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Title: Fingolimod interrupts the cross talk between estrogen metabolism and sphingolipid metabolism within prostate cancer cells.
Journal: Toxicology letters 20180701
Title: Disease modifying therapies for relapsing multiple sclerosis.
Journal: BMJ (Clinical research ed.) 20160822
Title: Elevated Nuclear and Cytoplasmic FTY720-Phosphate in Mouse Embryonic Fibroblasts Suggests the Potential for Multiple Mechanisms in FTY720-Induced Neural Tube Defects.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20160301
Title: A natural piper-amide-like compound NED-135 exhibits a potent inhibitory effect on the invasive breast cancer cells.
Journal: Chemico-biological interactions 20150725
Title: FTY720 induces autophagy-related apoptosis and necroptosis in human glioblastoma cells.
Journal: Toxicology letters 20150702
Title: Simultaneous and dose dependent melanoma cytotoxic and immune stimulatory activity of betulin.
Journal: PloS one 20150101
Title: Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3.
Journal: Journal of neuroinflammation 20150101
Title: Analysis of Onset Mechanisms of a Sphingosine 1-Phosphate Receptor Modulator Fingolimod-Induced Atrioventricular Conduction Block and QT-Interval Prolongation.
Journal: Toxicology and applied pharmacology 20141115
Title: FTY720 attenuates paraquat-induced lung injury in mice.
Journal: International immunopharmacology 20140801
Title: Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory.
Journal: Nature neuroscience 20140701
Title: Transcriptome-based functional classifiers for direct immunotoxicity.
Journal: Archives of toxicology 20140301
Title: ASP4058, a novel agonist for sphingosine 1-phosphate receptors 1 and 5, ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile.
Journal: PloS one 20140101
Title: Suppression of experimental autoimmune optic neuritis by the novel agent fingolimod.
Journal: Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 20130601
Title: Circulating monocytes are reduced by sphingosine-1-phosphate receptor modulators independently of S1P3.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20130401
Title: Sphingosine and FTY720 are potent inhibitors of the transient receptor potential melastatin 7 (TRPM7) channels.
Journal: British journal of pharmacology 20130301
Title: Early tolerability and safety of fingolimod in clinical practice.
Journal: Journal of the neurological sciences 20121215
Title: Fingolimod inhibits PDGF-B-induced migration of vascular smooth muscle cell by down-regulating the S1PR1/S1PR3 pathway.
Journal: Biochimie 20121201
Title: Hypoxic preconditioning induces stroke tolerance in mice via a cascading HIF, sphingosine kinase, and CCL2 signaling pathway.
Journal: Journal of neurochemistry 20121201
Title: Effect of alkyl chain length on sphingosine kinase 2 selectivity.
Journal: Bioorganic & medicinal chemistry letters 20121115
Title: Withdrawal of fingolimod treatment for relapsing-remitting multiple sclerosis: report of six cases.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England) 20121101
Title: Severe multiple sclerosis reactivation under fingolimod 3 months after natalizumab withdrawal.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England) 20121101
Title: Switching therapy from natalizumab to fingolimod in relapsing-remitting multiple sclerosis: clinical and magnetic resonance imaging findings.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England) 20121101
Title: Emerging tumefactive multiple sclerosis after switching therapy from natalizumab to fingolimod.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England) 20121101
Title: Focus on molecules: Sphingosine 1 Phosphate (S1P).
Journal: Experimental eye research 20121001
Title: Sudden unexpected death on fingolimod.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England) 20121001
Title: Effects of FTY720 and rapamycin on inflammation in taurocholate-induced acute pancreatitis in the rat.
Journal: Pancreas 20121001
Title: New disease-modifying therapies and new challenges for MS.
Journal: Current neurology and neuroscience reports 20121001
Title: Increased sphingoid base-1-phosphates and failure of neural tube closure after exposure to fumonisin or FTY720.
Journal: Birth defects research. Part A, Clinical and molecular teratology 20121001
Title: The safety risks of innovation: the FDA's Expedited Drug Development Pathway.
Journal: JAMA 20120905
Title: A randomized, controlled trial of fingolimod (FTY720) in Japanese patients with multiple sclerosis.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England) 20120901
Title: A patient with Leiden V mutation, multiple sclerosis, psoriasis, and sicca syndrome: could celecoxib and fingolimod adversely affect the heart?
Journal: Cardiovascular toxicology 20120901
Title: Fingolimod--a sphingosine-like molecule inhibits vesicle mobility and secretion in astrocytes.
Journal: Glia 20120901
Title: 4-aminopyridine toxicity: a case report and review of the literature.
Journal: Journal of medical toxicology : official journal of the American College of Medical Toxicology 20120901
Title: Fingolimod attenuates ceramide-induced blood-brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes.
Journal: Acta neuropathologica 20120901
Title: Effect of sphingosine 1-phosphate (S1P) receptor agonists FTY720 and CYM5442 on atherosclerosis development in LDL receptor deficient (LDL-R⁻/⁻) mice.
Journal: Vascular pharmacology 20120819
Title: S1PR1 is an effective target to block STAT3 signaling in activated B cell-like diffuse large B-cell lymphoma.
Journal: Blood 20120816
Title: [Infections and fingolimod].
Journal: Revista de neurologia 20120816
Title: Sphingosine-1-phosphate-induced airway hyper-reactivity in rodents is mediated by the sphingosine-1-phosphate type 3 receptor.
Journal: The Journal of pharmacology and experimental therapeutics 20120801
Title: Immunosuppressive drugs on inducing Ag-specific CD4(+)CD25(+)Foxp3(+) Treg cells during immune response in vivo.
Journal: Transplant immunology 20120801
Title: A fluorescent assay for ceramide synthase activity.
Journal: Journal of lipid research 20120801
Title: Pharmacokinetics of fingolimod (FTY720) and a combined oral contraceptive coadministered in healthy women: drug-drug interaction study results.
Journal: International journal of clinical pharmacology and therapeutics 20120801
Title: Sphingosine-1-phosphate modulates expression of vascular endothelial growth factor in human articular chondrocytes: a possible new role in arthritis.
Journal: International journal of rheumatic diseases 20120801
Title: Population pharmacokinetics of fingolimod phosphate in healthy participants.
Journal: Journal of clinical pharmacology 20120701
Title: Fingolimod potentiates the effects of sunitinib malate in a rat breast cancer model.
Journal: Breast cancer research and treatment 20120701
Title: The utility of pharmacokinetic-pharmacodynamic modeling in the discovery and optimization of selective S1P(1) agonists.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20120701
Title: The sphingosine-1-phosphate receptor agonist FTY720 and its phosphorylated form affect the function of CD4+CD25+ T cells in vitro.
Journal: International journal of molecular medicine 20120701
Title: [Basic mechanisms of action of fingolimod in relation to multiple sclerosis].
Journal: Revista de neurologia 20120701
Title: Cost-effectiveness of early initiation of fingolimod versus delayed initiation after 1 year of intramuscular interferon beta-1a in patients with multiple sclerosis.
Journal: Clinical therapeutics 20120701
Title: [Therapeutic approach to mite-induced intractable dermatitis using novel immunomodulator FTY720 (fingolimod) in combination with betamethasone ointment in NC/Nga mice].
Journal: Arerugi = [Allergy] 20120701
Title: Sphingosine 1-phosphate receptor activation enhances BMP-2-induced osteoblast differentiation.
Journal: Biochemical and biophysical research communications 20120622
Title: First-line disease-modifying therapies in paediatric multiple sclerosis: a comprehensive overview.
Journal: Drugs 20120618
Title: Identification of benzoxazole analogs as novel, S1P(3) sparing S1P(1) agonists.
Journal: Bioorganic & medicinal chemistry letters 20120615
Title: FTY720 (fingolimod) increases vascular tone and blood pressure in spontaneously hypertensive rats via inhibition of sphingosine kinase.
Journal: British journal of pharmacology 20120601
Title: FTY720 mediates activation suppression and G(0)/G (1) cell cycle arrest in a concanavalin A-induced mouse lymphocyte pan-activation model.
Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20120601
Title: Signaling and regulatory functions of bioactive sphingolipids as therapeutic targets in multiple sclerosis.
Journal: Neurochemical research 20120601
Title: [Assessment of the clinical and MRI results of the FREEDOMS and TRANSFORMS phase III. clinical trials].
Journal: Ideggyogyaszati szemle 20120530
Title: FTY720, sphingosine 1-phosphate receptor modulator, selectively radioprotects hippocampal neural stem cells.
Journal: Neuroscience letters 20120516
Title: Sphingosine analogue AAL-R increases TLR7-mediated dendritic cell responses via p38 and type I IFN signaling pathways.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20120515
Title: [Multiple sclerosis: beyong first line therapies].
Journal: Revue medicale suisse 20120502
Title: Annualized relapse rate of first-line treatments for multiple sclerosis: a meta-analysis, including indirect comparisons versus fingolimod.
Journal: Current medical research and opinion 20120501
Title: MS clinical trials: what can subgroup analyses teach us?
Journal: The Lancet. Neurology 20120501
Title: Relapse and disability outcomes in patients with multiple sclerosis treated with fingolimod: subgroup analyses of the double-blind, randomised, placebo-controlled FREEDOMS study.
Journal: The Lancet. Neurology 20120501
Title: Immunotherapies in neurologic disorders.
Journal: The Medical clinics of North America 20120501
Title: [New disease-modifying and symptomatic therapies for multiple sclerosis].
Journal: MMW Fortschritte der Medizin 20120419
Title: Treatment with a sphingosine-1-phosphate analog inhibits airway remodeling following repeated allergen exposure.
Journal: American journal of physiology. Lung cellular and molecular physiology 20120415
Title: Drugs: An injection of hope.
Journal: Nature 20120412
Title: Autophagy induced by FTY720 promotes apoptosis in U266 cells.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120411
Title: Treatments for relapsing-remitting multiple sclerosis: summarising current information by network meta-analysis.
Journal: European journal of clinical pharmacology 20120401
Title: Placebo-controlled study of the effects of fingolimod on cardiac rate and rhythm and pulmonary function in healthy volunteers.
Journal: European journal of clinical pharmacology 20120401
Title: Reactivating PP2A by FTY720 as a novel therapy for AML with C-KIT tyrosine kinase domain mutation.
Journal: Journal of cellular biochemistry 20120401
Title: Reactive murine lymph nodes uniquely permit parenchymal access for T cells that enter via the afferent lymphatics.
Journal: The Journal of pathology 20120401
Title: Rapid histamine-induced neutrophil recruitment is sphingosine kinase-1 dependent.
Journal: The American journal of pathology 20120401
Title: Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma.
Journal: Neuro-oncology 20120401
Title: FTY720 improves functional recovery after spinal cord injury by primarily nonimmunomodulatory mechanisms.
Journal: The American journal of pathology 20120401
Title: Network analysis of randomized controlled trials in multiple sclerosis.
Journal: Clinical therapeutics 20120401
Title: [2012: Update on diagnosis and treatment of multiple sclerosis].
Journal: Deutsche medizinische Wochenschrift (1946) 20120401
Title: Fingolimod: cardiovascular deaths.
Journal: Prescrire international 20120401
Title: Discovery of fingolimod, the sphingosine 1-phosphate receptor modulator and its application for the therapy of multiple sclerosis.
Journal: Future medicinal chemistry 20120401
Title: Severe multiple sclerosis relapse under fingolimod therapy: incident or coincidence?
Journal: Neurology 20120320
Title: Local delivery of FTY720 accelerates cranial allograft incorporation and bone formation.
Journal: Cell and tissue research 20120301
Title: Prevention of GVHD and graft rejection by a new S1P receptor agonist, W-061, in rat small bowel transplantation.
Journal: Transplant immunology 20120301
Title: LC-MS/MS determination of FTY720 and FTY720-phosphate in murine intracellular compartments and human plasma.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120301
Title: FTY720-induced blockage of autophagy enhances anticancer efficacy of milatuzumab in mantle cell lymphoma: is FTY720 the next autophagy-blocking agent in lymphoma treatment?
Journal: Autophagy 20120301
Title: FTY720 on the way from the base camp to the summit of the mountain: relevance for remyelination.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England) 20120301
Title: Fingolimod blocks immunosurveillance of myeloma and B-cell lymphoma resulting in cancer development in mice.
Journal: Blood 20120301
Title: Fingolimod-associated macular edema: incidence, detection, and management.
Journal: Neurology 20120227
Title: Agency is under fire for refusing to supply details of sudden deaths after first dose of multiple sclerosis drug.
Journal: BMJ (Clinical research ed.) 20120223
Title: FTY720 normalizes hyperglycemia by stimulating β-cell in vivo regeneration in db/db mice through regulation of cyclin D3 and p57(KIP2).
Journal: The Journal of biological chemistry 20120217
Title: Oral fingolimod rescues the functional deficits of synapses in experimental autoimmune encephalomyelitis.
Journal: British journal of pharmacology 20120201
Title: Targeting synaptic pathology in multiple sclerosis: fingolimod to the rescue?
Journal: British journal of pharmacology 20120201
Title: [Fingolimod treatment for multiple sclerosis patients. Infectiological aspects and recommendations for vaccinations].
Journal: Der Nervenarzt 20120201
Title: Inhibitors of specific ceramide synthases.
Journal: Biochimie 20120201
Title: S1P(1) receptor modulation with cyclical recovery from lymphopenia ameliorates mouse model of multiple sclerosis.
Journal: Molecular pharmacology 20120201
Title: Therapeutic dosing of fingolimod (FTY720) prevents cell infiltration, rapidly suppresses ocular inflammation, and maintains the blood-ocular barrier.
Journal: The American journal of pathology 20120201
Title: Does fingolimod in multiple sclerosis patients cause macular edema?
Journal: Journal of neurology 20120201
Title: Mouse model for probing tumor suppressor activity of protein phosphatase 2A in diverse signaling pathways.
Journal: Cell cycle (Georgetown, Tex.) 20120201
Title: Fingolimod for multiple sclerosis.
Journal: Drug and therapeutics bulletin 20120201
Title: Rebound of disease activity after withdrawal of fingolimod (FTY720) treatment.
Journal: Archives of neurology 20120201
Title: Synthesis and immunomodulating activity of new analogues of fingolimod.
