ligands in neuroprotection against glutamate-induced cytotoxicity in retinal ganglion cells.
Journal: Investigative ophthalmology & visual science 20030701
Title: Troglitazone induces CYP3A4 activity leading to falsely abnormal dexamethasone suppression test.
Journal: The Journal of clinical endocrinology and metabolism 20030701
Title: Physicochemical and crystal structure analyses of the antidiabetic agent troglitazone.
Journal: Chemical & pharmaceutical bulletin 20030701
Title: Peroxisome proliferator-activated receptor-gamma upregulates caveolin-1 and caveolin-2 expression in human carcinoma cells.
Journal: Oncogene 20030619
Title: Elevated plasma levels of the atherogenic mediator soluble CD40 ligand in diabetic patients: a novel target of thiazolidinediones.
Journal: Circulation 20030603
Title: Effect of thiazolidinediones and metformin on LDL oxidation and aortic endothelium relaxation in diabetic GK rats.
Journal: American journal of physiology. Endocrinology and metabolism 20030601
Title: Peroxisome proliferator-activated receptor ligands affect growth-related gene expression in human leukemic cells.
Journal: The Journal of pharmacology and experimental therapeutics 20030601
Title: The Diabetes Prevention Program.
Journal: Current diabetes reports 20030601
Title: Mechanisms of troglitazone hepatotoxicity.
Journal: Chemical research in toxicology 20030601
Title: Insulin sensitizers for polycystic ovary syndrome.
Journal: Clinical obstetrics and gynecology 20030601
Title: Use of the peroxisome proliferator-activated receptor (PPAR) gamma ligand troglitazone as treatment for refractory breast cancer: a phase II study.
Journal: Breast cancer research and treatment 20030601
Title: In vitro inhibition of human small intestinal and liver microsomal astemizole O-demethylation: different contribution of CYP2J2 in the small intestine and liver.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20030601
Title: Inhibitory activity of clinical thiazolidinedione peroxisome proliferator activating receptor-gamma ligands toward internal mammary artery, radial artery, and saphenous vein smooth muscle cell proliferation.
Journal: Circulation 20030527
Title: c-Fos-driven transcriptional activation of transforming growth factor beta-1: inhibition of high glucose-induced promoter activity by thiazolidinediones.
Journal: Biochemical and biophysical research communications 20030502
Title: Prevention of autoimmune diabetes in NOD mice by troglitazone is associated with modulation of ICAM-1 expression on pancreatic islet cells and IFN-gamma expression in splenic T cells.
Journal: Biochemical and biophysical research communications 20030502
Title: Expression of peroxisome proliferator-activated receptors (PPARs) in human urinary bladder carcinoma and growth inhibition by its agonists.
Journal: International journal of cancer 20030501
Title: Troglitazone stimulates repair of the endothelium and inhibits neointimal formation in denuded rat aorta.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20030501
Title: Usefulness of troglitazone administration to obese hyperglycaemic patients with near-normoglycaemia.
Journal: Diabetes, obesity & metabolism 20030501
Title: Utility of hepatocytes in predicting drug metabolism: comparison of hepatic intrinsic clearance in rats and humans in vivo and in vitro.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20030501
Title: Deleterious effects of acute treatment with a peroxisome proliferator-activated receptor-gamma activator in myocardial ischemia and reperfusion in pigs.
Journal: Diabetes 20030501
Title: Troglitazone induces p27Kip1-associated cell-cycle arrest through down-regulating Skp2 in human hepatoma cells.
Journal: Hepatology (Baltimore, Md.) 20030501
Title: A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus.
Journal: Clinical pharmacology and therapeutics 20030501
Title: Current best treatment for non-alcoholic fatty liver disease.
Journal: Expert opinion on pharmacotherapy 20030501
Title: Regulation of skeletal muscle morphology in type 2 diabetic subjects by troglitazone and metformin: relationship to glucose disposal.
Journal: Metabolism: clinical and experimental 20030501
Title: Differential effects of peroxisome proliferator-activated receptor activators on the mRNA levels of genes involved in lipid metabolism in primary human monocyte-derived macrophages.
Journal: Metabolism: clinical and experimental 20030501
Title: Hepatotoxicity of the thiazolidinediones.
Journal: Clinics in liver disease 20030501
Title: The UDP-glucuronosyltransferase 1A9 enzyme is a peroxisome proliferator-activated receptor alpha and gamma target gene.
Journal: The Journal of biological chemistry 20030418
Title: Acute effects of troglitazone and nitric oxide on glucose uptake in L929 fibroblast cells.
Journal: Life sciences 20030411
Title: Troglitazone stimulates IGF-binding protein-1 by a PPAR gamma-independent mechanism.
Journal: Biochemical and biophysical research communications 20030404
Title: Expression of PPARgamma in eosinophils and its functional role in survival and chemotaxis.
Journal: Immunology letters 20030403
Title: Adipose tissue sensitization to insulin induced by troglitazone and MEDICA 16 in obese Zucker rats in vivo.
Journal: American journal of physiology. Endocrinology and metabolism 20030401
Title: Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20030401
Title: Protein expression changes in the Sprague Dawley rat liver proteome following administration of peroxisome proliferator activated receptor alpha and gamma ligands.
Journal: Proteomics 20030401
Title: DR1-like element in human topoisomerase IIalpha gene involved in enhancement of etoposide-induced apoptosis by PPARgamma ligand.
Journal: Experimental hematology 20030401
Title: Long-term cardiovascular effects of insulin sensitizer troglitazone on non-diabetic individuals with insulin resistance: double blind, prospective randomized study.
Journal: Journal of cardiology 20030401
Title: Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites.
Journal: Pharmaceutical research 20030401
Title: Troglitazone decreases adrenal androgen levels in women with polycystic ovary syndrome.
Journal: Fertility and sterility 20030401
Title: PPAR gamma ligand-induced apoptosis through a p53-dependent mechanism in human gastric cancer cells.
Journal: Cancer science 20030401
Title: Inhibitory effects of troglitazone, a peroxisome proliferator-activated receptor gamma ligand, in rat tongue carcinogenesis initiated with 4-nitroquinoline 1-oxide.
Journal: Cancer science 20030401
Title: Dual activation of PPARalpha and PPARgamma by mono-(2-ethylhexyl) phthalate in rat ovarian granulosa cells.
Journal: Molecular and cellular endocrinology 20030328
Title: A cohort study of the incidence of serious acute liver injury in diabetic patients treated with hypoglycemic agents.
Journal: Archives of internal medicine 20030324
Title: Troglitazone but not rosiglitazone induces G1 cell cycle arrest and apoptosis in human and rat hepatoma cell lines.
Journal: Toxicology letters 20030320
Title: Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferator-activated receptor gamma ligands in uterine leiomyoma.
Journal: Cancer research 20030315
Title: Effect of heterozygous PPARgamma deficiency and TZD treatment on insulin resistance associated with age and high-fat feeding.
Journal: American journal of physiology. Endocrinology and metabolism 20030301
Title: Troglitazone-induced intracellular oxidative stress in rat hepatoma cells: a flow cytometric assessment.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20030301
Title: Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade.
Journal: Nature cell biology 20030301
Title: Distinct effects of ketone bodies on down-regulation of cell surface insulin receptor and insulin receptor substrate-1 phosphorylation in adrenal chromaffin cells.
Journal: The Journal of pharmacology and experimental therapeutics 20030301
Title: Modulation of circulating and adipose tissue adiponectin levels by antidiabetic therapy.
Journal: Diabetes 20030301
Title: Nocturnal and postprandial free fatty acid kinetics in normal and type 2 diabetic subjects: effects of insulin sensitization therapy.
Journal: Diabetes 20030301
Title: GATA-6 is involved in PPARgamma-mediated activation of differentiated phenotype in human vascular smooth muscle cells.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20030301
Title: Troglitazone-induced liver failure: a case study.
Journal: The American journal of medicine 20030301
Title: Differences in troglitazone action on glucose metabolism in freshly isolated vs long-term incubated rat skeletal muscle.
Journal: British journal of pharmacology 20030301
Title: Suppression of experimental crescentic glomerulonephritis by peroxisome proliferator-activated receptor (PPAR)gamma activators.
Journal: Clinical and experimental nephrology 20030301
Title: Structural studies on the impurities of troglitazone.
Journal: Journal of pharmaceutical and biomedical analysis 20030226
Title: Troglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma ) ligand, selectively induces the early growth response-1 gene independently of PPAR gamma. A novel mechanism for its anti-tumorigenic activity.
Journal: The Journal of biological chemistry 20030221
Title: Medical monitoring for pharmaceutical injuries: tort law for the public's health?
Journal: JAMA 20030219
Title: Critical role of c-Jun N-terminal protein kinase activation in troglitazone-induced apoptosis of human HepG2 hepatoma cells.
Journal: Molecular pharmacology 20030201
Title: Peroxisome proliferator-activated receptor gamma ligands suppress colon carcinogenesis induced by azoxymethane in mice.
Journal: Gastroenterology 20030201
Title: Agree that idiosyncratic hepatotoxicity in TRO-treated patients is uncertain, but concerned about the data.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20030201
Title: Troglitazone therapy improves endothelial function to near normal levels in women with polycystic ovary syndrome.
