Title: Water metabolism dysfunction via renin-angiotensin system activation caused by liver damage in mice treated with microcystin-RR.
Journal: Toxicology letters 20170505
Title: Inhibiting renin angiotensin system in rate limiting step by aliskiren as a new approach for preventing indomethacin induced gastric ulcers.
Journal: Chemico-biological interactions 20161025
Title: Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis.
Journal: Chemical research in toxicology 20150518
Title: Aliskiren toxicity in juvenile rats is determined by ontogenic regulation of intestinal P-glycoprotein expression.
Journal: Toxicology and applied pharmacology 20140215
Title: Azilsartan, aliskiren, and combination antihypertensives utilizing renin-angiotensin-aldosterone system antagonists.
Journal: American journal of therapeutics 20140101
Title: Antifungal properties of the anti-hypertensive drug: aliskiren.
Journal: Archives of oral biology 20130901
Title: The effect of direct renin inhibition alone and in combination with ACE inhibition on endothelial function, arterial stiffness, and renal function in type 1 diabetes.
Journal: Diabetes care 20121101
Title: The single pill triple combination of aliskiren, amlodipine, and hydrochlorothiazide in the treatment of hypertension.
Journal: Expert opinion on pharmacotherapy 20121101
Title: Incidence of angio-oedema associated with ARBs, ACE inhibitors, and aliskiren.
Journal: BMJ (Clinical research ed.) 20121017
Title: In vitro controlled release of antihypertensive drugs intercalated into unmodified SBA-15 and MgO modified SBA-15 matrices.
Journal: International journal of pharmaceutics 20121015
Title: Chronic direct renin inhibition with aliskiren prevents the development of hypertension in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent hypertension.
Journal: The American journal of the medical sciences 20121001
Title: A validated LC method for the determination of the enantiomeric purity of aliskiren hemifumarate in bulk drug samples.
Journal: Journal of chromatographic science 20121001
Title: AT1 antagonism and renin inhibition in mice: pivotal role of targeting angiotensin II in chronic kidney disease.
Journal: American journal of physiology. Renal physiology 20121001
Title: Combined use of direct renin inhibitor and carvedilol in heart failure with preserved systolic function.
Journal: Medical hypotheses 20121001
Title: Pharmacokinetics of aliskiren in patients with end-stage renal disease undergoing haemodialysis.
Journal: Clinical pharmacokinetics 20121001
Title: Aliskiren reduces portal pressure and intrahepatic resistance in biliary cirrhotic rats.
Journal: Journal of the Chinese Medical Association : JCMA 20121001
Title: Baseline characteristics in the Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE).
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20120901
Title: Exploring the substructural space of indole-3-carboxamide derivatives binding to renin: a novel active-site spatial partitioning approach.
Journal: Journal of molecular modeling 20120901
Title: Inhibition of renin activity slows down the progression of HIV-associated nephropathy.
Journal: American journal of physiology. Renal physiology 20120901
Title: High glucose potentiates and renin-angiotensin blockade downregulates LPS-induced tissue factor expression in human mononuclear cells.
Journal: Thrombosis research 20120901
Title: Treatment with aliskiren/amlodipine combination in patients with moderate-to-severe hypertension: a randomised, double-blind, active comparator trial.
Journal: International journal of clinical practice 20120901
Title: [Is there still a place for a dual blockade of the renin-angiotensin system in 2012?].
Journal: Revue medicale suisse 20120829
Title: Local delivery of a direct renin inhibitor into the kidney ameliorates progression of experimental glomerulonephritis.
Journal: Clinical and experimental nephrology 20120801
Title: How well do aliskiren's purported mechanisms track its effects on cardiovascular and renal disorders?
Journal: Cellular signalling 20120801
Title: Additive renoprotective effects of aliskiren on angiotensin receptor blocker and calcium channel blocker treatments for type 2 diabetic patients with albuminuria.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20120801
Title: Renin inhibitor aliskiren exerts neuroprotection against amyloid beta-peptide toxicity in rat cortical neurons.
Journal: Neurochemistry international 20120801
Title: Aliskiren alone or in combination with hydrochlorothiazide in Hispanic/Latino patients with systolic blood pressure 160 mm Hg to <180 mm Hg (Aliskiren Alone or in Combination with Hydrochlorothiazide in Patients with Stage 2 Hypertension to Provide Quick Intensive Control of Blood Pressure [ACQUIRE] substudy).
Journal: Journal of clinical hypertension (Greenwich, Conn.) 20120801
Title: Effects of aliskiren-based therapy on ambulatory blood pressure profile, central hemodynamics, and arterial stiffness in nondiabetic mild to moderate hypertensive patients.
Journal: Journal of clinical hypertension (Greenwich, Conn.) 20120801
Title: Rapid HILIC method with fluorescence detection using derivatization reaction utilizing o-phthaldialdehyde for determination of degradation product of aliskiren.
Journal: Journal of pharmaceutical and biomedical analysis 20120701
Title: Vitamin D receptor signaling inhibits atherosclerosis in mice.
Journal: Molecular endocrinology (Baltimore, Md.) 20120701
Title: Safety and efficacy of aliskiren in the treatment of hypertension: a systematic overview.
Journal: Expert opinion on drug safety 20120701
Title: Early signals.
Journal: Prescrire international 20120701
Title: Aliskiren: negative trial data.
Journal: Prescrire international 20120701
Title: Amlodidine + aliskiren.
Journal: Prescrire international 20120701
Title: Dual inhibitors for aspartic proteases HIV-1 PR and renin: advancements in AIDS-hypertension-diabetes linkage via molecular dynamics, inhibition assays, and binding free energy calculations.
Journal: Journal of medicinal chemistry 20120628
Title: ACP Journal Club. Review: Aliskiren plus ACEIs or ARBs increases hyperkalemia more than aliskiren, ACEIs, or ARBs alone.
Journal: Annals of internal medicine 20120619
Title: Add-on aliskiren elicits stronger renoprotection than high-dose valsartan in type 2 diabetic KKAy mice that do not respond to low-dose valsartan.
Journal: Journal of pharmacological sciences 20120616
Title: A new approach to the synthesis of peptidomimetic renin inhibitors: palladium-catalyzed asymmetric allylation of acyclic alkyl aryl ketones.
Journal: Organic letters 20120615
Title: Combination of direct renin inhibition with angiotensin type 1 receptor blockade improves aldosterone but does not improve kidney injury in the transgenic Ren2 rat.
Journal: Regulatory peptides 20120610
Title: Beneficial effect of aliskiren combined with olmesartan in reducing urinary protein excretion in patients with chronic kidney disease.
Journal: International urology and nephrology 20120601
Title: Impact of glycaemic control on the effect of direct renin inhibition in the AVOID study.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20120601
Title: Aliskiren and perindopril reduce the levels of transforming growth factor-β in patients with non-diabetic kidney disease.
Journal: American journal of hypertension 20120601
Title: Aliskiren improves left ventricular dysfunction and reduces cardiac dilation in Syrian cardiomyopathic hamsters.
Journal: Journal of cardiovascular pharmacology 20120601
Title: Solid-state nuclear magnetic resonance study of the physical stability of electrospun drug and polymer solid solutions.
Journal: Journal of pharmaceutical sciences 20120601
Title: Influence of diabetes on efficacy of aliskiren, losartan or both on left ventricular mass regression.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20120601
Title: Effect of aliskiren treatment on endothelium-dependent vasodilation and aortic stiffness in essential hypertensive patients.
Journal: European heart journal 20120601
Title: Beneficial effects of pioglitazone against cardiovascular injury are enhanced by combination with aliskiren in a rat model of diabetic nephropathy.
Journal: The Journal of pharmacy and pharmacology 20120601
Title: An observational, prospective, open-label, multicentre evaluation of aliskiren in treated, uncontrolled patients: a real-life, long-term, follow-up, clinical practice in Italy.
Journal: High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension 20120601
Title: Effective blockade of RAAS by combination of aliskiren and olmesartan improves glucose homeostasis, glomerular filtration rate along with renal variables in streptozotocin induced diabetic rats.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120512
Title: [Chronic kidney disease (CKD)--recent progress. Topics: VII. Management of chronic kidney disease (CKD) and treatment; 2. Renoprotective effects of novel drugs].
Journal: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20120510
Title: Clinical role of direct renin inhibition in hypertension.
Journal: American journal of therapeutics 20120501
Title: Pharmacokinetics and pharmacodynamics of aliskiren/hydrochlorothiazide single-pill combination tablets and free combination of aliskiren and hydrochlorothiazide.
Journal: Journal of clinical pharmacology 20120501
Title: Aliskiren reduces portal pressure in portal hypertensive rats.
Journal: European journal of clinical investigation 20120501
Title: Intestinal OATP1A2 inhibition as a potential mechanism for the effect of grapefruit juice on aliskiren pharmacokinetics in healthy subjects.
Journal: European journal of clinical pharmacology 20120501
Title: Sustained decrease in blood pressure following missed doses of aliskiren or telmisartan: the ASSERTIVE double-blind, randomized study.
Journal: Journal of hypertension 20120501
Title: RAS blockade, hyperkalemia and AKI--look and you will find.
Journal: Nature reviews. Nephrology 20120501
Title: Comparative efficacy of aliskiren/valsartan vs valsartan in nocturnal dipper and nondipper hypertensive patients: a pooled analysis.
Journal: Journal of clinical hypertension (Greenwich, Conn.) 20120501
Title: Failure to intensify hypertension therapy after rejected aliskiren claims.
Journal: Clinical therapeutics 20120501
Title: Anti-fibrotic effect of Aliskiren in rats with deoxycorticosterone induced myocardial fibrosis and its potential mechanism.
Journal: Bosnian journal of basic medical sciences 20120501
Title: Effects of aliskiren on QT duration and dispersion in hypertensive patients with type 2 diabetes mellitus.
Journal: Diabetes, obesity & metabolism 20120401
Title: Aliskiren-associated acute kidney injury in a patient with pre-existing chronic kidney disease and dilated cardiomyopathy.
Journal: Clinical and experimental nephrology 20120401
Title: Aliskiren reduces portal pressure in cirrhotic rats.
Journal: Liver international : official journal of the International Association for the Study of the Liver 20120401
Title: Solid-state NMR characterization of high-loading solid solutions of API and excipients formed by electrospinning.
Journal: Journal of pharmaceutical sciences 20120401
Title: Central infusion of aliskiren prevents sympathetic hyperactivity and hypertension in Dahl salt-sensitive rats on high salt intake.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20120401
Title: Aliskiren as a novel therapeutic agent for hypertension and cardio-renal diseases.
Journal: The Journal of pharmacy and pharmacology 20120401
Title: Aliskiren, ALTITUDE, and the implications for ATMOSPHERE.
Journal: European journal of heart failure 20120401
Title: 2-Cyano-2-methyl-propanamide.
Journal: Acta crystallographica. Section E, Structure reports online 20120401
Title: Key advances in antihypertensive treatment.
Journal: Nature reviews. Cardiology 20120320
Title: [Angio-oedema and medication that interferes with the renin-angiotensin-aldosterone system--a systematic review].
Journal: Ugeskrift for laeger 20120312
Title: Addition of aliskiren to angiotensin II receptor blockers ameliorates renal tubular injury and reduces intima media thickness of carotid artery in patients with diabetic nephropathy.
Journal: International journal of cardiology 20120308
Title: New roles for renin and prorenin in heart failure and cardiorenal crosstalk.
Journal: Heart failure reviews 20120301
Title: Impact of aliskiren treatment on urinary aldosterone levels in patients with type 2 diabetes and nephropathy: an AVOID substudy.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20120301
Title: Addition of aliskiren to olmesartan ameliorates tubular injury in chronic kidney disease patients partly by reducing proteinuria.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20120301
Title: Spectrofluorimetric determination of aliskiren in tablets and spiked human plasma through derivatization with dansyl chloride.
Journal: Journal of fluorescence 20120301
Title: Haemodynamic effects of aliskiren in decompensated severe heart failure.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20120301
Title: Comparative effects of different modes of renin angiotensin system inhibition on hypercholesterolaemia-induced atherosclerosis.
