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139298-40-1,MFCD00236424
Catalog No.:AA001AMT

139298-40-1 | Kn-93 hydrochloride

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Purity
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1mg
≥98%
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$153.00   $107.00
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5mg
>98.0%(HPLC)
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001AMT
Chemical Name:
Kn-93 hydrochloride
CAS Number:
139298-40-1
Molecular Formula:
C26H29ClN2O4S
Molecular Weight:
501.0375
MDL Number:
MFCD00236424
SMILES:
OCCN(S(=O)(=O)c1ccc(cc1)OC)c1ccccc1CN(CC=Cc1ccc(cc1)Cl)C
Properties
Properties
 
BP:
657.6±65.0°C at 760 mmHg  
Form:
Solid  
MP:
109 - 111°C  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
713  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
11  
XLogP3:
4.5  

Literature

Title: CaMKⅡ mediates cadmium induced apoptosis in rat primary osteoblasts through MAPK activation and endoplasmic reticulum stress.

Journal: Toxicology 20180801

Title: Tris (1,3-dichloro-2-propyl) phosphate induces toxicity by stimulating CaMK2 in PC12 cells.

Journal: Environmental toxicology 20170601

Title: Protective effect of rutaecarpine against t-BHP-induced hepatotoxicity by upregulating antioxidant enzymes via the CaMKII-Akt and Nrf2/ARE pathways.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20170201

Title: Involvement of calcium/calmodulin-dependent protein kinase II in methamphetamine-induced neural damage.

Journal: Journal of applied toxicology : JAT 20161101

Title: Pleiotropic roles of Ca(+2)/calmodulin-dependent pathways in regulating cadmium-induced toxicity in human osteoblast-like cell lines.

Journal: Toxicology letters 20161017

Title: The toxic effects of Bisphenol A on the mouse spermatocyte GC-2 cell line: the role of the Ca2+-calmodulin-Ca2+/calmodulin-dependent protein kinase II axis.

Journal: Journal of applied toxicology : JAT 20151101

Title: Oral administration of bisphenol A induces high blood pressure through angiotensin II/CaMKII-dependent uncoupling of eNOS.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20141101

Title: Cadmium-induced aggregation of iron regulatory protein-1.

Journal: Toxicology 20141003

Title: Caffeine induces cardiomyocyte hypertrophy via p300 and CaMKII pathways.

Journal: Chemico-biological interactions 20140925

Title: Phosphorylation of FOXO3a by PI3K/Akt pathway in HK-2 renal proximal tubular epithelial cells exposed to cadmium.

Journal: Archives of toxicology 20131201

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal 20130415

Title: Quantitative phosphoproteomic analysis of early alterations in protein phosphorylation by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Journal: Journal of proteome research 20130201

Title: Involvement of CaMK-IIδ and gelsolin in Cd(2+) -dependent cytoskeletal effects in mesangial cells.

Journal: Journal of cellular physiology 20130101

Title: Relevance of calmodulin/CaMKII activation for arrhythmogenesis in the AV block dog.

Journal: Heart rhythm 20121101

Title: Involvement of CaM kinase II in the impairment of endothelial function and eNOS activity in aortas of Type 2 diabetic rats.

Journal: Clinical science (London, England : 1979) 20120901

Title: Calcium/calmodulin-dependent kinase inhibitor induces growth inhibition, cell cycle arrest, and apoptosis in human choriocarcinoma cells.

Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20120801

Title: Acute exposure of L6 myotubes to cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid isomers stimulates glucose uptake by modulating Ca2+/calmodulin-dependent protein kinase II.

Journal: The international journal of biochemistry & cell biology 20120801

Title: CaMKII inhibition hyperpolarizes membrane and blocks nitrergic IJP by closing a Cl(-) conductance in intestinal smooth muscle.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20120715

Title: Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation.

Journal: Circulation 20120501

Title: Attention deficit/hyperactivity disorder-derived coding variation in the dopamine transporter disrupts microdomain targeting and trafficking regulation.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120418

Title: Calmodulin kinase II and protein kinase C mediate the effect of increased intracellular calcium to augment late sodium current in rabbit ventricular myocytes.

Journal: American journal of physiology. Cell physiology 20120415

Title: Calcium/calmodulin dependent kinase II contributes to persistent central neuropathic pain following spinal cord injury.

Journal: Pain 20120301

Title: Shortened Ca2+ signaling refractoriness underlies cellular arrhythmogenesis in a postinfarction model of sudden cardiac death.

Journal: Circulation research 20120217

Title: Chronic CaMKII inhibition blunts the cardiac contractile response to exercise training.

Journal: European journal of applied physiology 20120201

Title: Examining the effect of the CaMKII inhibitor administration in the locus coeruleus on the naloxone-precipitated morphine withdrawal signs in rats.

Journal: Behavioural brain research 20120115

Title: Domain-dependent modulation of insulin-induced AS160 phosphorylation and glucose uptake by Ca2+/calmodulin-dependent protein kinase II in L6 myotubes.

Journal: Cellular signalling 20120101

Title: Inhibition of Ca2+/calmodulin-dependent protein kinase II reverses oxaliplatin-induced mechanical allodynia in rats.

Journal: Molecular pain 20120101

Title: CaMKII is involved in cadmium activation of MAPK and mTOR pathways leading to neuronal cell death.

Journal: Journal of neurochemistry 20111201

Title: Calcium-calmodulin kinase II mediates digitalis-induced arrhythmias.

Journal: Circulation. Arrhythmia and electrophysiology 20111201

Title: CaMKII-dependent SR Ca leak contributes to doxorubicin-induced impaired Ca handling in isolated cardiac myocytes.

Journal: Journal of molecular and cellular cardiology 20111101

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111101

Title: Cross-talk among intracellular signaling pathways mediates the diphenyl ditelluride actions on the hippocampal cytoskeleton of young rats.

Journal: Chemical research in toxicology 20111017

Title: Ionizing radiation induces migration of glioblastoma cells by activating BK K(+) channels.

