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Home Aldehydes 114798-36-6
114798-36-6,MFCD00870256
Catalog No.:AA000F5A

114798-36-6 | 1H-Imidazole-5-carboxaldehyde, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$82.00   $57.00
- +
5mg
≥95%
in stock  
$218.00   $152.00
- +
10mg
≥95%
in stock  
$356.00   $249.00
- +
25mg
95%
in stock  
$669.00   $468.00
- +
50mg
95%
in stock  
$1,003.00   $702.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000F5A
Chemical Name:
1H-Imidazole-5-carboxaldehyde, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
CAS Number:
114798-36-6
Molecular Formula:
C22H21ClN6O
Molecular Weight:
420.8947
MDL Number:
MFCD00870256
SMILES:
CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C=O)Cl
Properties
Properties
 
BP:
666.7±65.0 °C(Predicted)  
Form:
Solid  
MP:
84-86°C  
Storage:
2-8℃;Inert atmosphere;  

Computed Properties
 
Complexity:
546  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
8  
XLogP3:
4.9  

Literature

Title: CYP2C9-mediated metabolic activation of losartan detected by a highly sensitive cell-based screening assay.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20110501

Title: Losartan metabolite EXP3179: an AT1-receptor-independent treatment strategy for patients with the metabolic syndrome?

Journal: Hypertension (Dallas, Tex. : 1979) 20091001

Title: Protein kinase C-inhibiting properties of the losartan metabolite EXP3179 make the difference.

Journal: Hypertension (Dallas, Tex. : 1979) 20091001

Title: Chronic treatment with losartan results in sufficient serum levels of the metabolite EXP3179 for PPARgamma activation.

Journal: Hypertension (Dallas, Tex. : 1979) 20091001

Title: Losartan metabolite EXP3179 blocks NADPH oxidase-mediated superoxide production by inhibiting protein kinase C: potential clinical implications in hypertension.

Journal: Hypertension (Dallas, Tex. : 1979) 20091001

Title: EXP3179 inhibits collagen-dependent platelet activation via glycoprotein receptor-VI independent of AT1-receptor antagonism: potential impact on atherothrombosis.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20070501

Title: Regulation of peroxisome proliferator-activated receptor gamma activity by losartan metabolites.

Journal: Hypertension (Dallas, Tex. : 1979) 20060301

Title: Losartan metabolite EXP3179 activates Akt and endothelial nitric oxide synthase via vascular endothelial growth factor receptor-2 in endothelial cells: angiotensin II type 1 receptor-independent effects of EXP3179.

Journal: Circulation 20050920

Title: Angiotensin II AT1 receptor antagonists. Clinical implications of active metabolites.

Journal: Journal of medicinal chemistry 20030605

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SDS
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Tags:114798-36-6 Molecular Formula|114798-36-6 MDL|114798-36-6 SMILES|114798-36-6 1H-Imidazole-5-carboxaldehyde, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-