Journal: Archiv der Pharmazie 20120201
Title: [Role of S1P acting both inside and outside the cells].
Journal: Seikagaku. The Journal of Japanese Biochemical Society 20120201
Title: Fingolimod for multiple sclerosis.
Journal: The New England journal of medicine 20120126
Title: Fast simultaneous quantitative analysis of FTY720 and its metabolite FTY720-P in human blood by on-line solid phase extraction coupled with liquid chromatography-tandem mass spectrometry.
Journal: Journal of pharmaceutical and biomedical analysis 20120125
Title: [Neurology].
Journal: Revue medicale suisse 20120111
Title: Fingolimod in multiple sclerosis: mechanisms of action and clinical efficacy.
Journal: Clinical immunology (Orlando, Fla.) 20120101
Title: Sphingosine 1-phosphate in coagulation and inflammation.
Journal: Seminars in immunopathology 20120101
Title: The sphingosine-1-phosphate receptor agonist FTY720 prevents the development of anti-glomerular basement membrane glomerulonephritis.
Journal: Molecular biology reports 20120101
Title: Novel immunomodulators based on an oxazolin-2-one-4-carboxamide scaffold.
Journal: Bioorganic & medicinal chemistry letters 20120101
Title: Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors.
Journal: Bioorganic & medicinal chemistry 20120101
Title: Development of extensive brain lesions following fingolimod (FTY720) treatment in a patient with neuromyelitis optica spectrum disorder.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England) 20120101
Title: Clinical pharmacokinetics of fingolimod.
Journal: Clinical pharmacokinetics 20120101
Title: Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs.
Journal: Annual review of immunology 20120101
Title: Both exogenous commensal and endogenous self antigens stimulate T cell proliferation under lymphopenic conditions.
Journal: Cellular immunology 20120101
Title: FTY720 suppresses liver tumor metastasis by reducing the population of circulating endothelial progenitor cells.
Journal: PloS one 20120101
Title: [Research progress of the selective sphingosine-1-phosphate receptor 1 agonists].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20120101
Title: Topical application of FTY720 and cyclosporin A prolong corneal graft survival in mice.
Journal: Molecular vision 20120101
Title: Lymphocyte modulation with FTY720 improves hemorrhagic shock survival in swine.
Journal: PloS one 20120101
Title: Disparate in vivo efficacy of FTY720 in xenograft models of Philadelphia positive and negative B-lineage acute lymphoblastic leukemia.
Journal: PloS one 20120101
Title: [Sphingosine-1-phosphate signaling system and the innovative mechanism of action of fingolimod in treatment of multiple sclerosis: review of foreign literature].
Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20120101
Title: Topographical and biological evidence revealed FTY720-mediated anergy-polarization of mouse bone marrow-derived dendritic cells in vitro.
Journal: PloS one 20120101
Title: Oral FTY720 administration induces immune tolerance and inhibits early development of atherosclerosis in apolipoprotein E-deficient mice.
Journal: International journal of immunopathology and pharmacology 20120101
Title: Effect of FTY720 on some physiological indexes of Non-Obese Diabetic (NOD) Mice.
Journal: International journal of molecular sciences 20120101
Title: Therapeutic approach to steroid-resistant dermatitis using novel immunomodulator FTY720 (Fingolimod) in combination with betamethasone ointment in NC/Nga mice.
Journal: Biological & pharmaceutical bulletin 20120101
Title: Dealing with excess of zeros in the statistical analysis of magnetic resonance imaging lesion count in multiple sclerosis.
Journal: Pharmaceutical statistics 20120101
Title: Development of oral agent in the treatment of multiple sclerosis: how the first available oral therapy, fingolimod will change therapeutic paradigm approach.
Journal: Drug design, development and therapy 20120101
Title: Fingolimod in the treatment algorithm of relapsing remitting multiple sclerosis: a statement of the Central and East European (CEE) MS Expert Group.
Journal: Wiener medizinische Wochenschrift (1946) 20120101
Title: Synthesis of a key intermediate for the preparation of FTY720 analogs.
Journal: Chemical & pharmaceutical bulletin 20120101
Title: FTY720 increases CD74 expression and sensitizes mantle cell lymphoma cells to milatuzumab-mediated cell death.
Journal: Blood 20111222
Title: Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart.
Journal: Circulation 20111213
Title: FTY720-induced conversion of conventional Foxp3- CD4+ T cells to Foxp3+ regulatory T cells in NOD mice.
Journal: American journal of reproductive immunology (New York, N.Y. : 1989) 20111101
Title: Delayed fingolimod-associated asystole.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England) 20111101
Title: Targeting sphingosine-1-phosphate in hematologic malignancies.
Journal: Anti-cancer agents in medicinal chemistry 20111101
Title: Oral fingolimod (FTY720) in relapsing multiple sclerosis: impact on health-related quality of life in a phase II study.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England) 20111101
Title: FTY720 combined with tacrolimus in de novo renal transplantation: 1-year, multicenter, open-label randomized study.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20111101
Title: Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules.
Journal: Cancer research 20111101
Title: Background and rationale for mechanism of action, efficacy, and safety of fingolimod (Gilenya), the first oral therapy for remitting-relapsing multiple sclerosis: with special emphasis upon visual safety.
Journal: Current opinion in ophthalmology 20111101
Title: Oral treatment for multiple sclerosis.
Journal: The Lancet. Neurology 20111101
Title: Short-term immunossupressive treatment of the donor does not prevent ischemia-reperfusion kidney damage in the rat.
Journal: Transplantation proceedings 20111101
Title: [Multiple sclerosis: current therapies and future perspectives].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20111101
Title: Non-phosphorylated FTY720 induces apoptosis of human microglia by activating SREBP2.
Journal: Cellular and molecular neurobiology 20111001
Title: (R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells.
Journal: Cellular signalling 20111001
Title: Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury.
Journal: American journal of physiology. Heart and circulatory physiology 20111001
Title: Fingolimod for multiple sclerosis: mechanism of action, clinical outcomes, and future directions.
Journal: Current neurology and neuroscience reports 20111001
Title: [The study of FTY720 on inducing apoptosis and autophagy in multiple myeloma cell line U266].
Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20111001
Title: Activation of sphingosine kinase 2 is an endogenous protective mechanism in cerebral ischemia.
Journal: Biochemical and biophysical research communications 20110923
Title: The effect of FTY720 in the Theiler's virus model of multiple sclerosis.
Journal: Journal of the neurological sciences 20110915
Title: Therapeutic potential of targeting sphingosine kinase 1 in prostate cancer.
Journal: Nature reviews. Urology 20110913
Title: Therapeutic efficacy of FTY720 in a rat model of NK-cell leukemia.
Journal: Blood 20110908
Title: FTY720 (Gilenya) phosphate selectivity of sphingosine 1-phosphate receptor subtype 1 (S1P1) G protein-coupled receptor requires motifs in intracellular loop 1 and transmembrane domain 2.
Journal: The Journal of biological chemistry 20110902
Title: There is more to a lipid than just being a fat: sphingolipid-guided differentiation of oligodendroglial lineage from embryonic stem cells.
Journal: Neurochemical research 20110901
Title: The sphingosine 1-phosphate receptor modulator FTY720 prevents iodide-induced autoimmune thyroiditis in non-obese diabetic mice.
Journal: Autoimmunity 20110901
Title: TLR2 and TLR4 expression after kidney ischemia and reperfusion injury in mice treated with FTY720.
Journal: International immunopharmacology 20110901
Title: Characterization of a sphingosine 1-phosphate receptor antagonist prodrug.
Journal: The Journal of pharmacology and experimental therapeutics 20110901
Title: MS Forum/MS Over the Past 17 Years.
Journal: International MS journal 20110901
Title: Multiple Sclerosis: The Big Questions- The MS Forum Workshop.
Journal: International MS journal 20110901
Title: Sphingosine 1-phosphate receptor modulator fingolimod (FTY720) does not promote remyelination in vivo.
Journal: Molecular and cellular neurosciences 20110901
Title: FTY720 blocks egress of T cells in part by abrogation of their adhesion on the lymph node sinus.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20110901
Title: Branch retinal vein occlusion during fingolimod treatment in a patient with multiple sclerosis.
Journal: Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 20110901
Title: A mechanistically novel, first oral therapy for multiple sclerosis: the development of fingolimod (FTY720, Gilenya).
Journal: Discovery medicine 20110901
Title: NICE rules out NHS prescription of fingolimod for multiple sclerosis.
Journal: BMJ (Clinical research ed.) 20110810
Title: Pharmacologic evaluation of sulfasalazine, FTY720, and anti-IL-12/23p40 in a TNBS-induced Crohn's disease model.
Journal: Digestive diseases and sciences 20110801
Title: The Sphingosine-1 Phosphate receptor agonist FTY720 dose dependently affected endothelial integrity in vitro and aggravated ventilator-induced lung injury in mice.
Journal: Pulmonary pharmacology & therapeutics 20110801
Title: Immunosuppression with FTY720 is insufficient to prevent secondary progressive neurodegeneration in experimental autoimmune encephalomyelitis.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England) 20110801
Title: Oral fingolimod for the treatment of patients with relapsing forms of multiple sclerosis.
Journal: International journal of clinical practice 20110801
Title: Natural product drug discovery: the successful optimization of ISP-1 and halichondrin B.
Journal: Current opinion in chemical biology 20110801
Title: Fingolimod: a review of its use in the management of relapsing-remitting multiple sclerosis.
Journal: CNS drugs 20110801
Title: Melanoma occurring during treatment with fingolimod for multiple sclerosis: a case report.
Journal: Archives of dermatology 20110801
Title: Multiple sclerosis treatment: First oral drug, new antibody therapies.
Journal: JAAPA : official journal of the American Academy of Physician Assistants 20110801
Title: Redirected tumor-specific allogeneic T cells for universal treatment of cancer.
Journal: Blood 20110728
Title: Targeting lymphangiogenesis after islet transplantation prolongs islet allograft survival.
Journal: Transplantation 20110715
Title: Multiple sclerosis: Cladribine--a contentious therapeutic contender for MS.
Journal: Nature reviews. Neurology 20110712
Title: FTY720-induced human pulmonary endothelial barrier enhancement is mediated by c-Abl.
Journal: The European respiratory journal 20110701
Title: FTY720 produces caspase-independent cell death of acute lymphoblastic leukemia cells.
Journal: Autophagy 20110701
Title: A novel lipid natriuretic factor in the renal medulla: sphingosine-1-phosphate.
Journal: American journal of physiology. Renal physiology 20110701
Title: Reduction of the peripheral blood CD56(bright) NK lymphocyte subset in FTY720-treated multiple sclerosis patients.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20110701
Title: Discovery of S1P agonists with a dihydronaphthalene scaffold.
Journal: Bioorganic & medicinal chemistry letters 20110701
Title: Sphingosine 1-phosphate receptor modulator FTY720 suppresses rat experimental autoimmune prostatitis.
Journal: Scandinavian journal of immunology 20110601
Title: Antitumor effects of OSU-2S, a nonimmunosuppressive analogue of FTY720, in hepatocellular carcinoma.
Journal: Hepatology (Baltimore, Md.) 20110601
Title: New drugs 2011 part 2.
Journal: Nursing 20110601
Title: Engagement of S1P₁-degradative mechanisms leads to vascular leak in mice.
Journal: The Journal of clinical investigation 20110601
Title: Transforming multiple sclerosis trials into practical reality.
Journal: The Lancet. Neurology 20110601
Title: Comparison of fingolimod with interferon beta-1a in relapsing-remitting multiple sclerosis: a randomised extension of the TRANSFORMS study.
Journal: The Lancet. Neurology 20110601
Title: Pharmacokinetics, pharmacodynamics, safety, and tolerability of single-dose fingolimod (FTY720) in adolescents with stable renal transplants.
Journal: Pediatric transplantation 20110601
Title: [Influence of PP2A activator on proliferation of HL-60 cells and analysis of PP2A activity changes in patients with acute myeloid leukemia].
Journal: Zhongguo shi yan xue ye xue za zhi 20110601
Title: FTY720 analogues as sphingosine kinase 1 inhibitors: enzyme inhibition kinetics, allosterism, proteasomal degradation, and actin rearrangement in MCF-7 breast cancer cells.
Journal: The Journal of biological chemistry 20110527
Title: Magnetic resonance imaging as surrogate for clinical endpoints in multiple sclerosis: data on novel oral drugs.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England) 20110501
Title: Neurobiological effects of sphingosine 1-phosphate receptor modulation in the cuprizone model.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110501
Title: Chronic sphingosine 1-phosphate 1 receptor activation attenuates early-stage diabetic nephropathy independent of lymphocytes.
Journal: Kidney international 20110501
Title: Managing MS in a changing treatment landscape.
Journal: Journal of neurology 20110501
Title: Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis.
Journal: Annals of neurology 20110501
Title: American academy of neurology annual meeting.
Journal: International MS journal 20110501
Title: Fingolimod (FTY720): a recently approved multiple sclerosis drug based on a fungal secondary metabolite.
Journal: Journal of natural products 20110425
Title: Essential role of protein phosphatase 2A in metaphase II arrest and activation of mouse eggs shown by okadaic acid, dominant negative protein phosphatase 2A, and FTY720.
Journal: The Journal of biological chemistry 20110422
Title: Differential effects of fingolimod (FTY720) on immune cells in the CSF and blood of patients with MS.
Journal: Neurology 20110405
Title: Sphingosine kinase and sphingosine 1-phosphate in asthma.
Journal: Bioscience reports 20110401
Title: Fingolimod: an oral disease-modifying therapy for relapsing multiple sclerosis.
Journal: Advances in therapy 20110401
Title: Anti-inflammatory effects of FTY720 do not prevent neuronal cell loss in a rat model of optic neuritis.
Journal: The American journal of pathology 20110401
Title: In vivo delivery of FTY720 prevents radiation-induced ovarian failure and infertility in adult female nonhuman primates.
Journal: Fertility and sterility 20110315
Title: Primary varicella zoster infection associated with fingolimod treatment.
Journal: Neurology 20110315
Title: Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers -- Letter.
Journal: Cancer research 20110315
Title: Prevention, but not cure, of autoimmune diabetes in a NOD.scid transfer model by FTY720 despite effective modulation of blood T cells.