Journal: The Journal of clinical endocrinology and metabolism 20030201
Title: The effects of troglitazone, an insulin-sensitizing agent, on the endothelial function in early and late type 2 diabetes: a placebo-controlled randomized clinical trial.
Journal: Metabolism: clinical and experimental 20030201
Title: Prevention of type 2 diabetes: are we ready?
Journal: Minerva medica 20030201
Title: Did this drug cause my patient's hepatitis?
Journal: Annals of internal medicine 20030121
Title: Hydrogen peroxide overproduction in megamitochondria of troglitazone-treated human hepatocytes.
Journal: Hepatology (Baltimore, Md.) 20030101
Title: Incidence of idiopathic acute liver failure and hospitalized liver injury in patients treated with troglitazone.
Journal: The American journal of gastroenterology 20030101
Title: Thiazolidinediones, a class of anti-diabetic drugs, inhibit Id2 expression through a PPARgamma-independent pathway in human aortic smooth muscle cells.
Journal: Cellular and molecular life sciences : CMLS 20030101
Title: Diabetes medicine update. Old dogs, new tricks.
Journal: Diabetes self-management 20030101
Title: Troglitazone reduces activity of the Na+/H+ exchanger in fructose-fed borderline hypertensive rats.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20030101
Title: Metformin, but not thiazolidinediones, inhibits plasminogen activator inhibitor-1 production in human adipose tissue in vitro.
Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20030101
Title: Induction mechanism of apoptosis by troglitazone through peroxisome proliferator-activated receptor-gamma in gastric carcinoma cells.
Journal: Anticancer research 20030101
Title: Decrease in serum leptin by troglitazone is associated with preventing bone loss in type 2 diabetic patients.
Journal: Journal of bone and mineral metabolism 20030101
Title: [Treatment of PCOS without IVF: weight loss, insulin-sensitizing agents].
Journal: Journal de gynecologie, obstetrique et biologie de la reproduction 20030101
Title: Troglitazone inhibits isolated cell proliferation, and induces apoptosis in isolated rat mesangial cells.
Journal: American journal of nephrology 20030101
Title: A retrospective review of thiazolidinediones with development of a troglitazone conversion protocol.
Journal: TheScientificWorldJournal 20030101
Title: Insulin-sensitising drugs (metformin, troglitazone, rosiglitazone, pioglitazone, D-chiro-inositol) for polycystic ovary syndrome.
Journal: The Cochrane database of systematic reviews 20030101
Title: Minireview: Up-date management of non responder to clomiphene citrate in polycystic ovary syndrome.
Journal: The Kobe journal of medical sciences 20030101
Title: Peroxisome proliferator-activated receptor-gamma agonist increases both low-density lipoprotein cholesterol particle size and small high-density lipoprotein cholesterol in patients with type 2 diabetes independent of diabetic control.
Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20030101
Title: Cholestasis: human disease and experimental animal models.
Journal: Annals of hepatology 20030101
Title: Receptor-dependent regulation of the CYP3A4 gene.
Journal: Toxicology 20021227
Title: Interleukin-11 as a stimulatory factor for bone formation prevents bone loss with advancing age in mice.
Journal: The Journal of biological chemistry 20021213
Title: Synergistic effects of troglitazone and oleate on the translatability of preproinsulin mRNA from INS-1 cells.
Journal: Biochemical pharmacology 20021201
Title: Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20021201
Title: Lipolysis in the absence of hormone-sensitive lipase: evidence for a common mechanism regulating distinct lipases.
Journal: Diabetes 20021201
Title: Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) activation suppresses ischemic induction of Egr-1 and its inflammatory gene targets.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20021201
Title: Apolipoprotein A-I expression in rats is not altered by troglitazone.
Journal: Experimental biology and medicine (Maywood, N.J.) 20021201
Title: Altered renal microvascular response in Zucker obese rats.
Journal: Metabolism: clinical and experimental 20021201
Title: Repaglinide in combination therapy.
Journal: Diabetes, nutrition & metabolism 20021201
Title: Prevention of type 2 diabetes.
Journal: The Malaysian journal of pathology 20021201
Title: Activation of MEK/ERK signaling promotes adipogenesis by enhancing peroxisome proliferator-activated receptor gamma (PPARgamma ) and C/EBPalpha gene expression during the differentiation of 3T3-L1 preadipocytes.
Journal: The Journal of biological chemistry 20021129
Title: [News on diabetes and public health perspectives].
Journal: Presse medicale (Paris, France : 1983) 20021123
Title: Peroxisome proliferator-activated receptor gamma ligand troglitazone induces cell cycle arrest and apoptosis of hepatocellular carcinoma cell lines.
Journal: Cancer 20021115
Title: Differential in vitro hepatotoxicity of troglitazone and rosiglitazone among cryopreserved human hepatocytes from 37 donors.
Journal: Chemico-biological interactions 20021110
Title: Correlation between troglitazone cytotoxicity and drug metabolic enzyme activities in cryopreserved human hepatocytes.
Journal: Chemico-biological interactions 20021110
Title: Identification of glutathione conjugates of troglitazone in human hepatocytes.
Journal: Chemico-biological interactions 20021110
Title: Physical property of troglitazone, an equal mixture of four stereoisomers.
Journal: International journal of pharmaceutics 20021106
Title: Troglitazone: the discovery and development of a novel therapy for the treatment of Type 2 diabetes mellitus.
Journal: Advanced drug delivery reviews 20021105
Title: Effective use of thiazolidinediones for the treatment of glucocorticoid-induced diabetes.
Journal: Diabetes research and clinical practice 20021101
Title: Insulin resistance, diabetes, and atherosclerosis: thiazolidinediones as therapeutic interventions.
Journal: Current cardiology reports 20021101
Title: Effects of berberine on glucose metabolism in vitro.
Journal: Metabolism: clinical and experimental 20021101
Title: Leptin induces endothelial cell migration through Akt, which is inhibited by PPARgamma-ligands.
Journal: Hypertension (Dallas, Tex. : 1979) 20021101
Title: Regulation of uncoupling protein-2 mRNA in L6 myotubules: I: Thiazolidinediones stimulate uncoupling protein-2 gene expression by a mechanism requiring ongoing protein synthesis and an active mitogen-activated protein kinase.
Journal: Endocrine 20021101
Title: Direct chiral separation of troglitazone stereoisomers using reversed-phase high-performance liquid chromatography.
Journal: Journal of pharmaceutical and biomedical analysis 20021015
Title: Effects of leptin, troglitazone, and dietary fat on stearoyl CoA desaturase.
Journal: Biochemical and biophysical research communications 20021011
Title: [Anti-inflammatory effect of peroxisome proliferator-activated receptor-gamma incultured human mesangial cells].
Journal: Zhonghua yi xue za zhi 20021010
Title: [Meta-analysis shows: insulin sensitizer is safe for the liver].
Journal: MMW Fortschritte der Medizin 20021003
Title: Glitazones regulate glutamine metabolism by inducing a cellular acidosis in MDCK cells.
Journal: American journal of physiology. Endocrinology and metabolism 20021001
Title: Troglitazone antagonizes metabolic effects of glucocorticoids in humans: effects on glucose tolerance, insulin sensitivity, suppression of free fatty acids, and leptin.
Journal: Diabetes 20021001
Title: Comparison of insulin monotherapy and combination therapy with insulin and metformin or insulin and troglitazone in type 2 diabetes.
Journal: Diabetes care 20021001
Title: Biochemical correlates of thiazolidinedione-induced adipocyte differentiation by high-resolution magic angle spinning NMR spectroscopy.
Journal: Magnetic resonance in medicine 20021001
Title: Regulation of proinflammatory cytokines in human gestational tissues by peroxisome proliferator-activated receptor-gamma: effect of 15-deoxy-Delta(12,14)-PGJ(2) and troglitazone.
Journal: The Journal of clinical endocrinology and metabolism 20021001
Title: Effect of peroxisome proliferator-activated receptor gamma on thromboxane A(2) and prostaglandin E(2) production in macrophage cell lines.
Journal: Prostaglandins, leukotrienes, and essential fatty acids 20021001
Title: [Combination therapy with biguanides].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20021001
Title: PPAR alpha stimulates the rat gastrin-producing cell.
Journal: Molecular and cellular endocrinology 20020930
Title: PPARgamma and vascular inflammation: adding another piece to the puzzle.
Journal: Circulation research 20020906
Title: Vascular inflammation is negatively autoregulated by interaction between CCAAT/enhancer-binding protein-delta and peroxisome proliferator-activated receptor-gamma.
Journal: Circulation research 20020906
Title: Troglitazone treatment increases protein kinase B phosphorylation in skeletal muscle of normoglycemic subjects at risk for the development of type 2 diabetes.
Journal: Diabetes 20020901
Title: Preservation of pancreatic beta-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk hispanic women.
Journal: Diabetes 20020901
Title: Effects of troglitazone on HepG2 viability and mitochondrial function.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20020901
Title: Agonists of peroxisome proliferator-activated receptor gamma inhibit cell growth in malignant melanoma.
Journal: The Journal of investigative dermatology 20020901
Title: Expression of peroxisome proliferator-activated receptors in human testicular cancer and growth inhibition by its agonists.