Journal: British journal of pharmacology 20120301
Title: Combined aliskiren and amlodipine reduce albuminuria via reduction in renal inflammation in diabetic rats.
Journal: Journal of cardiovascular pharmacology 20120301
Title: Aliskiren reduced renal fibrosis in mice with chronic ischemic kidney injury--beyond the direct renin inhibition.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20120301
Title: Aliskiren in patients with diabetes: a systematic review.
Journal: Current vascular pharmacology 20120301
Title: Mechanistic insights into the antifibrotic activity of aliskiren in the kidney.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20120301
Title: Aliskiren penetrates adipose and skeletal muscle tissue and reduces renin-angiotensin system activity in obese hypertensive patients.
Journal: Journal of hypertension 20120301
Title: Selective renin inhibition in obese hypertensive patients: perspectives from tissue penetration.
Journal: Journal of hypertension 20120301
Title: Aliskiren for the treatment of essential hypertension under real-life practice conditions: design and baseline data of the prospective 3A registry.
Journal: International journal of clinical practice 20120301
Title: Aliskiren for reninoma.
Journal: Nephrology (Carlton, Vic.) 20120301
Title: Aliskiren: a potential antiarrhythmic drug?
Journal: Journal of clinical hypertension (Greenwich, Conn.) 20120301
Title: Aliskiren attenuates myocardial apoptosis and oxidative stress in chronic murine model of cardiomyopathy.
Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20120301
Title: Aliskiren, amlodipine and hydrochlorothiazide triple combination for hypertension.
Journal: Expert review of cardiovascular therapy 20120301
Title: Use of direct renin inhibitor in an HIV positive subject.
Journal: Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 20120301
Title: Aliskiren combined with losartan in immunoglobulin A nephropathy: an open-labeled pilot study.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20120201
Title: Polycystic kidney disease presenting with hypertension and hypokalemia.
Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20120201
Title: Left ventricular systolic and diastolic function, remodelling, and clinical outcomes among patients with diabetes following myocardial infarction and the influence of direct renin inhibition with aliskiren.
Journal: European journal of heart failure 20120201
Title: Reversibility of the effects of aliskiren in the renal versus systemic circulation.
Journal: Clinical journal of the American Society of Nephrology : CJASN 20120201
Title: Aliskiren displays long-lasting interactions with human renin.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20120201
Title: Restoration of the blood pressure circadian rhythm by direct renin inhibition and blockade of angiotensin II receptors in mRen2.Lewis hypertensive rats.
Journal: Therapeutic advances in cardiovascular disease 20120201
Title: Effects of renin-angiotensin-aldosterone system blockade on chlorhexidine gluconate-induced sclerosing encapsulated peritonitis in rats.
Journal: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 20120201
Title: Current studies of diabetic cardiomyopathy and the advancement of our knowledge: time to learn from history, guidelines, ... and other disciplines?
Journal: European journal of heart failure 20120201
Title: Safety and efficacy of aliskiren in the treatment of hypertension and associated clinical conditions.
Journal: Current drug safety 20120201
Title: In brief: aliskiren trial terminated.
Journal: The Medical letter on drugs and therapeutics 20120123
Title: Aliskiren in combination with valsartan exerts synergistic protective effects against ventricular remodeling after myocardial infarction in mice.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20120101
Title: Efficacy and safety of aliskiren, a direct renin inhibitor, compared with ramipril in Asian patients with mild to moderate hypertension.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20120101
Title: Finding a place for aliskiren in the wide spectrum of blood pressure lowering agents.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20120101
Title: Renal functional responses to selective intrarenal renin inhibition in Cyp1a1-Ren2 transgenic rats with ANG II-dependent malignant hypertension.
Journal: American journal of physiology. Renal physiology 20120101
Title: Chronic renin inhibition with aliskiren improves glucose tolerance, insulin sensitivity, and skeletal muscle glucose transport activity in obese Zucker rats.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20120101
Title: Efficacy and tolerability of the single-pill combination of aliskiren 300 mg/amlodipine 10 mg in hypertensive patients not controlled by olmesartan 40 mg/amlodipine 10 mg.
Journal: Current medical research and opinion 20120101
Title: Aliskiren inhibits atherosclerosis development and improves plaque stability in APOE*3Leiden.CETP transgenic mice with or without treatment with atorvastatin.
Journal: Journal of hypertension 20120101
Title: Use of aliskiren in a 'real-life' model of hypertension management: analysis of national Web-based drug-monitoring system in Italy.
Journal: Journal of hypertension 20120101
Title: Does the combination of a renin inhibitor with a statin have potential for improved inhibition of atherosclerosis?
Journal: Journal of hypertension 20120101
Title: Assessing antihypertensive treatment by real life data.
Journal: Journal of hypertension 20120101
Title: The effect of combination treatment with aliskiren and blockers of the renin-angiotensin system on hyperkalaemia and acute kidney injury: systematic review and meta-analysis.
Journal: BMJ (Clinical research ed.) 20120101
Title: Trypanosoma cruzi trans-sialidase in complex with a neutralizing antibody: structure/function studies towards the rational design of inhibitors.
Journal: PLoS pathogens 20120101
Title: Efficacy of aliskiren in Japanese chronic kidney disease patients with hypertension.
Journal: Renal failure 20120101
Title: Aliskiren-induced chyloperitoneum in a patient on peritoneal dialysis.
Journal: Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 20120101
Title: Aliskiren-based dual- and triple-combination therapies in high-risk US minority patients with stage 2 hypertension.
Journal: Journal of the American Society of Hypertension : JASH 20120101
Title: Comparison of the effects of aliskiren/valsartan in combination versus valsartan alone in patients with stage 2 hypertension.
Journal: Journal of the American Society of Hypertension : JASH 20120101
Title: Diabetic macular edema: current and emerging therapies.
Journal: Middle East African journal of ophthalmology 20120101
Title: How full is our antihypertensives pipeline?
Journal: Journal of pharmacology & pharmacotherapeutics 20120101
Title: What differentiates primary care physicians who predominantly prescribe diuretics for treating mild to moderate hypertension from those who do not? A comparative qualitative study.
Journal: BMC family practice 20120101
Title: Aliskiren, the first direct renin inhibitor for treatment of hypertension: the path of its development.
Journal: Journal of postgraduate medicine 20120101
Title: Targeting NADPH oxidases in vascular pharmacology.
Journal: Vascular pharmacology 20120101
Title: [Recent advance in kidney and hypertension research].
Journal: Nihon Jinzo Gakkai shi 20120101
Title: Lycium barbarum extracts protect the brain from blood-brain barrier disruption and cerebral edema in experimental stroke.
Journal: PloS one 20120101
Title: Effect of direct renin inhibitor, aliskiren, on peripheral blood monocyte subsets and myocardial salvage in patients with primary acute myocardial infarction.
Journal: Circulation journal : official journal of the Japanese Circulation Society 20120101
Title: What is a preferred angiotensin II receptor blocker-based combination therapy for blood pressure control in hypertensive patients with diabetic and non-diabetic renal impairment?
Journal: Cardiovascular diabetology 20120101
Title: Long-term effects of aliskiren on blood pressure and the renin-angiotensin-aldosterone system in hypertensive hemodialysis patients.
Journal: International journal of nephrology and renovascular disease 20120101
Title: Emerging drug combinations to optimize renovascular protection and blood pressure goals.
Journal: International journal of nephrology and renovascular disease 20120101
Title: Renin-Angiotensin system hyperactivation can induce inflammation and retinal neural dysfunction.
Journal: International journal of inflammation 20120101
Title: Aliskiren prevents the toxic effects of peritoneal dialysis fluids during chronic dialysis in rats.
Journal: PloS one 20120101
Title: Aliskiren reduces morning blood pressure in hypertensive patients with diabetic nephropathy.
Journal: Clinical and experimental hypertension (New York, N.Y. : 1993) 20120101
Title: Cardiovascular magnetic resonance in systemic hypertension.
Journal: Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20120101
Title: Different roles of mast cells in obesity and diabetes: lessons from experimental animals and humans.
Journal: Frontiers in immunology 20120101
Title: Renin inhibitors inhibited the activity of recombinant human renin but not activity in healthy human plasma.
Journal: Clinical laboratory 20120101
Title: Direct renin inhibition exerts an anti-hypertrophic effect associated with improved mitochondrial function in post-infarction heart failure in diabetic rats.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101
Title: Assessing the association between omalizumab and arteriothrombotic events through spontaneous adverse event reporting.
Journal: Journal of asthma and allergy 20120101
Title: Antioxidants in kidney diseases: the impact of bardoxolone methyl.
Journal: International journal of nephrology 20120101
Title: Hyponatremia in a patient with scleroderma renal crisis: a potential role of activated renin-angiotensin system.
Journal: BMC nephrology 20120101
Title: Does direct inhibition bring direct benefit?
Journal: Circulation journal : official journal of the Japanese Circulation Society 20120101
Title: Three in one: safety, efficacy, and patient acceptability of triple fixed-dose combination medicine in the management of hypertension.
Journal: Patient preference and adherence 20120101
Title: Aldosterone breakthrough during aliskiren, valsartan, and combination (aliskiren + valsartan) therapy.
Journal: Journal of the American Society of Hypertension : JASH 20120101
Title: Aliskiren suppresses the renin-angiotensin-aldosterone system and reduces blood pressure and albuminuria in elderly chronic kidney disease patients with hypertension.
Journal: International journal of nephrology and renovascular disease 20120101
Title: Aliskiren reduces prorenin receptor expression and activity in cultured human aortic smooth muscle cells.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20111201
Title: Suppression of aldosterone mediates regression of left ventricular hypertrophy in patients with hypertension.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20111201
Title: Aliskiren and Valsartan reduce myocardial AT1 receptor expression and limit myocardial infarct size in diabetic mice.
Journal: Cardiovascular drugs and therapy 20111201
Title: Renal responses to three types of renin-angiotensin system blockers in patients with diabetes mellitus on a high-salt diet: a need for higher doses in diabetic patients?
Journal: Journal of hypertension 20111201
Title: Long-term safety and tolerability of the oral direct renin inhibitor aliskiren with optional add-on hydrochlorothiazide in patients with hypertension: a randomized, open-label, parallel-group, multicentre, dose-escalation study with an extension phase.
Journal: Clinical drug investigation 20111201
Title: Comparison of aliskiren/hydrochlorothiazide combination therapy and amlodipine monotherapy in patients with stage 2 systolic hypertension and type 2 diabetes mellitus.
Journal: Journal of clinical hypertension (Greenwich, Conn.) 20111201
Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Journal: PLoS computational biology 20111201
Title: [Aldosterone as an endogenous cardiovascular toxin and the options for its therapeutic management].
Journal: Vnitrni lekarstvi 20111201
Title: [Bartter syndrome: a new therapeutic approach].
Journal: Acta medica portuguesa 20111201
Title: Aliskiren prevents hypertension and reduces asymmetric dimethylarginine in young spontaneously hypertensive rats.
Journal: European journal of pharmacology 20111130
Title: Direct renin inhibition in a rat model of chronic allograft injury.
Journal: Transplantation 20111115
Title: Limitations of targeting rate-limiting step of renin-angiotensin-aldosterone system in experimental chronic allograft nephropathy.
Journal: Transplantation 20111115
Title: Effect of cyclosporine on the pharmacokinetics of aliskiren in healthy subjects.
Journal: Journal of clinical pharmacology 20111101
Title: 50 years of thiazides: should thiazide diuretics be considered third-line hypertension treatment?
Journal: American journal of therapeutics 20111101
Title: Electromechanical effects of the direct renin inhibitor (aliskiren) on the pulmonary vein and atrium.
Journal: Basic research in cardiology 20111101
Title: Evaluation of a direct prorenin assay making use of a monoclonal antibody directed against residues 32-39 of the prosegment.
Journal: Journal of hypertension 20111101
Title: Atorvastatin reduces sympathetic activity in patients with chronic kidney disease.
Journal: Journal of hypertension 20111101
Title: Therapeutic perspectives in hypertension: novel means for renin-angiotensin-aldosterone system modulation and emerging device-based approaches.