Journal: Autoimmunity 20110301
Title: Selective activation of sphingosine 1-phosphate receptors 1 and 3 promotes local microvascular network growth.
Journal: Tissue engineering. Part A 20110301
Title: Fingolimod (FTY720), sphingosine 1-phosphate receptor modulator, shows superior efficacy as compared with interferon-β in mouse experimental autoimmune encephalomyelitis.
Journal: International immunopharmacology 20110301
Title: Cis-4-methylsphingosine is a sphingosine-1-phosphate receptor modulator.
Journal: Biochemical pharmacology 20110301
Title: The regulatory mechanism of melanogenesis by FTY720, a sphingolipid analogue.
Journal: Experimental dermatology 20110301
Title: Structure-activity relationship studies of sphingosine-1-phosphate receptor agonists with N-cinnamyl-β-alanine moiety.
Journal: Bioorganic & medicinal chemistry letters 20110301
Title: Embryonic pig pancreatic tissue for the treatment of diabetes: potential role of immune suppression with 'off-the-shelf' third-party regulatory T cells.
Journal: Transplantation 20110227
Title: Impact of sphingosine 1-phosphate modulation on immune outcomes.
Journal: Neurology 20110222
Title: Clinical immunology of the sphingosine 1-phosphate receptor modulator fingolimod (FTY720) in multiple sclerosis.
Journal: Neurology 20110222
Title: Future clinical challenges in multiple sclerosis: Relevance to sphingosine 1-phosphate receptor modulator therapy.
Journal: Neurology 20110222
Title: Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation.
Journal: Neurology 20110222
Title: The neurobiology of sphingosine 1-phosphate signaling and sphingosine 1-phosphate receptor modulators.
Journal: Neurology 20110222
Title: Modulation of sphingosine 1-phosphate signaling in neurologic disease.
Journal: Neurology 20110222
Title: Sphingosine-1-phosphate receptor 3 promotes recruitment of monocyte/macrophages in inflammation and atherosclerosis.
Journal: Circulation research 20110204
Title: [Oral fingolimod in multiple sclerosis: therapeutic modulation of the sphingosine-1-phosphate system].
Journal: Der Nervenarzt 20110201
Title: Emerging disease-modifying oral therapies for multiple sclerosis.
Journal: Journal of neuroimmunology 20110201
Title: Autoimmune uveitis: the associated proinflammatory molecules and the search for immunoregulation.
Journal: Autoimmunity reviews 20110201
Title: Roles for lysophospholipid S1P receptors in multiple sclerosis.
Journal: Critical reviews in biochemistry and molecular biology 20110201
Title: Absorption and disposition of the sphingosine 1-phosphate receptor modulator fingolimod (FTY720) in healthy volunteers: a case of xenobiotic biotransformation following endogenous metabolic pathways.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110201
Title: CYP4F enzymes are responsible for the elimination of fingolimod (FTY720), a novel treatment of relapsing multiple sclerosis.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110201
Title: Fingolimod for the treatment of relapsing multiple sclerosis.
Journal: Expert review of neurotherapeutics 20110201
Title: Systemic influence of immunosuppressive drugs on small and large bowel transport and barrier function.
Journal: Transplant international : official journal of the European Society for Organ Transplantation 20110201
Title: Multiple sclerosis in 2010: Advances in monitoring and treatment of multiple sclerosis.
Journal: Nature reviews. Neurology 20110201
Title: Antigen-specific adaptive immune responses in fingolimod-treated multiple sclerosis patients.
Journal: Annals of neurology 20110201
Title: [Current treatment of multiple sclerosis].
Journal: Lege artis medicinae : uj magyar orvosi hirmondo 20110201
Title: The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720.
Journal: The Journal of biological chemistry 20110121
Title: Gilenya (FTY720) inhibits acid sphingomyelinase by a mechanism similar to tricyclic antidepressants.
Journal: Biochemical and biophysical research communications 20110107
Title: CD4+ CD25+ regulatory T cells partially mediate the beneficial effects of FTY720, a sphingosine-1-phosphate analogue, during ischaemia/reperfusion-induced acute kidney injury.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20110101
Title: Characterization of sphingosine-1-phosphate lyase activity by electrospray ionization-liquid chromatography/tandem mass spectrometry quantitation of (2E)-hexadecenal.
Journal: Analytical biochemistry 20110101
Title: Differential responses of human microglia and blood-derived myeloid cells to FTY720.
Journal: Journal of neuroimmunology 20110101
Title: Oral therapies for multiple sclerosis: a review of agents in phase III development or recently approved.
Journal: CNS drugs 20110101
Title: Therapeutic approach to multiple sclerosis by novel oral drug.
Journal: Recent patents on inflammation & allergy drug discovery 20110101
Title: New drugs: dabigatran etexilate mesylate, fingolimod hydrochloride, and ulipristal acetate.
Journal: Journal of the American Pharmacists Association : JAPhA 20110101
Title: Synthetic sphingosine 1-phosphate receptor modulators--opportunities and potential pitfalls.
Journal: Current topics in medicinal chemistry 20110101
Title: Fingolimod provides long-term protection in rodent models of cerebral ischemia.
Journal: Annals of neurology 20110101
Title: [Immunosuppressive agents in kidney transplantation].
Journal: Nihon Jinzo Gakkai shi 20110101
Title: Current disease-modifying treatment of multiple sclerosis.
Journal: The Mount Sinai journal of medicine, New York 20110101
Title: Multiple sclerosis therapeutic pipeline: opportunities and challenges.
Journal: The Mount Sinai journal of medicine, New York 20110101
Title: S1P is associated with protection in human and experimental cerebral malaria.
Journal: Molecular medicine (Cambridge, Mass.) 20110101
Title: Enhancement of neoangiogenesis and follicle survival by sphingosine-1-phosphate in human ovarian tissue xenotransplants.
Journal: PloS one 20110101
Title: Relapse of experimental autoimmune encephalomyelitis after discontinuation of FTY720 (Fingolimod) treatment, but not after combination of FTY720 and pathogenic autoantigen.
Journal: Biological & pharmaceutical bulletin 20110101
Title: Evaluation of cell cycle arrest in estrogen responsive MCF-7 breast cancer cells: pitfalls of the MTS assay.
Journal: PloS one 20110101
Title: FTY720 reduces post-ischemic brain lymphocyte influx but does not improve outcome in permanent murine cerebral ischemia.
Journal: PloS one 20110101
Title: FTY720 is neuroprotective and improves functional outcomes after intracerebral hemorrhage in mice.
Journal: Acta neurochirurgica. Supplement 20110101
Title: Fingolimod modulates microglial activation to augment markers of remyelination.
Journal: Journal of neuroinflammation 20110101
Title: Fingolimod.
Journal: Prescrire international 20110101
Title: Cost-effectiveness of natalizumab versus fingolimod for the treatment of relapsing multiple sclerosis.
Journal: Journal of medical economics 20110101
Title: Novel therapeutic approaches to autoimmune demyelinating disorders.
Journal: Current pharmaceutical design 20110101
Title: [A plan for risk management in the treatment of multiple sclerosis with gilenia (fingolimod)].
Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101
Title: The immunosuppressant FTY720 (fingolimod) enhances glycosaminoglycan depletion in articular cartilage.
Journal: BMC musculoskeletal disorders 20110101
Title: Oral fingolimod (gilenya) for multiple sclerosis.
Journal: The Medical letter on drugs and therapeutics 20101229
Title: Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury.
Journal: American journal of respiratory cell and molecular biology 20101201
Title: Effects of different dose of FTY720 on lymphocyte cell cycle arrest in cardiac transplantation model of rats.
Journal: Immunopharmacology and immunotoxicology 20101201
Title: Adoptive transfer of FTY720-treated immature BMDCs significantly prolonged cardiac allograft survival.
Journal: Transplant international : official journal of the European Society for Organ Transplantation 20101201
Title: T helper type 1 memory cells disseminate postoperative ileus over the entire intestinal tract.
Journal: Nature medicine 20101201
Title: Understanding the effects of FTY720 on leukocyte trafficking.
Journal: Archives of neurology 20101201
Title: Distinct properties of circulating CD8+ T cells in FTY720-treated patients with multiple sclerosis.
Journal: Archives of neurology 20101201
Title: Effect of FTY720 treatment on postischemic pancreatic microhemodynamics.
Journal: Transplantation proceedings 20101201
Title: FDA approves the first oral drug for reducing multiple sclerosis relapses.
Journal: Harvard women's health watch 20101201
Title: Sphingosine 1-phosphate receptor 4 uses HER2 (ERBB2) to regulate extracellular signal regulated kinase-1/2 in MDA-MB-453 breast cancer cells.
Journal: The Journal of biological chemistry 20101112
Title: FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: a protective role of autophagy.
Journal: Autophagy 20101101
Title: FTY720 (fingolimod) sensitizes prostate cancer cells to radiotherapy by inhibition of sphingosine kinase-1.
Journal: Cancer research 20101101
Title: Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis.
Journal: Nature reviews. Drug discovery 20101101
Title: Novartis eyes oral MS drug as potential blockbuster.
Journal: Nature biotechnology 20101101
Title: [Role of T lymphocytes in ischemic brain injury].
Journal: Rinsho shinkeigaku = Clinical neurology 20101101
Title: Design and synthesis of selective and potent orally active S1P5 agonists.
Journal: ChemMedChem 20101004
Title: FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells.
Journal: Cellular signalling 20101001
Title: Reconstitution of circulating lymphocyte counts in FTY720-treated MS patients.
Journal: Clinical immunology (Orlando, Fla.) 20101001
Title: Elimination of a hydroxyl group in FTY720 dramatically improves the phosphorylation rate.
Journal: Molecular pharmacology 20101001
Title: FTY720 regulates bone marrow egress of eosinophils and modulates late-phase skin reaction in mice.
Journal: The American journal of pathology 20101001
Title: Neurological S1P signaling as an emerging mechanism of action of oral FTY720 (fingolimod) in multiple sclerosis.
Journal: Archives of pharmacal research 20101001
Title: Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function.
Journal: Cellular signalling 20100901
Title: Emerging therapies in relapsing-remitting multiple sclerosis.
Journal: Reviews on recent clinical trials 20100901
Title: PTEN- and p53-mediated apoptosis and cell cycle arrest by FTY720 in gastric cancer cells and nude mice.
Journal: Journal of cellular biochemistry 20100901
Title: A key role for lung-resident memory lymphocytes in protective immune responses after BCG vaccination.
Journal: European journal of immunology 20100901
Title: The enhancement of bone allograft incorporation by the local delivery of the sphingosine 1-phosphate receptor targeted drug FTY720.
Journal: Biomaterials 20100901
Title: Sphingosine 1-phosphate receptor 1 and 3 are upregulated in multiple sclerosis lesions.
Journal: Glia 20100901
Title: Emerging oral agents for multiple sclerosis.
Journal: The American journal of managed care 20100901
Title: Th17 central memory T cells are reduced by FTY720 in patients with multiple sclerosis.
Journal: Neurology 20100803
Title: FTY720 and central memory: out of sight, out of mind.
Journal: Neurology 20100803
Title: Tumor masses support naive T cell infiltration, activation, and differentiation into effectors.
Journal: The Journal of experimental medicine 20100802
Title: Effect of combined treatment with FK506, FTY720, and ex vivo graft irradiation in rat small bowel transplantation: expression of mucosal addressin cell adhesion molecule-1.
Journal: Pediatric transplantation 20100801
Title: Effects of the novel immunosuppressant FTY720 in a murine rheumatoid arthritis model.
Journal: Clinical immunology (Orlando, Fla.) 20100801
Title: Diabetes prevention by immunomodulatory FTY720 treatment in the LEW.1AR1-iddm rat despite immune cell activation.
Journal: Endocrinology 20100801
Title: FTY720 mediates cytochrome c release from mitochondria during rat thymocyte apoptosis.
Journal: Transplant immunology 20100801
Title: Update on emerging therapies for multiple sclerosis.
Journal: Expert review of neurotherapeutics 20100801
Title: Avoiding infusion therapy prime benefit of new MS drug.
Journal: Managed care (Langhorne, Pa.) 20100801
Title: Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers.
Journal: Cancer research 20100701
Title: Fingolimod is a potential novel therapy for multiple sclerosis.
Journal: Nature reviews. Neurology 20100701
Title: Pharmacological pre- and post-conditioning with the sphingosine-1-phosphate receptor modulator FTY720 after myocardial ischaemia-reperfusion.
Journal: British journal of pharmacology 20100701
Title: [Fingolimod in the treatment of multiple sclerosis. Novelties presented at the annual congress of the American Academy of Neurology (Toronto, April 2010)].
Journal: Drugs of today (Barcelona, Spain : 1998) 20100701
Title: FTY720 shows promising in vitro and in vivo preclinical activity by downmodulating Cyclin D1 and phospho-Akt in mantle cell lymphoma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20100615
Title: Critical vasospasm during fingolimod (FTY720) treatment in a patient with multiple sclerosis.
Journal: Neurology 20100615
Title: [Emerging treatments for multiple sclerosis].
Journal: Revue medicale suisse 20100602
Title: FTY720 promotes local microvascular network formation and regeneration of cranial bone defects.
Journal: Tissue engineering. Part A 20100601
Title: Prevention of diabetes by FTY720-mediated stabilization of peri-islet tertiary lymphoid organs.
Journal: Diabetes 20100601
Title: Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury.
Journal: Journal of the American Society of Nephrology : JASN 20100601
Title: The impact of fingolimod (FTY720) in neuroimmunologic diseases: mechanisms beyond immunomodulation.
Journal: The American journal of pathology 20100601
Title: Fingolimod (FTY720) enhances remyelination following demyelination of organotypic cerebellar slices.
Journal: The American journal of pathology 20100601
Title: Sphingosine 1-phosphate receptor type 1 regulates egress of mature T cells from mouse bone marrow.
Journal: International immunology 20100601
Title: Oral cladribine and fingolimod for relapsing multiple sclerosis.
Journal: The New England journal of medicine 20100506
Title: Effects of the novel protein kinase C inhibitor AEB071 (Sotrastaurin) on rat cardiac allograft survival using single agent treatment or combination therapy with cyclosporine, everolimus or FTY720.
