Catalog No.:AA001TAC

162705-07-9 | (Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)aniline

Name: Name:(Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)aniline
Brand: AABLOCKS
SKU: AA001TAC
Availability: InStock
Rating: 90 (10 reviews)

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250mg

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$123.00 $86.00

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Technical Information
Properties
Downstream Synthesis Route
Literature
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Technical Information
Properties
Downstream Synthesis Route
Literature

Technical Information

Catalog Number:

AA001TAC

Chemical Name:

(Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)aniline

CAS Number:

162705-07-9

Molecular Formula:

C18H21NO4

Molecular Weight:

315.3636

MDL Number:

MFCD00937446

SMILES:

COc1cc(/C=C\c2ccc(c(c2)N)OC)cc(c1OC)OC

Properties

BP:

496.377°C at 760 mmHg

Form:

Solid

Storage:

Inert atmosphere;2-8℃;

Computed Properties

Complexity:

362

Covalently-Bonded Unit Count:

Defined Bond Stereocenter Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

XLogP3:

3.4

Downstream Synthesis Route

162705-13-7

162705-07-9

[1]EuropeanJournalofMedicinalChemistry,2018,vol.156,p.666-679

[2]ChineseChemicalLetters,2015,vol.26,p.993-999

[3]JournalofAgriculturalandFoodChemistry,2016,vol.64,p.746-751

[4]BioorganicandMedicinalChemistry,2016,vol.24,p.938-956

[5]JournalofMedicinalChemistry,2005,vol.48,p.4087-4099

[6]ChemMedChem,2017,vol.12,p.678-700

[7]BioorganicandMedicinalChemistryLetters,2010,vol.20,p.2780-2784

[8]JournalofMedicinalChemistry,1998,vol.41,p.3022-3032

[9]BioorganicandMedicinalChemistry,2013,vol.21,p.1248-1256

[10]PolishJournalofChemistry,2009,vol.83,p.81-85

[11]BioorganicandMedicinalChemistry,2000,vol.8,p.2417-2425

[12]Patent:US6350777,2002,B2.Locationinpatent:Pagecolumn34-35

[13]BioorganicandMedicinalChemistry,2006,vol.14,p.3231-3244

[14]BioorganicandMedicinalChemistry,2014,vol.22,p.5155-5167

[15]ACSMedicinalChemistryLetters,2019,vol.10,p.1115-1121

162705-07-9

(Z)-1-(3'-azido-4'-methoxyphenyl)-2-(3'',4'',5''-trimethoxyphenyl)ethene

[1]BioorganicandMedicinalChemistry,2000,vol.8,p.2417-2425

[2]Patent:US6350777,2002,B2.Locationinpatent:Pagecolumn35

162705-07-9

107-07-3

863116-52-3

[1]BioorganicandMedicinalChemistryLetters,2005,vol.15,p.3551-3554

162705-07-9

171778-17-9

286463-65-8

[1]BioorganicandMedicinalChemistry,2016,vol.24,p.938-956

[2]BioorganicandMedicinalChemistryLetters,2009,vol.19,p.6948-6951

[3]BioorganicandMedicinalChemistry,2006,vol.14,p.3231-3244

C18H19NO4

162705-07-9

[1]TetrahedronLetters,2007,vol.48,p.7007-7010

[2]BioorganicandMedicinalChemistryLetters,2009,vol.19,p.6948-6951

Literature

Title: Discovery of a potent tubulin polymerization inhibitor: synthesis and evaluation of water-soluble prodrugs of benzophenone analog.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Identification of CKD-516: a potent tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors.

Journal: Journal of medicinal chemistry 20100909

Title: Synthesis and biological evaluation of combretastatin analogs as cell cycle inhibitors of the G1 to S transition in Saccharomyces cerevisiae.

Journal: Bioorganic & medicinal chemistry letters 20100501

Title: Synthesis and antitumor-evaluation of cyclopropyl-containing combretastatin analogs.

Journal: Bioorganic & medicinal chemistry letters 20091215

Title: Design, synthesis, biochemical, and biological evaluation of nitrogen-containing trifluoro structural modifications of combretastatin A-4.

Journal: Bioorganic & medicinal chemistry letters 20080915

Title: Synthesis and biological activity of fluorinated combretastatin analogues.

Journal: Journal of medicinal chemistry 20080508

Title: 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents.

Journal: Journal of medicinal chemistry 20061019

Title: Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41.

Journal: Journal of medicinal chemistry 20050616

Title: Synthesis and structure-activity relationships of 3-aminobenzophenones as antimitotic agents.

Journal: Journal of medicinal chemistry 20040520

Title: Antineoplastic agents. 487. Synthesis and biological evaluation of the antineoplastic agent 3,4-methylenedioxy-5,4'-dimethoxy-3'-amino-Z-stilbene and derived amino acid amides.

Journal: Journal of medicinal chemistry 20030213

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