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Title: Naringenin suppresses TPA-induced tumor invasion by suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells.
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Title: Defining a role for acid sphingomyelinase in the p38/interleukin-6 pathway.
Journal: The Journal of biological chemistry 20140808
Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Journal: The Biochemical journal 20130415
Title: Role of P2X7 receptor-mediated IL-18/IL-18R signaling in morphine tolerance: multiple glial-neuronal dialogues in the rat spinal cord.
Journal: The journal of pain : official journal of the American Pain Society 20121001
Title: Calmodulin kinase II and protein kinase C mediate the effect of increased intracellular calcium to augment late sodium current in rabbit ventricular myocytes.
Journal: American journal of physiology. Cell physiology 20120415
Title: Binding of BIS like and other ligands with the GSK-3β kinase: a combined docking and MM-PBSA study.
Journal: Journal of molecular modeling 20120201
Title: Susceptibility to natural killer cell-mediated lysis of colon cancer cells is enhanced by treatment with epidermal growth factor receptor inhibitors through UL16-binding protein-1 induction.
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Title: High glucose-induced RhoA activation requires caveolae and PKCβ1-mediated ROS generation.
Journal: American journal of physiology. Renal physiology 20120101
Title: Affinity-based chemoproteomics with small molecule-peptide conjugates.
Journal: Methods in molecular biology (Clifton, N.J.) 20120101
Title: Toll-like receptor 3 activation promotes desensitization of histamine response in human gingival fibroblasts: Poly (I:C) induces histamine receptor desensitization in human gingival fibroblasts.
Journal: Cellular immunology 20120101
Title: Phospholipase C and protein kinase C-β 2 mediate insulin-like growth factor II-dependent sphingosine kinase 1 activation.
Journal: Molecular endocrinology (Baltimore, Md.) 20111201
Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.
Journal: Nature biotechnology 20111101
Title: Protein kinase C mediates peroxynitrite toxicity to oligodendrocytes.
Journal: Molecular and cellular neurosciences 20110901
Title: Biophoton emissions from cell cultures: biochemical evidence for the plasma membrane as the primary source.
Journal: General physiology and biophysics 20110901
Title: Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively.
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Title: Secretoneurin stimulates the production and release of luteinizing hormone in mouse L{beta}T2 gonadotropin cells.
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Title: A single amino acid residue controls Ca2+ signaling by an octopamine receptor from Drosophila melanogaster.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110701
Title: Quantitative chemical proteomics in small-scale culture of phorbol ester stimulated basal breast cancer cells.
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Title: The vanilloid capsaicin induces IL-6 secretion in prostate PC-3 cancer cells.
Journal: Cytokine 20110601
Title: Synthesis of N-methyl-bisindolylmaleimide amino acid methyl ester conjugates and cytotoxicity study.
Journal: European journal of medicinal chemistry 20100901
Title: Effect of pravastatin on ventricular arrhythmias in infarcted rats: role of connexin43.
Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20100801
Title: Piscine PTHrP regulation of calcium and phosphate transport in winter flounder renal proximal tubule primary cultures.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20100801
Title: Melatonin potentiates glycine currents through a PLC/PKC signalling pathway in rat retinal ganglion cells.
Journal: The Journal of physiology 20100715
Title: Phorbol ester phorbol-12-myristate-13-acetate induces epithelial to mesenchymal transition in human prostate cancer ARCaPE cells.
Journal: The Prostate 20100701
Title: PKC alpha phosphorylates cytosolic NF-kappaB/p65 and PKC delta delays nuclear translocation of NF-kappaB/p65 in U1242 glioblastoma cells.
Journal: Turkish neurosurgery 20100701
Title: Phosphatidic acid is a leukocyte chemoattractant that acts through S6 kinase signaling.
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Title: Regulation of VDR expression in rat and human intestine and liver--consequences for CYP3A expression.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20100401
Title: Role of HuR and p38MAPK in ultraviolet B-induced post-transcriptional regulation of COX-2 expression in the human keratinocyte cell line HaCaT.
Journal: The Journal of biological chemistry 20100205
Title: Filamin A is required for vimentin-mediated cell adhesion and spreading.
Journal: American journal of physiology. Cell physiology 20100201
Title: Rac/ROS-related protein kinase C and phosphatidylinositol-3-kinase signaling are involved in a negative regulating cascade in B cell activation by antibody-mediated cross-linking of MHC class II molecules.
Journal: Molecular immunology 20100101
Title: Synthesis and antitumor activity of bisindolylmaleimide and amino acid ester conjugates.
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Title: Modulation of K(ATP) currents in rat ventricular myocytes by hypoxia and a redox reaction.
Journal: Acta pharmacologica Sinica 20091001
Title: Negation of the cancer-preventive actions of selenium by over-expression of protein kinase Cepsilon and selenoprotein thioredoxin reductase.
Journal: Carcinogenesis 20090901
Title: Identification of bisindolylmaleimides and indolocarbazoles as inhibitors of HCV replication by tube-capture-RT-PCR.
Journal: Antiviral research 20090801
Title: Inhibition of P2X receptor-mediated inward current by protein kinase C in small-diameter dorsal root ganglion neurons of adult rats.
Journal: Neuroscience bulletin 20090801
Title: Theoretical study of photophysical properties of bisindolylmaleimide derivatives.
Journal: The journal of physical chemistry. A 20090723
Title: Regulation of c-Fos and c-Jun gene expression by phospholipase C activity in adult cardiomyocytes.
