Home Amines 98753-19-6
98753-19-6,MFCD08234364
Catalog No.:AA00IK36

98753-19-6 | 1-(((6R,7R)-7-((Z)-2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido)-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl)-6,7-dihydro-5h-cyclopenta[b]pyridin-1-ium hydrogensulfate

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250mg
≥98%
in stock  
$38.00   $26.00
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500mg
≥98%
in stock  
$66.00   $46.00
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1g
>95.0%(HPLC)(N)
in stock  
$93.00   $65.00
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5g
≥98%
in stock  
$365.00   $255.00
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100g
>95.0%
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$7,011.00   $4,908.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00IK36
Chemical Name:
1-(((6R,7R)-7-((Z)-2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido)-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl)-6,7-dihydro-5h-cyclopenta[b]pyridin-1-ium hydrogensulfate
CAS Number:
98753-19-6
Molecular Formula:
C22H24N6O9S3
Molecular Weight:
612.6558
MDL Number:
MFCD08234364
SMILES:
[O-]S(=O)(=O)O.CO/N=C(\C(=O)N[C@@H]1C(=O)N2[C@@H]1SCC(=C2C(=O)O)C[n+]1cccc2c1CCC2)/c1csc(n1)N
Properties
Computed Properties
 
Complexity:
1040  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
40  
Hydrogen Bond Acceptor Count:
14  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
7  

Literature

Title: BioDMET: a physiologically based pharmacokinetic simulation tool for assessing proposed solutions to complex biological problems.

Journal: Journal of pharmacokinetics and pharmacodynamics 20120201

Title: False extended-spectrum {beta}-lactamase phenotype in clinical isolates of Escherichia coli associated with increased expression of OXA-1 or TEM-1 penicillinases and loss of porins.

Journal: The Journal of antimicrobial chemotherapy 20110901

Title: Antibiotics in critically ill patients: a systematic review of the pharmacokinetics of β-lactams.

Journal: Critical care (London, England) 20110101

Title: Tigecycline resistance in Serratia marcescens associated with up-regulation of the SdeXY-HasF efflux system also active against ciprofloxacin and cefpirome.

Journal: The Journal of antimicrobial chemotherapy 20100301

Title: Microemulsion and mixed micelle for oral administration as new drug formulations for highly hydrophilic drugs.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20100201

Title: Development of an analytical method for cefpirome in plasma by simplified HPLC technique and its applications.

Journal: Arzneimittel-Forschung 20100101

Title: Daptomycin elimination by CVVH in vitro: evaluation of factors influencing sieving and membrane adsorption.

Journal: International journal of clinical pharmacology and therapeutics 20090301

Title: Emergence of a cefepime- and cefpirome-resistant Citrobacter freundii clinical isolate harbouring a novel chromosomally encoded AmpC beta-lactamase, CMY-37.

Journal: International journal of antimicrobial agents 20080901

Title: In vitro activity of cefadroxil, cephalexin, cefatrizine and cefpirome in presence of essential and trace elements.

Journal: Pakistan journal of pharmaceutical sciences 20071001

Title: Population pharmacokinetics and pharmacodynamics of cefpirome in critically ill patients against Gram-negative bacteria.

Journal: Intensive care medicine 20070501

Title: Disposition kinetics and urinary excretion of cefpirome after intravenous injection in buffalo calves.

Journal: Journal of veterinary science 20070301

Title: Cefpirome susceptibility in staphylococci isolates.

Journal: Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20070101

Title: Application of the ion pair concept to the n-octanol-water partitioning of cefepime and cefpirome.

Journal: International journal of pharmaceutics 20060619

Title: [Comparative studies on activities of antimicrobial agents against causative organisms isolated from patients with urinary tract infections (2004). I. Susceptibility distribution].

Journal: The Japanese journal of antibiotics 20060601

Title: Influence of absorption enhancers on the pharmacokinetic properties of non-oral beta-lactam-cefpirom using the rabbit (Chinchilla) in vivo model.

Journal: International journal of pharmaceutics 20060217

Title: [High effectiveness of the method with cefpirome in detection of extended-spectrum beta-lactamases in different species of gram-negative bacilli].

Journal: Medycyna doswiadczalna i mikrobiologia 20060101

Title: Susceptibility of Klebsiella spp. to cefpirome and cefepime.