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20111001

Title: Effects of increased systolic Ca²⁺ and phospholamban phosphorylation during β-adrenergic stimulation on Ca²⁺ transient kinetics in cardiac myocytes.

Journal: American journal of physiology. Heart and circulatory physiology 20111001

Title: Specific effects of BCL10 Serine mutations on phosphorylations in canonical and noncanonical pathways of NF-κB activation following carrageenan.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20110901

Title: TGF-β-activated kinase 1 mediates mechanical stress-induced IL-6 expression in osteoblasts.

Journal: Biochemical and biophysical research communications 20110506

Title: Excitotoxic neuroprotection and vulnerability with CaMKII inhibition.

Journal: Molecular and cellular neurosciences 20110401

Title: Nicotinic stimulation of catecholamine synthesis and tyrosine hydroxylase phosphorylation in cervine adrenal medullary chromaffin cells.

Journal: Journal of neuroendocrinology 20110301

Title: Activation of CaMKII and ERK1/2 contributes to the time-dependent potentiation of Ca2+ response elicited by repeated application of capsaicin in rat DRG neurons.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20110301

Title: Structure and activity relationship of 2-(substituted benzoyl)-hydroxyindoles as novel CaMKII inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20110301

Title: Peroxisome proliferator-activated receptor-{gamma} suppresses CYP11B2 expression and aldosterone production.

Journal: Journal of molecular endocrinology 20110201

Title: Ryanodine receptor-2 upregulation and nicotine-mediated plasticity.

Journal: The EMBO journal 20110105

Title: Aberrant calcium/calmodulin-dependent protein kinase II (CaMKII) activity is associated with abnormal dendritic spine morphology in the ATRX mutant mouse brain.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110105

Title: Calmodulin kinase II inhibition prevents arrhythmias in RyR2(R4496C+/-) mice with catecholaminergic polymorphic ventricular tachycardia.

Journal: Journal of molecular and cellular cardiology 20110101

Title: Angiotensin II induces afterdepolarizations via reactive oxygen species and calmodulin kinase II signaling.

Journal: Journal of molecular and cellular cardiology 20110101

Title: Signaling pathways in ascidian oocyte maturation: the roles of cAMP/Epac, intracellular calcium levels, and calmodulin kinase in regulating GVBD.

Journal: Molecular reproduction and development 20110101

Title: Inhibitory effect of chlorpromazine on RANKL-induced osteoclastogenesis in mouse bone marrow cells.

Journal: Journal of pharmacological sciences 20110101

Title: On the possible role of ERK, p38 and CaMKII in the regulation of CGRP expression in morphine-tolerant rats.

Journal: Molecular pain 20110101

Title: Calcium/calmodulin-dependent kinase II facilitated GluR6 subunit serine phosphorylation through GluR6-PSD95-CaMKII signaling module assembly in cerebral ischemia injury.

Journal: Brain research 20101217

Title: Akti-1/2, an allosteric inhibitor of Akt 1 and 2, efficiently inhibits CaMKIα activity and aryl hydrocarbon receptor pathway.

Journal: Chemico-biological interactions 20101205

Title: 5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidines as novel class of potent and highly selective CaMKII inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20101115

Title: Mechanosensitive transient receptor potential vanilloid type 1 channels contribute to vascular remodeling of rat fistula veins.

Journal: Journal of vascular surgery 20101101

Title: Murine vasa recta pericyte chloride conductance is controlled by calcium, depolarization, and kinase activity.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20101101

Title: The role of CaMKII in calcium-activated death pathways in bone marrow B cells.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20101101

Title: A crosstalk between β1 and β3 integrins controls glycine receptor and gephyrin trafficking at synapses.

Journal: Nature neuroscience 20101101

Title: Hyperactive mice show elevated D2(High) receptors, a model for schizophrenia: Calcium/calmodulin-dependent kinase II alpha knockouts.

Journal: Synapse (New York, N.Y.) 20101001

Title: Molecular mechanisms in hippocampus and basolateral amygdala but not in parietal or cingulate cortex are involved in extinction of one-trial avoidance learning.

Journal: Neurobiology of learning and memory 20100901

Title: Abscisic acid activates a Ca2+-calmodulin-stimulated protein kinase involved in antioxidant defense in maize leaves.

Journal: Acta biochimica et biophysica Sinica 20100901

Title: CaMKII triggers the diffusional trapping of surface AMPARs through phosphorylation of stargazin.

Journal: Neuron 20100729

Title: Effective post-insult neuroprotection by a novel Ca(2+)/ calmodulin-dependent protein kinase II (CaMKII) inhibitor.

Journal: The Journal of biological chemistry 20100702

Title: Ca(2+)/calmodulin-dependent protein kinase II contributes to intracellular pH recovery from acidosis via Na(+)/H(+) exchanger activation.

Journal: Journal of molecular and cellular cardiology 20100701

Title: Localised Ca channel phosphorylation modulates the distribution of L-type Ca current in cardiac myocytes.

Journal: Journal of molecular and cellular cardiology 20100701

Title: Effects of sarcolemmal Ca(2+) entry, ryanodine function, and kinase inhibitors on a rabbit model of heart failure.

Journal: International heart journal 20100701

Title: Regulation of intracellular pH by Ca2+-activated proton channel.

Journal: Immunopharmacology and immunotoxicology 20100601

Title: Ginsenoside Rg1 promotes glutamate release via a calcium/calmodulin-dependent protein kinase II-dependent signaling pathway.

Journal: Brain research 20100528

Title: The contribution of calcium/calmodulin-dependent protein-kinase II (CaMKII) to short-term plasticity at the neuromuscular junction.

Journal: Brain research bulletin 20100405

Title: CaMKII-dependent diastolic SR Ca2+ leak and elevated diastolic Ca2+ levels in right atrial myocardium of patients with atrial fibrillation.

Journal: Circulation research 20100402

Title: Ca2+/calmodulin-dependent protein kinase II alpha is required for the initiation and maintenance of opioid-induced hyperalgesia.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100106

Title: Angiotensin II-induced oxidative stress resets the Ca2+ dependence of Ca2+-calmodulin protein kinase II and promotes a death pathway conserved across different species.