Journal: Urology 20020901
Title: Stimulation of peroxisome proliferator-activated receptors alpha and gamma blocks HIV-1 replication and TNFalpha production in acutely infected primary blood cells, chronically infected U1 cells, and alveolar macrophages from HIV-infected subjects.
Journal: Journal of acquired immune deficiency syndromes (1999) 20020901
Title: [Primary prevention of diabetes mellitus by pharmacological intervention].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20020901
Title: [Insulin sensitizer drugs--review].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20020901
Title: [Efficacy of combination therapy of alpha-glucosidase inhibitor and insulin sensitizer in patients with type 2 diabetes].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20020901
Title: [Combination therapy of insulin sensitizer, thiazolidinedione drugs, and sulfonylurea].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20020901
Title: Peroxisome proliferator-activated receptor gamma agonist ligands stimulate a Th2 cytokine response and prevent acute colitis.
Journal: Inflammatory bowel diseases 20020901
Title: Rat liver acyl-CoA synthetase 4 is a peripheral-membrane protein located in two distinct subcellular organelles, peroxisomes, and mitochondrial-associated membrane.
Journal: Archives of biochemistry and biophysics 20020815
Title: Troglitazone inhibits growth and improves insulin signaling by suppression of angiotensin II action in vascular smooth muscle cells from spontaneously hypertensive rats.
Journal: Atherosclerosis 20020801
Title: Effects of different PPARgamma-agonists on MCP-1 expression and monocyte recruitment in experimental glomerulonephritis.
Journal: Kidney international 20020801
Title: Phenol sulfotransferase, ST1A3, as the main enzyme catalyzing sulfation of troglitazone in human liver.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20020801
Title: Ligands for the peroxisomal proliferator-activated receptor gamma and the retinoid X receptor inhibit aromatase cytochrome P450 (CYP19) expression mediated by promoter II in human breast adipose.
Journal: Endocrinology 20020801
Title: Troglitazone improves blood flow by inhibiting neointimal formation after balloon injury in Otsuka Long-Evans Tokushima fatty rats.
Journal: Metabolism: clinical and experimental 20020801
Title: Decreases in serum uric acid by amelioration of insulin resistance in overweight hypertensive patients: effect of a low-energy diet and an insulin-sensitizing agent.
Journal: American journal of hypertension 20020801
Title: Functional changes in rheumatoid fibroblast-like synovial cells through activation of peroxisome proliferator-activated receptor gamma-mediated signalling pathway.
Journal: Clinical and experimental immunology 20020801
Title: Peroxisome proliferator-activated receptor-gamma activators inhibit endothelin-1-related cardiac hypertrophy in rats.
Journal: Clinical science (London, England : 1979) 20020801
Title: [Uric acid metabolism and insulin resistance in type 2 diabetes].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20020801
Title: Troglitazone enhances the hepatotoxicity of acetaminophen by inducing CYP3A in rats.
Journal: Toxicology 20020701
Title: Nonsteroidal anti-inflammatory drugs induce apoptosis in association with activation of peroxisome proliferator-activated receptor gamma in rheumatoid synovial cells.
Journal: The Journal of pharmacology and experimental therapeutics 20020701
Title: Rodent carcinogenicity with the thiazolidinedione antidiabetic agent troglitazone.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20020701
Title: Growth inhibition of esophageal squamous carcinoma cells by peroxisome proliferator-activated receptor-gamma ligands.
Journal: The Journal of laboratory and clinical medicine 20020701
Title: Enhanced inhibition of L-type calcium currents by troglitazone in streptozotocin-induced diabetic rat cardiac ventricular myocytes.
Journal: British journal of pharmacology 20020701
Title: Severe cholestatic hepatitis caused by thiazolidinediones: risks associated with substituting rosiglitazone for troglitazone.
Journal: Digestive diseases and sciences 20020701
Title: Troglitazone induces G1 arrest by p27(Kip1) induction that is mediated by inhibition of proteasome in human gastric cancer cells.
Journal: Japanese journal of cancer research : Gann 20020701
Title: [Insulin resistance in myotonic dystrophy].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20020701
Title: Troglitazone ameliorates abnormal activity of protein tyrosine phosphatase in adipose tissues of Otsuka Long-Evans Tokushima Fatty rats.
Journal: The Tohoku journal of experimental medicine 20020701
Title: Effects of peroxisome proliferator-activated receptor agonists on LPS-induced neuronal death in mixed cortical neurons: associated with iNOS and COX-2.
Journal: Brain research 20020621
Title: PPAR gamma ligands, troglitazone and pioglitazone, up-regulate expression of HMG-CoA synthase and HMG-CoA reductase gene in THP-1 macrophages.
Journal: FEBS letters 20020605
Title: Troglitazone improves GLUT4 expression in adipose tissue in an animal model of obese type 2 diabetes mellitus.
Journal: Diabetes research and clinical practice 20020601
Title: Troglitazone induces a cellular acidosis by inhibiting acid extrusion in cultured rat mesangial cells.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20020601
Title: Risk of adverse events with concomitant use of atorvastatin or simvastatin and glucose-lowering drugs (thiazolidinediones, metformin, sulfonylurea, insulin, and acarbose).
Journal: The American journal of cardiology 20020601
Title: Humoral regulation of resistin expression in 3T3-L1 and mouse adipose cells.
Journal: Diabetes 20020601
Title: The effect of troglitazone on plasma homocysteine, hepatic and red blood cell S-adenosyl methionine, and S-adenosyl homocysteine and enzymes in homocysteine metabolism in Zucker rats.
Journal: Metabolism: clinical and experimental 20020601
Title: Expression of PPARgamma and its ligand-dependent growth inhibition in human brain tumor cell lines.
Journal: Japanese journal of cancer research : Gann 20020601
Title: Troglitazone activates p21Cip/WAF1 through the ERK pathway in HCT15 human colorectal cancer cells.
Journal: Cancer letters 20020528
Title: PPAR activators inhibit endothelial cell migration by targeting Akt.
Journal: Biochemical and biophysical research communications 20020524
Title: Troglitazone ameliorates lipotoxicity in the beta cell line INS-1 expressing PPAR gamma.
Journal: Diabetes research and clinical practice 20020501
Title: Troglitazone treatment of aging Brown Norway rats improves food intake and weight gain after fasting without increasing hypothalamic NPY gene expression.
Journal: Experimental gerontology 20020501
Title: Characteristics of the peroxisome proliferator activated receptor gamma (PPARgamma) ligand induced apoptosis in colon cancer cells.
Journal: Gut 20020501
Title: Ligand activation of peroxisome proliferator-activated receptor gamma induces apoptosis of leukemia cells by down-regulating the c-myc gene expression via blockade of the Tcf-4 activity.
Journal: Cell death and differentiation 20020501
Title: Nuclear receptor agonists as potential differentiation therapy agents for human osteosarcoma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20020501
Title: Troglitazone improves cardiac function in patients with congestive heart failure.
Journal: Cardiovascular drugs and therapy 20020501
Title: High glucose concentrations abolish the superoxide dismutase response of leukocytes to ascorbic acid or troglitazone in type 2 diabetes mellitus.
Journal: Life sciences 20020405
Title: A ligand for peroxisome proliferator activated receptor gamma inhibits cell growth and induces apoptosis in human liver cancer cells.
Journal: Gut 20020401
Title: Troglitazone stimulates pancreatic growth in normal rats.
Journal: Pancreas 20020401
Title: Thiazolidinedione derivatives ameliorate albuminuria in streptozotocin-induced diabetic spontaneous hypertensive rat.
Journal: Metabolism: clinical and experimental 20020401
Title: Troglitazone downregulates delta-6 desaturase gene expression in human skeletal muscle cell cultures.
Journal: Diabetes 20020401
Title: 15-Deoxy-Delta12,14-prostaglandin J2 regulates mesangial cell proliferation and death.
Journal: Kidney international 20020401
Title: Troglitazone suppresses the secretion of type I collagen by mesangial cells in vitro.
Journal: Kidney international 20020401
Title: A prospective, randomized comparison of the metabolic effects of pioglitazone or rosiglitazone in patients with type 2 diabetes who were previously treated with troglitazone.
Journal: Diabetes care 20020401
Title: Concentration-dependent stimulatory and inhibitory effect of troglitazone on insulin-induced fatty acid synthase expression and protein kinase B activity in 3T3-L1 adipocytes.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20020401
Title: Pioglitazone-induced hepatic injury in a patient previously receiving troglitazone with success.
Journal: Diabetic medicine : a journal of the British Diabetic Association 20020401
Title: Troglitazone does not protect rat pancreatic beta cells against free fatty acid-induced cytotoxicity.
Journal: Biochemical pharmacology 20020401
Title: Effect of PPARgamma ligands on the viability of gastric epithelial cells.
Journal: Alimentary pharmacology & therapeutics 20020401
Title: Troglitazione affects survival of human osteosarcoma cells.
Journal: International journal of cancer 20020320
Title: Peroxisome proliferator-activated receptor gamma plays a critical role in inhibition of cardiac hypertrophy in vitro and in vivo.
Journal: Circulation 20020312
Title: Ligands of peroxisome proliferator-activated receptor-gamma induce apoptosis in AR42J cells.