Journal: Transplant international : official journal of the European Society for Organ Transplantation 20100501
Title: Evaluation of experimental autoimmune uveitis in mice treated with FTY720.
Journal: Investigative ophthalmology & visual science 20100501
Title: Fingolimod for relapsing multiple sclerosis: an update.
Journal: Expert opinion on pharmacotherapy 20100501
Title: Oral fingolimod for the treatment of relapsing-remitting multiple sclerosis.
Journal: Drugs of today (Barcelona, Spain : 1998) 20100501
Title: FTY720 exerts a survival advantage through the prevention of end-stage glomerular inflammation in lupus-prone BXSB mice.
Journal: Biochemical and biophysical research communications 20100409
Title: FTY720 and SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release.
Journal: Cancer immunology, immunotherapy : CII 20100401
Title: Targeting the sphingolipid signaling pathway in stroke.
Journal: Stroke 20100401
Title: [How rare is tuberculosis?].
Journal: Medizinische Monatsschrift fur Pharmazeuten 20100401
Title: [Development of oral therapies for multiple sclerosis--fingolimod, cladribine and other drugs].
Journal: Medizinische Monatsschrift fur Pharmazeuten 20100401
Title: Multiple sclerosis: closing in on an oral treatment.
Journal: Nature 20100318
Title: FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages.
Journal: Circulation research 20100305
Title: [Progress of therapy in patients with multiple sclerosis].
Journal: MMW Fortschritte der Medizin 20100304
Title: United airways: circulating Th2 effector cells in an allergic rhinitis model are responsible for promoting lower airways inflammation.
Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20100301
Title: Discovery of a novel series of potent S1P1 agonists.
Journal: Bioorganic & medicinal chemistry letters 20100301
Title: S1P receptor mediated activity of FTY720 phosphate mimics.
Journal: Bioorganic & medicinal chemistry letters 20100301
Title: New drugs may improve, complicate treatment for multiple sclerosis.
Journal: Nature medicine 20100301
Title: Cell phenotype evaluation at various sites after skin transplantation and FTY720 plus sirolimus therapy.
Journal: Transplantation proceedings 20100301
Title: Leishmania (Leishmania) amazonensis infection in mice treated with FTY720.
Journal: Transplantation proceedings 20100301
Title: Sirolimus in combination with FTY720: analysis of urinary and serum parameters.
Journal: Transplantation proceedings 20100301
Title: Cytoprotective Actions of FTY720 Modulate Severe Preservation Reperfusion Injury in Rat Renal Transplants.
Journal: Transplantation 20100227
Title: Treatment with a sphingosine analog does not alter the outcome of a persistent virus infection.
Journal: Virology 20100220
Title: Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema.
Journal: American journal of respiratory and critical care medicine 20100215
Title: A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis.
Journal: The New England journal of medicine 20100204
Title: Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis.
Journal: The New England journal of medicine 20100204
Title: Oral therapy for multiple sclerosis--sea change or incremental step?
Journal: The New England journal of medicine 20100204
Title: FTY720 ameliorates MOG-induced experimental autoimmune encephalomyelitis by suppressing both cellular and humoral immune responses.
Journal: Journal of neuroscience research 20100201
Title: FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling.
Journal: Journal of molecular and cellular cardiology 20100201
Title: Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats.
Journal: Stroke 20100201
Title: Phase II study of oral fingolimod (FTY720) in multiple sclerosis: 3-year results.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England) 20100201
Title: A functional role for CCR6 on proallergic T cells in the gastrointestinal tract.
Journal: Gastroenterology 20100101
Title: FTY720, a sphingosine 1-phosphate receptor modulator, inhibits CD1d-restricted NKT cells by suppressing cytokine production but not migration.
Journal: Laboratory investigation; a journal of technical methods and pathology 20100101
Title: Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis.
Journal: Clinical neuropharmacology 20100101
Title: [FTY720-induced lymphocyte apoptosis inhibits acute graft versus host disease in rat small bowel transplantation].
Journal: Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery 20100101
Title: A role for S1P and S1P1 in immature-B cell egress from mouse bone marrow.
Journal: PloS one 20100101
Title: Development of proteoglycan-induced arthritis depends on T cell-supported autoantibody production, but does not involve significant influx of T cells into the joints.
Journal: Arthritis research & therapy 20100101
Title: Phosphorylation of the immunomodulator FTY720 inhibits programmed cell death of fibroblasts via the S1P3 receptor subtype and Bcl-2 activation.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101
Title: Targeting sphingosine 1-phosphate (S1P) levels and S1P receptor functions for therapeutic immune interventions.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101
Title: Naïve T cells re-distribute to the lungs of selectin ligand deficient mice.
Journal: PloS one 20100101
Title: Arthritis: where are the T cells?
Journal: Arthritis research & therapy 20100101
Title: Identification of targets and new developments in the treatment of multiple sclerosis--focus on cladribine.
Journal: Drug design, development and therapy 20100101
Title: Multiple sclerosis therapies: molecular mechanisms and future.
Journal: Results and problems in cell differentiation 20100101
Title: Altered expression of signaling genes in Jurkat cells upon FTY720 induced apoptosis.
Journal: International journal of molecular sciences 20100101
Title: FTY720-induced suicidal erythrocyte death.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101
Title: Lung tumor development in the presence of sphingosine 1-phosphate agonist FTY720.
Journal: Pathology oncology research : POR 20091201
Title: FTY720 reduces inflammation and promotes functional recovery after spinal cord injury.
Journal: Journal of neurotrauma 20091201
Title: T-cell activation in ischemic stroke: a new therapeutic target for delayed infarct expansion?
Journal: Neurosurgery 20091201
Title: Treatment with immunosuppressants FTY720 and tacrolimus promotes functional recovery after spinal cord injury in rats.
Journal: The Tohoku journal of experimental medicine 20091201
Title: Systemically circulating colitogenic memory CD4+T cells may be an ideal target for the treatment of inflammatory bowel diseases.
Journal: The Keio journal of medicine 20091201
Title: The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia.
Journal: Biochemical and biophysical research communications 20091113
Title: Activation of the lung S1P(1) receptor reduces allergen-induced plasma leakage in mice.
Journal: British journal of pharmacology 20091101
Title: FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system.
Journal: British journal of pharmacology 20091101
Title: [Multiple sclerosis, the therapeutic arsenal of today and tomorrow].
Journal: Soins; la revue de reference infirmiere 20091101
Title: News & views in ... Immunotherapy.
Journal: Immunotherapy 20091101
Title: Suppression of hepatocellular carcinoma recurrence after rat liver transplantation by FTY720, a sphingosine-1-phosphate analog.
Journal: Transplantation 20091027
Title: T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow.
Journal: The Journal of experimental medicine 20091026
Title: FTY720 attenuates lesional interleukin-17(+) cell accumulation in rat experimental autoimmune neuritis.
Journal: Neuropathology and applied neurobiology 20091001
Title: Synthetic analogs of FTY720 [2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol] differentially regulate pulmonary vascular permeability in vivo and in vitro.
Journal: The Journal of pharmacology and experimental therapeutics 20091001
Title: Hypoxic preconditioning-induced cerebral ischemic tolerance: role of microvascular sphingosine kinase 2.
Journal: Stroke 20091001
Title: Endothelial barrier protection by FTY720 under hyperglycemic condition: involvement of focal adhesion kinase, small GTPases, and adherens junction proteins.
Journal: American journal of physiology. Cell physiology 20091001
Title: The future of multiple sclerosis therapy.
Journal: Pharmacological research 20091001
Title: Cutting edge: contribution of lung-resident T cell proliferation to the overall magnitude of the antigen-specific CD8 T cell response in the lungs following murine influenza virus infection.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20091001
Title: [Fingolimod - a new immunomodulator].
Journal: Deutsche medizinische Wochenschrift (1946) 20091001
Title: New oral drugs for multiple sclerosis.
Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20091001
Title: Fingolimod and related compounds in a spontaneous autoimmune polyneuropathy.
Journal: Journal of neuroimmunology 20090929
Title: The sphingosine 1-phosphate receptor agonist FTY720 potently inhibits regulatory T cell proliferation in vitro and in vivo.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20090915
Title: Role of FTY720 on M1 and M2 macrophages, lymphocytes, and chemokines in 5/6 nephrectomized rats.
Journal: American journal of physiology. Renal physiology 20090901
Title: Fragile maintenance of allograft tolerance induced by lymphocyte sequestration and co-stimulation blockade.
Journal: Transplant immunology 20090901
Title: [Role of sphingosine 1-phosphate receptor signaling in hematopoietic stem/progenitor cell transmigration].
Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20090901
Title: Synthesis and biological evaluation of sphingosine kinase substrates as sphingosine-1-phosphate receptor prodrugs.
Journal: Bioorganic & medicinal chemistry 20090815
Title: Topical application of sphingosine-1-phosphate and FTY720 attenuate allergic contact dermatitis reaction through inhibition of dendritic cell migration.
Journal: The Journal of investigative dermatology 20090801
Title: Langerhans cell migration: not necessarily always at the center of the skin sensitization universe.
Journal: The Journal of investigative dermatology 20090801
Title: [Molecular target drug development for curing multiple sclerosis].
Journal: Brain and nerve = Shinkei kenkyu no shinpo 20090801
Title: Protective effects of sphingosine-1-phosphate receptor agonist treatment after myocardial ischaemia-reperfusion.
Journal: Cardiovascular research 20090715
Title: Pig embryonic pancreatic tissue as a source for transplantation in diabetes: transient treatment with anti-LFA1, anti-CD48, and FTY720 enables long-term graft maintenance in mice with only mild ongoing immunosuppression.
Journal: Diabetes 20090701
Title: The lymphocyte migration inhibitor FTY720 attenuates experimental hypertensive nephropathy.
Journal: American journal of physiology. Renal physiology 20090701
Title: Suppression of androgen-independent prostate cancer cell aggressiveness by FTY720: validating Runx2 as a potential antimetastatic drug screening platform.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090701
Title: Immunomodulatory drug FTY720 induces regulatory CD4(+)CD25(+) T cells in vitro.
Journal: Clinical and experimental immunology 20090701
Title: Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner.
Journal: The Journal of biological chemistry 20090612
Title: FTY720 and lung tumor development.
Journal: International immunopharmacology 20090601
Title: Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors.
Journal: Nature chemical biology 20090601
Title: [New therapeutic approach for autoimmune diseases by the sphingosine 1-phosphate receptor modulator, fingolimod (FTY720)].
Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20090601
Title: Expression of sphingosine kinase 2 in synovial fibroblasts of rheumatoid arthritis contributing to apoptosis by a sphingosine analogue, FTY720.
Journal: Pathology international 20090601
Title: [FTY720 reduces peritubular micrangium loss in renal interstitial fibrotic rats].
Journal: Zhonghua er ke za zhi = Chinese journal of pediatrics 20090601
Title: Novel implications for lysophospholipids, lysophosphatidic acid and sphingosine 1-phosphate, as drug targets in cancer.
Journal: Anti-cancer agents in medicinal chemistry 20090501
Title: Chiral vinylphosphonate and phosphonate analogues of the immunosuppressive agent FTY720.
Journal: The Journal of organic chemistry 20090417
Title: Synthesis and evaluation of arylalkoxy- and biarylalkoxy-phenylamide and phenylimidazoles as potent and selective sphingosine-1-phosphate receptor subtype-1 agonists.
Journal: Bioorganic & medicinal chemistry letters 20090415
Title: FTY720 rescue therapy in the dark agouti rat model of experimental autoimmune encephalomyelitis: expression of central nervous system genes and reversal of blood-brain-barrier damage.
Journal: Brain pathology (Zurich, Switzerland) 20090401
Title: Immunosuppressive therapy and post-transplant malignancy.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20090401
Title: Evaluation of the lymphocyte trafficking drug FTY720 in SHIVSF162P3-infected rhesus macaques.
Journal: The Journal of antimicrobial chemotherapy 20090401
Title: Thymic emigration: sphingosine-1-phosphate receptor-1-dependent models and beyond.
Journal: European journal of immunology 20090401
Title: Treatment with FTY720 during the induction or effector phase suppresses the development of experimental allergic conjunctivitis in mice.
Journal: Cell biology international 20090401
Title: [A new therapeutic approach for autoimmune diseases by the sphingosine 1-phosphate receptor modulator, fingolimod (FTY720)].
Journal: Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 20090401
Title: Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis.
Journal: Nature 20090326
Title: B lymphocytes exit lymph nodes through cortical lymphatic sinusoids by a mechanism independent of sphingosine-1-phosphate-mediated chemotaxis.
Journal: Immunity 20090320
Title: Hemorrhaging focal encephalitis under fingolimod (FTY720) treatment: a case report.
Journal: Neurology 20090317
Title: Accumulation of fingolimod (FTY720) in lymphoid tissues contributes to prolonged efficacy.
Journal: The Journal of pharmacology and experimental therapeutics 20090301
Title: Distribution of Foxp3(+) T-regulatory cells in experimental autoimmune neuritis rats.
Journal: Experimental neurology 20090301
Title: FTY720 Inhibits Tumor Necrosis Factor-alpha-Induced Proliferation and Extracellular Signal-Regulated Kinase Phosphorylation of Human Smooth Muscle Cells.
Journal: Transplantation proceedings 20090301
Title: FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells.
Journal: The Journal of biological chemistry 20090227
Title: Ketoconazole increases fingolimod blood levels in a drug interaction via CYP4F2 inhibition.
Journal: Journal of clinical pharmacology 20090201
Title: Trial watch: Phase III promise for oral multiple sclerosis therapy.
Journal: Nature reviews. Drug discovery 20090201
Title: [An additional role of FTY720 in chronic colitis].
Journal: Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 20090201
Title: Oral fingolimod (FTY720) in multiple sclerosis: two-year results of a phase II extension study.
Journal: Neurology 20090106
Title: The influence of sphingosine-1-phosphate receptor signaling on lymphocyte trafficking: how a bioactive lipid mediator grew up from an 'immature' vascular maturation factor to a 'mature' mediator of lymphocyte behavior and function.
Journal: Immunologic research 20090101
Title: Divergent roles of sphingosine kinases in kidney ischemia-reperfusion injury.