Journal: Circulation research 20091204

Title: Role of the AMPKgamma3 isoform in hypoxia-stimulated glucose transport in glycolytic skeletal muscle.

Journal: American journal of physiology. Endocrinology and metabolism 20091201

Title: Digoxin and ouabain induce P-glycoprotein by activating calmodulin kinase II and hypoxia-inducible factor-1alpha in human colon cancer cells.

Journal: Toxicology and applied pharmacology 20091101

Title: Increased susceptibility of aged hearts to ventricular fibrillation during oxidative stress.

Journal: American journal of physiology. Heart and circulatory physiology 20091101

Title: Phosphorylation alters the pharmacology of Ca(2+)-activated Cl channels in rabbit pulmonary arterial smooth muscle cells.

Journal: British journal of pharmacology 20091101

Title: Calcium/calmodulin-dependent protein kinase II contributes to cardiac arrhythmogenesis in heart failure.

Journal: Circulation. Heart failure 20091101

Title: Acetylcholine rescues two-cell block through activation of IP3 receptors and Ca2+/calmodulin-dependent kinase II in an ICR mouse strain.

Journal: Pflugers Archiv : European journal of physiology 20091001

Title: Mg2+- and MgATP-inhibited and Ca2+/calmodulin-sensitive TRPM7-like current in hepatoma and hepatocytes.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20091001

Title: Modulation of K(ATP) currents in rat ventricular myocytes by hypoxia and a redox reaction.

Journal: Acta pharmacologica Sinica 20091001

Title: Calmodulin kinase II initiates arrhythmogenicity during metabolic acidification in murine hearts.

Journal: Acta physiologica (Oxford, England) 20090901

Title: Role for CaMKII inhibition in rheumatoid arthritis: effects on HIF-1-induced VEGF production by rheumatoid synovial fibroblasts.

Journal: Annals of the New York Academy of Sciences 20090901

Title: Pleiotropic effects of cadmium in mesangial cells.

Journal: Toxicology and applied pharmacology 20090801

Title: Substance P enhances excitatory synaptic transmission on spinally projecting neurons in the rostral ventromedial medulla after inflammatory injury.

Journal: Journal of neurophysiology 20090801

Title: Calcium/calmodulin-dependent protein kinase II mediates cardioprotection of intermittent hypoxia against ischemic-reperfusion-induced cardiac dysfunction.

Journal: American journal of physiology. Heart and circulatory physiology 20090801

Title: Oestrogen confers cardioprotection by suppressing Ca2+/calmodulin-dependent protein kinase II.

Journal: British journal of pharmacology 20090701

Title: Ca2+/calmodulin-dependent protein kinase II mediates apoptosis of P19 cells expressing human tau during neural differentiation with retinoic acid treatment.

Journal: Journal of enzyme inhibition and medicinal chemistry 20090401

Title: TRPC6 mutations associated with focal segmental glomerulosclerosis cause constitutive activation of NFAT-dependent transcription.

Journal: American journal of physiology. Cell physiology 20090301

Title: miR-1 overexpression enhances Ca(2+) release and promotes cardiac arrhythmogenesis by targeting PP2A regulatory subunit B56alpha and causing CaMKII-dependent hyperphosphorylation of RyR2.

Journal: Circulation research 20090227

Title: Activity-dependent modulation of limbic dopamine D3 receptors by CaMKII.

Journal: Neuron 20090212

Title: Epac and phospholipase Cepsilon regulate Ca2+ release in the heart by activation of protein kinase Cepsilon and calcium-calmodulin kinase II.

Journal: The Journal of biological chemistry 20090116

Title: Resynthesis of phosphatidylinositol 4,5-bisphosphate mediates adaptation of the caffeine response in rat taste receptor cells.

Journal: The Journal of physiology 20090115

Title: Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export.

Journal: The Journal of biological chemistry 20090102

Title: Calcium/calmodulin-dependent kinase II regulates notch-1 signaling in prostate cancer cells.

Journal: Journal of cellular biochemistry 20090101

Title: Extracellular hypotonicity induces disturbance of sodium currents in rat ventricular myocytes.

Journal: Physiological research 20090101

Title: DY-9760e inhibits endothelin-1-induced cardiomyocyte hypertrophy through inhibition of CaMKII and ERK activities.

Journal: Cardiovascular therapeutics 20090101

Title: Activation of the aryl hydrocarbon receptor by the calcium/calmodulin-dependent protein kinase kinase inhibitor 7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid (STO-609).

Journal: Drug metabolism and disposition: the biological fate of chemicals 20081201

Title: Initiation of caspase-independent death in mouse mesangial cells by Cd2+: involvement of p38 kinase and CaMK-II.

Journal: Journal of cellular physiology 20081101

Title: Epac activation, altered calcium homeostasis and ventricular arrhythmogenesis in the murine heart.

Journal: Pflugers Archiv : European journal of physiology 20081101

Title: Nonclassical mechanisms of progesterone action in the brain: II. Role of calmodulin-dependent protein kinase II in progesterone-mediated signaling in the hypothalamus of female rats.

Journal: Endocrinology 20081101

Title: Inhibition of CaMKII in the nucleus accumbens shell decreases enhanced amphetamine intake in sensitized rats.

Journal: Neuroscience letters 20081024

Title: kappa-Opioid receptor stimulation inhibits augmentation of Ca(2+) transient and hypertrophy induced by isoprenaline in neonatal rat ventricular myocytes - Role of CaMKIIdelta(B).

Journal: European journal of pharmacology 20081024

Title: Differential expression of phosphorylated Ca2+/calmodulin-dependent protein kinase II and phosphorylated extracellular signal-regulated protein in the mouse hippocampus induced by various nociceptive stimuli.

Journal: Neuroscience 20081015

Title: Increased intracellular Ca2+ and SR Ca2+ load contribute to arrhythmias after acidosis in rat heart. Role of Ca2+/calmodulin-dependent protein kinase II.