Journal: Pancreas 20020301
Title: Thiazolidinedione derivatives as novel therapeutic agents to prevent the development of chronic pancreatitis.
Journal: Pancreas 20020301
Title: C(2)-ceramide influences the expression and insulin-mediated regulation of cyclic nucleotide phosphodiesterase 3B and lipolysis in 3T3-L1 adipocytes.
Journal: Diabetes 20020301
Title: Peroxisomal proliferator-activated receptor-gamma upregulates glucokinase gene expression in beta-cells.
Journal: Diabetes 20020301
Title: Differential effects of metformin and troglitazone on cardiovascular risk factors in patients with type 2 diabetes.
Journal: Diabetes care 20020301
Title: Troglitazone, an insulin-sensitizing thiazolidinedione, represses combined stimulation by LH and insulin of de novo androgen biosynthesis by thecal cells in vitro.
Journal: The Journal of clinical endocrinology and metabolism 20020301
Title: Effects of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)-ethane (p,p'-DDT) on 3T3-L1 and 3T3-F442A adipocyte differentiation.
Journal: Biochemical pharmacology 20020301
Title: PPARgamma ligand inhibits osteopontin gene expression through interference with binding of nuclear factors to A/T-rich sequence in THP-1 cells.
Journal: Circulation research 20020222
Title: Peroxisome proliferator-activated receptor gamma reduces the growth rate of pancreatic cancer cells through the reduction of cyclin D1.
Journal: Life sciences 20020215
Title: Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity.
Journal: Journal of medicinal chemistry 20020214
Title: Formation of a novel quinone epoxide metabolite of troglitazone with cytotoxicity to HepG2 cells.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20020201
Title: Biphasic vasodilator action of troglitazone on the renal microcirculation.
Journal: Journal of the American Society of Nephrology : JASN 20020201
Title: Impact of troglitazone on coronary stent implantation using small stents in patients with type 2 diabetes mellitus.
Journal: The American journal of cardiology 20020201
Title: Troglitazone but not metformin restores insulin-stimulated phosphoinositide 3-kinase activity and increases p110beta protein levels in skeletal muscle of type 2 diabetic subjects.
Journal: Diabetes 20020201
Title: Synergistic effect of 4-hydroxynonenal and PPAR ligands in controlling human leukemic cell growth and differentiation.
Journal: Free radical biology & medicine 20020201
Title: Thiazolidinediones enhance insulin-mediated suppression of fatty acid flux in type 2 diabetes mellitus.
Journal: Metabolism: clinical and experimental 20020201
Title: Troglitazone suppresses cell growth of KU812 cells independently of PPARgamma.
Journal: European journal of pharmacology 20020201
Title: Chronic toxicity in monkeys with the thiazolidinedione antidiabetic agent troglitazone.
Journal: The Journal of toxicological sciences 20020201
Title: [Polycystic ovary syndrome: treatment with insulin-sensitizing agents].
Journal: Annales d'endocrinologie 20020201
Title: Oral antihyperglycemic therapy for type 2 diabetes: scientific review.
Journal: JAMA 20020116
Title: Troglitazone inhibits both post-glutamate neurotoxicity and low-potassium-induced apoptosis in cerebellar granule neurons.
Journal: Brain research 20020111
Title: Fibrate and statin synergistically increase the transcriptional activities of PPARalpha/RXRalpha and decrease the transactivation of NFkappaB.
Journal: Biochemical and biophysical research communications 20020111
Title: Ligands of peroxisome proliferator-activated receptor-gamma block activation of pancreatic stellate cells.
Journal: The Journal of biological chemistry 20020104
Title: Troglitazone inhibits glutamine metabolism in rat mesangial cells.
Journal: American journal of physiology. Endocrinology and metabolism 20020101
Title: Growth inhibition and differentiation of pancreatic cancer cell lines by PPAR gamma ligand troglitazone.
Journal: Pancreas 20020101
Title: PPAR-gamma ligands modulate effects of LPS in stimulated rat synovial fibroblasts.
Journal: American journal of physiology. Cell physiology 20020101
Title: Increased lymphatic lipid transport in genetically diabetic obese rats.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20020101
Title: Putative activation of the peroxisome proliferator-activated receptor gamma impairs androgen and enhances progesterone biosynthesis in primary cultures of porcine theca cells.
Journal: Biology of reproduction 20020101
Title: Thiazolidinediones influence plasma steroids of male obese Zucker rats.
Journal: Endocrinology 20020101
Title: Unique ability of troglitazone to up-regulate peroxisome proliferator-activated receptor-gamma expression in hepatocytes.
Journal: The Journal of pharmacology and experimental therapeutics 20020101
Title: Regulation of glucose transport and insulin signaling by troglitazone or metformin in adipose tissue of type 2 diabetic subjects.
Journal: Diabetes 20020101
Title: Further insight on the hypoglycemic and nonhypoglycemic effects of troglitazone 400 or 600 mg/d: effects on the very-low-density and high-density lipoprotein particle distribution.
Journal: Metabolism: clinical and experimental 20020101
Title: Beneficial hepatic effect of troglitazone in a patient with antimitochondrial antibody-negative primary biliary cirrhosis.
Journal: The American journal of gastroenterology 20020101
Title: Effect of troglitazone on endothelial function in type 2 diabetic patients.
Journal: Arzneimittel-Forschung 20020101
Title: Prostaglandin D(2), its metabolite 15-d-PGJ(2), and peroxisome proliferator activated receptor-gamma agonists induce apoptosis in transformed, but not normal, human T lineage cells.
Journal: Immunology 20020101
Title: [Thiazolidinediones and PPARgamma system in repair of liver damage].
Journal: Recenti progressi in medicina 20020101
Title: A treatment for Mr WP: thiazolidinediones after troglitazone.
Journal: Diabetic medicine : a journal of the British Diabetic Association 20020101
Title: Are all glitazones the same?
Journal: Diabetes/metabolism research and reviews 20020101
Title: Differentiating members of the thiazolidinedione class: a focus on efficacy.
Journal: Diabetes/metabolism research and reviews 20020101
Title: Differentiating members of the thiazolidinedione class: a focus on safety.
Journal: Diabetes/metabolism research and reviews 20020101
Title: Where thiazolidinediones will fit.
Journal: Diabetes/metabolism research and reviews 20020101
Title: Effect of thiazolidinediones on high-density lipoprotein subfractions.
Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20020101
Title: Pharmacokinetics, tolerability, and fructosamine-lowering effect of a novel, controlled-release formulation of alpha-lipoic acid.
Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20020101
Title: Thiazolidinediones for the prevention of diabetes in the non-obese diabetic (NOD) mouse: implications for human type 1 diabetes.
Journal: Diabetes/metabolism research and reviews 20020101
Title: Troglitazone: a possible modulator of ovarian steroidogenesis.
Journal: Journal of the Society for Gynecologic Investigation 20020101
Title: Decreased synthesis of matrix metalloproteinase-7 and adhesion to the extracellular matrix proteins of human colon cancer cells treated with troglitazone.
Journal: Surgery today 20020101
Title: Results of use of metformin and replacement of starch with saturated fat in diets of patients with type 2 diabetes.
Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20020101
Title: Pretreatment with troglitazone decreases lethality during endotoxemia in mice.
Journal: Journal of endotoxin research 20020101
Title: Activation of peroxisome proliferator-activated receptor-gamma inhibits apoptosis induced by serum deprivation in LLC-PK1 cells.
Journal: Experimental nephrology 20020101
Title: A phase II study of troglitazone, an activator of the PPARgamma receptor, in patients with chemotherapy-resistant metastatic colorectal cancer.
Journal: Cancer journal (Sudbury, Mass.) 20020101
Title: Insulin and oral antidiabetic agents for treatment of polycystic ovary syndrome.
Journal: Medscape women's health 20020101
Title: Regulation of the glyoxalase pathway in human brain microvascular endothelium: effects of troglitazone and tertiary butylhydroperoxide.
Journal: Endothelium : journal of endothelial cell research 20020101
Title: Effects of the thiazolidinediones on cardiovascular risk factors.
Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20020101
Title: Lipoprotein effects of different thiazolidinediones in clinical practice.
Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20020101
Title: Selective suppressions of human CYP3A forms, CYP3A5 and CYP3A7, by troglitazone in HepG2 cells.
Journal: Drug metabolism and pharmacokinetics 20020101
Title: 15-Deoxy-delta 12,14-prostaglandin J2 and thiazolidinediones activate the MEK/ERK pathway through phosphatidylinositol 3-kinase in vascular smooth muscle cells.
Journal: The Journal of biological chemistry 20011228
Title: Peroxisome proliferator-activated receptor gamma ligands inhibit mitogenic induction of p21(Cip1) by modulating the protein kinase Cdelta pathway in vascular smooth muscle cells.
Journal: The Journal of biological chemistry 20011214
Title: Cytotoxicity and apoptosis produced by troglitazone in human hepatoma cells.
Journal: Life sciences 20011214
Title: Phosphodiesterase 3B gene expression is enhanced in the liver but reduced in the adipose tissue of obese insulin resistant db/db mouse.
Journal: Diabetes research and clinical practice 20011201
Title: Thiazolidinedione derivative improves fat distribution and multiple risk factors in subjects with visceral fat accumulation--double-blind placebo-controlled trial.