Journal: Kidney international 20090101
Title: An investigation of the impact of the location and timing of antigen-specific T cell division on airways inflammation.
Journal: Clinical and experimental immunology 20090101
Title: [Lysophospholipid mediators].
Journal: Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20090101
Title: The influence of commonly used immunosuppressive drugs on the small bowel functions - a comparative experimental study.
Journal: Annals of transplantation 20090101
Title: FTY720 and everolimus in de novo renal transplant patients at risk for delayed graft function: results of an exploratory one-yr multicenter study.
Journal: Clinical transplantation 20090101
Title: Impaired initiation of contact hypersensitivity by FTY720.
Journal: The Journal of investigative dermatology 20081201
Title: FTY720 suppresses the development of colitis in lymphoid-null mice by modulating the trafficking of colitogenic CD4+ T cells in bone marrow.
Journal: European journal of immunology 20081201
Title: Treatment of chronic allograft nephropathy at late stages using everolimus or FTY720 in combination with cyclosporine.
Journal: Transplantation proceedings 20081201
Title: Central nervous system-directed effects of FTY720 (fingolimod).
Journal: Journal of the neurological sciences 20081115
Title: Central nervous system effects of current and emerging multiple sclerosis-directed immuno-therapies.
Journal: Clinical neurology and neurosurgery 20081101
Title: Sphingosine 1-phosphate receptor agonism impairs skin dendritic cell migration and homing to secondary lymphoid tissue: association with prolonged allograft survival.
Journal: Transplant immunology 20081101
Title: A splicing isoform of LPP1, LPP1a, exhibits high phosphatase activity toward FTY720 phosphate.
Journal: Biochemical and biophysical research communications 20081031
Title: FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis.
Journal: Neurology 20081014
Title: Cyclical and dose-dependent responses of adult human mature oligodendrocytes to fingolimod.
Journal: The American journal of pathology 20081001
Title: The suppressive effect that myriocin has on hepatitis C virus RNA replication is independent of inhibition of serine palmitoyl transferase.
Journal: The Journal of infectious diseases 20081001
Title: Fingolimod (FTY720) as an acute rescue therapy for intraocular inflammatory disease.
Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20081001
Title: FTY720, a sphingosine-1-phosphate receptor modulator, reverses high-fat diet-induced weight gain, insulin resistance and adipose tissue inflammation in C57BL/6 mice.
Journal: Diabetes, obesity & metabolism 20080901
Title: Production and release of sphingosine 1-phosphate and the phosphorylated form of the immunomodulator FTY720.
Journal: Biochimica et biophysica acta 20080901
Title: Sphingosine 1-phosphate chemical biology.
Journal: Biochimica et biophysica acta 20080901
Title: Emerging oral drugs for multiple sclerosis.
Journal: Expert opinion on emerging drugs 20080901
Title: TX-2152: a conformationally rigid and electron-rich diyne analogue of FTY720 with in vivo antiangiogenic activity.
Journal: Bioorganic & medicinal chemistry 20080815
Title: Immunology: Surprising side effects.
Journal: Nature 20080814
Title: Transient FTY720 treatment promotes immune-mediated clearance of a chronic viral infection.
Journal: Nature 20080814
Title: The ability of atropine to prevent and reverse the negative chronotropic effect of fingolimod in healthy subjects.
Journal: British journal of clinical pharmacology 20080801
Title: Infections cast cloud over Novartis' MS therapy.
Journal: Nature biotechnology 20080801
Title: Azathioprine in multiple sclerosis.
Journal: Mini reviews in medicinal chemistry 20080801
Title: Sphingosine 1-phosphate restrains insulin-mediated keratinocyte proliferation via inhibition of Akt through the S1P2 receptor subtype.
Journal: The Journal of investigative dermatology 20080701
Title: Phosphorylation by sphingosine kinase 2 is essential for in vivo potency of FTY720 analogues.
Journal: ChemMedChem 20080701
Title: Attenuation of cell motility observed with high doses of sphingosine 1-phosphate or phosphorylated FTY720 involves RGS2 through its interactions with the receptor S1P.
Journal: Genes to cells : devoted to molecular & cellular mechanisms 20080701
Title: FTY720 inhibits S1P-mediated endothelial healing: relationship to S1P1-receptor surface expression.
Journal: Biochemical and biophysical research communications 20080613
Title: Early attenuation of lesional interleukin-16 up-regulation by dexamethasone and FTY720 in experimental traumatic brain injury.
Journal: Neuropathology and applied neurobiology 20080601
Title: Anti-inflammatory effects of FTY720 against viral-induced immunopathology: role of drug-induced conversion of T cells to become Foxp3+ regulators.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20080601
Title: Antinociceptive activity of the S1P-receptor agonist FTY720.
Journal: Journal of cellular and molecular medicine 20080601
Title: Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells.
Journal: Biological & pharmaceutical bulletin 20080601
Title: 'Inside-out' signaling of sphingosine-1-phosphate: therapeutic targets.
Journal: Pharmacological reviews 20080601
Title: Activity of nuclear factor of activated T cells is independent of the number of peripheral lymphocytes in FTY720-treated patients.
Journal: Transplantation proceedings 20080601
Title: Antiproliferative and overadditive effects of rapamycin and FTY720 in pancreatic cancer cells in vitro.
Journal: Transplantation proceedings 20080601
Title: New players on the center stage: sphingosine 1-phosphate and its receptors as drug targets.
Journal: Biochemical pharmacology 20080515
Title: The effect on heart rate of combining single-dose fingolimod with steady-state atenolol or diltiazem in healthy subjects.
Journal: European journal of clinical pharmacology 20080501
Title: Modulation of T cell homeostasis and alloreactivity under continuous FTY720 exposure.
Journal: International immunology 20080501
Title: FTY720 (fingolimod) for relapsing multiple sclerosis.
Journal: Expert review of neurotherapeutics 20080501
Title: The apoptotic pathway contributing to the deletion of naive CD8 T cells during the induction of peripheral tolerance to a cross-presented self-antigen.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20080415
Title: Sphingosine 1-phosphate regulates the egress of IgA plasmablasts from Peyer's patches for intestinal IgA responses.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20080415
Title: FTY720 ameliorates experimental autoimmune neuritis by inhibition of lymphocyte and monocyte infiltration into peripheral nerves.
Journal: Experimental neurology 20080401
Title: Sphingosine-1-phosphate and its analogue FTY720 diminish acute pulmonary injury in rats with acute necrotizing pancreatitis.
Journal: Pancreas 20080401
Title: Synthesis of the key intermediate, diethyl 2-acetylamino-2-(2-(4-octanoylphenyl)ethyl)propane-1,3-dioate, of the immunomodulatory agent FTY720 (fingolimod).
Journal: Chemical & pharmaceutical bulletin 20080401
Title: Skin allograft survival and analysis of renal parameters after FTY720 + tacrolimus treatment in mice.
Journal: Transplantation proceedings 20080401
Title: Cross-talk between PDGF and S1P signalling elucidates the inhibitory effect and potential antifibrotic action of the immunomodulator FTY720 in activated HSC-cultures.
Journal: Biochimica et biophysica acta 20080301
Title: A mechanistic study to assess whether isoproterenol can reverse the negative chronotropic effect of fingolimod.
Journal: Journal of clinical pharmacology 20080301
Title: [Therapeutic effect of S1P receptor modifying drugs for autoimmune diseases].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20080301
Title: FTY720 induces apoptosis in hepatocellular carcinoma cells through activation of protein kinase C delta signaling.
Journal: Cancer research 20080215
Title: Non-specific anti-proliferative effect of FTY720, a derivative of fungal metabolite from Iscaria sinclarii.
Journal: Archives of pharmacal research 20080201
Title: FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma.
Journal: Blood 20080101
Title: FTY720 modulates human oligodendrocyte progenitor process extension and survival.
Journal: Annals of neurology 20080101
Title: Brain sphingosine-1-phosphate receptors: implication for FTY720 in the treatment of multiple sclerosis.
Journal: Pharmacology & therapeutics 20080101
Title: Analysis of sphingosine 1-phosphate receptors involved in constriction of isolated cerebral arteries with receptor null mice and pharmacological tools.
Journal: British journal of pharmacology 20080101
Title: Follicular shuttling of marginal zone B cells facilitates antigen transport.
Journal: Nature immunology 20080101
Title: The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics.
Journal: Nature immunology 20080101
Title: Effect of FTY720 and ex vivo graft irradiation in rat small bowel transplantation: expression of mucosal addressin cell adhesion molecule-1.
Journal: Surgery today 20080101
Title: Antibody-mediated rejection with a striking interstitial monocyte/macrophage infiltration in a renal allograft under FTY720 treatment.
Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20080101
Title: Reversible cystoid macular edema secondary to fingolimod in a renal transplant recipient.
Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20080101
Title: Ascomycete derivative to MS therapeutic: S1P receptor modulator FTY720.
Journal: Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques 20080101
Title: FTY720 treatment in experimentally urethane-induced lung tumors.
Journal: Journal of experimental therapeutics & oncology 20080101
Title: Recent trials for FTY720 (fingolimod): a new generation of immunomodulators structurally similar to sphingosine.
Journal: Reviews on recent clinical trials 20080101
Title: Neurotherapeutics in multiple sclerosis: novel agents and emerging treatment strategies.
Journal: The Mount Sinai journal of medicine, New York 20080101
Title: Cell cycle arrest effects of large-dose FTY720 on lymphocytes in mouse skin transplantation models.
Journal: Immunopharmacology and immunotoxicology 20080101
Title: Inhibitors of ABL and the ABL-T315I mutation.
Journal: Current topics in medicinal chemistry 20080101
Title: [Cordyceps sinensis, a fungi used in the Chinese traditional medicine].
Journal: Revista iberoamericana de micologia 20071231
Title: Evaluation of stem cell administration in a model of kidney ischemia-reperfusion injury.
Journal: International immunopharmacology 20071215
Title: Asymmetric synthesis of conformationally constrained fingolimod analogues--discovery of an orally active sphingosine 1-phosphate receptor type-1 agonist and receptor type-3 antagonist.
Journal: Journal of medicinal chemistry 20071213
Title: [Regulation of immunity by sphingosine 1-phosphate and its G protein-coupled receptors--review].
Journal: Zhongguo shi yan xue ye xue za zhi 20071201
Title: FTY720 reduces extracellular matrix expansion associated with ischemia-reperfusion induced injury.
Journal: Transplantation proceedings 20071201
Title: Effect of FTY720 and ex vivo graft irradiation in rat small bowel transplantation: apoptosis of crypt cells and lymphocytes.
Journal: Transplantation proceedings 20071201
Title: Therapeutic targeting of leukocyte trafficking across the blood-brain barrier.
Journal: Inflammation & allergy drug targets 20071201
Title: [Effect of FTY720 on glomerulosclerosis and expression of cell cycle regulatory proteins in subtotally nephrectomized rats].
Journal: Zhonghua er ke za zhi = Chinese journal of pediatrics 20071201
Title: Reduction of CD4 positive T cells and improvement of pathological changes of collagen-induced arthritis by FTY720.
Journal: European journal of pharmacology 20071114
Title: Insights into the mechanism of FTY720 and compatibility with regulatory T cells for the inhibition of graft-versus-host disease (GVHD).
Journal: Blood 20071101
Title: Brain penetration of the oral immunomodulatory drug FTY720 and its phosphorylation in the central nervous system during experimental autoimmune encephalomyelitis: consequences for mode of action in multiple sclerosis.
Journal: The Journal of pharmacology and experimental therapeutics 20071101
Title: The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors.
Journal: The Journal of pharmacology and experimental therapeutics 20071101
Title: Sphingosine-1-phosphate analogue FTY720 causes lymphocyte redistribution and hypercholesterolemia in ApoE-deficient mice.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20071101
Title: Sphingosine-1 phosphate signaling regulates positioning of dendritic cells within the spleen.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20071101
Title: Synthesis and spectral properties of cholesterol- and FTY720-containing boron dipyrromethene dyes.
Journal: The Journal of organic chemistry 20071026
Title: FTY720 sustains and restores neuronal function in the DA rat model of MOG-induced experimental autoimmune encephalomyelitis.
Journal: Brain research bulletin 20071019
Title: FTY720 versus mycophenolate mofetil in de novo renal transplantation: six-month results of a double-blind study.
Journal: Transplantation 20071015
Title: [FTY720 (Fingolimod) as a new therapeutic option for multiple sclerosis].
Journal: Der Nervenarzt 20071001
Title: Fingolimod: a novel immunosuppressant for multiple sclerosis.
Journal: The Annals of pharmacotherapy 20071001
Title: The thymus is required for the ability of FTY720 to prolong skin allograft survival across different histocompatibility MHC barriers.
Journal: Transplant international : official journal of the European Society for Organ Transplantation 20071001
Title: Effect of FTY720 on apoptosis of smooth muscle cells.
Journal: Transplantation proceedings 20071001
Title: FTY720, a synthetic compound from Isaria sinclairii, inhibits proliferation and induces apoptosis in pancreatic cancer cells.
Journal: Cancer letters 20070908
Title: FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia.
Journal: The Journal of clinical investigation 20070904
Title: Sphingosine-1-phosphate and the immunosuppressant, FTY720-phosphate, regulate detrusor muscle tone.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070901
Title: Pulmonary endothelial cell barrier enhancement by FTY720 does not require the S1P1 receptor.
Journal: Cellular signalling 20070801
Title: Phosphorylated FTY720 promotes astrocyte migration through sphingosine-1-phosphate receptors.
Journal: Journal of neurochemistry 20070801
Title: The impact of FTY720 (fingolimod) on vasodilatory function and arterial elasticity in renal transplant patients.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20070801
Title: Human islet function is not impaired by the sphingosine-1-phosphate receptor modulator FTY720.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20070801
Title: Sphingosine 1-phosphate-mediated trafficking of pathogenic Th2 and mast cells for the control of food allergy.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20070801
Title: FTY720: a most promising immunosuppressant modulating immune cell functions.
Journal: Mini reviews in medicinal chemistry 20070801
Title: FTY720 improves survival after transient ischemia and reperfusion of the hind limbs.
Journal: The Journal of trauma 20070801
Title: The immunomodulator FTY720 is phosphorylated and released from platelets.