Journal: American journal of physiology. Heart and circulatory physiology 20081001

Title: Homocysteine activates calcium-mediated cell signaling mechanisms targeting the cytoskeleton in rat hippocampus.

Journal: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20080801

Title: CaMK-II promotes focal adhesion turnover and cell motility by inducing tyrosine dephosphorylation of FAK and paxillin.

Journal: Cell motility and the cytoskeleton 20080801

Title: Cyclic adenosine 3',5'-monophosphate responsive element binding protein phosphorylation is required but not sufficient for activation of corticotropin-releasing hormone transcription.

Journal: Endocrinology 20080701

Title: A cascade of Ca(2+)/calmodulin-dependent protein kinases regulates the differentiation and functional activation of murine neutrophils.

Journal: Experimental hematology 20080701

Title: Small-molecule activation of neuronal cell fate.

Journal: Nature chemical biology 20080701

Title: Nitric oxide-mediated modulation of calcium/calmodulin-dependent protein kinase II.

Journal: The Biochemical journal 20080601

Title: Ser515 phosphorylation-independent regulation of cytosolic phospholipase A2alpha (cPLA2alpha) by calmodulin-dependent protein kinase: possible interaction with catalytic domain A of cPLA2alpha.

Journal: Cellular signalling 20080501

Title: Identification of a molecular target for glutamate regulation of astrocyte water permeability.

Journal: Glia 20080415

Title: Reversal of chronic inflammatory pain by acute inhibition of Ca2+/calmodulin-dependent protein kinase II.

Journal: The Journal of pharmacology and experimental therapeutics 20080401

Title: Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure.

Journal: Circulation research 20080328

Title: Neuronal activity enhances aryl hydrocarbon receptor-mediated gene expression and dioxin neurotoxicity in cortical neurons.

Journal: Journal of neurochemistry 20080301

Title: Dioxin-mediated up-regulation of aryl hydrocarbon receptor target genes is dependent on the calcium/calmodulin/CaMKIalpha pathway.

Journal: Molecular pharmacology 20080301

Title: CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking.

Journal: Nature neuroscience 20080301

Title: Role of Ca2+/calmodulin-dependent protein kinase II in development of vascular dysfunction in diabetic rats with hypertension.

Journal: Cell biochemistry and function 20080101

Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20071218

Title: Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli.

Journal: Neuron 20071108

Title: Behavioral modulation of neuronal calcium/calmodulin-dependent protein kinase II activity: differential effects on nicotine-induced spinal and supraspinal antinociception in mice.

Journal: Biochemical pharmacology 20071015

Title: Calmodulin kinase II inhibition prevents arrhythmic activity induced by alpha and beta adrenergic agonists in rabbit pulmonary veins.

Journal: European journal of pharmacology 20071001

Title: Calcium/calmodulin-dependent kinase activity is required for efficient induction of osteoclast differentiation and bone resorption by receptor activator of nuclear factor kappa B ligand (RANKL).

Journal: Journal of cellular physiology 20070901

Title: Separation of early afterdepolarizations from arrhythmogenic substrate in the isolated perfused hypokalaemic murine heart through modifiers of calcium homeostasis.

Journal: Acta physiologica (Oxford, England) 20070901

Title: Involvement of Ca(2+)/calmodulin-dependent protein kinases in mycelial growth of the basidiomycetous mushroom, Coprinus cinereus.

Journal: Biochimica et biophysica acta 20070901

Title: Ca2+/calmodulin kinase II increases ryanodine binding and Ca2+-induced sarcoplasmic reticulum Ca2+ release kinetics during beta-adrenergic stimulation.

Journal: Journal of molecular and cellular cardiology 20070901

Title: Roles of hippocampal N-methyl-D-aspartate receptors and calcium/calmodulin-dependent protein kinase II in amphetamine-produced conditioned place preference in rats.

Journal: Behavioural pharmacology 20070901

Title: Role of glycolytically generated ATP for CaMKII-mediated regulation of intracellular Ca2+ signaling in bovine vascular endothelial cells.

Journal: American journal of physiology. Cell physiology 20070701

Title: ANG II and calmodulin/CaMKII regulate surface expression and functional activity of NBCe1 via separate means.

Journal: American journal of physiology. Renal physiology 20070701

Title: Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2.

Journal: Neuron 20070621

Title: iNOS regulation by calcium/calmodulin-dependent protein kinase II in vascular smooth muscle.

Journal: American journal of physiology. Heart and circulatory physiology 20070601

Title: Possible CaMKK-dependent regulation of AMPK phosphorylation and glucose uptake at the onset of mild tetanic skeletal muscle contraction.

Journal: American journal of physiology. Endocrinology and metabolism 20070501

Title: W-7 modulates Kv4.3: pore block and Ca2+-calmodulin inhibition.

Journal: American journal of physiology. Heart and circulatory physiology 20070501

Title: Calcium/calmodulin-dependent kinase II plays an important role in prostate cancer cell survival.

Journal: Cancer biology & therapy 20070501

Title: Activation of CaMKIIdeltaC is a common intermediate of diverse death stimuli-induced heart muscle cell apoptosis.

Journal: The Journal of biological chemistry 20070406

Title: CaM kinase II activation and phospholamban phosphorylation by SNP in murine gastric antrum smooth muscles.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20070401

Title: Phorbol esters induce intracellular accumulation of the anti-apoptotic protein PED/PEA-15 by preventing ubiquitinylation and proteasomal degradation.

Journal: The Journal of biological chemistry 20070323

Title: Bcl10 is phosphorylated on Ser138 by Ca2+/calmodulin-dependent protein kinase II.

Journal: Molecular immunology 20070301

Title: Dopamine transporter activity mediates amphetamine-induced inhibition of Akt through a Ca2+/calmodulin-dependent kinase II-dependent mechanism.

Journal: Molecular pharmacology 20070301

Title: CaMKII inhibition protects against necrosis and apoptosis in irreversible ischemia-reperfusion injury.

Journal: Cardiovascular research 20070301

Title: Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase.