Journal: Diabetes research and clinical practice 20011201
Title: Peroxisome proliferator-activated receptor-gamma activity is associated with renal microvasculature.
Journal: American journal of physiology. Renal physiology 20011201
Title: Peroxisome proliferator-activated receptor-gamma ligands inhibit nuclear but not cytosolic extracellular signal-regulated kinase/mitogen-activated protein kinase-regulated steps in vascular smooth muscle cell migration.
Journal: Journal of cardiovascular pharmacology 20011201
Title: The effect of troglitazone biliary excretion on metabolite distribution and cholestasis in transporter-deficient rats.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20011201
Title: Regulation of aromatase by nuclear receptors.
Journal: The Journal of steroid biochemistry and molecular biology 20011201
Title: Blood thrombogenicity in type 2 diabetes mellitus patients is associated with glycemic control.
Journal: Journal of the American College of Cardiology 20011101
Title: Limited cooperation between peroxisome proliferator-activated receptors and retinoid X receptor agonists in sebocyte growth and development.
Journal: Molecular genetics and metabolism 20011101
Title: [Evaluation of thiazolidinedione derivative drugs for safety].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20011101
Title: [Clinical usefulness of combination treatment with thiazolidinedione and insulin].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20011101
Title: Troglitazone selectively inhibits glyoxalase I gene expression.
Journal: Diabetologia 20011101
Title: PPARgamma agonists inhibit cell growth and suppress the expression of cyclin D1 and EGF-like growth factors in ras-transformed rat intestinal epithelial cells.
Journal: International journal of cancer 20011101
Title: Ligands for peroxisome proliferator-activated receptor gamma inhibit growth of pancreatic cancers both in vitro and in vivo.
Journal: International journal of cancer 20011101
Title: Troglitazone improves endothelial function and augments renal klotho mRNA expression in Otsuka Long-Evans Tokushima Fatty (OLETF) rats with multiple atherogenic risk factors.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20011101
Title: Inhibition of phosphoenolpyruvate carboxykinase (PEPCK) gene expression by troglitazone: a peroxisome proliferator-activated receptor-gamma (PPARgamma)-independent, antioxidant-related mechanism.
Journal: Biochemical pharmacology 20011015
Title: Troglitazone-induced intrahepatic cholestasis by an interference with the hepatobiliary export of bile acids in male and female rats. Correlation with the gender difference in troglitazone sulfate formation and the inhibition of the canalicular bile salt export pump (Bsep) by troglitazone and troglitazone sulfate.
Journal: Toxicology 20011005
Title: Peroxisome proliferator-activated receptor gamma activators inhibit cardiac hypertrophy in cardiac myocytes.
Journal: Circulation 20011002
Title: Troglitazone not only increases GLUT4 but also induces its translocation in rat adipocytes.
Journal: Diabetes 20011001
Title: Direct thiazolidinedione action on isolated rat skeletal muscle fuel handling is independent of peroxisome proliferator-activated receptor-gamma-mediated changes in gene expression.
Journal: Diabetes 20011001
Title: Thiazolidinedione treatment prevents free fatty acid-induced insulin resistance in male wistar rats.
Journal: Diabetes 20011001
Title: Cellular mechanisms in the development and progression of diabetic nephropathy: activation of the DAG-PKC-ERK pathway.
Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20011001
Title: Troglitazone use in polycystic ovary syndrome.
Journal: The Journal of clinical endocrinology and metabolism 20011001
Title: Antineoplastic and anti-inflammatory effects of PPAR ligands in colitis.
Journal: Gastroenterology 20011001
Title: Expression of peroxisome proliferator-activated receptor gamma in renal cell carcinoma and growth inhibition by its agonists.
Journal: Biochemical and biophysical research communications 20010928
Title: Troglitazone inhibits growth of MCF-7 breast carcinoma cells by targeting G1 cell cycle regulators.
Journal: Biochemical and biophysical research communications 20010907
Title: Serum leptin level as an indicator to predict the clinical efficacy of troglitazone in patients with type 2 diabetes mellitus.
Journal: Diabetes research and clinical practice 20010901
Title: PPAR-gamma ligands inhibit growth of human esophageal adenocarcinoma cells through induction of apoptosis, cell cycle arrest and reduction of ornithine decarboxylase activity.
Journal: International journal of oncology 20010901
Title: Thiazolidinediones, peroxisome proliferator-activated receptor gamma agonists, regulate endothelial cell growth and secretion of vasoactive peptides.
Journal: Atherosclerosis 20010901
Title: Magnitude of peroxisome proliferator-activated receptor-gamma activation is associated with important and seemingly opposite biological responses in breast cancer cells.
Journal: Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20010901
Title: Troglitazone enhances glucose uptake induced by alpha-adrenoceptor stimulation via phosphatidylinositol 3-kinase in rat heart.
Journal: Clinical and experimental pharmacology & physiology 20010901
Title: PPARgamma ligands inhibit TNF-alpha-induced LOX-1 expression in cultured endothelial cells.
Journal: Biochemical and biophysical research communications 20010824
Title: [Glitazone--a new class of drugs for the treatment of type 2 diabetes].
Journal: Deutsche medizinische Wochenschrift (1946) 20010824
Title: Liver enzyme monitoring in patients treated with troglitazone.
Journal: JAMA 20010815
Title: [The thiazolidinedione derivates: a new class of oral blood glucose lowering agents].
Journal: Nederlands tijdschrift voor geneeskunde 20010811
Title: Utilization of oral hypoglycemic agents in a drug-insured U.S. population.
Journal: Diabetes care 20010801
Title: The glutamine/glutamate couplet and cellular function.
Journal: News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society 20010801
Title: Role of peroxisome proliferator-activated receptor gamma and its ligands in non-neoplastic and neoplastic human urothelial cells.
Journal: The American journal of pathology 20010801
Title: Ca(2+)-sensitizing effect is involved in the positive inotropic effect of troglitazone.
Journal: British journal of pharmacology 20010801
Title: Enzyme-induction dependent bioactivation of troglitazone and troglitazone quinone in vivo.
Journal: Chemical research in toxicology 20010801
Title: PPARgamma and inflammatory bowel disease: a new therapeutic target for ulcerative colitis and Crohn's disease.
Journal: Trends in molecular medicine 20010801
Title: Mechanisms involved in tumor necrosis factor-alpha induction of insulin resistance and its reversal by thiazolidinedione(s).
Journal: The American journal of the medical sciences 20010801
Title: Arylhydrocarbon receptor (AhR) is involved in negative regulation of adipose differentiation in 3T3-L1 cells: AhR inhibits adipose differentiation independently of dioxin.
Journal: Journal of cell science 20010801
Title: [Thiazolidinediones--a new class of oral antidiabetic drugs].
Journal: Orvosi hetilap 20010722
Title: Troglitazone quinone formation catalyzed by human and rat CYP3A: an atypical CYP oxidation reaction.
Journal: Biochemical pharmacology 20010715
Title: 15-Deoxy-delta12,14-PGJ2, but not troglitazone, modulates IL-1beta effects in human chondrocytes by inhibiting NF-kappaB and AP-1 activation pathways.
Journal: FEBS letters 20010713
Title: Acyl-CoA synthetase isoforms 1, 4, and 5 are present in different subcellular membranes in rat liver and can be inhibited independently.
Journal: The Journal of biological chemistry 20010706
Title: Combined treatment with specific ligands for PPARgamma:RXR nuclear receptor system markedly inhibits the expression of cytochrome P450arom in human granulosa cancer cells.
Journal: Molecular and cellular endocrinology 20010705
Title: Gonadotropins at menopause: the influence of obesity, insulin resistance, and estrogens.
Journal: Steroids 20010701
Title: Troglitazone improves whole-body insulin resistance and skeletal muscle glucose use in type II diabetic patients.
Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20010701
Title: Troglitazone reduces the expression of PPARgamma while stimulating that of PPARalpha in mononuclear cells in obese subjects.
Journal: The Journal of clinical endocrinology and metabolism 20010701
Title: Nuclear factor-kappaB suppressive and inhibitor-kappaB stimulatory effects of troglitazone in obese patients with type 2 diabetes: evidence of an antiinflammatory action?
Journal: The Journal of clinical endocrinology and metabolism 20010701
Title: Case of the month. Hepatic and renal failure in a patient taking troglitazone and metformin.
Journal: The Journal of the Arkansas Medical Society 20010701
Title: Diabetic KKAy mice exhibit increased hepatic PPARgamma1 gene expression and develop hepatic steatosis upon chronic treatment with antidiabetic thiazolidinediones.
Journal: Journal of hepatology 20010701
Title: [Peroxisome proliferator-activated receptors (PPARs) in the vessel wall: new regulators of gene expression in vascular cells].
Journal: Zeitschrift fur Kardiologie 20010701
Title: Troglitazone treatment increases bone marrow adipose tissue volume but does not affect trabecular bone volume in mice.
Journal: Calcified tissue international 20010701
Title: Comparative actions of insulin sensitizers on ion channels in vascular smooth muscle.
Journal: European journal of pharmacology 20010629
Title: Design and synthesis of 2-methyl-2-[4-(2-[5-methyl-2-aryloxazol-4-yl]ethoxy)phenoxy]propionic acids: a new class of dual PPARalpha/gamma agonists.