Journal: Molecular and cellular biochemistry 20090701
Title: Synthesis and evaluation of novel 7-azaindazolyl-indolyl-maleimide derivatives as antitumor agents and protein kinase C inhibitors.
Journal: Bioorganic & medicinal chemistry 20090701
Title: Calcineurin and cytoskeleton in low-frequency depression.
Journal: Journal of neurochemistry 20090501
Title: Akt demoted in glioblastoma.
Journal: Science signaling 20090421
Title: PKC-dependent stimulation of the human MCT1 promoter involves transcription factor AP2.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20090201
Title: Involvement of GSK-3 in regulation of murine embryonic stem cell self-renewal revealed by a series of bisindolylmaleimides.
Journal: Chemistry & biology 20090130
Title: Peroxynitrite participates in mechanisms involved in capacitation of cryopreserved cattle.
Journal: Animal reproduction science 20090101
Title: Extracellular hypotonicity induces disturbance of sodium currents in rat ventricular myocytes.
Journal: Physiological research 20090101
Title: Effect of inhibitors of mitogen-activated protein kinase kinase on alpha(1B)-adrenoceptor phosphorylation.
Journal: Autonomic & autacoid pharmacology 20090101
Title: Mechanism of ethanol-induced insulin secretion from INS-1 and INS-1E tumor cell lines.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20090101
Title: YQ36: a novel bisindolylmaleimide analogue induces KB/VCR cell death.
Journal: Journal of biomedicine & biotechnology 20090101
Title: Ectodomain cleavage of the EGF ligands HB-EGF, neuregulin1-beta, and TGF-alpha is specifically triggered by different stimuli and involves different PKC isoenzymes.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20081201
Title: Small-molecule inhibitors of PDK1.
Journal: ChemMedChem 20081201
Title: Design and synthesis of AX4697, a bisindolylmaleimide exo-affinity probe that labels protein kinase C alpha and beta.
Journal: Bioorganic & medicinal chemistry letters 20081115
Title: Melatonin receptor-mediated protection against myocardial ischaemia/reperfusion injury: role of its anti-adrenergic actions.
Journal: Journal of pineal research 20081101
Title: Substrate-induced changes in the density of peptide transporter PEPT1 expressed in Xenopus oocytes.
Journal: American journal of physiology. Cell physiology 20081101
Title: Testosterone and dihydrotestosterone inhibit gallbladder motility through multiple signalling pathways.
Journal: Steroids 20081001
Title: Vasoactive intestinal peptide increases cystic fibrosis transmembrane conductance regulator levels in the apical membrane of Calu-3 cells through a protein kinase C-dependent mechanism.
Journal: The Journal of pharmacology and experimental therapeutics 20081001
Title: Activity of protein kinase C is important for 3alpha,5alpha-THP's actions at dopamine type 1-like and/or GABAA receptors in the ventral tegmental area for lordosis of rats.
Journal: Brain research bulletin 20080930
Title: Apical adenosine regulates basolateral Ca2+-activated potassium channels in human airway Calu-3 epithelial cells.
Journal: American journal of physiology. Cell physiology 20080601
Title: A direct redox regulation of protein kinase C isoenzymes mediates oxidant-induced neuritogenesis in PC12 cells.
Journal: The Journal of biological chemistry 20080523
Title: Aryl-indolyl maleimides as inhibitors of CaMKIIdelta. Part 2: SAR of the amine tether.
Journal: Bioorganic & medicinal chemistry letters 20080401
Title: Galectin-1 upregulates glucose transporter-1 expression level via protein kinase C, phosphoinositol-3 kinase, and mammalian target of rapamycin pathways in mouse embryonic stem cells.
Journal: The international journal of biochemistry & cell biology 20080101
Title: Bisindolylmaleimides in anti-cancer therapy - more than PKC inhibitors.
Journal: Advances in medical sciences 20080101
Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20071218
Title: Effects of protein kinase C activation on cardiac repolarization and arrhythmogenesis in Langendorff-perfused rabbit hearts.
Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20071101
Title: Effects of polychlorinated biphenyls (PCBs) on expression of neurotrophic factors in C6 glial cells in culture.
Journal: Neurotoxicology 20071101
Title: Effect of parathyroid-hormone-related protein on human platelet activation.
Journal: Clinical science (London, England : 1979) 20071001
Title: Effect of phorbol ester and platelet-derived growth factor on protein kinase C in rat hepatic stellate cells.
Journal: Liver international : official journal of the International Association for the Study of the Liver 20071001
Title: Implication of PKC in the seasonal variation of the immune response of the hemocytes of Mytilus galloprovincialis Lmk. and its role in interleukin-2-induced nitric oxide synthesis.
Journal: IUBMB life 20071001
Title: Novel bisindolylmaleimide derivative inhibits mitochondrial permeability transition pore and protects the heart from reperfusion injury.
Journal: Canadian journal of physiology and pharmacology 20071001
Title: In the ventral tegmental area, the membrane-mediated actions of progestins for lordosis of hormone-primed hamsters involve phospholipase C and protein kinase C.
Journal: Journal of neuroendocrinology 20070901
Title: Protein kinase C beta inhibition: the promise for treatment of diabetic nephropathy.
Journal: Current opinion in nephrology and hypertension 20070901
Title: Bisindolylmaleimides with large Stokes shift and long-lasting chemiluminescence properties.
Journal: Organic letters 20070830
Title: A novel bisindolylmaleimide derivative enhances functional recovery of heart after long-term hypothermic heart preservation.
Journal: Transplantation 20070627
Title: NMDA receptor-mediated extracellular adenosine accumulation is blocked by phosphatase 1/2A inhibitors.