Journal: European heart journal 20111101
Title: Angioedema due to the renin inhibitor aliskiren (MAY 2011).
Journal: Cleveland Clinic journal of medicine 20111101
Title: Single-pill triple-combination therapy: an alternative to multiple-drug treatment of hypertension.
Journal: Postgraduate medicine 20111101
Title: Bartter- and Gitelman-like syndromes: salt-losing tubulopathies with loop or DCT defects.
Journal: Pediatric nephrology (Berlin, Germany) 20111001
Title: Aliskiren reduces vascular pathology in diabetic retinopathy and oxygen-induced retinopathy in the transgenic (mRen-2)27 rat.
Journal: Diabetologia 20111001
Title: Aliskiren as add-on therapy in the treatment of hypertensive diabetic patients inadequately controlled with valsartan/HCT combination: a placebo-controlled study.
Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20111001
Title: The role of direct renin inhibition in clinical practice: focus on combination therapy.
Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20111001
Title: Initial treatment of hypertension with aliskiren and amlodipine combination gives 6.5 mm Hg greater reduction in systolic BP than does either monotherapy.
Journal: Evidence-based medicine 20111001
Title: Attenuation of brain damage and cognitive impairment by direct renin inhibition in mice with chronic cerebral hypoperfusion.
Journal: Hypertension (Dallas, Tex. : 1979) 20111001
Title: A simple test to appreciate compliance to aliskiren treatment.
Journal: Journal of hypertension 20111001
Title: Management of patients with chronic kidney disease.
Journal: Internal and emergency medicine 20111001
Title: (R,R(Fc),S(Ru))-Chlorido(η-p-cymene){1-[1-(diphenyl-phosphanyl)ethyl]-2-[2-(diphenyl-phosphanyl)phenyl]ferrocene-κP,P'}ruthenium(II) hexa-fluorido-phosphate.
Journal: Acta crystallographica. Section E, Structure reports online 20111001
Title: Updates on the treatment of essential hypertension: a summary of AHRQ's comparative effectiveness review of angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, and direct renin inhibitors.
Journal: Journal of managed care pharmacy : JMCP 20111001
Title: Aliskiren prevents and ameliorates metabolic syndrome in fructose-fed rats.
Journal: Archives of medical science : AMS 20111001
Title: Conformational analysis of aliskiren, a potent renin inhibitor, using high-resolution nuclear magnetic resonance and molecular dynamics simulations.
Journal: Journal of chemical information and modeling 20110926
Title: Characterization of a stable, hypertensive rat model suitable for the consecutive evaluation of human renin inhibitors.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20110901
Title: Aliskiren reduces sympathetic nerve activity and blood pressure in chronic kidney disease patients.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20110901
Title: NADPH oxidases in cardiovascular disease: insights from in vivo models and clinical studies.
Journal: Basic research in cardiology 20110901
Title: Aliskiren affects fatty-acid uptake and lipid-related genes in rodent and human cardiomyocytes.
Journal: Biochemical pharmacology 20110901
Title: Aliskiren increases bradykinin and tissue kallikrein mRNA levels in the heart.
Journal: Clinical and experimental pharmacology & physiology 20110901
Title: What is the role of direct renin inhibitors in the treatment of the hypertensive diabetic patient?
Journal: Advances in therapy 20110901
Title: Renin inhibitors.
Journal: Journal of clinical hypertension (Greenwich, Conn.) 20110901
Title: Angiotensin receptor blockers: pharmacology, efficacy, and safety.
Journal: Journal of clinical hypertension (Greenwich, Conn.) 20110901
Title: Direct renin inhibition: from pharmacological innovation to novel therapeutic opportunities.
Journal: High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension 20110901
Title: Cardiovascular MRI in clinical trials: expanded applications through novel surrogate endpoints.
Journal: Heart (British Cardiac Society) 20110815
Title: p90 ribosomal S6 kinase regulates activity of the renin-angiotensin system: a pathogenic mechanism for ischemia-reperfusion injury.
Journal: Journal of molecular and cellular cardiology 20110801
Title: Aliskiren ameliorates renal inflammation and fibrosis induced by unilateral ureteral obstruction in mice.
Journal: The Journal of urology 20110801
Title: Effect of aliskiren in patients with heart failure according to background dose of ACE inhibitor: a retrospective analysis of the Aliskiren Observation of Heart Failure Treatment (ALOFT) trial.
Journal: Cardiovascular drugs and therapy 20110801
Title: Comparative efficacy and safety of combination aliskiren/amlodipine and amlodipine monotherapy in African Americans with stage 2 hypertension.
Journal: Journal of clinical hypertension (Greenwich, Conn.) 20110801
Title: Prevalence, Awareness, and Control of Hypertension among Diabetic Koreans.
Journal: Diabetes & metabolism journal 20110801
Title: Synthesis, biological evaluation and docking studies of octane-carboxamide based renin inhibitors with extended segments toward S3' site of renin.
Journal: Bioorganic & medicinal chemistry 20110715
Title: Renin-angiotensin system antagonists in the perioperative setting: clinical consequences and recommendations for practice.
Journal: Postgraduate medical journal 20110701
Title: Associations of albuminuria in patients with chronic heart failure: findings in the ALiskiren Observation of heart Failure Treatment study.
Journal: European journal of heart failure 20110701
Title: Neurohumoral effects of aliskiren in patients with symptomatic heart failure receiving a mineralocorticoid receptor antagonist: the Aliskiren Observation of Heart Failure Treatment study.
Journal: European journal of heart failure 20110701
Title: The ACQUIRE trial.
Journal: Expert opinion on pharmacotherapy 20110701
Title: Safety and tolerability of the direct renin inhibitor aliskiren in combination with angiotensin receptor blockers and thiazide diuretics: a pooled analysis of clinical experience of 12,942 patients.
Journal: Journal of clinical hypertension (Greenwich, Conn.) 20110701
Title: A systematic review and meta-analysis of aliskiren and angiotension receptor blockers in the management of essential hypertension.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20110601
Title: Direct renin inhibition: update on clinical investigations with aliskiren.
Journal: European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology 20110601
Title: Antiproteinuric response to add-on aliskiren in proteinuric patients treated with dual blockade of the renin-angiotensin system: a 12-month prospective uncontrolled study.
Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20110601
Title: Effect of aliskiren addition to amlodipine on ankle edema in hypertensive patients: a three-way crossover study.
Journal: Expert opinion on pharmacotherapy 20110601
Title: Combined aliskiren-amlodipine treatment for hypertension in African Americans: clinical science and management issues.
Journal: Therapeutic advances in cardiovascular disease 20110601
Title: Possible involvement of the (pro)renin receptor-dependent system in the development of insulin resistance.
Journal: Frontiers in bioscience (Scholar edition) 20110601
Title: Managing erectile dysfunction in hypertensive patients.
Journal: Journal of clinical hypertension (Greenwich, Conn.) 20110601
Title: Aliskiren/amlodipine combination for the treatment of hypertension.
Journal: Drugs of today (Barcelona, Spain : 1998) 20110601
Title: [A powerful duo: antihypertensives aliskiren and amlodipine in one tablet. Combination tablet for hypertensive patients with diabetes and overweight].
Journal: MMW Fortschritte der Medizin 20110512
Title: Orange and apple juice greatly reduce the plasma concentrations of the OATP2B1 substrate aliskiren.
Journal: British journal of clinical pharmacology 20110501
Title: Current strategies to achieve further cardiac and renal protection through enhanced renin-angiotensin-aldosterone system inhibition.
Journal: Reviews on recent clinical trials 20110501
Title: Aliskiren vs. angiotensin receptor blockers in hypertension: meta-analysis of randomized controlled trials.
Journal: American journal of hypertension 20110501
Title: Effect of the direct renin inhibitor aliskiren on left ventricular remodelling following myocardial infarction with systolic dysfunction.
Journal: European heart journal 20110501
Title: Aliskiren in combination with losartan reduces albuminuria independent of baseline blood pressure in patients with type 2 diabetes and nephropathy.
Journal: Clinical journal of the American Society of Nephrology : CJASN 20110501
Title: Direct renin inhibition with aliskiren normalizes blood pressure in Cyp1a1-Ren2 transgenic rats with inducible angiotensin ii-dependent malignant hypertension.
Journal: The American journal of the medical sciences 20110501
Title: Pharmacotherapy: inhibiting LV remodeling—the need for a targeted approach.
Journal: Nature reviews. Cardiology 20110501
Title: Aliskiren-based stepped-care treatment algorithm provides effective blood pressure control.
Journal: International journal of clinical practice 20110501
Title: Hypertension treatment update: focus on direct renin inhibition.
Journal: Journal of the American Academy of Nurse Practitioners 20110501
Title: Peripheral and central blood pressure responses of combination aliskiren/hydrochlorothiazide and amlodipine monotherapy in African American patients with stage 2 hypertension: the ATLAAST trial.
Journal: Journal of clinical hypertension (Greenwich, Conn.) 20110501
Title: [Advantages and limitations of renin inhibition with aliskiren].
Journal: Annales pharmaceutiques francaises 20110501
Title: Initial combination therapy for treatment of hypertension.
Journal: Lancet (London, England) 20110430
Title: Initial combination therapy for treatment of hypertension.
Journal: Lancet (London, England) 20110430
Title: Initial combination therapy for treatment of hypertension.
Journal: Lancet (London, England) 20110430
Title: In brief: Another three-drug combination for hypertension.
Journal: The Medical letter on drugs and therapeutics 20110404
Title: Aliskiren improves insulin resistance and ameliorates diabetic vascular complications in db/db mice.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20110401
Title: Handle region peptide counteracts the beneficial effects of the Renin inhibitor aliskiren in spontaneously hypertensive rats.
Journal: Hypertension (Dallas, Tex. : 1979) 20110401
Title: Combination therapy with aliskiren and amlodipine in hypertension: treatment rationale and clinical results.
Journal: Expert review of cardiovascular therapy 20110401
Title: [Hypertension and hypokalemia - a reninoma as the cause of suspected liquorice-induced arterial hypertension].
Journal: Deutsche medizinische Wochenschrift (1946) 20110401
Title: Comparative efficacy and safety of aliskiren and irbesartan in patients with hypertension and metabolic syndrome.
Journal: Journal of human hypertension 20110301
Title: Itraconazole, a P-glycoprotein and CYP3A4 inhibitor, markedly raises the plasma concentrations and enhances the renin-inhibiting effect of aliskiren.
Journal: Journal of clinical pharmacology 20110301
Title: Effects of aliskiren on blood pressure and the predictive biomarkers for cardiovascular disease in hemodialysis-dependent chronic kidney disease patients with hypertension.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20110301
Title: Renal protective effects of aliskiren beyond its antihypertensive property in a mouse model of progressive fibrosis.
Journal: American journal of hypertension 20110301
Title: Are we ready to use aliskiren in children?
Journal: Pediatric nephrology (Berlin, Germany) 20110301
Title: Aliskiren reduces albuminuria and oxidative stress, and elevates glomerular filtration rates in Japanese patients with advanced diabetic nephropathy.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20110301
Title: Not ready for prime time: aliskiren for treatment of hypertension or proteinuria in children.
Journal: Pediatric nephrology (Berlin, Germany) 20110301
Title: Comparison of aliskiren/hydrochlorothiazide combination therapy with hydrochlorothiazide monotherapy in older patients with stage 2 systolic hypertension: results of the ACTION study.
Journal: Journal of clinical hypertension (Greenwich, Conn.) 20110301
Title: Effect of verapamil on the pharmacokinetics of aliskiren in healthy participants.
Journal: Journal of clinical pharmacology 20110201
Title: Protective effects of aliskiren in doxorubicin-induced acute cardiomyopathy in rats.
Journal: Human & experimental toxicology 20110201
Title: Renin inhibition mitigates anti-angiogenesis in spontaneously hypertensive rats.
Journal: Journal of hypertension 20110201
Title: Aliskiren in the treatment of hypertension and organ damage.
Journal: Cardiovascular therapeutics 20110201
Title: Recent insights into diabetic renal injury from the db/db mouse model of type 2 diabetic nephropathy.