Journal: Journal of medicinal chemistry 20010621
Title: Treatment of lipodystrophy with troglitazone.
Journal: Annals of internal medicine 20010619
Title: Lessons from the glitazones: a story of drug development.
Journal: Lancet (London, England) 20010609
Title: Beneficial effect of troglitazone, an insulin-sensitizing antidiabetic agent, on coronary circulation in patients with non-insulin-dependent diabetes mellitus.
Journal: Japanese circulation journal 20010601
Title: Effects of troglitazone and voluntary running on insulin resistance induced high fat diet in the rat.
Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20010601
Title: Thiazolidinediones but not metformin directly inhibit the steroidogenic enzymes P450c17 and 3beta -hydroxysteroid dehydrogenase.
Journal: The Journal of biological chemistry 20010518
Title: Feedback control of the arachidonate cascade in rheumatoid synoviocytes by 15-deoxy-Delta(12,14)-prostaglandin J2.
Journal: Biochemical and biophysical research communications 20010518
Title: Efficacy and safety of troglitazone for lipodystrophy syndromes.
Journal: Annals of internal medicine 20010515
Title: Troglitazone stimulates pancreatic growth in congenitally CCK-A receptor-deficient OLETF rats.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20010501
Title: Amelioration of experimental autoimmune encephalomyelitis in C57BL/6 mice by an agonist of peroxisome proliferator-activated receptor-gamma.
Journal: Journal of neuroimmunology 20010501
Title: Peroxisome proliferator-activated receptor-gamma agonist troglitazone protects against nondiabetic glomerulosclerosis in rats.
Journal: Kidney international 20010501
Title: The effect of a thiazolidinedione drug, troglitazone, on glycemia in patients with type 2 diabetes mellitus poorly controlled with sulfonylurea and metformin. A multicenter, randomized, double-blind, placebo-controlled trial.
Journal: Annals of internal medicine 20010501
Title: Troglitazone induces GLUT4 translocation in L6 myotubes.
Journal: Diabetes 20010501
Title: Troglitazone treatment increases plasma vascular endothelial growth factor in diabetic patients and its mRNA in 3T3-L1 adipocytes.
Journal: Diabetes 20010501
Title: Involvement of p21(WAF1/Cip1), p27(Kip1), and p18(INK4c) in troglitazone-induced cell-cycle arrest in human hepatoma cell lines.
Journal: Hepatology (Baltimore, Md.) 20010501
Title: Antidiabetic treatment for NASH?
Journal: Hepatology (Baltimore, Md.) 20010501
Title: Ligands for peroxisome proliferator-activated receptor gamma inhibit growth and induce apoptosis of human papillary thyroid carcinoma cells.
Journal: The Journal of clinical endocrinology and metabolism 20010501
Title: Response of experimental retinal neovascularization to thiazolidinediones.
Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20010501
Title: Interactions between simvastatin and troglitazone or pioglitazone in healthy subjects.
Journal: Journal of clinical pharmacology 20010501
Title: Combined effects of troglitazone and muscle contraction on insulin sensitization in Balb-c mouse muscle.
Journal: Biochimie 20010501
Title: Severe cholestatic hepatitis from troglitazone in a patient with nonalcoholic steatohepatitis and diabetes mellitus.
Journal: The American journal of gastroenterology 20010501
Title: Differential effects among thiazolidinediones on the transcription of thromboxane receptor and angiotensin II type 1 receptor genes.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20010501
Title: Peroxisome proliferator-activated receptor-gamma activation inhibits interleukin-1beta -mediated platelet-derived growth factor-alpha receptor gene expression via CCAAT/enhancer-binding protein-delta in vascular smooth muscle cells.
Journal: The Journal of biological chemistry 20010420
Title: Peroxisome proliferator-activated receptor gamma ligands suppress the transcriptional activation of cyclooxygenase-2. Evidence for involvement of activator protein-1 and CREB-binding protein/p300.
Journal: The Journal of biological chemistry 20010413
Title: Dual function of troglitazone in ICAM-1 gene expression in human vascular endothelium.
Journal: Biochemical and biophysical research communications 20010406
Title: Differential regulation of expression of genes encoding uncoupling proteins 2 and 3 in brown adipose tissue during lactation in mice.
Journal: The Biochemical journal 20010401
Title: Troglitazone prevents the rise in visceral adiposity and improves fatty liver associated with sulfonylurea therapy--a randomized controlled trial.
Journal: Metabolism: clinical and experimental 20010401
Title: Other novel agents: Rationale and current status as chemopreventive agents.
Journal: Urology 20010401
Title: Troglitazone improves ovulation and hirsutism in the polycystic ovary syndrome: a multicenter, double blind, placebo-controlled trial.
Journal: The Journal of clinical endocrinology and metabolism 20010401
Title: The nuclear receptor PPAR gamma is expressed by mouse T lymphocytes and PPAR gamma agonists induce apoptosis.
Journal: European journal of immunology 20010401
Title: Administration of troglitazone, but not pioglitazone, reduces insulin resistance caused by short-term dexamethasone (DXM) treatment by accelerating the metabolism of DXM.
Journal: Diabetes care 20010401
Title: [Glitazones. Profile of a new class of substances].
Journal: Der Internist 20010401
Title: Effect of obesity and troglitazone on expression of two glutathione peroxidases: cellular and extracellular types in serum, kidney and adipose tissue.
Journal: Free radical research 20010401
Title: Troglitazone, a ligand for peroxisome proliferator-activated receptor gamma, inhibits chemically-induced aberrant crypt foci in rats.
Journal: Japanese journal of cancer research : Gann 20010401
Title: Peroxisome proliferator-activated receptor (PPAR) gamma and retinoid X receptor (RXR) agonists have complementary effects on glucose and lipid metabolism in human skeletal muscle.
Journal: Diabetologia 20010401
Title: [The expression of PPAR gamma in gastric cancer].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20010401
Title: Effect of troglitazone on urinary albumin excretion and serum type IV collagen concentrations in Type 2 diabetic patients with microalbuminuria or macroalbuminuria.
Journal: Diabetic medicine : a journal of the British Diabetic Association 20010401
Title: [Thiazolidinediones: clinical data and perspectives].
Journal: Diabetes & metabolism 20010401
Title: Company played down drug's risks, report says.
Journal: BMJ (Clinical research ed.) 20010324
Title: Troglitazone corrects metabolic changes but not vascular dysfunction in dietary-obese rats.
Journal: European journal of pharmacology 20010323
Title: Ligands for peroxisome proliferator-activated receptors alpha and gamma inhibit chemically induced colitis and formation of aberrant crypt foci in rats.
Journal: Cancer research 20010315
Title: Bezafibrate attenuates the overexpression of plasminogen activator inhibitor-1 messenger RNA by a combination of mono-unsaturated fatty acid and insulin in hepG2 cells.
Journal: Life sciences 20010309
Title: Toxic effect of troglitazone on cultured rat hepatocytes.
Journal: Life sciences 20010309
Title: Regulation of cardiac and skeletal muscle malonyl-CoA decarboxylase by fatty acids.
Journal: American journal of physiology. Endocrinology and metabolism 20010301
Title: The transcription factor Fos-related antigen 1 is induced by thiazolidinediones during differentiation of 3T3-L1 cells.
Journal: Molecular pharmacology 20010301
Title: Cholestatic potential of troglitazone as a possible factor contributing to troglitazone-induced hepatotoxicity: in vivo and in vitro interaction at the canalicular bile salt export pump (Bsep) in the rat.
Journal: Molecular pharmacology 20010301
Title: Enzymatic characterization and interspecies difference of phenol sulfotransferases, ST1A forms.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20010301
Title: Antiatherogenic effects of thiazolidinediones?
Journal: Arteriosclerosis, thrombosis, and vascular biology 20010301
Title: Troglitazone inhibits formation of early atherosclerotic lesions in diabetic and nondiabetic low density lipoprotein receptor-deficient mice.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20010301
Title: Troglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice: pleiotropic effects on CD36 expression and HDL.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20010301
Title: Suppression of nuclear factor-kappaB and stimulation of inhibitor kappaB by troglitazone: evidence for an anti-inflammatory effect and a potential antiatherosclerotic effect in the obese.
Journal: The Journal of clinical endocrinology and metabolism 20010301
Title: Troglitazone is a competitive inhibitor of 3beta-hydroxysteroid dehydrogenase enzyme in the ovary.
Journal: American journal of obstetrics and gynecology 20010301
Title: Effects of troglitazone and temocapril in spontaneously hypertensive rats with chronic renal failure.
Journal: Journal of hypertension 20010301
Title: Inhibitory effect of troglitazone on glucuronidation catalyzed by human uridine diphosphate-glucuronosyltransferase 1A6.
Journal: European journal of clinical pharmacology 20010301
Title: [Lipodystrophia].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20010301
Title: Comparison of the metabolic effects of metformin and troglitazone on fructose-induced insulin resistance in male Sprague-Dawley rats.
Journal: Journal of the Formosan Medical Association = Taiwan yi zhi 20010301
Title: Biorelevant dissolution testing to predict the plasma profile of lipophilic drugs after oral administration.
Journal: Pharmaceutical research 20010301
Title: Troglitazone amplifies counterregulatory responses to hypoglycemia in nondiabetic subjects.