Journal: Brain research 20070625
Title: Adrenergic control of a constitutively active acetylcholine-regulated potassium current in canine atrial cardiomyocytes.
Journal: Cardiovascular research 20070601
Title: Potentiation of glutamatergic synaptic transmission by protein kinase C-mediated sensitization of TRPV1 at the first sensory synapse.
Journal: The Journal of physiology 20070601
Title: Downregulation of the reduced folate carrier transport activity by phenobarbital-type cytochrome P450 inducers and protein kinase C activators.
Journal: Biochimica et biophysica acta 20070601
Title: Inhibition of ABCG2-mediated transport by protein kinase inhibitors with a bisindolylmaleimide or indolocarbazole structure.
Journal: Molecular cancer therapeutics 20070601
Title: ERK-dependent and -independent pathways trigger human neural progenitor cell migration.
Journal: Toxicology and applied pharmacology 20070515
Title: The role of proline-rich protein tyrosine kinase 2 in differentiation-dependent signaling in human epidermal keratinocytes.
Journal: The Journal of investigative dermatology 20070501
Title: Sphingosylphosphorylcholine-induced interleukin-6 production is mediated by protein kinase C and p42/44 extracellular signal-regulated kinase in human dermal fibroblasts.
Journal: Journal of dermatological science 20070501
Title: The PKC inhibitor, bisindolymaleimide, blocks DOI's attenuation of the effects of 8-OH-DPAT on female rat lordosis behavior.
Journal: Behavioural brain research 20070416
Title: Signaling mechanisms leading to regulation of proliferation and differentiation of the mesenchymal chondrogenic cell line RCJ3.1C5.18 in response to IGF-I.
Journal: Journal of molecular endocrinology 20070401
Title: Cross-regulation of VPAC(2) receptor desensitization by M(3) receptors via PKC-mediated phosphorylation of RKIP and inhibition of GRK2.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20070301
Title: Restoration of diabetes-induced abnormal local Ca2+ release in cardiomyocytes by angiotensin II receptor blockade.
Journal: American journal of physiology. Heart and circulatory physiology 20070201
Title: Effects of calmodulin and protein kinase C modulators on transient Ca2+ increase and capacitative Ca2+ entry in human platelets: relevant to pathophysiology of bipolar disorder.
Journal: Progress in neuro-psychopharmacology & biological psychiatry 20070130
Title: Differential regulation of CREB and ERK phosphorylation through corticotropin-releasing factor receptors type 1 and 2 in AtT-20 and A7r5 cells.
Journal: Molecular and cellular endocrinology 20070115
Title: Dual mechanism of autoregulation of protein kinase C in myocardial ischemia.
Journal: Molecular and cellular biochemistry 20070101
Title: Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition.
Journal: Journal of medicinal chemistry 20061214
Title: [Phosphorylation of PKCdelta participates in the toxicity of 6-hydroxydopamine on dopaminergic neuroblastoma cell].
Journal: Zhonghua yi xue za zhi 20061205
Title: Signal pathways involved in the regulation of prostaglandin E synthase-1 in human gingival fibroblasts.
Journal: Cellular signalling 20061201
Title: Structure of the catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor.
Journal: Biochemistry 20061128
Title: A practical method for the synthesis of indolylaryl- and bisindolylmaleimides.
Journal: Organic letters 20061012
Title: Mechanism of inhibition of TREK-2 (K2P10.1) by the Gq-coupled M3 muscarinic receptor.
Journal: American journal of physiology. Cell physiology 20061001
Title: Propofol inhibits phorbol 12, 13-dibutyrate-induced, protein kinase C-mediated contraction of rat aortic smooth muscle.
Journal: Acta anaesthesiologica Scandinavica 20061001
Title: Reactive oxygen species mediated sustained activation of protein kinase C alpha and extracellular signal-regulated kinase for migration of human hepatoma cell Hepg2.
Journal: Molecular cancer research : MCR 20061001
Title: The chemiluminescence mechanism of 3,4-bis(3-indolyl)-1H-pyrrole-2,5-dione, and the characteristics of chemiluminescence developed in the reaction with CH(3)CNH(2)O(2)NaOH.
Journal: Talanta 20060815
Title: Activation of extracellular signal-regulated kinase (ERK) in G2 phase delays mitotic entry through p21CIP1.
Journal: Cell proliferation 20060801
Title: The regulatory mechanism by which interleukin-6 stimulates GH-gene expression in rat GH3 cells.
Journal: The Journal of endocrinology 20060801
Title: Role of the sodium-dependent phosphate co-transporters and of the phosphate complexes of uranyl in the cytotoxicity of uranium in LLC-PK1 cells.
Journal: Toxicology and applied pharmacology 20060715
Title: Bryostatin enhancement of memory in Hermissenda.
Journal: The Biological bulletin 20060601
Title: Roles of Ca2+ and protein kinase C in the excitatory response to serotonin in embryonic molluscan ciliary cells.
Journal: Canadian journal of physiology and pharmacology 20060601
Title: Optimal Sox-based fluorescent chemosensor design for serine/threonine protein kinases.
Journal: Analytical biochemistry 20060515
Title: Infection of HEp2 epithelial cells with Candida albicans: adherence and postadherence events.
Journal: FEMS immunology and medical microbiology 20060401
Title: Effects of tyrosine phosphorylation of cortactin on podosome formation in A7r5 vascular smooth muscle cells.