Journal: Circulation research 20070216

Title: Enhancement of acetyl-CoA: 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity by hydrogen peroxide.

Journal: Biological & pharmaceutical bulletin 20070201

Title: Uniaxial cyclic stretch-stimulated glucose transport is mediated by a ca-dependent mechanism in cultured skeletal muscle cells.

Journal: Pathobiology : journal of immunopathology, molecular and cellular biology 20070101

Title: Changes in subcellular distribution and phosphorylation of GluR1 in lesioned striatum of 6-hydroxydopamine-lesioned and l-dopa-treated rats.

Journal: Neurochemical research 20061101

Title: Calcium-calmodulin-dependent protein kinase II phosphorylation modulates PSD-95 binding to NMDA receptors.

Journal: The European journal of neuroscience 20061101

Title: Death, cardiac dysfunction, and arrhythmias are increased by calmodulin kinase II in calcineurin cardiomyopathy.

Journal: Circulation 20060926

Title: Activation of the extracellular calcium-sensing receptor initiates insulin secretion from human islets of Langerhans: involvement of protein kinases.

Journal: The Journal of endocrinology 20060901

Title: Calmodulin kinase II interacts with the dopamine transporter C terminus to regulate amphetamine-induced reverse transport.

Journal: Neuron 20060817

Title: CaMKII-independent effects of KN93 and its inactive analog KN92: reversible inhibition of L-type calcium channels.

Journal: Biochemical and biophysical research communications 20060714

Title: Effects of protein kinase inhibitors on the in vitro growth of Babesia bovis.

Journal: Parasitology 20060601

Title: The regulation of calcium/calmodulin-dependent protein kinase II during oocyte activation in the rat.

Journal: The Journal of reproduction and development 20060601

Title: Ser-2030, but not Ser-2808, is the major phosphorylation site in cardiac ryanodine receptors responding to protein kinase A activation upon beta-adrenergic stimulation in normal and failing hearts.

Journal: The Biochemical journal 20060515

Title: Reversal of morphine antinociceptive tolerance and dependence by the acute supraspinal inhibition of Ca(2+)/calmodulin-dependent protein kinase II.

Journal: The Journal of pharmacology and experimental therapeutics 20060501

Title: KN-93 (2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated potassium channels.

Journal: The Journal of pharmacology and experimental therapeutics 20060401

Title: Sigma2 (sigma2) receptors as a target for cocaine action in the rat striatum.

Journal: European journal of pharmacology 20060327

Title: Regulation of aldosterone production from zona glomerulosa cells by ANG II and cAMP: evidence for PKA-independent activation of CaMK by cAMP.

Journal: American journal of physiology. Endocrinology and metabolism 20060301

Title: Calcium signaling stimulates translation of HIF-alpha during hypoxia.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060301

Title: Multiple, disparate roles for calcium signaling in apoptosis of human prostate and cervical cancer cells exposed to diindolylmethane.

Journal: Molecular cancer therapeutics 20060301

Title: Loss of leukemia inhibitory factor receptor beta or cardiotrophin-1 causes similar deficits in preganglionic sympathetic neurons and adrenal medulla.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20060208

Title: CaM kinase II phosphorylation of slo Thr107 regulates activity and ethanol responses of BK channels.

Journal: Nature neuroscience 20060101

Title: Effect of epidermal growth factor and prostaglandin on the expression of aromatase (CYP19) in human adrenocortical carcinoma cell line NCI-H295R cells.

Journal: The Journal of endocrinology 20060101

Title: Developmental changes of CaMKII localization, activity and function during postembryonic CNS remodelling in Manduca sexta.

Journal: The European journal of neuroscience 20060101

Title: Molecular pathways leading to oxidative stress-induced phosphorylation of Akt.

Journal: Antioxidants & redox signaling 20060101

Title: Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure.

Journal: Circulation research 20051209

Title: Modulation of intracellular Ca2+ release and capacitative Ca2+ entry by CaMKII inhibitors in bovine vascular endothelial cells.

Journal: American journal of physiology. Cell physiology 20051201

Title: NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII.

Journal: Neuron 20051020

Title: Membrane association of nitric oxide-sensitive guanylyl cyclase in cardiomyocytes.

Journal: Cardiovascular research 20051001

Title: Inhibition of Ca2+/calmodulin-dependent protein kinase II, RAS-GTPase and 20-hydroxyeicosatetraenoic acid attenuates the development of diabetes-induced vascular dysfunction in the rat carotid artery.

Journal: Pharmacological research 20050901

Title: Calcium/calmodulin-dependent kinase II mediates critical components of the hypoxic ventilatory response within the nucleus of the solitary tract in adult rats.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20050901

Title: Ca2+/calmodulin-dependent protein kinase II is an essential mediator in the coordinated regulation of electrocyte Ca2+-ATPase by calmodulin and protein kinase A.

Journal: The Journal of biological chemistry 20050826

Title: Characterization of cAMP-dependent proteolysis of GATA-6.

Journal: Biochemical and biophysical research communications 20050715

Title: Calcium/calmodulin-dependent kinase I and calcium/calmodulin-dependent kinase kinase participate in the control of cell cycle progression in MCF-7 human breast cancer cells.

Journal: Cancer research 20050615

Title: Honokiol-induced neurite outgrowth promotion depends on activation of extracellular signal-regulated kinases (ERK1/2).

Journal: European journal of pharmacology 20050601

Title: Increase of phosphorylation of calcium/calmodulin-dependent protein kinase-II in several brain regions by substance P administered intrathecally in mice.

Journal: Brain research bulletin 20050515

Title: Carboxy-terminal PTH fragments stimulate [3H]thymidine incorporation in vascular endothelial cells.

Journal: Peptides 20050501

Title: Galphaq potentiation of adenylate cyclase type 9 activity through a Ca2+/calmodulin-dependent pathway.

Journal: Biochemical pharmacology 20050415

Title: Repeated administration of AMPA or a metabotropic glutamate receptor agonist into the rat ventral tegmental area augments the subsequent behavioral hyperactivity induced by cocaine.