Journal: The Journal of clinical endocrinology and metabolism 20010201
Title: Does pioglitazone, like troglitazone, increase serum levels of lipoprotein(a) in diabetic patients?
Journal: Diabetes care 20010201
Title: Troglitazone and rosiglitazone induce apoptosis of vascular smooth muscle cells through an extracellular signal-regulated kinase-independent pathway.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20010201
Title: Expression and function of peroxisome proliferator-activated receptor-gamma in mesangial cells.
Journal: Hypertension (Dallas, Tex. : 1979) 20010201
Title: Insulin resistance and nonalcoholic steatohepatitis: fat or fiction?
Journal: The American journal of gastroenterology 20010201
Title: A pilot study of a thiazolidinedione, troglitazone, in nonalcoholic steatohepatitis.
Journal: The American journal of gastroenterology 20010201
Title: Effects of troglitazone in patients with type 2 diabetes mellitus not adequately controlled by sulfonylureas.
Journal: Diabetes research and clinical practice 20010201
Title: Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover.
Journal: Diabetes 20010201
Title: Myositis, microvesicular hepatitis, and progression to cirrhosis from troglitazone added to simvastatin.
Journal: Digestive diseases and sciences 20010201
Title: Effects of troglitazone on cellular differentiation, insulin signaling, and glucose metabolism in cultured human skeletal muscle cells.
Journal: Biochemical and biophysical research communications 20010126
Title: Combination therapy in type 2 diabetes: the role of repaglinide.
Journal: The Journal of the Association of Physicians of India 20010125
Title: Abundant expression of uncoupling protein-2 in the small intestine: up-regulation by dietary fish oil and fibrates.
Journal: Biochimica et biophysica acta 20010115
Title: Troglitazone, an antidiabetic drug, improves left ventricular mass and diastolic function in normotensive diabetic patients.
Journal: International journal of cardiology 20010101
Title: New oral therapies for type 2 diabetes mellitus: The glitazones or insulin sensitizers.
Journal: Annual review of medicine 20010101
Title: Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission.
Journal: Chemical research in toxicology 20010101
Title: The ligands/activators for peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARgamma increase Cu2+,Zn2+-superoxide dismutase and decrease p22phox message expressions in primary endothelial cells.
Journal: Metabolism: clinical and experimental 20010101
Title: Failure to develop hepatic injury from rosiglitazone in a patient with a history of troglitazone-induced hepatitis.
Journal: Diabetes care 20010101
Title: Pulmonary edema associated with rosiglitazone and troglitazone.
Journal: The Annals of pharmacotherapy 20010101
Title: Improvement of left ventricular diastolic dynamics in prediabetic stage of a type II diabetic rat model after troglitazone treatment.
Journal: Angiology 20010101
Title: Survival activity of troglitazone in rat motoneurones.
Journal: Journal of neurochemistry 20010101
Title: Troglitazone and liver function abnormalities: lessons from a prescription event monitoring study and spontaneous reporting.
Journal: Drug safety 20010101
Title: Insulin resistance and its treatment by thiazolidinediones.
Journal: Recent progress in hormone research 20010101
Title: Effects of type-2 diabetes and troglitazone on the expression patterns of small intestinal sugar transporters and PPAR-gamma in the Zucker diabetic fatty rat.
Journal: Digestion 20010101
Title: Pilot study of prescription-event monitoring in Japan comparing troglitazone with alternative oral hypoglycemics.
Journal: European journal of clinical pharmacology 20010101
Title: Troglitazone stimulates basolateral rheogenic Na+/HCO3- cotransport activity in rabbit proximal straight tubules.
Journal: Experimental nephrology 20010101
Title: Troglitazone, but not rosiglitazone, inhibits Na/H exchange activity and proliferation of macrovascular endothelial cells.
Journal: Journal of diabetes and its complications 20010101
Title: Therapeutic treatment of DMBA-induced mammary tumors with PPAR ligands.
Journal: Anticancer research 20010101
Title: Comparison of effects of thiazolidinediones on cardiovascular risk factors: observations from a clinical practice.
Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20010101
Title: Troglitazone and rosiglitazone inhibit the low density lipoprotein-induced vascular smooth muscle cell growth.
Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20010101
Title: Serious liver injury. Leading reason for drug removals, restrictions.
Journal: FDA consumer 20010101
Title: Use of insulin-sensitizing agents in patients with polycystic ovary syndrome.
Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20010101
Title: Conversion from troglitazone to rosiglitazone.
Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20010101
Title: A comparison of the effects of troglitazone and vitamin E on the fatty acid composition of serum phospholipids in an experimental model of insulin resistance.
Journal: Physiological research 20010101
Title: Novel phthalazinone and benzoxazinone containing thiazolidinediones as antidiabetic and hypolipidemic agents.
Journal: European journal of medicinal chemistry 20010101
Title: Effects of high-dose troglitaz one on insulin sensitivity and beta-cell function in Watanabe heritable hyperlipidemic rabbits.
Journal: European journal of drug metabolism and pharmacokinetics 20010101
Title: Hepatotoxicity with thiazolidinediones: is it a class effect?
Journal: Drug safety 20010101
Title: Structure toxicity relationships--how useful are they in predicting toxicities of new drugs?
Journal: Advances in experimental medicine and biology 20010101
Title: Biological reactive intermediates in drug discovery and development: a perspective from the pharmaceutical industry.
Journal: Advances in experimental medicine and biology 20010101
Title: Troglitazone (Rezulin) and hepatic injury.
Journal: Pharmacoepidemiology and drug safety 20010101
Title: Cardiac hypertrophy in diabetes patients with and without hypertension: effects of troglitazone, a novel antidiabetic drug, on diastolic function.
Journal: Advances in experimental medicine and biology 20010101
Title: [Diabetic dyslipoproteinemia: physiopathological bases and treatment prospects].
Journal: Fortschritte der Medizin. Originalien 20010101
Title: [Antioxidant and anti-AGE therapeutics: evaluation and perspectives].
Journal: Journal de la Societe de biologie 20010101
Title: Activation of peroxisome proliferator-activated receptor gamma inhibits the growth of human pancreatic cancer.
Journal: Pathobiology : journal of immunopathology, molecular and cellular biology 20010101
Title: UCP3 gene expression does not correlate with muscle oxidation rates in troglitazone-treated Zucker fatty rats.
Journal: Biochimica et biophysica acta 20001215
Title: 15-Deoxy-Delta(12,14)-prostaglandin J(2) facilitates thyroglobulin production by cultured human thyrocytes.
Journal: American journal of physiology. Cell physiology 20001201
Title: Vitamin K(2) inhibits adipogenesis, osteoclastogenesis, and ODF/RANK ligand expression in murine bone marrow cell cultures.
Journal: Bone 20001201
Title: Troglitazone halts diabetic glomerulosclerosis by blockade of mesangial expansion.
Journal: Kidney international 20001201
Title: Characterization of UDP-glucuronosyltransferases (UGTS) involved in the metabolism of troglitazone in rats and humans.
Journal: The Journal of toxicological sciences 20001201
Title: Enhancing effect of troglitazone on porcine adipocyte differentiation in primary culture: a comparison with dexamethasone.
Journal: Obesity research 20001201
Title: Dehydroepiandrosterone suppresses elevated hepatic glucose-6-phosphatase mRNA level in C57BL/KsJ-db/db mice: comparison with troglitazone.
Journal: Endocrine journal 20001201
Title: Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone.
Journal: Biochemical and biophysical research communications 20001130
Title: Troglitazone induces apoptosis via the p53 and Gadd45 pathway in vascular smooth muscle cells.
Journal: European journal of pharmacology 20001103
Title: Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice.
Journal: Endocrinology 20001101
Title: Regulation of leptin release by troglitazone in human adipose tissue.
Journal: Metabolism: clinical and experimental 20001101
Title: Down-regulation of uncoupling protein-3 and -2 by thiazolidinediones in C2C12 myotubes.
Journal: FEBS letters 20001027
Title: Activation of peroxisome proliferator-activated receptor gamma by troglitazone inhibits cell growth through the increase of p27KiP1 in human. Pancreatic carcinoma cells.
Journal: Cancer research 20001001
Title: Two opposing effects of non-steroidal anti-inflammatory drugs on the expression of the inducible cyclooxygenase. Mediation through different signaling pathways.
Journal: The Journal of biological chemistry 20000908
Title: Leptin production in adipocytes from morbidly obese subjects: stimulation by dexamethasone, inhibition with troglitazone, and influence of gender.
Journal: The Journal of clinical endocrinology and metabolism 20000801
Title: Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20000718
Title: Down-regulation by troglitazone of hepatic tumor necrosis factor-alpha and interleukin-6 mRNA expression in a murine model of non-insulin-dependent diabetes.
Journal: Biochemical pharmacology 20000701
Title: Impaired expression of the uncoupling protein-3 gene in skeletal muscle during lactation: fibrates and troglitazone reverse lactation-induced downregulation of the uncoupling protein-3 gene.
Journal: Diabetes 20000701
Title: Inhibitory effect of troglitazone on TNF-alpha-induced expression of monocyte chemoattractant protein-1 (MCP-1) in human endothelial cells.