Journal: European journal of pharmacology 20070730
Title: Reduction of ischemia-reperfusion injury in the rat kidney by FTY720, a synthetic derivative of sphingosine.
Journal: Transplantation 20070727
Title: FTY720 ameliorates oxazolone colitis in mice by directly affecting T helper type 2 functions.
Journal: Molecular immunology 20070701
Title: Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology.
Journal: Pharmacology & therapeutics 20070701
Title: FTY720-phosphate is dephosphorylated by lipid phosphate phosphatase 3.
Journal: FEBS letters 20070626
Title: S1P modulator FTY720 limits matrix expansion in acute anti-thy1 mesangioproliferative glomerulonephritis.
Journal: American journal of physiology. Renal physiology 20070601
Title: The perivascular space as a path of hematopoietic progenitor cells and mature T cells between the blood circulation and the thymic parenchyma.
Journal: International immunology 20070601
Title: Compared benefit of approved and experimental immunosuppressive therapeutic approaches in multiple sclerosis.
Journal: Expert opinion on pharmacotherapy 20070601
Title: Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues.
Journal: The Journal of biological chemistry 20070525
Title: The immunosuppressant FTY720 inhibits tumor angiogenesis via the sphingosine 1-phosphate receptor 1.
Journal: Journal of cellular biochemistry 20070501
Title: Sphingosine 1-phosphate regulates peritoneal B-cell trafficking for subsequent intestinal IgA production.
Journal: Blood 20070501
Title: Cutting edge: Alternative signaling of Th17 cell development by sphingosine 1-phosphate.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20070501
Title: Novel oral agents for multiple sclerosis.
Journal: Current neurology and neuroscience reports 20070501
Title: Immunology. The sources of a lipid conundrum.
Journal: Science (New York, N.Y.) 20070413
Title: Mechanism of mitochondrial 7A6 antigen exposure triggered by distinct apoptotic pathways: involvement of caspases.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20070401
Title: FTY720 suppresses interleukin-1beta-induced secretory phospholipase A2 expression in renal mesangial cells by a transcriptional mechanism.
Journal: British journal of pharmacology 20070401
Title: Current perspectives on FTY720.
Journal: Expert opinion on investigational drugs 20070401
Title: Phosphorylated FTY720 stimulates ERK phosphorylation in astrocytes via S1P receptors.
Journal: Neuropharmacology 20070401
Title: Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor.
Journal: The Journal of biological chemistry 20070323
Title: Migration of CD4 T cells and dendritic cells toward sphingosine 1-phosphate (S1P) is mediated by different receptor subtypes: S1P regulates the functions of murine mature dendritic cells via S1P receptor type 3.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20070315
Title: Impact of long-term therapy with FTY720 or mycophenolate mofetil on cardiac conduction and rhythm in stable adult renal transplant patients.
Journal: Transplantation 20070315
Title: Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics.
Journal: The Journal of biological chemistry 20070309
Title: The sphingosine-1-phosphate analogue FTY720 reduces atherosclerosis in apolipoprotein E-deficient mice.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20070301
Title: Oral-intravenous crossover study of fingolimod pharmacokinetics, lymphocyte responses and cardiac effects.
Journal: Biopharmaceutics & drug disposition 20070301
Title: Tipping the gatekeeper: S1P regulation of endothelial barrier function.
Journal: Trends in immunology 20070301
Title: FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis.
Journal: Expert opinion on investigational drugs 20070301
Title: Sphingosine-1-phosphate and FTY720 as anti-atherosclerotic lipid compounds.
Journal: European journal of clinical investigation 20070301
Title: FTY720 application following isolated warm liver ischemia improves long-term survival and organ protection in a mouse model.
Journal: Transplantation proceedings 20070301
Title: FTY720 for treatment of ischemia-reperfusion injury following complete renal ischemia; impact on long-term survival and T-lymphocyte tissue infiltration.
Journal: Transplantation proceedings 20070301
Title: Chemokines and chemokine receptors in renal transplantation--from bench to bedside.
Journal: Acta physiologica Hungarica 20070301
Title: FTY720 attenuates accumulation of EMAP-II+ and MHC-II+ monocytes in early lesions of rat traumatic brain injury.
Journal: Journal of cellular and molecular medicine 20070301
Title: FTY720 ameliorates Th1-mediated colitis in mice by directly affecting the functional activity of CD4+CD25+ regulatory T cells.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20070215
Title: The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors.
Journal: Blood 20070201
Title: Sphingosine-1-phosphate stimulates the functional capacity of progenitor cells by activation of the CXCR4-dependent signaling pathway via the S1P3 receptor.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20070201
Title: Marked suppression of tumor growth by FTY720 in a rat liver tumor model: the significance of down-regulation of cell survival Akt pathway.
Journal: International journal of oncology 20070201
Title: Oral pharmacokinetic and pharmacodynamic effects of FTY720 in cats.
Journal: Journal of veterinary pharmacology and therapeutics 20070201
Title: Ethnic sensitivity study of fingolimod in white and Asian subjects.
Journal: International journal of clinical pharmacology and therapeutics 20070201
Title: [Effect of mono and combination therapy with FTY720 and ICAM-1 mAb for mouse-to-rat cardiac xenotransplantation].
Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20070201
Title: FTY720, a synthetic sphingosine 1 phosphate analogue, inhibits development of atherosclerosis in low-density lipoprotein receptor-deficient mice.
Journal: Circulation 20070130
Title: Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1-phosphate receptors.
Journal: Bioorganic & medicinal chemistry letters 20070115
Title: FTY720 enhances the activation-induced apoptosis of donor T cells and modulates graft-versus-host disease.
Journal: European journal of immunology 20070101
Title: Differential effects of single dose FTY720 on CD62L+ B-cells in stable renal allograft recipients.
Journal: International immunopharmacology 20070101
Title: Multiple sclerosis: new insights and therapeutic progress.
Journal: The Lancet. Neurology 20070101
Title: Immunomodulator FTY720 induces myofibroblast differentiation via the lysophospholipid receptor S1P3 and Smad3 signaling.
Journal: The American journal of pathology 20070101
Title: New immunosuppresor strategies in the treatment of murine lupus nephritis.
Journal: Lupus 20070101
Title: FTY720 induced Bcl-associated and Fas-independent apoptosis in human renal cancer cells in vitro and significantly reduced in vivo tumor growth in mouse xenograft.
Journal: Anticancer research 20070101
Title: Long-term effect of FTY720 on lymphocyte count and islet allograft survival in mice.
Journal: Microsurgery 20070101
Title: Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat heart.
Journal: Journal of biochemical and molecular toxicology 20070101
Title: Sphingosine-1-phosphate signaling and the skin.
Journal: American journal of clinical dermatology 20070101
Title: Randomized controlled trial of FTY720 versus MMF in de novo renal transplantation.
Journal: Transplantation 20061227
Title: FTY720 preferentially depletes naive T cells from peripheral and lymphoid organs.
Journal: International immunopharmacology 20061220
Title: FTY720 in combination with cyclosporine--an analysis of skin allograft survival and renal function.
Journal: International immunopharmacology 20061220
Title: Tacrolimus in combination with FTY720--an analysis of renal and blood parameters.
Journal: International immunopharmacology 20061220
Title: FTY720 versus MMF with cyclosporine in de novo renal transplantation: a 1-year, randomized controlled trial in Europe and Australasia.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20061201
Title: Regulation of donor T cells in the tolerant rats to graft-versus-host disease by FTY720 following small bowel transplantation.
Journal: Transplantation proceedings 20061201
Title: Exposure-efficacy relationships of a fingolimod-everolimus regimen in kidney transplant patients at risk for delayed graft function.
Journal: Transplantation proceedings 20061201
Title: Measurement and stability of FTY720 in human whole blood by high-performance liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061107
Title: Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.
Journal: The Journal of clinical investigation 20061101
Title: Effect of FTY720 in rat small bowel transplantation: apoptosis of crypt cells and lymphocytes in gut-associated lymphoid tissues.
Journal: Transplantation proceedings 20061101
Title: The curtain is drawn for both natalizumab and fingolimod (FTY720): a new era of multiple sclerosis therapy has arrived.
Journal: Expert review of neurotherapeutics 20061101
Title: Bioactive sphingolipids in the modulation of the inflammatory response.
Journal: Pharmacology & therapeutics 20061001
Title: Inhibition of donor-derived T cells trafficking into target organs by FTY720 during acute graft-versus-host disease in small bowel transplantation.
Journal: Clinical and experimental immunology 20061001
Title: The S1P receptor modulator FTY720 prevents the development of experimental colitis in mice.
Journal: Oncology reports 20061001
Title: Fingolimod and sphingosine-1-phosphate--modifiers of lymphocyte migration.
Journal: The New England journal of medicine 20060914
Title: Oral fingolimod (FTY720) for relapsing multiple sclerosis.
Journal: The New England journal of medicine 20060914
Title: Physiologically based pharmacokinetic modeling of FTY720 (2-amino-2[2-(-4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) in rats after oral and intravenous doses.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20060901
Title: FTY720 suppresses CD4+CD44highCD62L- effector memory T cell-mediated colitis.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20060801
Title: FTY720/cyclosporine regimens in de novo renal transplantation: a 1-year dose-finding study.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20060801
Title: FTY720: placebo-controlled study of the effect on cardiac rate and rhythm in healthy subjects.
Journal: Journal of clinical pharmacology 20060801
Title: [Multifunctional sphingolipid, sphingosine (long-chain base) 1-phosphate: physiological role, metabolism, and intracellular dynamics].
Journal: Seikagaku. The Journal of Japanese Biochemical Society 20060801
Title: Sphingosine and its analog, the immunosuppressant 2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol, interact with the CB1 cannabinoid receptor.
Journal: Molecular pharmacology 20060701
Title: Sphingosine-1-phosphate receptor agonists suppress concanavalin A-induced hepatic injury in mice.
Journal: Biochemical and biophysical research communications 20060623
Title: Preparation of antibodies against a novel immunosuppressant, FTY720, and development of an enzyme immunoassay for FTY720.
Journal: Bioorganic & medicinal chemistry 20060615
Title: Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney.
Journal: American journal of physiology. Renal physiology 20060601
Title: Pulmonary and vascular pharmacology of sphingosine 1-phosphate.
Journal: Current opinion in pharmacology 20060601
Title: Evidence that a significant number of naive T cells enter non-lymphoid organs as part of a normal migratory pathway.
Journal: European journal of immunology 20060601
Title: In vitro evaluation of the effect of a novel immunosuppressive agent, FTY720, on the function of feline neutrophils.
Journal: American journal of veterinary research 20060401
Title: Evidence that FTY720 induces rat thymocyte apoptosis.
Journal: Transplant immunology 20060401
Title: FTY720 treatment of kidney transplant patients: a differential effect on B cells, naïve T cells, memory T cells and NK cells.
Journal: Transplant immunology 20060401
Title: FTY720 for treatment of ischemia-reperfusion injury following complete renal ischemia in C57/BL6 mice.
Journal: Transplantation proceedings 20060401
Title: A photoreactive analogue of the immunosuppressant FTY720.
Journal: The Journal of organic chemistry 20060303
Title: Fat-derived hormone adiponectin combined with FTY720 significantly improves small-for-size fatty liver graft survival.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20060301
Title: FTY720, a fungus metabolite, inhibits invasion ability of androgen-independent prostate cancer cells through inactivation of RhoA-GTPase.
Journal: Cancer letters 20060220
Title: Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720.
Journal: Blood 20060215
Title: Enhanced FTY720-mediated lymphocyte homing requires G alpha i signaling and depends on beta 2 and beta 7 integrin.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20060201
Title: Fingolimod (FTY720) in severe hepatic impairment: pharmacokinetics and relationship to markers of liver function.
Journal: Journal of clinical pharmacology 20060201
Title: [Molecular action mechanisms of the therapeutic agents for kidney diseases: Immunosuppressants].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20060201
Title: Role of sphingosine 1-phosphate receptor type 1 in lymphocyte egress from secondary lymphoid tissues and thymus.
Journal: Cellular & molecular immunology 20060201
Title: Lymphoid sequestration of alloreactive memory CD4 T cells promotes cardiac allograft survival.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20060115
Title: NBD-labeled derivatives of the immunomodulatory drug FTY720 as tools for metabolism and mode of action studies.
Journal: Bioorganic & medicinal chemistry letters 20060101
Title: The immunomodulator FTY720 and its phosphorylated derivative activate the Smad signalling cascade and upregulate connective tissue growth factor and collagen type IV expression in renal mesangial cells.
Journal: British journal of pharmacology 20060101
Title: Novel insights into the mechanism of action of FTY720 in a transgenic model of allograft rejection: implications for therapy of chronic rejection.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20060101
Title: Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization.
Journal: Cancer research 20060101
Title: The role of the lysophospholipid sphingosine 1-phosphate in immune cell biology.
Journal: Archivum immunologiae et therapiae experimentalis 20060101
Title: FTY720 (fingolimod) in renal transplantation.
Journal: Clinical transplantation 20060101
Title: Sphingosine 1-phosphate receptor modulators: a new class of immunosuppressants.
Journal: Clinical transplantation 20060101
Title: Altering the sphingosine-1-phosphate/ceramide balance: a promising approach for tumor therapy.
Journal: Current pharmaceutical design 20060101
Title: FTY720, a fungus metabolite, inhibits in vivo growth of androgen-independent prostate cancer.
Journal: International journal of cancer 20051220
Title: The sphingosine 1-phosphate receptor agonist FTY720 differentially affects the sequestration of CD4+/CD25+ T-regulatory cells and enhances their functional activity.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20051215
Title: FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors.
Journal: Pharmacology & therapeutics 20051201
Title: Transient T cell accumulation in lymph nodes and sustained lymphopenia in mice treated with FTY720.
Journal: European journal of immunology 20051201
Title: Sphingosine-1-phosphate agonists increase macrophage homing, lymphocyte contacts, and endothelial junctional complex formation in murine lymph nodes.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20051201
Title: FTY720: a promising agent for treatment of metastatic hepatocellular carcinoma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20051201
Title: Multiple sclerosis poses tough drug development challenges.