Journal: Psychopharmacology 20050401

Title: Ca(2+)/calmodulin-protein kinase IIalpha in the trigeminal subnucleus caudalis contributes to neuropathic pain following inferior alveolar nerve transection.

Journal: Experimental neurology 20050401

Title: Role of phosphorylation of Thr(17) residue of phospholamban in mechanical recovery during hypercapnic acidosis.

Journal: Cardiovascular research 20050401

Title: Visualization of synaptic Ca2+ /calmodulin-dependent protein kinase II activity in living neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050323

Title: Peroxisome proliferator-activated receptor gamma-independent activation of p38 MAPK by thiazolidinediones involves calcium/calmodulin-dependent protein kinase II and protein kinase R: correlation with endoplasmic reticulum stress.

Journal: The Journal of biological chemistry 20050318

Title: Ca2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia.

Journal: The Journal of biological chemistry 20050211

Title: CaMKII activates ASK1 and NF-kappaB to induce cardiomyocyte hypertrophy.

Journal: Biochemical and biophysical research communications 20050204

Title: Calcium/calmodulin dependent protein kinase II regulates the phosphorylation of cyclic AMP-responsive element-binding protein of spinal cord in rats following noxious stimulation.

Journal: Neuroscience letters 20050201

Title: Learning twice is different from learning once and from learning more.

Journal: Neuroscience 20050101

Title: Memory consolidation induces N-methyl-D-aspartic acid-receptor- and Ca2+/calmodulin-dependent protein kinase II-dependent modifications in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor properties.

Journal: Neuroscience 20050101

Title: Extracellular zinc triggers ERK-dependent activation of Na+/H+ exchange in colonocytes mediated by the zinc-sensing receptor.

Journal: The Journal of biological chemistry 20041210

Title: In vivo recruitment by painful stimuli of AMPA receptor subunits to the plasma membrane of spinal cord neurons.

Journal: Pain 20041201

Title: The role of calcium/calmodulin-dependent protein kinase II on the inactivation of MAP kinase and p34cdc2 kinase during fertilization and activation in pig oocytes.

Journal: Reproduction (Cambridge, England) 20041001

Title: Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20040922

Title: NMDA receptors and associated signaling pathways: a role in knee joint blood flow regulation.

Journal: European journal of pharmacology 20040919

Title: A CaMKII/calcineurin switch controls the direction of Ca(2+)-dependent growth cone guidance.

Journal: Neuron 20040916

Title: Effect of angiotensin II type 1 receptor on delayed rectifier potassium current in catecholaminergic CATH.a cells.

Journal: Acta pharmacologica Sinica 20040901

Title: Activation of Ca2+/calmodulin-dependent protein kinase II is involved in hyperosmotic induction of the human taurine transporter.

Journal: FEBS letters 20040702

Title: Abnormal Ca2+-calmodulin-dependent protein kinase II function mediates synaptic and motor deficits in experimental parkinsonism.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20040609

Title: Sustained potentiation by substance P of NMDA-activated current in rat primary sensory neurons.

Journal: Brain research 20040604

Title: Diurnal, circadian and photic regulation of calcium/calmodulin-dependent kinase II and neuronal nitric oxide synthase in the hamster suprachiasmatic nuclei.

Journal: Neurochemistry international 20040601

Title: Regulation of cyclin D1/Cdk4 complexes by calcium/calmodulin-dependent protein kinase I.

Journal: The Journal of biological chemistry 20040409

Title: Presynaptic CaMKII is necessary for synaptic plasticity in cultured hippocampal neurons.

Journal: Neuron 20040408

Title: Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor.

Journal: Circulation research 20040402

Title: Mechanisms of action of melanin-concentrating hormone in the teleost fish erythrophoroma cell line (GEM-81).

Journal: General and comparative endocrinology 20040401

Title: Signaling pathway of magnolol-stimulated lipolysis in sterol ester-loaded 3T3-L1 preadipocyes.

Journal: Journal of cellular biochemistry 20040401

Title: Hypoxic up-regulation of triosephosphate isomerase expression in mouse brain capillary endothelial cells.

Journal: Archives of biochemistry and biophysics 20040315

Title: Roles of CaMKII, PKA, and PKC in the induction and maintenance of LTP of C-fiber-evoked field potentials in rat spinal dorsal horn.

Journal: Journal of neurophysiology 20040301

Title: The orphan nuclear receptors NURR1 and NGFIB regulate adrenal aldosterone production.

Journal: Molecular endocrinology (Baltimore, Md.) 20040201

Title: Protein kinase A and calcium/calmodulin-dependent protein kinase II regulate glycine and GABA release in auditory brain stem nuclei.

Journal: Journal of neuroscience research 20040201

Title: Alpha-keto-beta-methylvaleric acid increases the in vitro phosphorylation of intermediate filaments in cerebral cortex of young rats through the gabaergic system.

Journal: Journal of the neurological sciences 20040115

Title: Suppressing calcium/calmodulin-dependent protein kinase II activity in the ventral tegmental area enhances the acute behavioural response to cocaine but attenuates the initiation of cocaine-induced behavioural sensitization in rats.

Journal: The European journal of neuroscience 20040101

Title: Phospholamban is required for CaMKII-dependent recovery of Ca transients and SR Ca reuptake during acidosis in cardiac myocytes.

Journal: Journal of molecular and cellular cardiology 20040101

Title: Role of the calcium/calmodulin-dependent protein kinase ii (CaMKII) in the morphine-induced pharmacological effects in the mouse.

Journal: Neuroscience 20040101

Title: CaM kinase II regulation of CRHSP-28 phosphorylation in cultured mucosal T84 cells.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20031201

Title: CaMKII-dependent phosphorylation regulates SAP97/NR2A interaction.

Journal: The Journal of biological chemistry 20031107

Title: Trans-cellular proliferating cell nuclear antigen gene activation in cerebral vascular smooth muscle by endothelial oxidative injury in vivo.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20031101

Title: Hormone-sensitive lipase activity and triacylglycerol hydrolysis are decreased in rat soleus muscle by cyclopiazonic acid.