Journal: American journal of physiology. Renal physiology 20110201
Title: Impact of prolonged antihypertensive duration of action on predicted clinical outcomes in imperfectly adherent patients: comparison of aliskiren, irbesartan and ramipril.
Journal: International journal of clinical practice 20110201
Title: Rationale for combining a direct renin inhibitor with other renin- angiotensin system blockers. Focus on aliskiren and combinations.
Journal: Cardiovascular drugs and therapy 20110201
Title: Determination of aliskiren in tablet dosage forms by a validated stability-indicating RP-LC method.
Journal: Journal of chromatographic science 20110201
Title: Effect of renin-angiotensin system blockade on calcium channel blocker-associated peripheral edema.
Journal: The American journal of medicine 20110201
Title: Management of uncomplicated hypertension during pregnancy.
Journal: Prescrire international 20110201
Title: Initial combination antihypertensives: let's ACCELERATE.
Journal: Lancet (London, England) 20110122
Title: Aliskiren and the calcium channel blocker amlodipine combination as an initial treatment strategy for hypertension control (ACCELERATE): a randomised, parallel-group trial.
Journal: Lancet (London, England) 20110122
Title: Pharmacokinetic, pharmacodynamic and clinical evaluation of aliskiren for hypertension treatment.
Journal: Expert opinion on drug metabolism & toxicology 20110101
Title: Design and synthesis of potent macrocyclic renin inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20110101
Title: Efficacy and tolerability of aliskiren 300 mg/hydrochlorothiazide 25 mg (± amlodipine 5 mg) in hypertensive patients not controlled by candesartan 32 mg plus HCT 25 mg.
Journal: Current medical research and opinion 20110101
Title: Rationale and design of the multicentre, randomized, double-blind, placebo-controlled Aliskiren Trial on Acute Heart Failure Outcomes (ASTRONAUT).
Journal: European journal of heart failure 20110101
Title: Compliance, persistence, healthcare resource use, and treatment costs associated with aliskiren plus ARB versus ACE inhibitor plus ARB combination therapy: in US patients with hypertension.
Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20110101
Title: Antihypertensive effectiveness of aliskiren for the 'real-world' management of hypertension: multilevel modelling of 180-day blood pressure outcomes (the Belgian DRIVER Study).
Journal: International journal of clinical practice 20110101
Title: Direct renin inhibition in addition to or as an alternative to angiotensin converting enzyme inhibition in patients with chronic systolic heart failure: rationale and design of the Aliskiren Trial to Minimize OutcomeS in Patients with HEart failuRE (ATMOSPHERE) study.
Journal: European journal of heart failure 20110101
Title: Integrative bioinformatics analysis of proteins associated with the cardiorenal syndrome.
Journal: International journal of nephrology 20110101
Title: Aliskiren as an add-on treatment reduces albuminuria in patients with diabetes.
Journal: Nature reviews. Nephrology 20110101
Title: The renin inhibitor aliskiren attenuates high-glucose induced extracellular matrix synthesis and prevents apoptosis in cultured podocytes.
Journal: Nephron. Experimental nephrology 20110101
Title: Resistant hypertension workup and approach to treatment.
Journal: International journal of hypertension 20110101
Title: Potential benefits of aliskiren beyond blood pressure reduction.
Journal: Cardiology in review 20110101
Title: Regulation of vascular tone by adipocytes.
Journal: BMC medicine 20110101
Title: Efficacy and safety of aliskiren-based dual and triple combination therapies in US minority patients with stage 2 hypertension.
Journal: Journal of the American Society of Hypertension : JASH 20110101
Title: Treatment options for hypertension in high-risk patients.
Journal: Vascular health and risk management 20110101
Title: Real-world effectiveness of valsartan on hypertension and total cardiovascular risk: review and implications of a translational research program.
Journal: Vascular health and risk management 20110101
Title: Angiotensin receptor blockers and risk of myocardial infarction: meta-analyses and trial sequential analyses of 147 020 patients from randomised trials.
Journal: BMJ (Clinical research ed.) 20110101
Title: Roles of the WHHL rabbit in translational research on hypercholesterolemia and cardiovascular diseases.
Journal: Journal of biomedicine & biotechnology 20110101
Title: [Salvage therapy with aliskiren in malignant familial hypertension in a breast-fed baby].
Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20110101
Title: Clinical utility of valsartan in the treatment of hypertension in children and adolescents.
Journal: Patient preference and adherence 20110101
Title: A current evaluation of the safety of angiotensin receptor blockers and direct renin inhibitors.
Journal: Vascular health and risk management 20110101
Title: Treatment and landmark clinical trials for renoprotection.
Journal: Contributions to nephrology 20110101
Title: Efficacy of aliskiren/hydrochlorothiazide combination for the treatment of hypertension: a meta-analytical approach.
Journal: The open cardiovascular medicine journal 20110101
Title: [Correction of aldosterone level as marker of RAAS dysfunction in patients with arterial hypertension degree II-III and chronic kidney diseases].
Journal: Eksperimental'naia i klinicheskaia farmakologiia 20110101
Title: Aliskiren: An orally active renin inhibitor.
Journal: Journal of pharmacy & bioallied sciences 20110101
Title: Stroke, high blood pressure and the Renin-Angiotensin-aldosterone system - new developments.
Journal: Frontiers in pharmacology 20110101
Title: Role of aliskiren in blood pressure control and renoprotection.
Journal: International journal of nephrology and renovascular disease 20110101
Title: Multi-step usage of in vivo models during rational drug design and discovery.
Journal: International journal of molecular sciences 20110101
Title: Assessment of glucagon-like peptide-1 analogue and renin inhibitor on the binding and regulation of GLP-1 receptor in type 1 diabetic rat hearts.
Journal: Experimental diabetes research 20110101
Title: Hypertension in chronic kidney disease: navigating the evidence.
Journal: International journal of hypertension 20110101
Title: Left ventricular hypertrophy: major risk factor in patients with hypertension: update and practical clinical applications.
Journal: International journal of hypertension 20110101
Title: (Pro)renin Receptor in Kidney Development and Disease.
Journal: International journal of nephrology 20110101
Title: Diabetic nephropathy - Epidemiology in Asia and the current state of treatment.
Journal: Indian journal of nephrology 20110101
Title: Aliskiren: the first direct renin inhibitor available for clinical use.
Journal: Journal of nephrology 20110101
Title: Comparative efficacy and safety of combination aliskiren/amlodipine and amlodipine monotherapy in African Americans with stage 2 hypertension and obesity or metabolic syndrome.
Journal: Journal of the American Society of Hypertension : JASH 20110101
Title: Pharmacovigilance analysis of adverse event reports for aliskiren hemifumarate, a first-in-class direct renin inhibitor.
Journal: Therapeutics and clinical risk management 20110101
Title: Long-term use and tolerability of irbesartan for control of hypertension.
Journal: Integrated blood pressure control 20110101
Title: Short- and long-term physiologic and pharmacologic control of blood pressure in pediatric patients.
Journal: Integrated blood pressure control 20110101
Title: Validation of a therapeutic scheme for the treatment of resistant hypertension.
Journal: Journal of the American Society of Hypertension : JASH 20110101
Title: Targeted therapies in diabetic nephropathy: an update.
Journal: Journal of nephrology 20110101
Title: Role of natural herbs in the treatment of hypertension.
Journal: Pharmacognosy reviews 20110101
Title: Indications for and utilization of angiotensin receptor II blockers in patients at high cardiovascular risk.
Journal: Vascular health and risk management 20110101
Title: Elevation of the antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline: a blood pressure-independent beneficial effect of angiotensin I-converting enzyme inhibitors.
Journal: Fibrogenesis & tissue repair 20110101
Title: Benefits of once-daily therapies in the treatment of hypertension.
Journal: Vascular health and risk management 20110101
Title: Development, evaluation and application of 3D QSAR Pharmacophore model in the discovery of potential human renin inhibitors.
Journal: BMC bioinformatics 20110101
Title: Influence of body weight and gender on the pharmacokinetics, pharmacodynamics, and antihypertensive efficacy of aliskiren.
Journal: Journal of clinical pharmacology 20101201
Title: Comparative efficacy of aliskiren monotherapy and ramipril monotherapy in patients with stage 2 systolic hypertension: subgroup analysis of a double-blind, active comparator trial.
Journal: Cardiovascular therapeutics 20101201
Title: Genetically determined angiotensin converting enzyme level and myocardial tolerance to ischemia.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20101201
Title: Aliskiren, a renin inhibitor, downregulates TNF-α-induced tissue factor expression in HUVECS.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20101201
Title: Effects of high- and low-sodium diets on ambulatory blood pressure in patients with hypertension receiving aliskiren.
Journal: Journal of cardiovascular pharmacology and therapeutics 20101201
Title: Renin-angiotensin-aldosterone system blockade in high-risk hypertensive patients: current approaches and future trends.
Journal: Therapeutic advances in cardiovascular disease 20101201
Title: Long-term safety and efficacy of aliskiren and valsartan combination with or without the addition of HCT in patients with hypertension.
Journal: Current medical research and opinion 20101201
Title: Angiotensin II, tissue factor and the thrombotic paradox of hypertension.
Journal: Expert review of cardiovascular therapy 20101201
Title: Aliskiren alone or in combination with hydrochlorothiazide in patients with the lower ranges of stage 2 hypertension: The ACQUIRE randomized double-blind study.
Journal: Journal of clinical hypertension (Greenwich, Conn.) 20101201
Title: Aliskiren/amlodipine (Tekamlo): another combination tablet for hypertension.
Journal: The Medical letter on drugs and therapeutics 20101129
Title: Efficacy, safety and tolerability of aliskiren, a direct renin inhibitor, in women with hypertension: a pooled analysis of eight studies.
Journal: Journal of human hypertension 20101101
Title: A reduction of unilateral ureteral obstruction-induced renal fibrosis by a therapy combining valsartan with aliskiren.
Journal: American journal of physiology. Renal physiology 20101101
Title: Impact of baseline renal function on the efficacy and safety of aliskiren added to losartan in patients with type 2 diabetes and nephropathy.
Journal: Diabetes care 20101101
Title: Different effects of aliskiren and losartan on fibrinolysis and insulin sensitivity in hypertensive patients with metabolic syndrome.
Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20101101
Title: The renin inhibitor aliskiren upregulates pro-angiogenic cells and reduces atherogenesis in mice.
Journal: Basic research in cardiology 20101101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20101101
Title: Aliskiren: a review of its use as monotherapy and as combination therapy in the management of hypertension.
Journal: Drugs 20101022
Title: [The role of direct inhibitors of renin].
Journal: Revue medicale suisse 20101020
Title: Beneficial cardiac effects of the renin inhibitor aliskiren in spontaneously hypertensive rats.
Journal: Journal of hypertension 20101001
Title: Aliskiren binds to renin and prorenin bound to (pro)renin receptor in vitro.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20101001
Title: Persistent antihypertensive effect of aliskiren is accompanied by reduced proteinuria and normalization of glomerular area in Ren-2 transgenic rats.
Journal: American journal of physiology. Renal physiology 20101001
Title: Aliskiren: beyond blood pressure reduction.
Journal: Expert opinion on investigational drugs 20101001
Title: [New modalities of renin-angiotensin system inhibition: Renin inhibitors and active immunization against angiotensin II].
Journal: La Revue de medecine interne 20101001
Title: Renin-angiotensin system dual blockade using angiotensin receptor plus aliskiren decreases severe proteinuria in kidney transplant recipients.
Journal: Transplantation proceedings 20101001
Title: Safety and tolerability of the direct renin inhibitor aliskiren: a pooled analysis of clinical experience in more than 12,000 patients with hypertension.
Journal: Journal of clinical hypertension (Greenwich, Conn.) 20101001
Title: Aliskiren for geriatric lowering of systolic hypertension: a randomized controlled trial.
Journal: Journal of human hypertension 20100901
Title: Effect of ABCB1 haplotypes on the pharmacokinetics and renin-inhibiting effect of aliskiren.
