Home Sulfonamines 150725-87-4
150725-87-4,MFCD00918670
Catalog No.:AA001MQZ

150725-87-4 | Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(3-methoxyphenoxy)-4-pyrimidinyl]-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$32.00   $22.00
- +
5mg
98%
in stock  
$76.00   $54.00
- +
10mg
98%
in stock  
$148.00   $103.00
- +
25mg
98%
in stock  
$309.00   $217.00
- +
50mg
98%
in stock  
$402.00   $281.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001MQZ
Chemical Name:
Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(3-methoxyphenoxy)-4-pyrimidinyl]-
CAS Number:
150725-87-4
Molecular Formula:
C23H27N3O6S
Molecular Weight:
473.5420
MDL Number:
MFCD00918670
SMILES:
OCCOc1ncnc(c1Oc1cccc(c1)OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C
Properties
Computed Properties
 
Complexity:
687  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
10  
XLogP3:
4  

Literature

Title: Potent and selective ET-A antagonists. 1. Syntheses and structure-activity relationships of N-(6-(2-(aryloxy)ethoxy)-4-pyrimidinyl)sulfonamide derivatives.

Journal: Journal of medicinal chemistry 20011011

Title: Discovery and optimization of a novel class of orally active nonpeptidic endothelin-A receptor antagonists.

Journal: Journal of medicinal chemistry 19960524

Title: Breu V, et al. In vitro characterization of Ro 46-2005, a novel synthetic non-peptide endothelin antagonist of ETA and ETBreceptors. FEBS Lett. 1993 Nov 15;334(2):210-214.

Title: Clozel M, et al. Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist. Nature. 1993 Oct 21;365(6448):759-761.

Title: N.R. Sibson, et al. MRI Determination of the Mechanisms Underlying TNF-a-induced Changes in Cerebral Blood Volume, Tissue Water Diffusion and BBB Permeability. Proc. Intl. Soc. Mag. Reson. Med. 10 (2002)

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SDS
Tags:150725-87-4 Molecular Formula|150725-87-4 MDL|150725-87-4 SMILES|150725-87-4 Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(3-methoxyphenoxy)-4-pyrimidinyl]-