Journal: American journal of physiology. Endocrinology and metabolism 20030801

Title: The involvement of calcineurin in acetylcholine receptor redistribution in muscle.

Journal: Molecular and cellular neurosciences 20030801

Title: Linker for activation of T cells, zeta-associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarization.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20030715

Title: Calcineurin-independent regulation of plasma membrane Ca2+ ATPase-4 in the vascular smooth muscle cell cycle.

Journal: American journal of physiology. Cell physiology 20030701

Title: Involvement of Ca2+/calmodulin-dependent protein kinase II in endothelial NO production and endothelium-dependent relaxation.

Journal: American journal of physiology. Heart and circulatory physiology 20030601

Title: The calcium component of gonadotropin-releasing hormone-stimulated luteinizing hormone subunit gene transcription is mediated by calcium/calmodulin-dependent protein kinase type II.

Journal: Endocrinology 20030601

Title: Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release.

Journal: Circulation research 20030502

Title: Calcium-dependent, D2 receptor-independent induction of c-fos by haloperidol in dopamine neurons.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20030501

Title: Raising Ca2+ in L6 myotubes mimics effects of exercise on mitochondrial biogenesis in muscle.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030401

Title: Reversal of morphine antinociceptive tolerance by acute spinal inhibition of Ca(2+)/calmodulin-dependent protein kinase II.

Journal: European journal of pharmacology 20030328

Title: Effect of SNI-2011 on amylase secretion from parotid tissue in rats and in neuronal nitric oxide synthase knockout mice.

Journal: European journal of pharmacology 20030319

Title: Calcium/calmodulin-dependent kinase II is involved in the facilitating effect of clozapine on NMDA- and electrically evoked responses in the medial prefrontal cortical pyramidal cells.

Journal: Synapse (New York, N.Y.) 20030315

Title: Prevention of neurotoxicity in hypoxic cortical neurons by the noble gas xenon.

Journal: Life sciences 20030314

Title: Modulation of IA currents by capsaicin in rat trigeminal ganglion neurons.

Journal: Journal of neurophysiology 20030301

Title: Cellular mechanisms of the acute increase of glutamate release induced by nerve growth factor in rat cerebral cortex.

Journal: Neuropharmacology 20030301

Title: Calcium/calmodulin-dependent protein kinase II regulation of c-FLIP expression and phosphorylation in modulation of Fas-mediated signaling in malignant glioma cells.

Journal: The Journal of biological chemistry 20030227

Title: Hypoxia up-regulates glyceraldehyde-3-phosphate dehydrogenase in mouse brain capillary endothelial cells: involvement of Na+/Ca2+ exchanger.

Journal: Biochimica et biophysica acta 20030217

Title: Calmodulin and calmodulin-dependent kinase II mediate neuronal cell death induced by depolarization.

Journal: Brain research 20030207

Title: Modulation of the hyperpolarization-activated current (I(f)) by calcium and calmodulin in the guinea-pig sino-atrial node.

Journal: Cardiovascular research 20030201

Title: Ca2+/calmodulin-dependent protein kinase II stimulates c-fos transcription and DNA synthesis by a Src-based mechanism in glomerular mesangial cells.

Journal: Journal of the American Society of Nephrology : JASN 20030101

Title: Degranulation in RBL-2H3 cells: regulation by calmodulin pathway.

Journal: Cell biology international 20030101

Title: Early pathophysiological changes in cerebral vessels predisposing to stroke.

Journal: Clinical hemorheology and microcirculation 20030101

Title: Differential autophosphorylation of CaM kinase II from phasic and tonic smooth muscle tissues.

Journal: American journal of physiology. Cell physiology 20021101

Title: Activation of extracellular-regulated kinase by 5-hydroxytryptamine(2A) receptors in PC12 cells is protein kinase C-independent and requires calmodulin and tyrosine kinases.

Journal: The Journal of pharmacology and experimental therapeutics 20021101

Title: Inhibition of the inositol trisphosphate receptor of mouse eggs and A7r5 cells by KN-93 via a mechanism unrelated to Ca2+/calmodulin-dependent protein kinase II antagonism.

Journal: The Journal of biological chemistry 20020920

Title: Calmodulin kinase II and arrhythmias in a mouse model of cardiac hypertrophy.

Journal: Circulation 20020903

Title: Calmodulin-dependent kinase I regulates adrenal cell expression of aldosterone synthase.

Journal: Endocrinology 20020901

Title: Phosphorylation of neuronal nitric oxide synthase at Ser847 by CaM-KII in the hippocampus of rat brain after transient forebrain ischemia.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20020901

Title: Lack of PSD-95 drives hippocampal neuronal cell death through activation of an alpha CaMKII transduction pathway.

Journal: The European journal of neuroscience 20020901

Title: Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1)-cells.

Journal: The Journal of endocrinology 20020801

Title: Regulation of CDPKs, including identification of PAL kinase, in biotically stressed cells of French bean.

Journal: Plant molecular biology 20020701

Title: Ca(2+)-calmodulin-dependent protein kinase II plays a major role in halothane-induced dose-dependent relaxation in the skinned pulmonary artery.

Journal: Anesthesiology 20020701

Title: Co-requirement of cyclic AMP- and calcium-dependent protein kinases for transcriptional activation of cholecystokinin gene by protein hydrolysates.

Journal: The Journal of biological chemistry 20020621

Title: Calcium-calmodulin-dependent protein kinase II contributes to spinal cord central sensitization.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20020515

Title: CaM kinase II-dependent activation of tyrosine kinases and ERK1/2 in vascular smooth muscle.

Journal: American journal of physiology. Cell physiology 20020401

Title: Phase I and phase II of short-term mechanical restitution in perfused rat left ventricles.

Journal: American journal of physiology. Heart and circulatory physiology 20020401

Title: Decorin suppresses transforming growth factor-beta-induced expression of plasminogen activator inhibitor-1 in human mesangial cells through a mechanism that involves Ca2+-dependent phosphorylation of Smad2 at serine-240.