Journal: European journal of clinical pharmacology 20100901
Title: Renin inhibition and microalbuminuria development: meaningful predictor of kidney disease progression.
Journal: Current opinion in nephrology and hypertension 20100901
Title: Grapefruit juice greatly reduces the plasma concentrations of the OATP2B1 and CYP3A4 substrate aliskiren.
Journal: Clinical pharmacology and therapeutics 20100901
Title: Of fads, fashion, surrogate endpoints and dual RAS blockade.
Journal: European heart journal 20100901
Title: Progress toward novel treatments for chronic kidney disease.
Journal: Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 20100901
Title: Renin inhibitors in chronic heart failure: the Aliskiren Observation of Heart Failure Treatment study in context.
Journal: Clinical cardiology 20100901
Title: [Antihypertensive drugs in 2010: old and new agents].
Journal: Revue medicale de Bruxelles 20100901
Title: Mast cell degranulation mediates bronchoconstriction via serotonin and not via renin release.
Journal: European journal of pharmacology 20100825
Title: Optimal antiproteinuric dose of aliskiren in type 2 diabetes mellitus: a randomised crossover trial.
Journal: Diabetologia 20100801
Title: Drug mechanisms to help in managing resistant hypertension in obesity.
Journal: Current hypertension reports 20100801
Title: Patients with acute coronary syndromes and elevated levels of natriuretic peptides: the results of the AVANT GARDE-TIMI 43 Trial.
Journal: European heart journal 20100801
Title: Novel therapeutic targets for hypertension.
Journal: Nature reviews. Cardiology 20100801
Title: [Renal protection in the patients with idiopathic hypertensia: the possibilities of the combined blockade of the reninangiotensinaldosterone system].
Journal: Voenno-meditsinskii zhurnal 20100801
Title: Optimal antagonism of the Renin-Angiotensin-aldosterone system: do we need dual or triple therapy?
Journal: Drugs 20100709
Title: Aliskiren enhances protective effects of valsartan against type 2 diabetic nephropathy in mice.
Journal: Journal of hypertension 20100701
Title: Direct renin inhibition improved insulin resistance and adipose tissue dysfunction in type 2 diabetic KK-A(y) mice.
Journal: Journal of hypertension 20100701
Title: Hotline update of clinical trials and registries presented at the American College of Cardiology Congress 2010: ACCORD, INVEST, NAVIGATOR, RACE II, SORT OUT III, CSP-474, DOSE, ASPIRE and more.
Journal: Clinical research in cardiology : official journal of the German Cardiac Society 20100601
Title: Aliskiren versus ramipril in hypertension.
Journal: Therapeutic advances in cardiovascular disease 20100601
Title: Direct Renin inhibition: promising treatment in renoprotection?
Journal: Recent patents on cardiovascular drug discovery 20100601
Title: New pharmacological treatments for improving renal outcomes in diabetes.
Journal: Nature reviews. Nephrology 20100601
Title: Clinical trials update from the American College of Cardiology meeting 2010: DOSE, ASPIRE, CONNECT, STICH, STOP-AF, CABANA, RACE II, EVEREST II, ACCORD, and NAVIGATOR.
Journal: European journal of heart failure 20100601
Title: Recent advances in tissue (pro)renin imaging.
Journal: Frontiers in bioscience (Elite edition) 20100601
Title: The (pro)renin receptor and the mystic HRP--is there a role in cardiovascular disease?
Journal: Frontiers in bioscience (Elite edition) 20100601
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20100601
Title: Aliskiren inhibits intracellular angiotensin II levels without affecting (pro)renin receptor signals in human podocytes.
Journal: American journal of hypertension 20100501
Title: Rifampicin reduces the plasma concentrations and the renin-inhibiting effect of aliskiren.
Journal: European journal of clinical pharmacology 20100501
Title: Aliskiren, a direct renin inhibitor, in clinical practice: a new approach in the treatment of hypertension.
Journal: Current vascular pharmacology 20100501
Title: Is there a future for direct renin inhibitors?
Journal: Expert opinion on investigational drugs 20100501
Title: Unmet needs in managing hypertension: potential role of direct renin inhibition.
Journal: Postgraduate medicine 20100501
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20100501
Title: Physiologic tailoring of treatment in resistant hypertension.
Journal: Current cardiology reviews 20100501
Title: Total synthesis of 'aliskiren': the first Renin inhibitor in clinical practice for hypertension.
Journal: Organic letters 20100416
Title: New insights into the renoprotective actions of the renin inhibitor aliskiren in experimental renal disease.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20100401
Title: [The pharmacological profile and clinical findings on aliskiren (Rasilez tablet), direct renin inhibitor].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20100401
Title: Best strategies for hypertension management in type 2 diabetes and obesity.
Journal: Current diabetes reports 20100401
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20100401
Title: Aliskiren ameliorates chlorhexidine digluconate-induced peritoneal fibrosis in rats.
Journal: European journal of clinical investigation 20100401
Title: Application of direct renin inhibition to chronic kidney disease.
Journal: Cardiovascular drugs and therapy 20100401
Title: Aliskiren + hydrochlorothiazide.
Journal: Prescrire international 20100401
Title: Current status of dual Renin Angiotensin aldosterone system blockade for the treatment of cardiovascular diseases.
Journal: The American journal of cardiology 20100315
Title: Comparative effect of direct renin inhibition and AT1R blockade on glomerular filtration barrier injury in the transgenic Ren2 rat.
Journal: American journal of physiology. Renal physiology 20100301
Title: Blood pressure and diabetic nephropathy.
Journal: Diabetes care 20100301
Title: [Current status of antihypertensive drug treatment in primary care practice at launch of the new renin inhibitor aliskiren (RASANT)].
Journal: Medizinische Klinik (Munich, Germany : 1983) 20100301
Title: The antihypertensive effectiveness and safety of dual RAAS blockade with aliskiren and valsartan.
Journal: Drugs of today (Barcelona, Spain : 1998) 20100301
Title: Addressing the theoretical and clinical advantages of combination therapy with inhibitors of the renin-angiotensin-aldosterone system: antihypertensive effects and benefits beyond BP control.
Journal: Life sciences 20100227
Title: Maintenance of blood-pressure-lowering effect following a missed dose of aliskiren, irbesartan or ramipril: results of a randomized, double-blind study.
Journal: Journal of human hypertension 20100201
Title: Effect of direct renin inhibition on renal hemodynamic function, arterial stiffness, and endothelial function in humans with uncomplicated type 1 diabetes: a pilot study.
Journal: Diabetes care 20100201
Title: Signal transduction of the (pro)renin receptor as a novel therapeutic target for preventing end-organ damage.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20100201
Title: [Direct renin inhibitor aliskiren in the treatment of cardiovascular and renal diseases].
Journal: Vnitrni lekarstvi 20100201
Title: Pleiotropic effects of inhibitors of the RAAS in the diabetic population: above and beyond blood pressure lowering.
Journal: Current diabetes reports 20100201
Title: [Renal effects of combined anti-hypertensive treatments].
Journal: Recenti progressi in medicina 20100201
Title: Inhibition of the renin angiotensin aldosterone system: focus on aliskiren.
Journal: The Journal of the Association of Physicians of India 20100201
Title: [Pharmacovigilance update].
Journal: Revue medicale suisse 20100120
Title: Renin inhibition for hypertension: selecting the right role for a new class of drug.
Journal: American journal of therapeutics 20100101
Title: The increase in renin during renin inhibition: does it result in harmful effects by the (pro)renin receptor?
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20100101
Title: Aliskiren prevents cardiovascular complications and pancreatic injury in a mouse model of obesity and type 2 diabetes.
Journal: Diabetologia 20100101
Title: Aliskiren monotherapy does not cause paradoxical blood pressure rises: meta-analysis of data from 8 clinical trials.
Journal: Hypertension (Dallas, Tex. : 1979) 20100101
Title: Efficacy and safety of aliskiren in Japanese hypertensive patients with renal dysfunction.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20100101
Title: Successful applications of computer aided drug discovery: moving drugs from concept to the clinic.
Journal: Current topics in medicinal chemistry 20100101
Title: Direct renin inhibition and the kidney.
Journal: Nature reviews. Nephrology 20100101
Title: Aliskiren/valsartan combination for the treatment of cardiovascular and renal diseases.
Journal: Expert review of cardiovascular therapy 20100101
Title: [An experience with the use of direct renin inhibitor aliskiren in a patient with obesity and arterial hypertension].
Journal: Kardiologiia 20100101
Title: Pharmacokinetics, safety and tolerability of single and multiple oral doses of aliskiren in healthy Chinese subjects: a randomized, single-blind, parallel-group, placebo-controlled study.
Journal: Clinical drug investigation 20100101
Title: Aliskiren: a new drug for an old problem.
Journal: Cardiovascular & hematological agents in medicinal chemistry 20100101
Title: [Progress in hypertension and diabetes mellitus].
Journal: Revista espanola de cardiologia 20100101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20100101
Title: [Overview of the RAAS in renal damage and hypertension].
Journal: Nihon Jinzo Gakkai shi 20100101
Title: [Recent clinical evidences of RAS inhibitors on chronic kidney diseases].
Journal: Nihon Jinzo Gakkai shi 20100101
Title: The role of renin angiotensin system inhibition in kidney repair.
Journal: Fibrogenesis & tissue repair 20100101
Title: Direct renin inhibitors as antihypertensive agents.
Journal: American journal of therapeutics 20100101
Title: Aldosterone-producing adenoma and other surgically correctable forms of primary aldosteronism.
Journal: Orphanet journal of rare diseases 20100101
Title: [Renin, prorenin, and the direct renin inhibitor aliskiren].
Journal: Casopis lekaru ceskych 20100101
Title: Despite similar reduction of blood pressure and renal ANG II and ET-1 levels aliskiren but not losartan normalizes albuminuria in hypertensive Ren-2 rats.
Journal: Physiological research 20100101
Title: New approaches to blockade of the renin-angiotensin-aldosterone system: characteristics and usefulness of the direct renin inhibitor aliskiren.
Journal: Journal of pharmacological sciences 20100101
Title: Blocking the RAAS at different levels: an update on the use of the direct renin inhibitors alone and in combination.
Journal: Vascular health and risk management 20100101
Title: Aliskiren and valsartan combination therapy for the management of hypertension.
Journal: Vascular health and risk management 20100101
Title: New class of agents for treatment of hypertension: focus on direct renin inhibition.
Journal: Vascular health and risk management 20100101
Title: [Renin inhibitors--new direction in the treatment of arterial hypertension].
Journal: Terapevticheskii arkhiv 20100101
Title: Aliskiren in the management of hypertension.
Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20100101
Title: Effects of aliskiren on stroke in rats expressing human renin and angiotensinogen genes.
Journal: PloS one 20100101
Title: First orally active DRI Aliskiren--a new prospect in management of hypertension and beyond.
Journal: Indian heart journal 20100101
Title: Cardio classics revisited--focus on the role of candesartan.
Journal: Vascular health and risk management 20100101
Title: Renovascular and renoprotective properties of telmisartan: clinical utility.
Journal: International journal of nephrology and renovascular disease 20100101
Title: Polycystic kidney disease: inheritance, pathophysiology, prognosis, and treatment.
Journal: International journal of nephrology and renovascular disease 20100101
Title: Fifteen years of losartan: what have we learned about losartan that can benefit chronic kidney disease patients?
Journal: International journal of nephrology and renovascular disease 20100101
Title: Evidence-based approach for managing hypertension in type 2 diabetes.
Journal: Integrated blood pressure control 20100101
Title: Fixed combinations in the pragmatic management of hypertension: focus on aliskiren and hydrochlorothiazide as a single pill.
Journal: Integrated blood pressure control 20100101
Title: Critical appraisal of amlodipine and olmesartan medoxomil fixed-dose combination in achieving blood pressure goals.
Journal: Integrated blood pressure control 20100101
Title: Is tetrahydrobiopterin a therapeutic option in diabetic hypertensive patients?
Journal: Integrated blood pressure control 20100101
Title: Renoprotection, renin inhibition, and blood pressure control: the impact of aliskiren on integrated blood pressure control.
