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985-12-6,MFCD00347721
Catalog No.:AA006RTM

985-12-6 | Drotaverine Hydrochloride

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10mg
≥98%
in stock  
$99.00   $69.00
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50mg
≥98%
in stock  
$370.00   $259.00
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100mg
≥98%
in stock  
$642.00   $449.00
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500mg
≥98%
in stock  
$1,233.00   $863.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA006RTM
Chemical Name:
Drotaverine Hydrochloride
CAS Number:
985-12-6
Molecular Formula:
C24H32ClNO4
Molecular Weight:
433.9682
MDL Number:
MFCD00347721
SMILES:
CCOc1cc(ccc1OCC)C=C1NCCc2c1cc(OCC)c(c2)OCC.Cl
Properties
Properties
 
Form:
Solid  
MP:
>197ºC (dec.)  
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
511  
Covalently-Bonded Unit Count:
2  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
9  

Literature

Title: Biodegradation of drotaverine hydrochloride by free and immobilized cells of Rhodococcus rhodochrous IEGM 608.

Journal: World journal of microbiology & biotechnology 20121001

Title: Simultaneous determination of diclofenac potassium and drotaverine hydrochloride in human plasma using reversed-phase high-performance liquid chromatography.

Journal: Journal of chromatographic science 20120901

Title: Intramuscular drotaverine and diclofenac in acute renal colic: a comparative study of analgesic efficacy and safety.

Journal: Pain medicine (Malden, Mass.) 20120301

Title: Effects of drotaverine hydrochloride on viability of rat cultured cerebellar granulocytes.

Journal: Bulletin of experimental biology and medicine 20120201

Title: [Influence of Perftoran nanoemulsion on blood plasma concentrations of lipophilic drugs].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20120101

Title: Efficacy and safety of aceclofenac and drotaverine fixed-dose combination in the treatment of primary dysmenorrhoea: a double-blind, double-dummy, randomized comparative study with aceclofenac.

Journal: European journal of obstetrics, gynecology, and reproductive biology 20100901

Title: A randomised controlled study comparing Drotaverine hydrochloride and Valethamate bromide in the augmentation of labour.

Journal: Archives of gynecology and obstetrics 20100701

Title: Validation and application of chemometrics-assisted spectrophotometry and liquid chromatography for simultaneous determination of two ternary mixtures containing drotaverine hydrochloride.

Journal: Journal of AOAC International 20100101

Title: Effect of elevated intra-abdominal pressure on the contractile activity and reactivity of smooth muscle tissue from rat gastrointestinal tract to galantamine and drotaverine (No-Spa).

Journal: Folia medica 20100101

Title: Comparison of efficacy of oral drotaverine plus mefenamic acid with paracervical block and with intravenous sedation for pain relief during hysteroscopy and endometrial biopsy.

Journal: Indian journal of medical sciences 20090601

Title: Interactions between symptoms and motor and visceral sensory responses of irritable bowel syndrome patients to spasmolytics (antispasmodics).

Journal: Journal of gastrointestinal and liver diseases : JGLD 20090301

Title: Drotaverine hydrochloride versus hyoscine-N-butylbromide in augmentation of labor.

Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20080301

Title: Simultaneous determination of nifuroxazide and drotaverine hydrochloride in pharmaceutical preparations by bivariate and multivariate spectral analysis.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080201

Title: In vitro antioxidant properties of pentoxifylline and vinpocetine in a rheological model.

Journal: Clinical hemorheology and microcirculation 20080101

Title: [Comparative efficacy and tolerability of drotaverine 80 mg and ibuprofen 400 mg in patients with primary dysmenorrhoea--protocol DOROTA].

Journal: Ginekologia polska 20071201

Title: Study of drotaverine on first stage of labour and pregnancy outcome.

Journal: Journal of the Indian Medical Association 20070801

Title: Spectrophotometric determination of pipazethate HCl, dextromethorphan HBr and drotaverine HCl in their pharmaceutical preparations.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20070701

Title: Spectrophotometric and spectrodensitometric determination of paracetamol and drotaverine HCl in combination.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20070401

Title: Application of derivative, derivative ratio, and multivariate spectral analysis and thin-layer chomatography-densitometry for determination of a ternary mixture containing drotaverine hydrochloride, caffeine, and paracetamol.

Journal: Journal of AOAC International 20070101

Title: Hemorheological efficiency of drugs, targeting on intracellular phosphodiesterase activity: in vitro study.

Journal: Clinical hemorheology and microcirculation 20070101

Title: No-Spa and Remantadin are the novel complex preparations that inhibit effectively reproduction of the avian influenza viruses.

Journal: Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20070101

Title: [Vegetotropic therapy and hypobaric hypoxic adaptation in gallbladder motor dysmotility].

Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20070101

Title: [Dynamics of indices of visceral sensitivity in patients with irritable bowel syndrome treated with spasmolytics].

Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20070101

Title: Application of new membrane selective electrodes for the determination of drotaverine hydrochloride in tablets and plasma.

Journal: Journal of pharmaceutical and biomedical analysis 20060607

Title: A comparative study on various spectrometries with thin layer chromatography for simultaneous analysis of drotaverine and nifuroxazide in capsules.

Journal: Chemical & pharmaceutical bulletin 20060601

Title: Determination of nifuroxazide and drotaverine hydrochloride in pharmaceutical preparations by three independent analytical methods.

Journal: Journal of AOAC International 20060101

Title: Transport properties and electroanalytical response characteristics of drotaverine ion-selective sensors.

Journal: Analytical and bioanalytical chemistry 20050801

Title: [Using prostaglandin inhibitor dicloberl in patients with ureteral calculi].

Journal: Likars'ka sprava 20040301

Title: Drotaverine hydrochloride for augmentation of labor.

Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20040101

Title: Bioavailability study of drotaverine from capsule and tablet preparations in healthy volunteers.

Journal: Arzneimittel-Forschung 20040101

Title: [New approaches to diagnosing and treating hyperkinetic biliary dyskinesia associated with chronic acalculous cholecystitis].

Journal: Klinicheskaia meditsina 20040101

Title: The effect of drotaverine hydrochloride in acute colicky pain caused by renal and ureteric stones.

Journal: BJU international 20030701

Title: Drotaverine interacts with the L-type Ca(2+) channel in pregnant rat uterine membranes.

Journal: European journal of pharmacology 20020802

Title: [Safety profile of NO-SPA].

Journal: Orvosi hetilap 20020317

Title: Drotaverine hydrochloride vs. valethamate bromide in acceleration of labor.

Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20010901

Title: Role of the enteric nervous plexus in rectal motile activity: an experimental study.

Journal: Journal of investigative surgery : the official journal of the Academy of Surgical Research 20010101

Title: Pharmacokinetics and bioavailability of drotaverine in humans.

Journal: European journal of drug metabolism and pharmacokinetics 19960101

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