Name: Name:(Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)aniline
Brand: AABLOCKS
SKU: AA001TAC
Rating: 90 (10 reviews)

Catalog No.: AA001TAC

162705-07-9 | (Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)aniline

Pack Size： 250mg

Purity： 95%

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$125.00 $87.00

Pack Size： 1g

Purity： 95%

in stock

$357.00 $250.00

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Technical Information

Catalog Number: AA001TAC

Chemical Name: (Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)aniline

CAS Number: 162705-07-9

Molecular Formula: C18H21NO4

Molecular Weight: 315.3636

MDL Number: MFCD00937446

SMILES: COc1cc(/C=C\c2ccc(c(c2)N)OC)cc(c1OC)OC

Properties

BP: 496.377°C at 760 mmHg

Form: Solid

Storage: Inert atmosphere;2-8℃;

Complexity: 362

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 1

Formal Charge: 0

Heavy Atom Count: 23

Hydrogen Bond Acceptor Count: 5

Hydrogen Bond Donor Count: 1

Isotope Atom Count: 0

Rotatable Bond Count: 6

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 3.4

Downstream Synthesis Route

162705-13-7

162705-07-9

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[12]Patent:US6350777,2002,B2.Locationinpatent:Pagecolumn34-35

[13]BioorganicandMedicinalChemistry,2006,vol.14,p.3231-3244

[14]BioorganicandMedicinalChemistry,2014,vol.22,p.5155-5167

[15]ACSMedicinalChemistryLetters,2019,vol.10,p.1115-1121

162705-07-9

(Z)-1-(3'-azido-4'-methoxyphenyl)-2-(3'',4'',5''-trimethoxyphenyl)ethene

[1]BioorganicandMedicinalChemistry,2000,vol.8,p.2417-2425

[2]Patent:US6350777,2002,B2.Locationinpatent:Pagecolumn35

162705-07-9

107-07-3

863116-52-3

[1]BioorganicandMedicinalChemistryLetters,2005,vol.15,p.3551-3554

162705-07-9

171778-17-9

286463-65-8

[1]BioorganicandMedicinalChemistry,2016,vol.24,p.938-956

[2]BioorganicandMedicinalChemistryLetters,2009,vol.19,p.6948-6951

[3]BioorganicandMedicinalChemistry,2006,vol.14,p.3231-3244

C18H19NO4

162705-07-9

[1]TetrahedronLetters,2007,vol.48,p.7007-7010

[2]BioorganicandMedicinalChemistryLetters,2009,vol.19,p.6948-6951

Literature fold

Title: Discovery of a potent tubulin polymerization inhibitor: synthesis and evaluation of water-soluble prodrugs of benzophenone analog.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: Identification of CKD-516: a potent tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors.

Journal: Journal of medicinal chemistry20100909

Title: Synthesis and biological evaluation of combretastatin analogs as cell cycle inhibitors of the G1 to S transition in Saccharomyces cerevisiae.

Journal: Bioorganic & medicinal chemistry letters20100501

Title: Synthesis and antitumor-evaluation of cyclopropyl-containing combretastatin analogs.

Journal: Bioorganic & medicinal chemistry letters20091215

Title: Design, synthesis, biochemical, and biological evaluation of nitrogen-containing trifluoro structural modifications of combretastatin A-4.

Journal: Bioorganic & medicinal chemistry letters20080915

Title: Synthesis and biological activity of fluorinated combretastatin analogues.

Journal: Journal of medicinal chemistry20080508

Title: 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents.

Journal: Journal of medicinal chemistry20061019

Title: Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41.

Journal: Journal of medicinal chemistry20050616

Title: Synthesis and structure-activity relationships of 3-aminobenzophenones as antimitotic agents.

Journal: Journal of medicinal chemistry20040520

Title: Antineoplastic agents. 487. Synthesis and biological evaluation of the antineoplastic agent 3,4-methylenedioxy-5,4'-dimethoxy-3'-amino-Z-stilbene and derived amino acid amides.

Journal: Journal of medicinal chemistry20030213

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