Journal: Diabetes research and clinical practice 20000601
Title: Insulin sensitizer, troglitazone, directly inhibits aromatase activity in human ovarian granulosa cells.
Journal: Biochemical and biophysical research communications 20000519
Title: Severe but reversible hepatitis induced by troglitazone.
Journal: Digestive diseases and sciences 20000501
Title: Troglitazone inhibits mitogenic signaling by insulin in vascular smooth muscle cells.
Journal: Journal of cardiovascular pharmacology 20000501
Title: Troglitazone improves psoriasis and normalizes models of proliferative skin disease: ligands for peroxisome proliferator-activated receptor-gamma inhibit keratinocyte proliferation.
Journal: Archives of dermatology 20000501
Title: Stimulation by eicosapentaenoic acids of leptin mRNA expression and its secretion in mouse 3T3-L1 adipocytes in vitro.
Journal: Biochemical and biophysical research communications 20000413
Title: Differential activation of peroxisome proliferator-activated receptor-gamma by troglitazone and rosiglitazone.
Journal: Diabetes 20000401
Title: Troglitazone enhances glycolysis and improves intracellular glucose metabolism in rat mesangial cells.
Journal: Metabolism: clinical and experimental 20000301
Title: Troglitazone-induced fulminant hepatic failure. Acute Liver Failure Study Group.
Journal: Digestive diseases and sciences 20000301
Title: Effect of troglitazone on cytochrome P450 enzymes in primary cultures of human and rat hepatocytes.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20000301
Title: Troglitazone reduces plasminogen activator inhibitor-1 expression and secretion in cultured human adipocytes.
Journal: Diabetologia 20000301
Title: The PPARs: from orphan receptors to drug discovery.
Journal: Journal of medicinal chemistry 20000224
Title: Subacute hepatic failure associated with a new antidiabetic agent, troglitazone: a case report with autopsy examination.
Journal: Human pathology 20000201
Title: Troglitazone-associated hepatic failure.
Journal: The American journal of gastroenterology 20000201
Title: Inhibitory effect of troglitazone on tumor necrosis factor alpha-induced expression of monocyte chemoattractant protein-1 in human mesangial cells.
Journal: Metabolism: clinical and experimental 20000201
Title: Peroxisome proliferator-activated receptor (PPAR)-gamma expression in human vascular smooth muscle cells: inhibition of growth, migration, and c-fos expression by the peroxisome proliferator-activated receptor (PPAR)-gamma activator troglitazone.
Journal: American journal of hypertension 20000101
Title: Inhibition by troglitazone of the antigen-induced production of leukotrienes in immunoglobulin E-sensitized RBL-2H3 cells.
Journal: British journal of pharmacology 20000101
Title: Troglitazone-induced fulminant hepatitis: report of a case with autopsy findings.
Journal: Journal of diabetes and its complications 20000101
Title: Troglitazone, a PPARgamma ligand, inhibits osteopontin gene expression in human monocytes/macrophage THP-1 cells.
Journal: Journal of atherosclerosis and thrombosis 20000101
Title: Growth inhibition of myeloid leukemia cells by troglitazone, a ligand for peroxisome proliferator activated receptor gamma, and retinoids.
Journal: International journal of oncology 19991101
Title: Chemoprevention of heterocyclic amine-induced carcinogenesis by phenolic compounds in rats.
Journal: Cancer letters 19990901
Title: Troglitazone inhibits expression of the phosphoenolpyruvate carboxykinase gene by an insulin-independent mechanism.
Journal: Biochimica et biophysica acta 19990812
Title: Troglitazone suppresses cell growth of myeloid leukemia cell lines by induction of p21WAF1/CIP1 cyclin-dependent kinase inhibitor.
Journal: Biochemical and biophysical research communications 19990811
Title: Endrin inhibits adipocyte differentiation by selectively altering expression pattern of CCAAT/enhancer binding protein-alpha in 3T3-L1 cells.
Journal: Molecular pharmacology 19990701
Title: A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat.
Journal: Diabetes 19990701
Title: Vasodilatory effects of troglitazone improve blood pressure at rest and during mental stress in type 2 diabetes mellitus.
Journal: Hypertension (Dallas, Tex. : 1979) 19990701
Title: Troglitazone inhibits alpha1-adrenoceptor-induced DNA synthesis in vascular smooth muscle cells.
Journal: European journal of pharmacology 19990611
Title: p53 is not inactivated in B6C3F1 mouse vascular tumors arising spontaneously or associated with long-term administration of the thiazolidinedione troglitazone.
Journal: Toxicology and applied pharmacology 19990415
Title: Troglitazone upregulates nitric oxide synthesis in vascular smooth muscle cells.
Journal: Hypertension (Dallas, Tex. : 1979) 19990401
Title: Effect of troglitazone on plasma lipid metabolism and lipoprotein lipase.
Journal: British journal of clinical pharmacology 19990401
Title: Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma.
Journal: Proceedings of the National Academy of Sciences of the United States of America 19990330
Title: (3-substituted benzyl)thiazolidine-2,4-diones as structurally new antihyperglycemic agents.
Journal: Bioorganic & medicinal chemistry letters 19990222
Title: Troglitazone-associated hepatic failure.
Journal: Annals of internal medicine 19990216
Title: Thiazolidinediones suppress endothelin-1 secretion from bovine vascular endothelial cells: a new possible role of PPARgamma on vascular endothelial function.
Journal: Biochemical and biophysical research communications 19990127
Title: Pharmacological profiles of a novel oral antidiabetic agent, JTT-501, an isoxazolidinedione derivative.
Journal: European journal of pharmacology 19990108
Title: BM 17.0744: a structurally new antidiabetic compound with insulin-sensitizing and lipid-lowering activity.
Journal: Metabolism: clinical and experimental 19990101
Title: Troglitazone induces expression of PPARgamma in liver.
Journal: Molecular cell biology research communications : MCBRC 19990101
Title: N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents.
Journal: Journal of medicinal chemistry 19981203
Title: N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 3. Structure-activity relationship and optimization of the N-aryl substituent.
Journal: Journal of medicinal chemistry 19981203
Title: A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and PPAR-gamma: effect of PPAR-alpha activation on abnormal lipid metabolism in liver of Zucker fatty rats.
Journal: Diabetes 19981201
Title: An autopsy case of troglitazone-induced fulminant hepatitis.
Journal: Diabetes care 19981201
Title: Troglitazone reduces plasma leptin concentration but increases hunger in NIDDM patients.
Journal: Diabetes care 19980901
Title: Troglitazone upregulates LDL receptor activity in HepG2 cells.
Journal: Diabetes 19980801
Title: Troglitazone effects on gene expression in human skeletal muscle of type II diabetes involve up-regulation of peroxisome proliferator-activated receptor-gamma.
Journal: The Journal of clinical endocrinology and metabolism 19980801
Title: Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice.
Journal: Proceedings of the National Academy of Sciences of the United States of America 19980721
Title: Troglitazone-induced hepatic failure leading to liver transplantation. A case report.
Journal: Annals of internal medicine 19980701
Title: Troglitazone regulation of glucose metabolism in human skeletal muscle cultures from obese type II diabetic subjects.
Journal: The Journal of clinical endocrinology and metabolism 19980501
Title: Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats.
Journal: The Journal of clinical investigation 19980315
Title: Troglitazone lowers islet fat and restores beta cell function of Zucker diabetic fatty rats.
Journal: The Journal of biological chemistry 19980206
Title: Identification of high-affinity binding sites for the insulin sensitizer rosiglitazone (BRL-49653) in rodent and human adipocytes using a radioiodinated ligand for peroxisomal proliferator-activated receptor gamma.
Journal: The Journal of pharmacology and experimental therapeutics 19980201
Title: Troglitazone enhances glucose uptake and inhibits mitogen-activated protein kinase in human aortic smooth muscle cells.
Journal: Atherosclerosis 19980101
Title: Troglitazone action is independent of adipose tissue.
Journal: The Journal of clinical investigation 19971201
Title: Leptin- or troglitazone-induced lipopenia protects islets from interleukin 1beta cytotoxicity.
Journal: The Journal of clinical investigation 19971001
Title: Induction of uncoupling protein-2 mRNA by troglitazone in the pancreatic islets of Zucker diabetic fatty rats.
Journal: Biochemical and biophysical research communications 19970818
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Journal: Nihon rinsho. Japanese journal of clinical medicine 19970801
Title: Troglitazone enhances differentiation, basal glucose uptake, and Glut1 protein levels in 3T3-L1 adipocytes.
Journal: Endocrinology 19961101
Title: Troglitazone inhibits vascular smooth muscle cell growth and intimal hyperplasia.
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Title: Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor-gamma: binding and activation correlate with antidiabetic actions in db/db mice.
Journal: Endocrinology 19961001
Title: Effect of troglitazone on leptin production. Studies in vitro and in human subjects.
Journal: Diabetes 19960901
Title: Effect of troglitazone (CS-045) and bezafibrate on glucose tolerance, liver glycogen synthase activity, and beta-oxidation in fructose-fed rats.
Journal: Metabolism: clinical and experimental 19951201
Title: Troglitazone prevents the inhibitory effects of inflammatory cytokines on insulin-induced adipocyte differentiation in 3T3-L1 cells.
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