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99011-02-6,MFCD00866946
Catalog No.:AA0034XW

99011-02-6 | Imiquimod

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1g
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$19.00   $14.00
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5g
99%
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0034XW
Chemical Name:
Imiquimod
CAS Number:
99011-02-6
Molecular Formula:
C14H16N4
Molecular Weight:
240.3036
MDL Number:
MFCD00866946
SMILES:
CC(Cn1cnc2c1c1ccccc1nc2N)C
Properties
Properties
 
BP:
456.7°C at 760 mmHg  
Form:
Solid  
MP:
292-294°C  
Solubility:
DMSO: soluble  
Storage:
Inert atmosphere;-20 ℃;  

Computed Properties
 
Complexity:
294  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
2.6  

Downstream Synthesis Route

[1]ChemicalandPharmaceuticalBulletin,1996,vol.44,p.709-714

[1]Patent:US2007/100146,2007,A1.Locationinpatent:Page/Pagecolumn3-4

[2]JournalofMedicinalChemistry,2005,vol.48,p.3481-3491

[3]JournalofMedicinalChemistry,2005,vol.48,p.3481-3491

[4]JournalofMedicinalChemistry,2005,vol.48,p.3481-3491

[1]Patent:US2008/194822,2008,A1.Locationinpatent:Page/Pagecolumn2-3

[2]JournalofMedicinalChemistry,2005,vol.48,p.3481-3491

[3]Patent:US2007/135640,2007,A1.Locationinpatent:Page/Pagecolumn4

[4]Patent:US2008/177074,2008,A1.Locationinpatent:Page/Pagecolumn2;4

[5]Patent:US4988815,1991,A

[6]Patent:EP1609792,2005,A1.Locationinpatent:Page/Pagecolumn5

[7]Patent:US2007/135640,2007,A1.Locationinpatent:Page/Pagecolumn3-4

[8]Patent:US2007/135640,2007,A1.Locationinpatent:Page/Pagecolumn4

[9]Patent:US4988815,1991,A

[1]JournalofMedicinalChemistry,2005,vol.48,p.3481-3491

[1]JournalofMedicinalChemistry,2005,vol.48,p.3481-3491

[2]Patent:WO2004/58759,2004,A1.Locationinpatent:Page84

[3]Patent:WO2004/58759,2004,A1.Locationinpatent:Page255

Literature

Title: Athina Angelopoulou, et al. Imiquimod - A toll like receptor 7 agonist - Is an ideal option for management of COVID 19. Environ Res. 2020 Sep; 188: 109858.

Title: Aditya K Gupta, et al. Imiquimod: a review. J Cutan Med Surg. Nov-Dec 2002;6(6):554-60.

Title: Yuji Kan, et al. Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway. J Virol. 2012 Oct;86(19):10338-46.

Title: Michael P Schön, et al. The small antitumoral immune response modifier imiquimod interacts with adenosine receptor signaling in a TLR7- and TLR8-independent fashion. J Invest Dermatol. 2006 Jun;126(6):1338-47.

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SDS
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