Journal: American journal of physiology. Cell physiology 20060201
Title: Involvement of reduced sensitivity to Ca in beta-adrenergic action on airway smooth muscle.
Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20060201
Title: Development of autonomic receptors and their function in the chick heart and influence of continuous infusion of carbachol.
Journal: Prague medical report 20060101
Title: Role of protein kinase C in hydroxyapatite- induced phagocytosis by a murine macrophage cell line (RAW264.7).
Journal: Immunopharmacology and immunotoxicology 20060101
Title: Differential actin isoform reorganization in the contracting A7r5 cell.
Journal: Canadian journal of physiology and pharmacology 20060101
Title: Psychoactive substrates stimulate dopamine transporter phosphorylation and down-regulation by cocaine-sensitive and protein kinase C-dependent mechanisms.
Journal: The Journal of biological chemistry 20051209
Title: Pityriarubins, novel highly selective inhibitors of respiratory burst from cultures of the yeast Malassezia furfur: comparison with the bisindolylmaleimide arcyriarubin A.
Journal: Chembiochem : a European journal of chemical biology 20051201
Title: Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase.
Journal: Journal of medicinal chemistry 20051201
Title: Suppression of protein kinase Cepsilon mediates 17beta-estradiol-induced neuroprotection in an immortalized hippocampal cell line.
Journal: Journal of neurochemistry 20051101
Title: Configurational stability of bisindolylmaleimide cyclophanes: from conformers to the first configurationally stable, atropisomeric bisindolylmaleimides.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20051021
Title: Enhanced ubiquitylation and accelerated degradation of the dopamine transporter mediated by protein kinase C.
Journal: The Journal of biological chemistry 20051021
Title: Inhibitory effects of 12-O-tetradecanoylphorbol-13-acetate alone or in combination with all-trans retinoic acid on the growth of cultured human pancreas cancer cells and pancreas tumor xenografts in immunodeficient mice.
Journal: The Journal of pharmacology and experimental therapeutics 20051001
Title: Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif.
Journal: Journal of molecular biology 20050930
Title: The role of PKCalpha and RLIP76 in transport-mediated doxorubicin-resistance in lung cancer.
Journal: FEBS letters 20050829
Title: Keratin 8 phosphorylation by protein kinase C delta regulates shear stress-mediated disassembly of keratin intermediate filaments in alveolar epithelial cells.
Journal: The Journal of biological chemistry 20050826
Title: Sequential phosphorylation mediates receptor- and kinase-induced inhibition of TREK-1 background potassium channels.
Journal: The Journal of biological chemistry 20050826
Title: Comparison of the ATP binding sites of protein kinases using conformationally diverse bisindolylmaleimides.
Journal: Journal of the American Chemical Society 20050824
Title: PKC-dependent, burn-induced adherens junction reorganization and barrier dysfunction in pulmonary microvascular endothelial cells.
Journal: American journal of physiology. Lung cellular and molecular physiology 20050801
Title: Angiotensin II induced increase in frequency of cytosolic and nuclear calcium waves of heart cells via activation of AT1 and AT2 receptors.
Journal: Peptides 20050801
Title: Angiotensin II-induced increase of T-type Ca2+ current and decrease of L-type Ca2+ current in heart cells.
Journal: Peptides 20050801
Title: Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons.
Journal: Brain : a journal of neurology 20050701
Title: Activity-dependent subcellular localization of NAC1.
Journal: The European journal of neuroscience 20050701
Title: PKC alpha-dependent regulation of the IGF1 receptor in adult and embryonic rat cardiomyocytes.
Journal: Molecular and cellular biochemistry 20050701
Title: The protein kinase C inhibitor, bisindolylmaleimide (I), inhibits voltage-dependent K+ channels in coronary arterial smooth muscle cells.
Journal: Life sciences 20050617
Title: Structure-activity relationship of N-methyl-bisindolylmaleimide derivatives as cell death inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20050615
Title: New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum.
Journal: Bioorganic & medicinal chemistry letters 20050602
Title: Sphingosine 1-phosphate protects mouse extensor digitorum longus skeletal muscle during fatigue.
Journal: American journal of physiology. Cell physiology 20050601
Title: The interaction of isoflurane and protein kinase C-activators on sarcolemmal KATP channels.
Journal: Anesthesia and analgesia 20050601
Title: Production of NGF, BDNF and GDNF in mouse astrocyte cultures is strongly enhanced by a cerebral vasodilator, ifenprodil.
Journal: Neuroscience letters 20050513
Title: Insulin stimulates Ca2+ uptake via PKC, cAMP, and p38 MAPK in mouse embryonic stem cells.
Journal: Life sciences 20050506
Title: Exaggerated coronary vasoreactivity to endothelin-1 in aged rats: role of protein kinase C.
Journal: Cardiovascular research 20050501
Title: Positive and negative transcriptional regulation of aromatase expression in human breast cancer tissue.
Journal: The Journal of steroid biochemistry and molecular biology 20050501
Title: Galphaq potentiation of adenylate cyclase type 9 activity through a Ca2+/calmodulin-dependent pathway.
Journal: Biochemical pharmacology 20050415
Title: IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner.
Journal: The Journal of biological chemistry 20050408
Title: Bradykinin upregulates IL-8 production in human gingival fibroblasts stimulated by interleukin-1beta and tumor necrosis factor alpha.
Journal: Regulatory peptides 20050330
Title: Casein kinase II (CK2) enhances death-inducing signaling complex (DISC) activity in TRAIL-induced apoptosis in human colon carcinoma cell lines.