Journal: Drug discovery today 20051201
Title: Use of FTY 720 and ICAM-1 antisense oligonucleotides for attenuating chronic renal damage secondary to ischemia-reperfusion injury.
Journal: Transplantation proceedings 20051201
Title: Effect of FTY720 in rat small bowel transplantation: expression of mucosal addressin cell adhesion molecule-1.
Journal: Transplantation proceedings 20051201
Title: FTY720, sphingosine 1-phosphate receptor modulator, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration.
Journal: Cellular & molecular immunology 20051201
Title: Effect of FTY720 on chronic cyclosporine nephropathy in rats.
Journal: Transplantation 20051115
Title: Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720.
Journal: The Journal of biological chemistry 20051104
Title: The sphingosine-1-phosphate receptor agonist FTY720 modulates dendritic cell trafficking in vivo.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20051101
Title: FTY720, a novel immunomodulator in de novo kidney transplant patients: pharmacokinetics and exposure-response relationship.
Journal: Journal of clinical pharmacology 20051101
Title: FTY720 inhibits TH1-mediated allogeneic humoral immune response.
Journal: Transplantation proceedings 20051101
Title: The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity.
Journal: The Journal of biological chemistry 20051007
Title: [Multiple sclerosis. A new oral immunomodulator].
Journal: Medizinische Monatsschrift fur Pharmazeuten 20051001
Title: Tolerability of cyclosphosphamide and methotrexate induction immunosuppression in nonhuman primates.
Journal: Toxicology 20050915
Title: Immunology. Dietary factors and immunological consequences.
Journal: Science (New York, N.Y.) 20050909
Title: Sphingosine 1-phosphate receptors regulate chemokine-driven transendothelial migration of lymph node but not splenic T cells.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20050901
Title: Sphingosine-1-phosphate mediates migration of mature dendritic cells.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20050901
Title: Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepatocellular carcinoma.
Journal: Molecular cancer therapeutics 20050901
Title: The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches.
Journal: Blood 20050815
Title: FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance.
Journal: Cancer research 20050815
Title: Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer.
Journal: Journal of medicinal chemistry 20050811
Title: Sphingosine 1-phosphate receptor agonist FTY720-phosphate causes marginal zone B cell displacement.
Journal: Journal of leukocyte biology 20050801
Title: Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: discovery of potent S1P1 receptor agonists.
Journal: Bioorganic & medicinal chemistry letters 20050801
Title: [Effects of sphingosine 1-phosphate on functions of T cell - review].
Journal: Zhongguo shi yan xue ye xue za zhi 20050801
Title: Protection of mouse small bowel allografts by FTY720 and costimulation blockade.
Journal: Transplantation 20050627
Title: FTY720, a novel immunomodulator: efficacy and safety results from the first phase 2A study in de novo renal transplantation.
Journal: Transplantation 20050615
Title: Ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging in experimental autoimmune encephalitis.
Journal: Journal of magnetic resonance imaging : JMRI 20050601
Title: Prevention and cure of autoimmune diabetes in nonobese diabetic mice by continuous administration of FTY720.
Journal: Transplantation 20050515
Title: Pharmacokinetic/pharmacodynamic relationships of FTY720 in kidney transplant recipients.
Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20050501
Title: Immunomodulator FTY720 Induces eNOS-dependent arterial vasodilatation via the lysophospholipid receptor S1P3.
Journal: Circulation research 20050429
Title: A novel immunosuppressant FTY720 ameliorates proteinuria and alterations of intrarenal adrenomedullin in rats with autoimmune glomerulonephritis.
Journal: Regulatory peptides 20050415
Title: FTY720 pharmacokinetics in mild to moderate hepatic impairment.
Journal: Journal of clinical pharmacology 20050401
Title: FTY720, an immunosuppressant, attenuates chronic pancreatitis in rats by suppressing T-cell infiltration.
Journal: Pancreas 20050401
Title: A novel immunomodulator, FTY720, prevents development of experimental autoimmune myasthenia gravis in C57BL/6 mice.
Journal: Biological & pharmaceutical bulletin 20050401
Title: Sphingosine 1-phosphate analogs as receptor antagonists.
Journal: The Journal of biological chemistry 20050318
Title: [Study of the effects of immunosuppressive agents on human islet cells in vitro].
Journal: Zhonghua yi xue za zhi 20050316
Title: Significance of the Rac signaling pathway in HCC cell motility: implications for a new therapeutic target.
Journal: Carcinogenesis 20050301
Title: The heart rate decrease caused by acute FTY720 administration is mediated by the G protein-gated potassium channel I.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20050301
Title: On the prediction of the human response: a recycled mechanistic pharmacokinetic/pharmacodynamic approach.
Journal: Basic & clinical pharmacology & toxicology 20050301
Title: Fingolimod. Mitsubishi Pharma/Novartis.
Journal: IDrugs : the investigational drugs journal 20050301
Title: Preoperative administration of FTY720 prolonged renal allograft survival.
Journal: Transplant immunology 20050301
Title: Novel mediators of FTY720 in human lymphocytes.
Journal: Transplantation 20050227
Title: FTY720 in corneal concordant xenotransplantation.
Journal: Transplantation 20050215
Title: The immunomodulator FTY720 interferes with effector functions of human monocyte-derived dendritic cells.
Journal: European journal of immunology 20050201
Title: Effect of 2-amino-2-(2-(4-octylphenyl) ethyl) propane-1,3-diol hydrochloride (FTY 720) on immune liver injury in mice.
Journal: World journal of gastroenterology 20050128
Title: KRP-203, a novel synthetic immunosuppressant, prolongs graft survival and attenuates chronic rejection in rat skin and heart allografts.
Journal: Circulation 20050118
Title: Asymmetric synthesis and biological evaluation of the enantiomeric isomers of the immunosuppressive FTY720-phosphate.
Journal: Bioorganic & medicinal chemistry 20050117
Title: A convenient synthesis of immunosuppressive agent FTY720 using the petasis reaction.
Journal: Chemical & pharmaceutical bulletin 20050101
Title: FTY720 attenuates hepatic ischemia-reperfusion injury in normal and cirrhotic livers.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20050101
Title: Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs.
Journal: Annual review of immunology 20050101
Title: [New immunodepressant drugs for the prevention and control of kidney transplant rejection].
Journal: Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia 20050101
Title: Immunosuppressive activity of FTY720, sphingosine 1-phosphate receptor agonist: I. Prevention of allograft rejection in rats and dogs by FTY720 and FTY720-phosphate.
Journal: Transplantation proceedings 20050101
Title: Immunosuppressive activity of FTY720, sphingosine 1-phosphate receptor agonist: II. Effect of FTY720 and FTY720-phosphate on host-versus-graft and graft-versus-host reaction in mice.
Journal: Transplantation proceedings 20050101
Title: FTY720 inhibits tumor growth and angiogenesis.
Journal: Transplantation proceedings 20050101
Title: Prolonged administration of FTY720 does not cause renal toxicity in mice.
Journal: Transplantation proceedings 20050101
Title: Control of intestinal allograft rejection by FTY720 and costimulation blockade.
Journal: Transplantation proceedings 20050101
Title: FTY720 prevents renal T-cell infiltration after ischemia/reperfusion injury.
Journal: Transplantation proceedings 20050101
Title: The effect of a novel immunosuppressant, FTY720, in mice without secondary lymphoid organs.
Journal: Surgery today 20050101
Title: FTY720: mechanism of action and potential benefit in organ transplantation.
Journal: Yonsei medical journal 20041231
Title: FTY720 suppresses humoral immunity by inhibiting germinal center reaction.
Journal: Blood 20041215
Title: Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720.
Journal: The Journal of biological chemistry 20041210
Title: FTY720 induces apoptosis of human hepatoma cell lines through PI3-K-mediated Akt dephosphorylation.
Journal: Carcinogenesis 20041201
Title: Overview of FTY720 clinical pharmacokinetics and pharmacology.
Journal: Therapeutic drug monitoring 20041201
Title: Novel immunosuppressants.
Journal: Pediatric transplantation 20041201
Title: Rejection following donor or recipient preoperative treatment with FTY720 in rat small bowel transplantation.
Journal: Transplant immunology 20041101
Title: Editorial overview: Tie me up, tie me down: immunosuppressive therapies for the 21st century.
Journal: Current opinion in investigational drugs (London, England : 2000) 20041101
Title: A new immunosuppressant, FTY720, in canine kidney transplantation: effect of single-drug, induction and combination treatments.
Journal: Transplant international : official journal of the European Society for Organ Transplantation 20041101
Title: Sphingosine mediates FTY720-induced apoptosis in LLC-PK1 cells.
Journal: Experimental & molecular medicine 20041031
Title: Modulation of adaptive immune responses by sphingosine-1-phosphate.
Journal: Seminars in cell & developmental biology 20041001
Title: Selective lymphocyte inhibition by FTY720 slows the progressive course of chronic anti-thy 1 glomerulosclerosis.
Journal: Kidney international 20041001
Title: Effects of FTY720 on rat lymphoid organs.
Journal: Transplantation proceedings 20041001
Title: [Immunossupresive drugs in renal transplantation].
Journal: Polskie Archiwum Medycyny Wewnetrznej 20041001
Title: Synthesis, stereochemical determination and biochemical characterization of the enantiomeric phosphate esters of the novel immunosuppressive agent FTY720.
Journal: Bioorganic & medicinal chemistry 20040915
Title: Attenuation of small-for-size liver graft injury by FTY720: significance of cell-survival Akt signaling pathway.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20040901
Title: Protective effects of FTY720 on chronic allograft nephropathy by reducing late lymphocytic infiltration.
Journal: Kidney international 20040901
Title: A novel immunomodulator, FTY720, prevents spontaneous dermatitis in NC/Nga mice.
Journal: Biological & pharmaceutical bulletin 20040901
Title: Genetic, biochemical, and transcriptional responses of Saccharomyces cerevisiae to the novel immunomodulator FTY720 largely mimic those of the natural sphingolipid phytosphingosine.
Journal: The Journal of biological chemistry 20040827
Title: The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040801
Title: Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice.
Journal: Journal of neuroimmunology 20040801
Title: FTY720-enhanced T cell homing is dependent on CCR2, CCR5, CCR7, and CXCR4: evidence for distinct chemokine compartments.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20040715
Title: Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone.
Journal: Nature immunology 20040701
Title: FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20040701
Title: FTY720--the first compound of a new promising class of immunosuppressive drugs.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20040701
Title: FTY720 prolongs clear corneal allograft survival with a differential effect on different lymphocyte populations.
Journal: The British journal of ophthalmology 20040701
Title: Predictability of FTY720 efficacy in experimental autoimmune encephalomyelitis by in vivo macrophage tracking: clinical implications for ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging.
Journal: Journal of magnetic resonance imaging : JMRI 20040701
Title: Should we B-leavin' now?
Journal: Nature immunology 20040701
Title: FTY720, a novel immunomodulator: efficacy and safety results from the first phase 2A study in de novo renal transplantation.
Journal: Transplantation 20040627
Title: Effect of FTY720 on rat small bowel transplantation.
Journal: Transplantation 20040627
Title: Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720.
Journal: Bioorganic & medicinal chemistry letters 20040621
Title: The sphingosine 1-phosphate receptor agonist FTY720 supports CXCR4-dependent migration and bone marrow homing of human CD34+ progenitor cells.
Journal: Blood 20040615
Title: Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury.
Journal: American journal of respiratory and critical care medicine 20040601
Title: FTY720 prevents anti-CD4 mAb-induced tolerance but cannot reverse established tolerance in a rat kidney transplantation model.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20040601
Title: Sphingosine-1-phosphate receptors: receptor specificity versus functional redundancy.
Journal: Biochimica et biophysica acta 20040601
Title: ['Vegetable wasps and plant worms' and G-protein-coupled receptors].
Journal: Journal of UOEH 20040601
Title: Future immunosuppressive agents in solid-organ transplantation.
Journal: Progress in transplantation (Aliso Viejo, Calif.) 20040601
Title: Iron-catalyzed cross-coupling reactions. A scalable synthesis of the immunosuppressive agent FTY720.
Journal: The Journal of organic chemistry 20040528
Title: FTY: not just a homely drug.
Journal: Transplantation 20040515
Title: FTY720 mediates apoptosis-independent lymphopenia in human renal allograft recipients: different effects on CD62L+ and CCR5+ T lymphocytes.
Journal: Transplantation 20040515
Title: Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes.
Journal: The Journal of pharmacology and experimental therapeutics 20040501
Title: Immunoregulatory lysophospholipids: new stars in the mast cell constellation.
Journal: Current allergy and asthma reports 20040501
Title: Single-dose FTY720 pharmacokinetics, food effect, and pharmacological responses in healthy subjects.
Journal: British journal of clinical pharmacology 20040501
Title: Multiple-dose FTY720: tolerability, pharmacokinetics, and lymphocyte responses in healthy subjects.
Journal: Journal of clinical pharmacology 20040501
Title: FTY720 impairs necrosis development after ischemia-reperfusion injury.
Journal: Transplantation proceedings 20040501
Title: FTY720 treatment prolongs skin graft survival in a completely incompatible strain combination.
Journal: Transplantation proceedings 20040501
Title: Therapeutic effects of a new lymphocyte homing reagent FTY720 in interleukin-10 gene-deficient mice with colitis.
Journal: Inflammatory bowel diseases 20040501
Title: Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate.
Journal: The Journal of biological chemistry 20040402
Title: Islet allograft survival in nonhuman primates immunosuppressed with basiliximab, RAD, and FTY720.
Journal: Transplantation 20040327
Title: The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040301
Title: FTY720 exerts differential effects on CD4+ and CD8+ T-lymphocyte subpopulations expressing chemokine and adhesion receptors.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20040301
Title: FTY720-induced lymphocyte homing modulates post-transplant preservation/reperfusion injury.
Journal: Kidney international 20040301
Title: FTY720: from bench to bedside.
Journal: Transplantation proceedings 20040301
Title: FTY720: early clinical experience.
Journal: Transplantation proceedings 20040301
Title: FTY720 immunomodulation: optimism for improved transplant regimens.
Journal: Transplantation proceedings 20040301
Title: The effect of immunomodulators on prevention of autoimmune diabetes is stage dependent: FTY720 prevents diabetes at three different stages in the diabetes-resistant biobreeding rat.