Journal: Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20060101

Title: [Application of four variants of the diagnostic disc test (CD01, CD02, CD03, CD04) for detection of ESBL-positive strains of gram-negative rods].

Journal: Medycyna doswiadczalna i mikrobiologia 20050101

Title: In vitro activity of cefepime and cefpirome compared to other third-generation cephem antibiotics against gram-negative nosocomial pathogens.

Journal: Die Pharmazie 20041101

Title: Resistance to imipenem, cefepime, and cefpirome associated with mutation in Omp36 osmoporin of Enterobacter aerogenes.

Journal: Biochemical and biophysical research communications 20040507

Title: Effect of norepinephrine on cefpirome tissue concentrations in healthy subjects.

Journal: The Journal of antimicrobial chemotherapy 20040301

Title: In vitro combined bactericidal activity of cefpirome and glycopeptides against glycopeptides and oxacillin-resistant staphylococci.

Journal: International journal of antimicrobial agents 20040301

Title: [The trend and susceptibility to antibacterial agents of enterococcus species from urinary tract infections].

Journal: Nihon Hinyokika Gakkai zasshi. The japanese journal of urology 20040101

Title: In-vitro and in-vivo studies of cefpirom using bile salts as absorption enhancers.

Journal: The Journal of pharmacy and pharmacology 20031201

Title: Cefepime versus cefpirome: the importance of creatinine clearance.

Journal: Anesthesia and analgesia 20031001

Title: Post-exposure effects of cefepime and cefpirome on isogenic Escherichia coli hosts producing SHV-extended-spectrum beta-lactamases.

Journal: Journal of chemotherapy (Florence, Italy) 20030801

Title: [Yearly changes in antibacterial activities of cefozopran against various clinical isolates between 1996 and 2001--II. Gram-negative bacteria].

Journal: The Japanese journal of antibiotics 20030801

Title: Target site bacterial killing of cefpirome and fosfomycin in critically ill patients.

Journal: International journal of antimicrobial agents 20030601

Title: Determination of the dissociation constants of the cephalosporins cefepime and cefpirome using UV spectrometry and pH potentiometry.

Journal: Journal of pharmaceutical and biomedical analysis 20030410

Title: [Pharmacokinetics of antibiotics in inflamed and healthy lung tissue].

Journal: Wiener medizinische Wochenschrift (1946) 20030101

Title: [Activity of fourth generation cephalosporins against clinical isolates of Enterobacteriaceae].

Journal: Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20030101

Title: Antimicrobial susceptibility of major pathogens of orofacial odontogenic infections to 11 beta-lactam antibiotics.

Journal: Oral microbiology and immunology 20021001

Title: Cefpirome sulphate for gynaecological infections and prophylaxis of non-laparotomy surgery in patients with benign disease.

Journal: International journal of antimicrobial agents 20020501

Title: [Importance of a cefpirome-vancomycin combination on bactericidal kinetics in severe MRSA infections in intensive care].

Journal: Pathologie-biologie 20020401

Title: Effect of inoculum size on the antibacterial activity of cefpirome and cefepime against Klebsiella pneumoniae strains producing SHV extended-spectrum beta-lactamases.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20011101

Title: A randomized prospective multicentre trial of cefpirome versus piperacillin-tazobactam in febrile neutropenia.

Journal: Leukemia & lymphoma 20010701

Title: In vitro activity of cefpirome and vancomycin in combination against gentamicin-susceptible and gentamicin-resistant Staphylococcus aureus.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20010401

Title: Extension of resistance to cefepime and cefpirome associated to a six amino acid deletion in the H-10 helix of the cephalosporinase of an Enterobacter cloacae clinical isolate.

Journal: FEMS microbiology letters 20010220

Title: Low cefpirome levels during twice daily dosing in critically ill septic patients: pharmacokinetic modelling calls for more frequent dosing.

Journal: Intensive care medicine 20010201

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Tags:98753-19-6 Molecular Formula|98753-19-6 MDL|98753-19-6 SMILES|98753-19-6 1-(((6R,7R)-7-((Z)-2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido)-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl)-6,7-dihydro-5h-cyclopenta[b]pyridin-1-ium hydrogensulfate