Journal: Oncogene 20050317
Title: In vivo effects of protein kinase and phosphatase inhibitors on CYP2B induction in rat liver.
Journal: Toxicology 20050214
Title: Moraxella catarrhalis--infected alveolar epithelium induced monocyte recruitment and oxidative burst.
Journal: American journal of respiratory cell and molecular biology 20050201
Title: Atypical protein kinase C is a novel mediator of dopamine-enhanced firing in nucleus accumbens neurons.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050126
Title: Activation of protein kinase C alpha is required for TPA-triggered ERK (MAPK) signaling and growth inhibition of human hepatoma cell HepG2.
Journal: Journal of biomedical science 20050101
Title: Prevotella intermedia lipopolysaccharide stimulates release of nitric oxide by inducing expression of inducible nitric oxide synthase.
Journal: Journal of periodontal research 20041201
Title: Specificity of action of bisindolylmaleimide protein kinase C inhibitors: do they inhibit the 70kDa ribosomal S6 kinase in cardiac myocytes?
Journal: Biochemical pharmacology 20041115
Title: Autocrine transforming growth factor alpha regulates cell adhesion by multiple signaling via specific phosphorylation sites of p70S6 kinase in colon cancer cells.
Journal: The Journal of biological chemistry 20041105
Title: Protein kinase C inhibitors produce mitochondrial flavoprotein oxidation in cardiac myocytes.
Journal: Anesthesia and analgesia 20041101
Title: Synthesis of anilino-monoindolylmaleimides as potent and selective PKCbeta inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20041018
Title: Evaluation of alternative approaches for the synthesis of macrocyclic bisindolylmaleimides.
Journal: Organic & biomolecular chemistry 20041007
Title: Reversible connexin 43 dephosphorylation during hypoxia and reoxygenation is linked to cellular ATP levels.
Journal: Circulation research 20041001
Title: Inhibition of Chk1 by the G2 DNA damage checkpoint inhibitor isogranulatimide.
Journal: Molecular cancer therapeutics 20041001
Title: Deregulation of PKB influences antiapoptotic signaling by PKC in breast cancer cells.
Journal: International journal of oncology 20040901
Title: Development of a respiratory burst assay using zebrafish kidneys and embryos.
Journal: Journal of immunological methods 20040901
Title: Involvement of MAP-kinase, PI3-kinase and EGF-receptor in the stimulatory effect of Neurotensin on DNA synthesis in PC3 cells.
Journal: Regulatory peptides 20040815
Title: Atypical protein-kinase Czeta, but neither conventional Ca2+ -dependent protein-kinase C isoenzymes nor Ca2+ -calmodulin, participates in regulation of telomerase activity in Burkitt's lymphoma cells.
Journal: Cancer chemotherapy and pharmacology 20040801
Title: LDL oxidized by hypochlorous acid causes irreversible platelet aggregation when combined with low levels of ADP, thrombin, epinephrine, or macrophage-derived chemokine (CCL22).
Journal: Blood 20040715
Title: Gender differences in ANG II levels and action on multiple K+ current modulation pathways in diabetic rats.
Journal: American journal of physiology. Heart and circulatory physiology 20040701
Title: PKC-epsilon regulation of extracellular signal-regulated kinase: a potential role in phenylephrine-induced cardiocyte growth.
Journal: American journal of physiology. Heart and circulatory physiology 20040601
Title: Injured brain endothelial cells release neurotoxic thrombin.
Journal: Journal of Alzheimer's disease : JAD 20040601
Title: Prostaglandin F2alpha amplifies tumor necrosis factor-alpha promoter activity by the FPB prostanoid receptor.
Journal: Biochemical and biophysical research communications 20040514
Title: Towards configurationally stable bisindolylmaleimide cyclophanes: potential tools for investigating protein kinase function.
Journal: Chemical communications (Cambridge, England) 20040507
Title: Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors.
Journal: Molecular & cellular proteomics : MCP 20040501
Title: Substance P can stimulate prostaglandin D2 and leukotriene C4 generation without granule exocytosis in murine mast cells.
Journal: European journal of pharmacology 20040405
Title: Deletion mutant of FGFR4 induces onion-like membrane structures in the nucleus.
Journal: Journal of cell science 20040401
Title: Evidence of a role for TRPC channels in VEGF-mediated increased vascular permeability in vivo.
Journal: American journal of physiology. Heart and circulatory physiology 20040301
Title: Interactions of LY333531 and other bisindolyl maleimide inhibitors with PDK1.
Journal: Structure (London, England : 1993) 20040201
Title: Direct block by bisindolylmaleimide of the voltage-dependent K+ currents of rat mesenteric arterial smooth muscle.
Journal: European journal of pharmacology 20040112
Title: Novel form of LTD induced by transient, partial inhibition of the Na,K-pump in rat hippocampal CA1 cells.
Journal: Journal of neurophysiology 20040101
Title: Topical application of a protein kinase C inhibitor reduces skin and hair pigmentation.
Journal: The Journal of investigative dermatology 20040101
Title: Signal transduction pathway in endothelial dysfunction.
Journal: Surgical infections 20040101
Title: Cell surface receptors activate p21-activated kinase 1 via multiple Ras and PI3-kinase-dependent pathways.
Journal: Cellular signalling 20031201
Title: Sensitization of adenylate cyclase by short-term activation of 5-HT1A receptors.
Journal: Cellular signalling 20031201
Title: 1,10-Phenanthroline phosphorylates (activates) MAP kinase in Xenopus oocytes.
