[1]TetrahedronLetters,2003,vol.44,p.1149-1152
[2]TetrahedronLetters,2003,vol.44,p.1149-1152
[1]Patent:US2008/90885,2008,A1.Locationinpatent:Page/Pagecolumn2
[2]Patent:CN104496971,2016,B.Locationinpatent:Paragraph0042-0044
[3]Patent:CN104447899,2017,B.Locationinpatent:Paragraph0119;0120;0121
[1]Patent:WO2006/115834,2006,A1.Locationinpatent:Page/Pagecolumn13
[1]Patent:US2008/90885,2008,A1.Locationinpatent:Page/Pagecolumn2
[2]Patent:WO2006/115834,2006,A1.Locationinpatent:Page/Pagecolumn12-13
Title: Effects of CYP2C9*1/*3 and *1/*13 on the pharmacokinetics of losartan and its active metabolite E-3174.
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Title: High-sensitivity liquid chromatography-tandem mass spectrometry for the simultaneous determination of five drugs and their cytochrome P450-specific probe metabolites in human plasma.
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Title: Pharmacokinetics of losartan and its active carboxylic acid metabolite E-3174 in five ethnic populations of China.
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Journal: European journal of medicinal chemistry 20120401
Title: Pre-treatment with curcumin enhances plasma concentrations of losartan and its metabolite EXP3174 in rats.
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Title: Frequency of CYP2C9 alleles in Koreans and their effects on losartan pharmacokinetics.
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Title: Effects of ticlopidine on pharmacokinetics of losartan and its main metabolite EXP-3174 in rats.
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Title: CYP2C9-mediated metabolic activation of losartan detected by a highly sensitive cell-based screening assay.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110501
Title: Effects of HMG-CoA reductase inhibitors on the pharmacokinetics of losartan and its main metabolite EXP-3174 in rats: possible role of CYP3A4 and P-gp inhibition by HMG-CoA reductase inhibitors.
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Title: Effects of myricetin, an antioxidant, on the pharmacokinetics of losartan and its active metabolite, EXP-3174, in rats: possible role of cytochrome P450 3A4, cytochrome P450 2C9 and P-glycoprotein inhibition by myricetin.
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Title: Hypertension study in anaesthetized rabbits: protocol proposal for AT1 antagonists screening.
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Title: A single-nucleotide polymorphism of alanine to threonine at position 163 of the human angiotensin II type 1 receptor impairs Losartan affinity.
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Title: Effects of the CYP2C9*13 allele on the pharmacokinetics of losartan in healthy male subjects.
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Title: Chronic treatment with losartan results in sufficient serum levels of the metabolite EXP3179 for PPARgamma activation.
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Title: Losartan metabolite EXP3179 blocks NADPH oxidase-mediated superoxide production by inhibiting protein kinase C: potential clinical implications in hypertension.
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Title: Simultaneous determination of losartan, EXP-3174 and hydrochlorothiazide in plasma via fully automated 96-well-format-based solid-phase extraction and liquid chromatography-negative electrospray tandem mass spectrometry.
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Title: Inhibitory effect of 5-fluorouracil on cytochrome P450 2C9 activity in cancer patients.
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Title: Simultaneous determination of losartan and EXP3174 in human plasma and urine utilizing liquid chromatography/tandem mass spectrometry.
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Title: Binding of KRH-594, an antagonist of the angiotensin II type 1 receptor, to cloned human and rat angiotensin II receptors.
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Title: Studies on the antithrombotic action of AT1 receptor antagonists.
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