Journal: Pediatric diabetes 20040301
Title: Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1.
Journal: Nature 20040122
Title: CD4+ CD25+ CD62+ T-regulatory cell subset has optimal suppressive and proliferative potential.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20040101
Title: Pharmacologic immunosuppression.
Journal: Frontiers in bioscience : a journal and virtual library 20040101
Title: FTY720 and cyclosporine: evaluation for a pharmacokinetic interaction.
Journal: The Annals of pharmacotherapy 20040101
Title: Functional characterization of sphingosine 1-phosphate receptor agonist in human endothelial cells.
Journal: Prostaglandins & other lipid mediators 20040101
Title: Role of extracelluar regulated protein kinases in FTY720-induced apoptosis of leukemia cell lines HL-60 and U937.
Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20040101
Title: Inhibition of Th1- and Th2-mediated airway inflammation by the sphingosine 1-phosphate receptor agonist FTY720.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20031201
Title: Current immunosuppressive agents: efficacy, side effects, and utilization.
Journal: Pediatric clinics of North America 20031201
Title: Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases.
Journal: The Journal of biological chemistry 20031128
Title: Significant prolongation of orthotopic corneal-graft survival in FTY720-treated mice.
Journal: Transplantation 20031127
Title: Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability.
Journal: The Journal of biological chemistry 20031121
Title: The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2.
Journal: FEBS letters 20031106
Title: FTY720 does not abrogate acute graft-versus-host disease in the dog leukocyte antigen-nonidentical unrelated canine model.
Journal: Transplantation 20031027
Title: Pharmacodynamics, pharmacokinetics, and safety of multiple doses of FTY720 in stable renal transplant patients: a multicenter, randomized, placebo-controlled, phase I study.
Journal: Transplantation 20031015
Title: Egress: a receptor-regulated step in lymphocyte trafficking.
Journal: Immunological reviews 20031001
Title: Pharmacodynamics of FTY720, the first member of a new class of immune-modulating therapeutics in transplantation medicine.
Journal: International journal of clinical pharmacology and therapeutics 20031001
Title: [Study the mechanisms and inducing transplantation immune tolerance of FTY720].
Journal: Zhonghua wai ke za zhi [Chinese journal of surgery] 20031001
Title: FTY720, a new immunosuppressant, as rescue therapy in mouse cardiac transplantation.
Journal: Acta pharmacologica Sinica 20030901
Title: Sphingosine 1-phosphate pathway therapeutics: a lipid ligand-receptor paradigm.
Journal: Current opinion in chemical biology 20030801
Title: Ubiquitin pathway proteins influence the mechanism of action of the novel immunosuppressive drug FTY720 in Saccharomyces cerevisiae.
Journal: The Journal of biological chemistry 20030718
Title: Pharmacodynamics of single doses of the novel immunosuppressant FTY720 in stable renal transplant patients.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20030701
Title: FTY720: A new kid on the block for transplant immunosuppression.
Journal: Expert opinion on biological therapy 20030701
Title: Induction of apoptosis in human bladder cancer cells in vitro and in vivo caused by FTY720 treatment.
Journal: The Journal of urology 20030601
Title: The effect of FTY 720 on engraftment in a model of spontaneous allograft acceptance.
Journal: Transplant international : official journal of the European Society for Organ Transplantation 20030601
Title: Prevention of renal ischemic reperfusion injury using FTY 720 and ICAM-1 antisense oligonucleotides.
Journal: Transplantation proceedings 20030601
Title: FTY720 reduces T-cell recruitment into murine intestinal allograft and prevents activation of graft-infiltrating cells.
Journal: Transplantation 20030515
Title: Immunosuppression with FTY720 and cyclosporine A inhibits rejection of adult porcine islet xenografts in rats.
Journal: Transplantation 20030427
Title: FTY720, an immunosuppressant that alters lymphocyte trafficking, abrogates chronic rejection in combination with cyclosporine A.
Journal: Transplantation 20030415
Title: Sphingosine-1-phosphate receptor agonism impairs the efficiency of the local immune response by altering trafficking of naive and antigen-activated CD4+ T cells.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20030401
Title: Amelioration of experimental autoimmune encephalomyelitis in Lewis rats by FTY720 treatment.
Journal: The Journal of pharmacology and experimental therapeutics 20030401
Title: A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells.
Journal: British journal of pharmacology 20030401
Title: The immune modulator FYT720 prevents autoimmune diabetes in nonobese diabetic mice.
Journal: Clinical immunology (Orlando, Fla.) 20030401
Title: FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes.
Journal: The Journal of clinical investigation 20030301
Title: Graft-versus-host disease can be separated from graft-versus-lymphoma effects by control of lymphocyte trafficking with FTY720.
Journal: The Journal of clinical investigation 20030301
Title: Elimination of cell-cycle regulators during caspase-3-dependent apoptosis caused by an immunosuppressant, FTY720.
Journal: Bioscience, biotechnology, and biochemistry 20030301
Title: [Effects of three different immunosuppressive drugs on SD rat islet cell viability].
Journal: Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20030201
Title: CTLA4Ig-gene transfection with FTY720 administration markedly inhibits the obliterative airway disease in heterotopically transplanted rat tracheas.
Journal: Transplantation proceedings 20030201
Title: Pretreatment with FTY720 alone induced long-term survival of mouse heart allograft.
Journal: Transplantation proceedings 20030201
Title: Linking Chinese medicine and G-protein-coupled receptors.
Journal: Trends in pharmacological sciences 20030101
Title: Selective cancer cell apoptosis induced by FTY720; evidence for a Bcl-dependent pathway and impairment in ERK activity.
Journal: Anticancer research 20030101
Title: Renal transplantation: basic concepts and evolution of therapy.
Journal: Journal of clinical apheresis 20030101
Title: New paradigms in immunosuppression.
Journal: CANNT journal = Journal ACITN 20030101
Title: Different mechanisms for membrane and nuclear damages in apoptosis induced by an immunosuppressant, FTY720.
Journal: Molecules and cells 20021231
Title: Prevention of autoimmune diabetes by FTY720 in nonobese diabetic mice.
Journal: Transplantation 20021227
Title: T cell selective apoptosis by a novel immunosuppressant, FTY720, is closely regulated with Bcl-2.
Journal: British journal of pharmacology 20021201
Title: Efficacy of mycophenolate sodium as monotherapy and in combination with FTY720 in a DA-to-Lewis-rat heart-transplantation model.
Journal: Transplantation 20021127
Title: Sirolimus and FTY720: new approaches to transplant immunosuppression.
Journal: Transplantation proceedings 20021101
Title: Effects of mycophenolate sodium with or without FTY720 in a DA-to-Lewis rat heart transplantation model.
Journal: Transplantation proceedings 20021101
Title: Oral efficacy of the new immunomodulator FTY720 in cynomolgus monkey kidney allotransplantation, given alone or in combination with cyclosporine or RAD.
Journal: Transplantation 20021015
Title: Transplantation.
Journal: Current opinion in immunology 20021001
Title: FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity.
Journal: Current opinion in immunology 20021001
Title: FTY720 pretreatment reduces warm hepatic ischemia reperfusion injury through inhibition of T-lymphocyte infiltration.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20021001
Title: Effects of immunosuppressant FTY720 on renal and hepatic hemodynamics in the rat.
Journal: Transplantation 20020915
Title: FTY720 alters the composition of T-lymphocyte subpopulations in the peripheral blood compartment of renal transplant patients.
Journal: Transplantation proceedings 20020901
Title: Combined therapy of CTLA4Ig-gene transfection with FTY720 administration in rat lung allografts.
Journal: Transplantation proceedings 20020801
Title: FTY720: a novel approach to the treatment of hepatic ischemia-reperfusion injury.
Journal: Transplantation proceedings 20020801
Title: A novel immunosuppressive drug, FTY720, prevents the cancer progression induced by cyclosporine.
Journal: Cancer letters 20020726
Title: The immune modulator FTY720 targets sphingosine 1-phosphate receptors.
Journal: The Journal of biological chemistry 20020614
Title: Combination treatment with FTY720 and CTLA4IgG preserves the respiratory epithelium and prevents obliterative disease in a murine airway model.
Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20020601
Title: Long-term islet graft survival in streptozotocin- and autoimmune-induced diabetes models by immunosuppressive and potential insulinotropic agent FTY720.
Journal: Transplantation 20020515
Title: Pharmacokinetics and cell trafficking dynamics of 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride (FTY720) in cynomolgus monkeys after single oral and intravenous doses.
Journal: The Journal of pharmacology and experimental therapeutics 20020501
Title: Combined use of FTY720 and cyclosporine A prevents chronic allograft vasculopathy.
Journal: Transplantation proceedings 20020501
Title: Donor pretreatment with FTY720 increases graft lymphocytes but does not affect graft survival following rat small bowel transplantation.
Journal: Transplantation proceedings 20020501
Title: Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists.
Journal: Science (New York, N.Y.) 20020412
Title: First human trial of FTY720, a novel immunomodulator, in stable renal transplant patients.
Journal: Journal of the American Society of Nephrology : JASN 20020401
Title: Effects of FTY720 in MRL-lpr/lpr mice: therapeutic potential in systemic lupus erythematosus.
Journal: The Journal of rheumatology 20020401
Title: Anticarcinogenic effect of FTY720 in human prostate carcinoma DU145 cells: modulation of mitogenic signaling, FAK, cell-cycle entry and apoptosis.
Journal: International journal of cancer 20020310
Title: Distinct pathways of apoptosis triggered by FTY720, etoposide, and anti-Fas antibody in human T-lymphoma cell line (Jurkat cells).
Journal: The Journal of pharmacology and experimental therapeutics 20020301
Title: Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models.
Journal: Cancer research 20020301
Title: L-selectin-dependent lymphoid occupancy is required to induce alloantigen-specific tolerance.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20020215
Title: Update on pharmacokinetic/pharmacodynamic studies with FTY720 and sirolimus.
Journal: Therapeutic drug monitoring 20020201
Title: What role for FTY720, a novel immunosuppressive agent, in canine nonmyeloablative hematopoietic stem cell transplantation?
Journal: Transplantation 20020127
Title: Activation of caspases and mitochondria in FTY720-mediated apoptosis in human T cell line Jurkat.
Journal: International immunopharmacology 20011001
Title: FTY720: altered lymphocyte traffic results in allograft protection.
Journal: Transplantation 20010915
Title: [mTOR and FTY 720 inhibitors].
Journal: Presse medicale (Paris, France : 1983) 20010901
Title: [What is new on transplantation in 2001?].
Journal: Presse medicale (Paris, France : 1983) 20010901
Title: Proteasome inhibitors and immunosuppressive drugs promote the cleavage of eIF4GI and eIF4GII by caspase-8-independent mechanisms in Jurkat T cell lines.
Journal: FEBS letters 20010817
Title: Coexpression of CD4 and CD8alpha on rat T-cells in whole blood: a sensitive marker for monitoring T-cell immunosuppressive drugs.
Journal: Journal of immunological methods 20010801
Title: Combined FTY720/cyclosporine treatment promotes graft survival and lowers the peripheral lymphocyte count in a murine cardiac allotransplantation model.
Journal: Transplantation 20010715
Title: A high-capacity quantitative mouse model of drug-mediated immunosuppression based on rejection of an allogeneic subcutaneous tumor.
Journal: The Journal of pharmacology and experimental therapeutics 20010601
Title: Coordinate involvement of cell cycle arrest and apoptosis strengthen the effect of FTY720.
Journal: Japanese journal of cancer research : Gann 20010601
Title: Therapeutic effects of FTY720, a new immunosuppressive agent, in a murine model of acute viral myocarditis.
Journal: Journal of the American College of Cardiology 20010501
Title: Neointima suppression in rat carotid allografts by FTY720 combined with a small fixed cyclosporine dose is related to a diminution of the peripheral lymphocyte count.
Journal: Transplantation proceedings 20010501
Title: FTY-720 is efficacious in monkey kidney transplantation.
Journal: Transplantation proceedings 20010501
Title: Long-term graft acceptance in rat heart transplantation by CTLA4Ig gene transfection combined with FTY720 treatment.
Journal: World journal of surgery 20010401
Title: New immunosuppressive drugs: an update.
Journal: Current opinion in urology 20010301
Title: Treatment of transplant rejection: are the traditional immunosuppressants good enough?
Journal: Current opinion in investigational drugs (London, England : 2000) 20010301
Title: FTY720, a novel immunosuppressive agent, induces apoptosis in human glioma cells.
Journal: Biochemical and biophysical research communications 20010223
Title: Induction of lymphocyte apoptosis in rat liver allograft with ongoing rejection by FTY720.
Journal: Clinical and experimental immunology 20010201
Title: Combined FTY720/cyclosporine A treatment promotes graft survival and lowers the peripheral lymphocyte count in DA to lewis heart and skin transplantation models.
Journal: Transplant immunology 20010201
Title: Immunosuppressive drugs in paediatric liver transplantation.
Journal: Paediatric drugs 20010101
Title: FTY720 alters lymphocyte homing and protects allografts without inducing general immunosuppression.
Journal: Transplantation proceedings 20010101
Title: FTY720 prevents chronic rejection of rat heterotopic cardiac allografts.
Journal: Transplantation proceedings 20010101
Title: FTY720, a novel immunosuppressive agent with insulinotropic activity, prolongs graft survival in a mouse islet transplantation model.
Journal: Transplantation proceedings 20010101
Title: FTY 720 prevents ischemic reperfusion damage in rat kidneys.
Journal: Transplantation proceedings 20010101
Title: FTY720, a novel transplantation drug, modulates lymphocyte migratory responses to chemokines.
Journal: Transplantation proceedings 20010101
Title: FTY720: dissection of membrane receptor-operated, stereospecific effects on cell migration from receptor-independent antiproliferative and apoptotic effects.
Journal: Transplantation proceedings 20010101
Title: FTY720: a new dimension in transplantation.
Journal: Transplantation proceedings 20010101
Title: T-cell apoptosis triggered by FTY720 via mitochondrial pathway.
Journal: Transplantation proceedings 20010101
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Title: Arielle M Bryan, et al. Sphingosine-1-phosphate receptors and innate immunity. Cell Microbiol. 2018 May;20(5):e12836.