Journal: Cellular signalling 20031201
Title: Bisindolylmaleimide IX is a potent inducer of apoptosis in chronic lymphocytic leukaemic cells and activates cleavage of Mcl-1.
Journal: Leukemia 20031001
Title: Macrocyclic bisindolylmaleimides as inhibitors of protein kinase C and glycogen synthase kinase-3.
Journal: Bioorganic & medicinal chemistry letters 20030915
Title: Agonist function of the neurokinin receptor antagonist, [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, in monocytes.
Journal: Regulatory peptides 20030915
Title: ATP augments peptide release from rat sensory neurons in culture through activation of P2Y receptors.
Journal: The Journal of pharmacology and experimental therapeutics 20030901
Title: Protein kinase C-mediated Ca2+ entry in HEK 293 cells transiently expressing human TRPV4.
Journal: British journal of pharmacology 20030901
Title: Distinct mechanisms mediate the initial and sustained phases of cell migration in epidermal growth factor receptor-overexpressing cells.
Journal: Molecular cancer research : MCR 20030901
Title: Differential effects of calmodulin and protein kinase C antagonists on bone resorption and acid transport activity.
Journal: Calcified tissue international 20030901
Title: Human beta(3)-adrenoreceptors couple to KvLQT1/MinK potassium channels in Xenopus oocytes via protein kinase C phosphorylation of the KvLQT1 protein.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20030801
Title: Ca(2+)-independent protein kinase C activity is required for alpha1-adrenergic-receptor-mediated regulation of ribosomal protein S6 kinases in adult cardiomyocytes.
Journal: The Biochemical journal 20030715
Title: Regulation of hyaluronan secretion into rabbit synovial joints in vivo by protein kinase C.
Journal: The Journal of physiology 20030715
Title: Role of protein kinase C, Ca2+/calmodulin-dependent protein kinase II, and mitogen-activated protein kinases in volatile anesthetic-induced relaxation in newborn rabbit pulmonary artery.
Journal: Anesthesiology 20030701
Title: High glucose potentiates palmitate-induced NO-mediated cytotoxicity through generation of superoxide in clonal beta-cell HIT-T15.
Journal: FEBS letters 20030619
Title: Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCbeta.
Journal: Bioorganic & medicinal chemistry letters 20030602
Title: Vitamin D enhances mitogenesis mediated by keratinocyte growth factor receptor in keratinocytes.
Journal: Journal of cellular biochemistry 20030601
Title: Cocaine produces cardiac hypertrophy by protein kinase C dependent mechanisms.
Journal: Journal of cardiovascular pharmacology and therapeutics 20030601
Title: Incadronate amplifies prostaglandin F2 alpha-induced vascular endothelial growth factor synthesis in osteoblasts. Enhancement of MAPK activity.
Journal: The Journal of biological chemistry 20030523
Title: Interferon-gamma stimulates the expression of the inducible cAMP early repressor in macrophages through the activation of casein kinase 2. A potentially novel pathway for interferon-gamma-mediated inhibition of gene transcription.
Journal: The Journal of biological chemistry 20030516
Title: Multiprotein bridging factor 1 cooperates with c-Jun and is necessary for cardiac hypertrophy in vitro.
Journal: Experimental cell research 20030515
Title: Prostaglandin F(2alpha) stimulation of cyclooxygenase-2 promoter activity by the FP(B) prostanoid receptor.
Journal: European journal of pharmacology 20030328
Title: Role of Na+/H+ exchanger in acetylcholine-mediated pulmonary artery contraction of spontaneously hypertensive rats.
Journal: European journal of pharmacology 20030319
Title: Facilitation of fas mediated apoptosis of human chondrocytes by the proteasome inhibitor and actinomycin D.
Journal: The Journal of rheumatology 20030301
Title: Metabotropic glutamate receptors activate phospholipase D in astrocytes through a protein kinase C-dependent and Rho-independent pathway.
Journal: Neuropharmacology 20030201
Title: Activation of microglia with lipopolysaccharide leads to the prolonged decrease of conventional protein kinase C activity.
Journal: Brain research. Molecular brain research 20030131
Title: Role of protein kinase C-angiotensin II pathway for extracellular matrix production in cultured human mesangial cells exposed to high glucose levels.
Journal: Diabetes research and clinical practice 20030101
Title: ETA, mixed ETA/ETB receptor antagonists, and protein kinase C inhibitor prevent acute hypoxic pulmonary vasoconstriction: influence of potassium channels.
Journal: Journal of cardiovascular pharmacology 20030101
Title: Pityrialactone- a new fluorochrome from the tryptophan metabolism of Malassezia furfur.
Journal: Antonie van Leeuwenhoek 20030101
Title: Phospholipase C axis is the preferential pathway leading to PKC activation following PTH or PTHrP stimulation in human term placenta.
Journal: Life sciences 20021129
Title: Activation of proteinase-activated receptor 1 stimulates epithelial chloride secretion through a unique MAP kinase- and cyclo-oxygenase-dependent pathway.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20021001
Title: Protein kinase C mediates potentiation of synaptic transmission by phorbol ester at parallel fibers in the dorsal cochlear nucleus.
Journal: Brain research 20020927
Title: Protein kinase C(alpha) is required for vanilloid receptor 1 activation. Evidence for multiple signaling pathways.
Journal: The Journal of biological chemistry 20020920
Title: Bisindolylmaleimide IX facilitates tumor necrosis factor receptor family-mediated cell death and acts as an inhibitor of transcription.
Journal: The Journal of biological chemistry 20020906
Title: Role of protein phosphatases in hypoxic preconditioning.