Journal: Integrated blood pressure control 20100101
Title: First-line treatment of hypertension: critical appraisal of potential role of aliskiren and hydrochlorothiazide in a fixed combination.
Journal: Integrated blood pressure control 20100101
Title: Combination renin-angiotensin system blockade with the renin inhibitor aliskiren in hypertension.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20091201
Title: Aldosterone status associated with insulin resistance in patients with heart failure--data from the ALOFT study.
Journal: Heart (British Cardiac Society) 20091201
Title: Optimal nephroprotection: use, misuse and misconceptions about blockade of the renin-angiotensin system. Lessons from the ONTARGET and other recent trials.
Journal: Diabetes & metabolism 20091201
Title: Direct renin inhibition: an update.
Journal: Current hypertension reports 20091201
Title: What is the role of renin inhibition in the treatment of diabetic kidney disease?
Journal: Current diabetes reports 20091201
Title: Comparative role of angiotensin receptor blockers versus other agents in the management of hypertension, cardiovascular disease and nephropathy.
Journal: Southern medical journal 20091201
Title: Rational of the use of aliskiren in hypertension and beyond.
Journal: Minerva cardioangiologica 20091201
Title: Aliskiren: a new inhibitor of renin-angiotensin aldosterone system activity.
Journal: Minerva endocrinologica 20091201
Title: Evaluation of the dose--response relationship of aliskiren, a direct renin inhibitor, in an 8-week, multicenter, randomized, double-blind, parallel-group, placebo-controlled study in adult patients with stage 1 or 2 essential hypertension.
Journal: Clinical therapeutics 20091201
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20091201
Title: Aliskiren/valsartan (Valturna) for hypertension.
Journal: The Medical letter on drugs and therapeutics 20091130
Title: Effect of a triple blockade of the renin-angiotensin-system in recurrent focal segmental glomerulosclerosis after kidney transplantation.
Journal: Transplant international : official journal of the European Society for Organ Transplantation 20091101
Title: Dynamic observation of mechanically-injured mouse femoral artery reveals an antiinflammatory effect of renin inhibitor.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20091101
Title: Dual blockade of the renin-angiotensin system in diabetic nephropathy.
Journal: Diabetes care 20091101
Title: Recent changes in the landscape of combination RAS blockade.
Journal: Expert review of cardiovascular therapy 20091101
Title: Aliskiren.
Journal: British journal of clinical pharmacology 20091101
Title: [Advances concerning aliskiren, direct renin inhibitor and aliskiren-hydrochlorothiazide].
Journal: Revue medicale de Liege 20091101
Title: The biochemical pharmacology of renin inhibitors: implications for translational medicine in hypertension, diabetic nephropathy and heart failure: expectations and reality.
Journal: Biochemical pharmacology 20091015
Title: Aliskiren and its rapidly, evolving role in the management of cardio-thoracic diseases.
Journal: Heart, lung & circulation 20091001
Title: Endothelin receptor antagonism and renin inhibition as treatment options for scleroderma kidney.
Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20091001
Title: Renal effects of aliskiren compared with and in combination with irbesartan in patients with type 2 diabetes, hypertension, and albuminuria.
Journal: Diabetes care 20091001
Title: Long-term effect of modification of dietary protein intake on the progression of diabetic nephropathy: a randomised controlled trial.
Journal: Diabetologia 20091001
Title: Dual blockade of the renin-angiotensin-aldosterone system: beyond the ACE inhibitor and angiotensin-II receptor blocker combination.
Journal: American journal of hypertension 20091001
Title: Aliskiren reduces body-weight gain, adiposity and plasma leptin during diet-induced obesity.
Journal: British journal of pharmacology 20091001
Title: Cost-effectiveness of aliskiren in type 2 diabetes, hypertension, and albuminuria.
Journal: Journal of the American Society of Nephrology : JASN 20091001
Title: Cost-effectiveness of treating resistant hypertension with an implantable carotid body stimulator.
Journal: Journal of clinical hypertension (Greenwich, Conn.) 20091001
Title: [What is renin inhibition? Mechanism of action].
Journal: Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 20091001
Title: [Renin inhibition in hypertension].
Journal: Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 20091001
Title: [Renin and the heart].
Journal: Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 20091001
Title: [Renin inhibition and the kidney].
Journal: Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 20091001
Title: [The future of renin inhibition].
Journal: Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 20091001
Title: (R)-(-)-N-isovalerylcamphorsultam.
Journal: Acta crystallographica. Section E, Structure reports online 20091001
Title: Application of 3D QSAR CoMFA/CoMSIA and in silico docking studies on novel renin inhibitors against cardiovascular diseases.
Journal: European journal of medicinal chemistry 20090901
Title: Aliskiren monotherapy results in the greatest and the least blood pressure lowering in patients with high- and low-baseline PRA levels, respectively.
Journal: American journal of hypertension 20090901
Title: Potential roles of melatonin and chronotherapy among the new trends in hypertension treatment.
Journal: Journal of pineal research 20090901
Title: Is there a role for direct renin inhibitors in chronic kidney disease?
Journal: Current opinion in nephrology and hypertension 20090901
Title: Aliskiren enhances the protective effects of valsartan against cardiovascular and renal injury in endothelial nitric oxide synthase-deficient mice.
Journal: Hypertension (Dallas, Tex. : 1979) 20090901
Title: Comparative effects of aliskiren-based and ramipril-based therapy on the renin system during long-term (6 months) treatment and withdrawal in patients with hypertension.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20090901
Title: ACE inhibitors, angiotensin receptor blockers and direct renin inhibitors in combination: a review of their role after the ONTARGET trial.
Journal: Current medical research and opinion 20090901
Title: Using plasma renin (PRA) testing to design follow-up drug treatment strategies in hypertensive patients already taking antirenin system drugs.
Journal: American journal of hypertension 20090901
Title: Direct inhibition of renin: a physiological approach to treat hypertension and cardiovascular disease.
Journal: Future cardiology 20090901
Title: Aliskiren corrects recurrent hyperreninemia and hyperaldosteronism in autosomal dominant polycystic kidney disease.
Journal: Clinical nephrology 20090901
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20090901
Title: Clinical trials of the past decade in the management of chronic kidney disease.
Journal: Reviews on recent clinical trials 20090901
Title: The P1N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues of aliskiren are in vitro potent inhibitors of the human aspartyl protease renin.
Journal: Bioorganic & medicinal chemistry letters 20090815
Title: Blood pressure lowering efficacy of renin inhibitors for primary hypertension: a Cochrane systematic review.
Journal: Journal of human hypertension 20090801
Title: Aliskiren as an antiproteinuric add-on therapy in primary membranous nephropathy.
Journal: Clinical and experimental nephrology 20090801
Title: The renin-angiotensin system, adrenomedullins and urotensin II in the kidney: possible renoprotection via the kidney peptide systems.
Journal: Peptides 20090801
Title: Cardiac Renin levels are not influenced by the amount of resident mast cells.
Journal: Hypertension (Dallas, Tex. : 1979) 20090801
Title: Aliskiren: a novel renoprotective agent or simply an alternative to ACE inhibitors?
Journal: Kidney international 20090701
Title: (Pro)renin receptor-mediated signal transduction and tissue renin-angiotensin system contribute to diabetes-induced retinal inflammation.
Journal: Diabetes 20090701
Title: [Optimal therapy of diabetic nephropathy: AVOID Study (Aliskiren in the evaluation of proteinuria in diabetes)].
Journal: Der Internist 20090701
Title: Aliskiren-based therapy lowers blood pressure more effectively than hydrochlorothiazide-based therapy in obese patients with hypertension: sub-analysis of a 52-week, randomized, double-blind trial.
Journal: Journal of hypertension 20090701
Title: Aliskiren, the first approved renin inhibitor: Clinical application and safety in the treatment of hypertension.
Journal: Advances in therapy 20090701
Title: Renin inhibition--benefit beyond hypertension control.
Journal: The Journal of the Association of Physicians of India 20090701
Title: Design and preparation of potent, nonpeptidic, bioavailable renin inhibitors.
Journal: Journal of medicinal chemistry 20090625
Title: Direct renin inhibition improves systemic insulin resistance and skeletal muscle glucose transport in a transgenic rodent model of tissue renin overexpression.
Journal: Endocrinology 20090601
Title: New therapeutic options in patients prone to hypertension: a focus on direct Renin inhibition and aldosterone blockade.
Journal: The American journal of the medical sciences 20090601
Title: Managing cardiovascular and renal risk: the potential of direct renin inhibition.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20090601
Title: Combination therapy with various combinations of aliskiren, valsartan, and hydrochlorothiazide in hypertensive patients not adequately responsive to hydrochlorothiazide alone.
Journal: Journal of clinical hypertension (Greenwich, Conn.) 20090601
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20090601
Title: [New therapeutic strategies against resistant hypertension].
Journal: MMW Fortschritte der Medizin 20090507
Title: Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE): rationale and study design.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20090501
Title: Valsartan vs. other angiotensin II receptor blockers in the treatment of hypertension: a meta-analytical approach.
Journal: International journal of clinical practice 20090501
Title: Renin-angiotensin-aldosterone system blockade in diabetes: role of direct renin inhibitors.
Journal: Postgraduate medicine 20090501
Title: Antihypertensive efficacy and tolerability of aliskiren/hydrochlorothiazide (HCT) single-pill combinations in patients who are non-responsive to HCT 25 mg alone.
Journal: Current medical research and opinion 20090401
Title: Long-term safety, tolerability and efficacy of combination therapy with aliskiren and amlodipine in patients with hypertension.
Journal: Current medical research and opinion 20090401
Title: Successful utilization of aliskiren, a direct renin inhibitor in Bartter syndrome.
Journal: Southern medical journal 20090401
Title: Adverse event in response to aliskiren.
Journal: Southern medical journal 20090401
Title: Aliskiren-induced QT interval prolongation.
Journal: Southern medical journal 20090401
Title: [Direct renin inhibition: a new and promising treatment principle in heart failure?].
Journal: Deutsche medizinische Wochenschrift (1946) 20090401
Title: [Aliskiren combined with losartan in type 2-diabetes and nephropathy - secondary publication].
Journal: Ugeskrift for laeger 20090309
Title: Energy metabolism in human renin-gene transgenic rats: does renin contribute to obesity?
Journal: Hypertension (Dallas, Tex. : 1979) 20090301
Title: Long-term safety, tolerability, and antihypertensive efficacy of aliskiren, an oral direct renin inhibitor, in Japanese patients with hypertension.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20090301
Title: Aliskiren-associated acute renal failure with hyperkalemia.
Journal: Clinical nephrology 20090301
Title: Review: renal protection by inhibition of the renin-angiotensin-aldosterone system.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20090301
Title: Cardio-renal protection with aliskiren, a direct renin inhibitor, in the ASPIRE HIGHER program.
Journal: Expert review of cardiovascular therapy 20090301
Title: Improving microvascular outcomes in patients with diabetes through management of hypertension.
Journal: Postgraduate medicine 20090301
Title: Novel therapies of diabetic nephropathy.
Journal: Current opinion in nephrology and hypertension 20090301
Title: Effect of the direct Renin inhibitor aliskiren, the Angiotensin receptor blocker losartan, or both on left ventricular mass in patients with hypertension and left ventricular hypertrophy.
Journal: Circulation 20090203
Title: Aliskiren therapy will have minimal effect on intracellular renin of renin-producing cells.
Journal: Hypertension (Dallas, Tex. : 1979) 20090201
Title: Aliskiren: an oral direct renin inhibitor for the treatment of hypertension.
Journal: Pharmacotherapy 20090201
Title: An issue of dependence: implications from the Aliskiren in the Evaluation of Proteinuria in Diabetes (AVOID) trial.
Journal: Journal of clinical hypertension (Greenwich, Conn.) 20090201
Title: Long-term antihypertensive efficacy and safety of the oral direct renin inhibitor aliskiren: a 12-month randomized, double-blind comparator trial with hydrochlorothiazide.
Journal: Circulation 20090127
Title: Antihypertensive efficacy of aliskiren: is hydrochlorothiazide an appropriate benchmark?
