Home Amines 1135280-28-2
1135280-28-2,MFCD24369012
Catalog No.:AA008TEE

1135280-28-2 | N-[2-({[(2E)-3-(4-chlorophenyl)prop-2-en-1-yl](methyl)amino}methyl)phenyl]-4-methoxybenzenesulfonamide; phosphoric acid

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5mg
in stock  
$497.00   $348.00
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10mg
in stock  
$663.00   $464.00
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50mg
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$1,818.00   $1,273.00
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200mg
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$4,097.00   $2,868.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008TEE
Chemical Name:
N-[2-({[(2E)-3-(4-chlorophenyl)prop-2-en-1-yl](methyl)amino}methyl)phenyl]-4-methoxybenzenesulfonamide; phosphoric acid
CAS Number:
1135280-28-2
Molecular Formula:
C24H28ClN2O7PS
Molecular Weight:
554.9801
MDL Number:
MFCD24369012
SMILES:
OP(=O)(O)O.COc1ccc(cc1)S(=O)(=O)Nc1ccccc1CN(CC=Cc1ccc(cc1)Cl)C
Properties
Computed Properties
 
Complexity:
700  
Covalently-Bonded Unit Count:
2  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
9  

Literature

Title: CaMKII inhibition hyperpolarizes membrane and blocks nitrergic IJP by closing a Cl(-) conductance in intestinal smooth muscle.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20120715

Title: Examining the effect of the CaMKII inhibitor administration in the locus coeruleus on the naloxone-precipitated morphine withdrawal signs in rats.

Journal: Behavioural brain research 20120115

Title: Calmodulin kinase II inhibition prevents arrhythmias in RyR2(R4496C+/-) mice with catecholaminergic polymorphic ventricular tachycardia.

Journal: Journal of molecular and cellular cardiology 20110101

Title: Modulations of NeuroD activity contribute to the differential effects of morphine and fentanyl on dendritic spine stability.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100616

Title: L-type Ca(2+) channel facilitation mediated by H(2)O(2)-induced activation of CaMKII in rat ventricular myocytes.

Journal: Journal of molecular and cellular cardiology 20100401

Title: CaMKII-independent effects of KN93 and its inactive analog KN92: reversible inhibition of L-type calcium channels.

Journal: Biochemical and biophysical research communications 20060714

Title: KN-93 (2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated potassium channels.

Journal: The Journal of pharmacology and experimental therapeutics 20060401

Title: Calcium signaling stimulates translation of HIF-alpha during hypoxia.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060301

Title: CaM kinase II phosphorylation of slo Thr107 regulates activity and ethanol responses of BK channels.

Journal: Nature neuroscience 20060101

Title: Ca(2+)/calmodulin-protein kinase IIalpha in the trigeminal subnucleus caudalis contributes to neuropathic pain following inferior alveolar nerve transection.

Journal: Experimental neurology 20050401

Title: Visualization of synaptic Ca2+ /calmodulin-dependent protein kinase II activity in living neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050323

Title: A CaMKII/calcineurin switch controls the direction of Ca(2+)-dependent growth cone guidance.

Journal: Neuron 20040916

Title: Regulation of cyclin D1/Cdk4 complexes by calcium/calmodulin-dependent protein kinase I.

Journal: The Journal of biological chemistry 20040409

Title: Roles of CaMKII, PKA, and PKC in the induction and maintenance of LTP of C-fiber-evoked field potentials in rat spinal dorsal horn.

Journal: Journal of neurophysiology 20040301

Title: Ca2+ and AMPK both mediate stimulation of glucose transport by muscle contractions.

Journal: Diabetes 20040201

Title: Reversal of morphine antinociceptive tolerance by acute spinal inhibition of Ca(2+)/calmodulin-dependent protein kinase II.

Journal: European journal of pharmacology 20030328

Title: Calcium/calmodulin-dependent kinase II is involved in the facilitating effect of clozapine on NMDA- and electrically evoked responses in the medial prefrontal cortical pyramidal cells.

Journal: Synapse (New York, N.Y.) 20030315

Title: Cellular mechanisms of the acute increase of glutamate release induced by nerve growth factor in rat cerebral cortex.

Journal: Neuropharmacology 20030301

Title: Calcium-calmodulin-dependent protein kinase II contributes to spinal cord central sensitization.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20020515

Title: KN-93 inhibition of G protein signaling is independent of the ability of Ca2+/calmodulin-dependent protein kinase II to phosphorylate phospholipase Cbeta3 on 537-Ser.

Journal: Molecular and cellular endocrinology 20010425

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Tags:1135280-28-2 Molecular Formula|1135280-28-2 MDL|1135280-28-2 SMILES|1135280-28-2 N-[2-({[(2E)-3-(4-chlorophenyl)prop-2-en-1-yl](methyl)amino}methyl)phenyl]-4-methoxybenzenesulfonamide; phosphoric acid