Journal: American journal of physiology. Heart and circulatory physiology 20020901
Title: Bisindolylmaleimide VIII enhances DR5-mediated apoptosis through the MKK4/JNK/p38 kinase and the mitochondrial pathways.
Journal: The Journal of biological chemistry 20020809
Title: Acid- and bile-induced PGE(2) release and hyperproliferation in Barrett's esophagus are COX-2 and PKC-epsilon dependent.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20020801
Title: Effect of Cu,Zn superoxide dismutase on cholesterol metabolism in human hepatocarcinoma (HepG2) cells.
Journal: Biochemical and biophysical research communications 20020719
Title: Ca(2+)-calmodulin-dependent protein kinase II plays a major role in halothane-induced dose-dependent relaxation in the skinned pulmonary artery.
Journal: Anesthesiology 20020701
Title: Angiotensin II inhibits renin gene transcription via the protein kinase C pathway.
Journal: Pflugers Archiv : European journal of physiology 20020701
Title: Chromaffin cell catecholamine secretion: bisindolylmaleimide compounds exhibit novel and potent antagonist effects at the nicotinic cholinergic receptor in pheochromocytoma cells.
Journal: Molecular pharmacology 20020601
Title: Divergent pathways account for two distinct effects of amyloid beta peptides on exocytosis and Ca(2+) currents: involvement of ROS and NF-kappaB.
Journal: Journal of neurochemistry 20020601
Title: Phosphorylation of the salivary Na(+)-K(+)-2Cl(-) cotransporter.
Journal: American journal of physiology. Cell physiology 20020401
Title: Nitric oxide production by a murine macrophage cell line (RAW264.7) stimulated with lipopolysaccharide from Actinobacillus actinomycetemcomitans.
Journal: Oral microbiology and immunology 20020401
Title: Intracellular Ca(2+) modulation of ATP-sensitive K(+) channel activity in acetylcholine-induced activation of rat pancreatic beta-cells.
Journal: Endocrinology 20020201
Title: myo-Inositol 1,4,5-trisphosphate and Ca(2+)/calmodulin-dependent factors mediate transduction of compression-induced signals in bovine articular chondrocytes.
Journal: The Biochemical journal 20020201
Title: Time-dependent potentiation of the beta-cell is a Ca2+-independent phenomenon.
Journal: The Journal of endocrinology 20020201
Title: Regulation of transepithelial phosphate transport by PTH in chicken proximal tubule epithelium.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20020101
Title: Role of PKC in isoflurane-induced biphasic contraction in skinned pulmonary arterial strips.
Journal: Anesthesiology 20020101
Title: The N-formylpeptide receptor (FPR) and a second G(i)-coupled receptor mediate fMet-Leu-Phe-stimulated activation of NADPH oxidase in murine neutrophils.
Journal: Cellular immunology 20020101
Title: Insulin increases plasma membrane content and reduces phosphorylation of Na(+)-K(+) pump alpha(1)-subunit in HEK-293 cells.
Journal: American journal of physiology. Cell physiology 20011201
Title: Accelerating the induction of Fas-mediated T cell apoptosis: a strategy for transplant tolerance?
Journal: Clinical and experimental immunology 20011201
Title: Different subtypes of alpha1-adrenoceptor modulate different K+ currents via different signaling pathways in canine ventricular myocytes.
Journal: The Journal of biological chemistry 20011102
Title: Protein kinase C suppresses rat organic anion transporting polypeptide 1- and 2-mediated uptake.
Journal: The Journal of pharmacology and experimental therapeutics 20011101
Title: Regulation and mechanism of L-type calcium channel activation via V1a vasopressin receptor activation in cultured cortical neurons.
Journal: Neurobiology of learning and memory 20011101
Title: Synthesis and biological evaluation of novel bisindolylmaleimides that inhibit vascular endothelial cell proliferation.
Journal: Bioorganic & medicinal chemistry letters 20011022
Title: Protein kinase c increases the apparent affinity of the release machinery to Ca2+ by enhancing the release machinery downstream of the Ca2+ sensor.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20011015
Title: Agonist-induced signaling, desensitization, and internalization of a phosphorylation-deficient AT1A angiotensin receptor.
Journal: The Journal of biological chemistry 20011012
Title: Down-regulation of protein kinase C activity by sorbitol rapidly induces apoptosis in human gastric cancer cell lines.
Journal: Apoptosis : an international journal on programmed cell death 20011001
Title: Pulmonary artery vasoconstriction but not [Ca2+]i signal stimulated by thromboxane A2 is partially resistant to NO.
Journal: Pediatric research 20011001
Title: Major vault protein is a substrate of endogenous protein kinases in CHO and PC12 cells.
Journal: Biological chemistry 20011001
Title: Inhibition of the glutamate transporter EAAC1 expressed in Xenopus oocytes by phorbol esters.
Journal: Brain research 20010928
Title: Involvement of protein kinase C-delta in DNA damage-induced apoptosis.
Journal: Cell death and differentiation 20010901
Title: Effects of hydrogen peroxide on the transient outward current in rabbit atrial myocytes.
Journal: Clinical and experimental pharmacology & physiology 20010901
Title: Induction of B(1)-kinin receptors in vascular smooth muscle cells: cellular mechanisms of map kinase activation.
Journal: Hypertension (Dallas, Tex. : 1979) 20010901
Title: The protein kinase C pathway inhibits iodide uptake by calf thyroid cells via sodium potassium-adenosine triphosphatase.