Journal: The Biochemical journal 20020315

Title: Impairing the amphetamine conditioning in rats through the inhibition of hippocampal calcium/calmodulin-dependent protein kinase II activity.

Journal: Neuropharmacology 20020301

Title: Dual effect of blocking agents on Ca2+-activated Cl(-) currents in rabbit pulmonary artery smooth muscle cells.

Journal: The Journal of physiology 20020215

Title: myo-Inositol 1,4,5-trisphosphate and Ca(2+)/calmodulin-dependent factors mediate transduction of compression-induced signals in bovine articular chondrocytes.

Journal: The Biochemical journal 20020201

Title: Discovery of a 3-amino-6-phenyl-pyridazine derivative as a new synthetic antineuroinflammatory compound.

Journal: Journal of medicinal chemistry 20020131

Title: The aniracetam metabolite 2-pyrrolidinone induces a long-term enhancement in AMPA receptor responses via a CaMKII pathway.

Journal: Brain research. Molecular brain research 20020131

Title: Predominant role by CaM kinase in NPY Y(1) receptor signaling: involvement of CREB [corrected].

Journal: Peptides 20020101

Title: Angiotensin II promotes the phosphorylation of cyclic AMP-responsive element binding protein (CREB) at Ser133 through an ERK1/2-dependent mechanism.

Journal: Journal of neurochemistry 20011201

Title: Different subtypes of alpha1-adrenoceptor modulate different K+ currents via different signaling pathways in canine ventricular myocytes.

Journal: The Journal of biological chemistry 20011102

Title: PKC- and ERK-dependent activation of I kappa B kinase by lipopolysaccharide in macrophages: enhancement by P2Y receptor-mediated CaMK activation.

Journal: British journal of pharmacology 20011101

Title: Nicotine-induced phosphorylation of extracellular signal-regulated protein kinase and CREB in PC12h cells.

Journal: Journal of neurochemistry 20011101

Title: Mechanisms in fluoride-induced interleukin-8 synthesis in human lung epithelial cells.

Journal: Toxicology 20011015

Title: Essential role for extracellular Ca(2+) in JNK activation by mechanical stretch in bladder smooth muscle cells.

Journal: American journal of physiology. Cell physiology 20011001

Title: Activation of p42/p44 mitogen-activated protein kinase and contraction by prostaglandin F2alpha, ionomycin, and thapsigargin in cat iris sphincter smooth muscle: inhibition by PD98059, KN-93, and isoproterenol.

Journal: The Journal of pharmacology and experimental therapeutics 20011001

Title: The neuropeptide head activator induces activation and translocation of the growth-factor-regulated Ca(2+)-permeable channel GRC.

Journal: Journal of cell science 20011001

Title: Ca2+/calmodulin-dependent protein kinase II and cytosolic phospholipase A2 contribute to mitogenic signaling in myeloblastic leukemia U-937 cells.

Journal: The Journal of pharmacology and experimental therapeutics 20010701

Title: Compensatory role of CaMKII on ICa and SR function during acidosis in rat ventricular myocytes.

Journal: Pflugers Archiv : European journal of physiology 20010601

Title: Phospholipase D activation by norepinephrine is mediated by 12(s)-, 15(s)-, and 20-hydroxyeicosatetraenoic acids generated by stimulation of cytosolic phospholipase a2. tyrosine phosphorylation of phospholipase d2 in response to norepinephrine.

Journal: The Journal of biological chemistry 20010511

Title: Induction of differentiation of human myeloid leukemia cells by immunosuppressant macrolides (rapamycin and FK506) and calcium/calmodulin-dependent kinase inhibitors.

Journal: Experimental hematology 20010501

Title: The Ca2+-sensing receptor activates cytosolic phospholipase A2 via a Gqalpha -dependent ERK-independent pathway.

Journal: The Journal of biological chemistry 20010427

Title: KN-93 inhibition of G protein signaling is independent of the ability of Ca2+/calmodulin-dependent protein kinase II to phosphorylate phospholipase Cbeta3 on 537-Ser.

Journal: Molecular and cellular endocrinology 20010425

Title: Ca2+ mediates the effect of inhibition of Na+-K+-ATPase on the basolateral K+ channels in the rat CCD.

Journal: American journal of physiology. Cell physiology 20010401

Title: Calcium/calmodulin-dependent protein kinase inhibition potentiates thapsigargin-mediated cell death in SH-SY5Y human neuroblastoma cells.

Journal: Neuroscience letters 20010330

Title: Regulation of InsP3-mediated Ca2+ release by CaMKII in Xenopus oocytes.

Journal: Pflugers Archiv : European journal of physiology 20010301

Title: Calcium-mediated second messengers modulate the expression of behavioral sensitization to cocaine.

Journal: The Journal of pharmacology and experimental therapeutics 19980901

Title: The novel insulinotropic mechanism of pimobendan: direct enhancement of the exocytotic process of insulin secretory granules by increased Ca2+ sensitivity in beta-cells.

Journal: Endocrinology 19980301

Title: The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells.

Journal: Biochemical and biophysical research communications 19911231

Title: Tombes RM, et al. G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK (the multifunctional Ca2+/CaM kinase). Cell Growth Differ. 1995 Sep;6(9):1063-70.

Title: Mamiya N, et al. Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitorKN-93. Biochem Biophys Res Commun. 1993 Sep 15;195(2):608-15.

Title: Anderson ME, et al. KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J Pharmacol Exp Ther. 1998 Dec;287(3):996-1006.

Title: Li J, et al. Curcumin Attenuates Retinal Vascular Leakage by Inhibiting Calcium/Calmodulin-Dependent Protein Kinase II Activity in Streptozotocin-Induced Diabetes. Cell Physiol Biochem. 2016;39(3):1196-208.

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Tags:139298-40-1 Molecular Formula|139298-40-1 MDL|139298-40-1 SMILES|139298-40-1 Kn-93 hydrochloride