Journal: Circulation 20090127
Title: Aliskiren fails to lower blood pressure in patients who have either low PRA levels or whose PRA falls insufficiently or reactively rises.
Journal: American journal of hypertension 20090101
Title: (Pro)renin receptors: are they biologically relevant?
Journal: Current opinion in nephrology and hypertension 20090101
Title: Standards of medical care in diabetes--2009.
Journal: Diabetes care 20090101
Title: Inhibiting the renin-angiotensin system: why and in which patients.
Journal: Journal of the American Academy of Nurse Practitioners 20090101
Title: The renin-angiotensin system modulates inflammatory processes in atherosclerosis: evidence from basic research and clinical studies.
Journal: Mediators of inflammation 20090101
Title: The effect of angiotensin receptor blockers on C-reactive protein and other circulating inflammatory indices in man.
Journal: Vascular health and risk management 20090101
Title: Angiotensin receptor blockers for the reduction of proteinuria in diabetic patients with overt nephropathy: results from the AMADEO study.
Journal: Vascular health and risk management 20090101
Title: Aliskiren/hydrochlorothiazide combination: in mild to moderate hypertension.
Journal: Drugs 20090101
Title: Choice of ACE inhibitor combinations in hypertensive patients with type 2 diabetes: update after recent clinical trials.
Journal: Vascular health and risk management 20090101
Title: Role of aliskiren in cardio-renal protection and use in hypertensives with multiple risk factors.
Journal: Vascular health and risk management 20090101
Title: Renin-angiotensin-aldosterone system in the elderly: rational use of aliskiren in managing hypertension.
Journal: Clinical interventions in aging 20090101
Title: Role of aliskiren in cardio-renal protection and use in hypertensives with multiple risk factors.
Journal: Therapeutics and clinical risk management 20090101
Title: Prevention of atherosclerosis by interference with the vascular nitric oxide system.
Journal: Current pharmaceutical design 20090101
Title: Drugs associated with more suicidal ideations are also associated with more suicide attempts.
Journal: PloS one 20090101
Title: [Renin as a target of direct pharmacological block in arterial hypertension].
Journal: Terapevticheskii arkhiv 20090101
Title: Diabetic nephropathy.
Journal: Diabetology & metabolic syndrome 20090101
Title: Randomized study to compare valsartan +/- HCTZ versus amlodipine +/- HCTZ strategies to maximize blood pressure control.
Journal: Vascular health and risk management 20090101
Title: Quantitative assessment of the expanding complementarity between public and commercial databases of bioactive compounds.
Journal: Journal of cheminformatics 20090101
Title: Is aliskiren superior to inhibitors of angiotensin-converting enzyme and angiotensin receptor blockers in renin-angiotensin system blockade?
Journal: Medicinski arhiv 20090101
Title: Renal plasma flow: glomerular filtration rate relationships in man during direct renin inhibition with aliskiren.
Journal: Journal of the American Society of Hypertension : JASH 20090101
Title: Current concepts in combination therapy for the treatment of hypertension: combined calcium channel blockers and RAAS inhibitors.
Journal: Integrated blood pressure control 20090101
Title: First renin inhibitor, aliskiren, for the treatment of hypertension.
Journal: Pharmacy world & science : PWS 20081201
Title: Intracellular angiotensin II production in diabetic rats is correlated with cardiomyocyte apoptosis, oxidative stress, and cardiac fibrosis.
Journal: Diabetes 20081201
Title: Dual inhibition with losartan and aliskiren: a promising therapeutic option for type 2 diabetic nephropathy?
Journal: Nature clinical practice. Nephrology 20081201
Title: Renin inhibition improves cardiac function and remodeling after myocardial infarction independent of blood pressure.
Journal: Hypertension (Dallas, Tex. : 1979) 20081201
Title: Aliskiren combined with losartan: Thor's hammer or Sigurd's sword?
Journal: Current hypertension reports 20081201
Title: Aliskiren accumulates in Renin secretory granules and binds plasma prorenin.
Journal: Hypertension (Dallas, Tex. : 1979) 20081201
Title: Aliskiren and valsartan in stage 2 hypertension: subgroup analysis of a randomized, double-blind study.
Journal: Advances in therapy 20081201
Title: Efficacy of aliskiren/hydrochlorothiazide single-pill combinations in aliskiren non-responders.
Journal: Blood pressure. Supplement 20081201
Title: Gateways to clinical trials. December 2008.
Journal: Methods and findings in experimental and clinical pharmacology 20081201
Title: Renin inhibition with aliskiren in hypertension: focus on aliskiren/hydrochlorothiazide combination therapy.
Journal: Vascular health and risk management 20081201
Title: The evolution of systolic blood pressure as a strong predictor of cardiovascular risk and the effectiveness of fixed-dose ARB/CCB combinations in lowering levels of this preferential target.
Journal: Vascular health and risk management 20081201
Title: Hypotension after ingestion of Aliskiren.
Journal: Clinical toxicology (Philadelphia, Pa.) 20081101
Title: Renin inhibition attenuates insulin resistance, oxidative stress, and pancreatic remodeling in the transgenic Ren2 rat.
Journal: Endocrinology 20081101
Title: Pharmacokinetics of the oral direct renin inhibitor aliskiren in combination with digoxin, atorvastatin, and ketoconazole in healthy subjects: the role of P-glycoprotein in the disposition of aliskiren.
Journal: Journal of clinical pharmacology 20081101
Title: Renin inhibitors: novel agents for renoprotection or a better angiotensin receptor blocker for blood pressure lowering?
Journal: Cardiology clinics 20081101
Title: Direct renin inhibition--commonly asked questions.
Journal: Journal of clinical hypertension (Greenwich, Conn.) 20081101
Title: Blood pressure lowering efficacy of renin inhibitors for primary hypertension.
Journal: The Cochrane database of systematic reviews 20081008
Title: Aliskiren for hypertension in adults.
Journal: Drug and therapeutics bulletin 20081001
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20081001
Title: The renin angiotensin system in the development of cardiovascular disease: role of aliskiren in risk reduction.
Journal: Vascular health and risk management 20081001
Title: Aliskiren combined with losartan in diabetes and nephropathy.
Journal: The New England journal of medicine 20080904
Title: Aliskiren combined with losartan in diabetes and nephropathy.
Journal: The New England journal of medicine 20080904
Title: Aliskiren combined with losartan in diabetes and nephropathy.
Journal: The New England journal of medicine 20080904
Title: Aliskiren combined with losartan in diabetes and nephropathy.
Journal: The New England journal of medicine 20080904
Title: Aliskiren improves nitric oxide bioavailability and limits atherosclerosis.
Journal: Hypertension (Dallas, Tex. : 1979) 20080901
Title: Renin inhibitor aliskiren improves impaired nitric oxide bioavailability and protects against atherosclerotic changes.
Journal: Hypertension (Dallas, Tex. : 1979) 20080901
Title: Effect of aliskiren, an oral direct renin inhibitor, on the pharmacokinetics and pharmacodynamics of a single dose of acenocoumarol in healthy volunteers.
Journal: Current medical research and opinion 20080901
Title: Direct renin inhibition: an evaluation of the safety and tolerability of aliskiren.
Journal: Current medical research and opinion 20080901
Title: Renin inhibition: should it supplant ACE inhibitors and ARBS in high risk patients?
Journal: Current opinion in nephrology and hypertension 20080901
Title: Prorenin engages the (pro)renin receptor like renin and both ligand activities are unopposed by aliskiren.
Journal: Journal of hypertension 20080901
Title: The development of the direct renin inhibitor aliskiren: treating hypertension and beyond.
Journal: Expert opinion on emerging drugs 20080901
Title: Effects of the direct renin inhibitor aliskiren and atenolol alone or in combination in patients with hypertension.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20080901
Title: Can aliskiren reduce the incidence of cough caused by ramipril?
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20080901
Title: Prorenin and the (pro)renin receptor: binding kinetics, signalling and interaction with aliskiren.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20080901
Title: Which strategy in inhibition of the renin-angiotensin system is the most efficient for heart failure?
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20080901
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20080901
Title: [Aliskiren (Rasilez), direct renin inhibitor].
Journal: Revue medicale de Liege 20080901
Title: [What is the purpose of dual or triple inhibition of the renin-angiotensin-aldosterone system?].
Journal: Revue medicale suisse 20080827
Title: Aliskiren/hydrochlorothiazide (Tekturna HCT) for hypertension.
Journal: The Medical letter on drugs and therapeutics 20080825
Title: Aliskiren.
Journal: Circulation 20080812
Title: Renin inhibition and atherosclerosis.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20080801
Title: It is the plasma renin activity level that counts, not stoichiometry.
Journal: Hypertension (Dallas, Tex. : 1979) 20080801
Title: Direct renin inhibition: an analysis of possible benefits.
Journal: Current hypertension reports 20080801
Title: Under pressure: future prospects in hypertension management. Interview by Laura Dormer.
Journal: Expert review of cardiovascular therapy 20080801
Title: Coventina is always eager to popularise newer methods of diagnosing and treating cardiac conditions.
Journal: Scottish medical journal 20080801
Title: A study of the pharmacokinetic interactions of the direct renin inhibitor aliskiren with metformin, pioglitazone and fenofibrate in healthy subjects.
Journal: Current medical research and opinion 20080801
Title: Aliskiren: will a novel mechanism improve clinical outcomes?
Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080715
Title: Aliskiren.
Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080715
Title: Pharmacokinetic/pharmacodynamic modeling of renin biomarkers in subjects treated with the renin inhibitor aliskiren.
Journal: Clinical pharmacology and therapeutics 20080701
Title: Effect of renin inhibition and AT1R blockade on myocardial remodeling in the transgenic Ren2 rat.
Journal: American journal of physiology. Endocrinology and metabolism 20080701
Title: Effects of aliskiren, a direct Renin inhibitor, on cardiac repolarization and conduction in healthy subjects.
Journal: Journal of clinical pharmacology 20080701
Title: Effects of aliskiren on blood pressure, albuminuria, and (pro)renin receptor expression in diabetic TG(mRen-2)27 rats.
Journal: Hypertension (Dallas, Tex. : 1979) 20080701
Title: Antihypertensive and renoprotective mechanisms of Renin inhibition in diabetic rats.
Journal: Hypertension (Dallas, Tex. : 1979) 20080701
Title: Renal and hormonal responses to direct renin inhibition with aliskiren in healthy humans.
Journal: Circulation 20080624
Title: Aliskiren combined with losartan in type 2 diabetes and nephropathy.
Journal: The New England journal of medicine 20080605
Title: Aliskiren and dual therapy in type 2 diabetes mellitus.
Journal: The New England journal of medicine 20080605
Title: Prorenin anno 2008.
Journal: Journal of molecular medicine (Berlin, Germany) 20080601
Title: Involvement of (pro)renin receptor in the glomerular filtration barrier.
Journal: Journal of molecular medicine (Berlin, Germany) 20080601
Title: PLZF and the (pro)renin receptor.
Journal: Journal of molecular medicine (Berlin, Germany) 20080601
Title: Time course of the antiproteinuric and antihypertensive effects of direct renin inhibition in type 2 diabetes.
Journal: Kidney international 20080601
Title: Direct renin inhibition: clinical pharmacology.
Journal: Journal of molecular medicine (Berlin, Germany) 20080601
Title: Aliskiren-binding increases the half life of renin and prorenin in rat aortic vascular smooth muscle cells.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20080601
Title: Renin inhibitors, clinical experience.
Journal: Journal of molecular medicine (Berlin, Germany) 20080601
Title: Aliskiren--mode of action and preclinical data.
Journal: Journal of molecular medicine (Berlin, Germany) 20080601
Title: [Aliskiren hemifumarate].
Journal: Deutsche medizinische Wochenschrift (1946) 20080601
Title: [Oral inhibitors of renin and their potential use as therapeutic agents in treating hypertension].
Journal: Harefuah 20080601
Title: Now that we have a direct renin inhibitor, what should we do with it?
Journal: Current hypertension reports 20080601
Title: Aliskiren reduces plasma Renin activity.
