Home Indole and Oxindoles 97730-95-5
97730-95-5,MFCD01719099
Catalog No.:AA01EPJO

97730-95-5 | 4-[3-[4-(diphenylmethyl)-1-piperazinyl]-2-hydroxypropoxy]-1H-indole-2-carbonitrile

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10mg
≥98%
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25mg
≥98%
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  • Technical Information
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Technical Information
Catalog Number:
AA01EPJO
Chemical Name:
4-[3-[4-(diphenylmethyl)-1-piperazinyl]-2-hydroxypropoxy]-1H-indole-2-carbonitrile
CAS Number:
97730-95-5
Molecular Formula:
C29H30N4O2
Molecular Weight:
466.5741
MDL Number:
MFCD01719099
SMILES:
N#Cc1[nH]c2c(c1)c(OCC(CN1CCN(CC1)C(c1ccccc1)c1ccccc1)O)ccc2
Properties
Computed Properties
 
Complexity:
672  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
8  
Undefined Atom Stereocenter Count:
1  
XLogP3:
4.5  

Literature

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Actions of ATX-II and other gating-modifiers on Na(+) currents in HEK-293 cells expressing WT and DeltaKPQ hNa(V) 1.5 Na(+) channels.

Journal: Toxicon : official journal of the International Society on Toxinology 20090101

Title: Models of torsades de pointes: effects of FPL64176, DPI201106, dofetilide, and chromanol 293B in isolated rabbit and guinea pig hearts.

Journal: Journal of pharmacological and toxicological methods 20090101

Title: Use of the X-ray structure of the beta2-adrenergic receptor for drug discovery. Part 2: Identification of active compounds.

Journal: Bioorganic & medicinal chemistry letters 20081015

Title: Evidence for state-dependent block of DPI 201-106, a synthetic inhibitor of Na+ channel inactivation, on delayed-rectifier K+ current in pituitary tumor (GH3) cells.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20080901

Title: Functional interaction between DPI 201-106, a drug that mimics congenital long QT syndrome, and sevoflurane on the guinea-pig cardiac action potential.

Journal: Clinical and experimental pharmacology & physiology 20071201

Title: Mg-ATPase and Ca+ activated myosin AtPase activity in ventricular myofibrils from non-failing and diseased human hearts--effects of calcium sensitizing agents MCI-154, DPI 201-106, and caffeine.

Journal: Molecular and cellular biochemistry 20030301

Title: Molecular cloning and functional characterization of a unique mammalian cardiac Na(v) channel isoform with low sensitivity to the synthetic inactivation inhibitor (-)-(S)-6-amino-alpha-[(4-diphenylmethyl-1-piperazinyl)-methyl]-9H-purine-9-ethanol (SDZ 211-939).

Journal: The Journal of pharmacology and experimental therapeutics 20021001

Title: Cardiac and hemodynamic profile of the new cardiotonic agent, DPI 201-106, in the conscious dog.

Journal: European journal of pharmacology 19890608

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Tags:97730-95-5 Molecular Formula|97730-95-5 MDL|97730-95-5 SMILES|97730-95-5 4-[3-[4-(diphenylmethyl)-1-piperazinyl]-2-hydroxypropoxy]-1H-indole-2-carbonitrile