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99873-43-5,MFCD01326592
Catalog No.:AA01B128

99873-43-5 | Droxinostat

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Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$19.00   $14.00
- +
5mg
98%
in stock  
$50.00   $35.00
- +
10mg
98%
in stock  
$66.00   $47.00
- +
50mg
98%
in stock  
$221.00   $155.00
- +
100mg
98%
in stock  
$304.00   $213.00
- +
1g
98%
in stock  
$1,016.00   $711.00
- +
  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01B128
Chemical Name:
Droxinostat
CAS Number:
99873-43-5
Molecular Formula:
C11H14ClNO3
Molecular Weight:
243.6868
MDL Number:
MFCD01326592
SMILES:
ONC(=O)CCCOc1ccc(cc1C)Cl
Properties
Computed Properties
 
Complexity:
225  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
2.8  

Literature

Title: 4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide (CMH) targets mRNA of the c-FLIP variants and induces apoptosis in MCF-7 human breast cancer cells.

Journal: Molecular and cellular biochemistry 20100901

Title: Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands.

Journal: Molecular cancer therapeutics 20100101

Title: Liu J, et al. Droxinostat, a Histone Deacetylase Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cell Lines via Activation of the Mitochondrial Pathway and Downregulation of FLIP. Transl Oncol. 2016 Feb;9(1):70-8.

Title: Wood TE et al. Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands. Mol Cancer Ther. 2010 Jan;9(1):246-56.

Title: MMcCourt C, Maxwell P, Mazzucchelli R, Montironi R, Scarpelli M, Salto-Tellez M, O'Sullivan JM, Longley DB, Waugh DJ.,Elevation of c-FLIP in Castrate-Resistant Prostate Cancer Antagonizes Therapeutic Response to Androgen Receptor-Targeted Therapy.,Clin Cancer Res. 2012 Jul 15;18(14):3822-33. Epub 2012 May 23

Title: Bijangi-Vishehsaraei K, Saadatzadeh MR, Huang S, Murphy MP, Safa AR.,4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide (CMH) targets mRNA of the c-FLIP variants and induces apoptosis in MCF-7 human breast cancer cells.,Mol Cell Biochem. 2010 Sep;342(1-2):133-42. Epub 2010 May 6.

Title: Wood TE, Dalili S, Simpson CD, Sukhai MA, Hurren R, Anyiwe K, Mao X, Suarez Saiz F, Gronda M, Eberhard Y, MacLean N, Ketela T, Reed JC, Moffat J, Minden MD, Batey RA, Schimmer AD.,Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands.,Mol Cancer Ther. 2010 Jan;9(1):246-56. Epub 2010 Jan 6.

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