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1627503-67-6,MFCD28168043
Catalog No.:AA001TBA

1627503-67-6 | LDN-214117

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
≥98%
in stock  
$156.00   $109.00
- +
10mg
≥98%
in stock  
$263.00   $184.00
- +
25mg
≥98%(HPLC)
in stock  
$484.00   $339.00
- +
50mg
≥98%(HPLC)
in stock  
$795.00   $557.00
- +
100mg
≥98%(HPLC)
in stock  
$1,204.00   $843.00
- +
500mg
98% by HPLC
in stock  
$5,515.00   $3,861.00
- +
1000mg
98% by HPLC
in stock  
$8,787.00   $6,151.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001TBA
Chemical Name:
LDN-214117
CAS Number:
1627503-67-6
Molecular Formula:
C25H29N3O3
Molecular Weight:
419.5161
MDL Number:
MFCD28168043
SMILES:
COc1cc(cc(c1OC)OC)c1cc(cnc1C)c1ccc(cc1)N1CCNCC1
Properties
Computed Properties
 
Complexity:
522  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
3.9  

Literature

Title: Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants.

Journal: Journal of medicinal chemistry 20141009

Title: ACVR1 (587T>C) mutation in a variant form of fibrodysplasia ossificans progressiva: second report.

Journal: American journal of medical genetics. Part A 20140101

Title: Fibrodysplasia ossificans progressiva: clinical and genetic aspects.

Journal: Orphanet journal of rare diseases 20110101

Title: Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1.

Journal: Human mutation 20090301

Title: A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva.

Journal: Nature genetics 20060501

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