Journal: Thyroid : official journal of the American Thyroid Association 20010901
Title: Rapid fusion of granules with neutrophil cell membranes in hypertensive patients may increase vascular damage.
Journal: American journal of hypertension 20010901
Title: Role of lysophosphatidylcholine in the desensitization of beta-adrenergic receptors by Ca(2+) sensitization in tracheal smooth muscle.
Journal: American journal of respiratory cell and molecular biology 20010901
Title: Neurotrophin secretion from cultured microglia.
Journal: Journal of neuroscience research 20010815
Title: Protein kinase C epsilon suppresses Abeta production and promotes activation of alpha-secretase.
Journal: Biochemical and biophysical research communications 20010727
Title: Evidence that protein kinase C (PKC) participates in the meiosis I to meiosis II transition in mouse oocytes.
Journal: Developmental biology 20010715
Title: In vivo mechanisms of vascular endothelial growth factor-mediated increased hydraulic conductivity of Rana capillaries.
Journal: The Journal of physiology 20010715
Title: Heat shock prevents simulated ischemia-induced apoptosis in renal tubular cells via a PKC-dependent mechanism.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20010701
Title: Antigonadotropic action of adenosine triphosphate in human granulosa-luteal cells: involvement of protein kinase Calpha.
Journal: The Journal of clinical endocrinology and metabolism 20010701
Title: Albumin in the mg/l-range activates NF-kappaB in renal proximal tubule-derived cell lines via tyrosine kinases and protein kinase C.
Journal: European journal of medical research 20010628
Title: Receptor-mediated inhibition of G protein-coupled inwardly rectifying potassium channels involves G(alpha)q family subunits, phospholipase C, and a readily diffusible messenger.
Journal: The Journal of biological chemistry 20010518
Title: Targeted inhibition of calcineurin signaling blocks calcium-dependent reactivation of Kaposi sarcoma-associated herpesvirus.
Journal: Blood 20010415
Title: Use of A-192621 to provide evidence for involvement of endothelin ET(B)-receptors in endothelin-1-mediated cardiomyocyte hypertrophy.
Journal: European journal of pharmacology 20010413
Title: Down-regulation of Na-K-Cl cotransport by protein kinase C is mediated by protein phosphatase 1 in pigmented ciliary epithelial cells.
Journal: Experimental eye research 20010401
Title: Interaction of CD163 with the regulatory subunit of casein kinase II (CKII) and dependence of CD163 signaling on CKII and protein kinase C.
Journal: European journal of immunology 20010401
Title: The role of protein kinase C in the regulation of serotonin-2A receptor expression.
Journal: Journal of neurochemistry 20010401
Title: Cyclization strategies for the synthesis of macrocyclic bisindolylmaleimides.
Journal: The Journal of organic chemistry 20010323
Title: Sp1-p53 heterocomplex mediates activation of HTLV-I long terminal repeat by 12-O-tetradecanoylphorbol-13-acetate that is antagonized by protein kinase C.
Journal: Virology 20010301
Title: Ceramide-induced cell death in the prostate cancer cell line LNCaP has both necrotic and apoptotic features.
Journal: The Prostate 20010301
Title: Protein kinase C-dependent and -independent inhibition of Ca(2+) influx by phorbol ester in rat pancreatic beta-cells.
Journal: Cellular signalling 20010301
Title: Potent direct inhibition of mammalian phospholipase D isoenzymes by calphostin-c.
Journal: Biochemistry 20010227
Title: Signaling events mediating the additive effects of oleic acid and angiotensin II on vascular smooth muscle cell migration.
Journal: Hypertension (Dallas, Tex. : 1979) 20010201
Title: Differential sensitivity of breast cancer cells to tumor necrosis factor-alpha: involvement of protein kinase C.
Journal: Biochemical and biophysical research communications 20010126
Title: A proposed mechanism for the potentiation of cAMP-mediated acid secretion by carbachol.
Journal: American journal of physiology. Cell physiology 20010101
Title: Induction of vanilloid receptor channel activity by protein kinase C.
Journal: Nature 20001201
Title: Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Journal: The Biochemical journal 20001001
Title: Transcriptional activation of the human manganese superoxide dismutase gene mediated by tetradecanoylphorbol acetate.
Journal: The Journal of biological chemistry 19991224
Title: Tumor necrosis factor-alpha stimulates attachment of small cell lung carcinoma to endothelial cells.
Journal: The Journal of laboratory and clinical medicine 19990301
Title: Calcium-mediated second messengers modulate the expression of behavioral sensitization to cocaine.
Journal: The Journal of pharmacology and experimental therapeutics 19980901
Title: Design of new inhibitors for cdc2 kinase based on a multiple pseudosubstrate structure.
Journal: Bioorganic & medicinal chemistry letters 19980505
Title: Protein kinase C activity is required for aryl hydrocarbon receptor pathway-mediated signal transduction.
Journal: Molecular pharmacology 19980401
Title: Transcriptional activity of the hamster CYP11B2 promoter in NCI-H295 cells stimulated by angiotensin II, potassium, forskolin and bisindolylmaleimide.
Journal: Journal of molecular endocrinology 19980401
Title: Inhibition of telomerase activity by PKC inhibitors in human nasopharyngeal cancer cells in culture.
Journal: Biochemical and biophysical research communications 19971229
Title: Davis PD, et al. Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. J Med Chem. 1992 Jan;35(1):177-84.
Title: Slater MJ, et al. Indolocarbazoles: potent, selective inhibitors of human cytomegalovirus replication. Bioorg Med Chem. 1999 Jun;7(6):1067-74.