Journal: P & T : a peer-reviewed journal for formulary management 20080601
Title: Effects of aliskiren, a renin inhibitor, on biomarkers of platelet activity, coagulation and fibrinolysis in subjects with multiple risk factors for vascular disease.
Journal: Journal of human hypertension 20080501
Title: Therapeutic strategies to slow chronic kidney disease progression.
Journal: Pediatric nephrology (Berlin, Germany) 20080501
Title: Aliskiren: the first renin inhibitor for clinical treatment.
Journal: Nature reviews. Drug discovery 20080501
Title: Renin inhibition by aliskiren prevents atherosclerosis progression: comparison with irbesartan, atenolol, and amlodipine.
Journal: Hypertension (Dallas, Tex. : 1979) 20080501
Title: A study of dose-proportionality in the pharmacokinetics of the oral direct renin inhibitor aliskiren in healthy subjects.
Journal: International journal of clinical pharmacology and therapeutics 20080501
Title: Effects of the oral direct renin inhibitor aliskiren in patients with symptomatic heart failure.
Journal: Circulation. Heart failure 20080501
Title: Activation of a local renin angiotensin system in podocytes by glucose.
Journal: American journal of physiology. Renal physiology 20080401
Title: The putative (pro)renin receptor blocker HRP fails to prevent (pro)renin signaling.
Journal: Journal of the American Society of Nephrology : JASN 20080401
Title: The renin rise with aliskiren: it's simply stoichiometry.
Journal: Hypertension (Dallas, Tex. : 1979) 20080401
Title: Activation of the intracellular renin-angiotensin system in cardiac fibroblasts by high glucose: role in extracellular matrix production.
Journal: American journal of physiology. Heart and circulatory physiology 20080401
Title: Renin inhibition with aliskiren.
Journal: Clinical and experimental pharmacology & physiology 20080401
Title: Long-term safety, tolerability and efficacy of aliskiren in combination with valsartan in patients with hypertension: a 6-month interim analysis.
Journal: Current medical research and opinion 20080401
Title: Current concepts: renin inhibition in the treatment of hypertension.
Journal: Current opinion in pharmacology 20080401
Title: Aliskiren: clinical experience and future perspectives of renin inhibition.
Journal: Expert opinion on pharmacotherapy 20080401
Title: Oral direct renin inhibition: premise, promise, and potential limitations of a new antihypertensive drug.
Journal: The American journal of medicine 20080401
Title: New drug update: 2007.
Journal: The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists 20080401
Title: Aliskiren: new drug. Arterial hypertension: no evidence of clinical efficacy.
Journal: Prescrire international 20080401
Title: [How I treat... by optimizing the blockade of the renin-angiotensin-aldosterone system].
Journal: Revue medicale de Liege 20080401
Title: What's new in clinical pharmacology and therapeutics.
Journal: WMJ : official publication of the State Medical Society of Wisconsin 20080401
Title: Renin inhibition reduces hypercholesterolemia-induced atherosclerosis in mice.
Journal: The Journal of clinical investigation 20080303
Title: Antihypertensive therapy with aliskiren.
Journal: Kidney international 20080301
Title: Prorenin and renin-induced extracellular signal-regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide.
Journal: Hypertension (Dallas, Tex. : 1979) 20080301
Title: A study of the pharmacokinetic interactions of the direct renin inhibitor aliskiren with allopurinol, celecoxib and cimetidine in healthy subjects.
Journal: Current medical research and opinion 20080301
Title: Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension.
Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20080301
Title: Aliskiren as an alternative in a patient with life-threatening ACE inhibitor-induced angioedema.
Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20080301
Title: Comparative efficacy and safety of aliskiren, an oral direct renin inhibitor, and ramipril in hypertension: a 6-month, randomized, double-blind trial.
Journal: Journal of hypertension 20080301
Title: Aliskiren-hydrochlorothiazide combination for the treatment of hypertension.
Journal: Expert review of cardiovascular therapy 20080301
Title: [Is there a need for direct renin inhibitors?].
Journal: Harefuah 20080301
Title: Renin inhibition in hypertension.
Journal: Journal of the American College of Cardiology 20080205
Title: Dietary n-3 polyunsaturated fatty acids and direct renin inhibition improve electrical remodeling in a model of high human renin hypertension.
Journal: Hypertension (Dallas, Tex. : 1979) 20080201
Title: Novel druggable hot spots in avian influenza neuraminidase H5N1 revealed by computational solvent mapping of a reduced and representative receptor ensemble.
Journal: Chemical biology & drug design 20080201
Title: Aliskiren (tekturna), a novel antihypertensive approach to inhibition of the Renin-Angiotensin-aldosterone system.
Journal: P & T : a peer-reviewed journal for formulary management 20080201
Title: Interpretation of plasma renin concentration in patients receiving aliskiren therapy.
Journal: Hypertension (Dallas, Tex. : 1979) 20080101
Title: Aliskiren: renin inhibitor for hypertension management.
Journal: Clinical therapeutics 20080101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20080101
Title: [Is the combination aliskiren /valsartan as effective and safe as either drug in monotherapy for treating hypertension?].
Journal: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20080101
Title: [spACE, the last frontier? Renin inhibition in hypertension].
Journal: Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia 20080101
Title: Purification and characterization of recombinant human renin for X-ray crystallization studies.
Journal: BMC biochemistry 20080101
Title: Clinical pharmacokinetics and pharmacodynamics of aliskiren.
Journal: Clinical pharmacokinetics 20080101
Title: Inhibition of the renin-angiotensin system and chronic kidney disease.
Journal: International urology and nephrology 20080101
Title: Aliskiren: a rapidly, expanding role in the management of recalcitrant hypertension and renal disease.
Journal: International urology and nephrology 20080101
Title: [Therapeutic novelties in the management of arterial hypertension].
Journal: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20080101
Title: Gateways to clinical trials. July-August 2008.
Journal: Methods and findings in experimental and clinical pharmacology 20080101
Title: Pharmacokinetic interaction of the direct renin inhibitor aliskiren with furosemide and extended-release isosorbide-5-mononitrate in healthy subjects.
Journal: Cardiovascular therapeutics 20080101
Title: Pharmacokinetics and pharmacodynamics of aliskiren, an oral direct renin inhibitor.
Journal: Pharmacological reports : PR 20080101
Title: Cognitive-enhancing effects of angiotensin IV.
Journal: BMC neuroscience 20080101
Title: Aliskiren: a novel renin inhibitor for hypertension.
Journal: Indian heart journal 20080101
Title: Renin-angiotensin-aldosterone system (RAAS) block revisited.
Journal: The National medical journal of India 20080101
Title: Mechanisms of progression of chronic kidney disease.
Journal: Pediatric nephrology (Berlin, Germany) 20071201
Title: Clinical trials update from the European Society of Cardiology Congress in Vienna, 2007: PROSPECT, EVEREST, ARISE, ALOFT, FINESSE, Prague-8, CARESS in MI and ACUITY.
Journal: Cardiovascular drugs and therapy 20071201
Title: Structure-based drug design and the discovery of aliskiren (Tekturna): perseverance and creativity to overcome a R&D pipeline challenge.
Journal: Chemical biology & drug design 20071201
Title: Aliskiren.
Journal: Drugs of today (Barcelona, Spain : 1998) 20071201
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20071201
Title: Aliskiren--an orally active renin inhibitor. Review of pharmacology, pharmacodynamics, kinetics, and clinical potential in the treatment of hypertension.
Journal: Vascular health and risk management 20071201
Title: Regulation of the renin-angiotensin system in coronary atherosclerosis: a review of the literature.
Journal: Vascular health and risk management 20071201
Title: Efficacy and safety of the direct renin inhibitor aliskiren and ramipril alone or in combination in patients with diabetes and hypertension.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20071201
Title: Renin academy in focus.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20071201
Title: The latest advances in kidney diseases and related disorders.
Journal: Drug news & perspectives 20071201
Title: Aliskiren, a novel renin inhibitor, is renoprotective in a model of advanced diabetic nephropathy in rats.
Journal: Diabetologia 20071101
Title: Neurohumoral effects of the new orally active renin inhibitor, aliskiren, in chronic heart failure.
Journal: European journal of heart failure 20071101
Title: Aliskiren, the first in a new class of direct renin inhibitors for hypertension: present and future perspectives.
Journal: Expert opinion on pharmacotherapy 20071101
Title: Aliskiren: the first direct renin inhibitor for hypertension.
Journal: Current cardiology reports 20071101
Title: [New therapeutic goals--new drugs in heart failure treatment].
Journal: Kardiologia polska 20071101
Title: Anti-angiotensin therapy: new perspectives.
Journal: Cardiology clinics 20071101
Title: Aliskiren and blood pressure control in patients with hypertension.
Journal: Current hypertension reports 20071101
Title: Renin inhibitors: optimal strategy for renal protection.
Journal: Current hypertension reports 20071101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20071101
Title: Structural modification of the P2' position of 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamides: the discovery of aliskiren, a potent nonpeptide human renin inhibitor active after once daily dosing in marmosets.
Journal: Journal of medicinal chemistry 20071004
Title: Renin inhibition: the holy grail of renin-angiotensin system blockade?
Journal: Journal of human hypertension 20071001
Title: A comparison of the tolerability of the direct renin inhibitor aliskiren and lisinopril in patients with severe hypertension.
Journal: Journal of human hypertension 20071001
Title: Clinical trials update from the European Society of Cardiology Congress 2007: 3CPO, ALOFT, PROSPECT and statins for heart failure.
Journal: European journal of heart failure 20071001
Title: Antihypertensive efficacy of the oral direct renin inhibitor aliskiren as add-on therapy in patients not responding to amlodipine monotherapy.
Journal: Journal of clinical hypertension (Greenwich, Conn.) 20071001
Title: The renin-angiotensin aldosterone system: pathophysiological role and pharmacologic inhibition.
Journal: Journal of managed care pharmacy : JMCP 20071001
Title: Direct renin inhibition: focus on aliskiren.
Journal: Journal of managed care pharmacy : JMCP 20071001
Title: Aliskiren for hypertension: just another option or something truly unique?
Journal: South Dakota medicine : the journal of the South Dakota State Medical Association 20071001
Title: Dual inhibition of the renin system by aliskiren and valsartan.
Journal: Lancet (London, England) 20070929
Title: Plasma renin and the antihypertensive effect of the orally active renin inhibitor aliskiren in clinical hypertension.
Journal: International journal of clinical practice 20070901
Title: Renin excess after renin inhibition: malefactor or innocent bystander?
Journal: International journal of clinical practice 20070901
Title: Hormonal and hemodynamic effects of aliskiren and valsartan and their combination in sodium-replete normotensive individuals.
Journal: Clinical journal of the American Society of Nephrology : CJASN 20070901
Title: Inhibition of renin: an updated review of the development of renin inhibitors.
Journal: Current opinion in investigational drugs (London, England : 2000) 20070901
Title: The difficult conception, birth and delivery of a renin inhibitor: controversies around aliskiren.
Journal: Journal of hypertension 20070901
Title: Aliskiren, the future of renin-angiotensin system blockade?
Journal: Expert review of cardiovascular therapy 20070901
Title: [Renin inhibitors. Aliskiren for the treatment of high blood pressure].
Journal: Medizinische Monatsschrift fur Pharmazeuten 20070901
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20070901
Title: An update on non-peptide angiotensin receptor antagonists and related RAAS modulators.
Journal: Life sciences 20070802
Title: Absorption, distribution, metabolism, and elimination of the direct renin inhibitor aliskiren in healthy volunteers.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20070801
Title: Renin gene polymorphisms and haplotypes, blood pressure, and responses to renin-angiotensin system inhibition.
Journal: Hypertension (Dallas, Tex. : 1979) 20070801
Title: Direct renin inhibitors: a new approach to antihypertensive drug treatment.
Journal: Journal of clinical hypertension (Greenwich, Conn.) 20070801
Title: Renin inhibition: a new modality for hypertension management.
Journal: Current hypertension reports 20070801
Title: Novel drugs targeting hypertension: renin inhibitors.
Journal: Journal of cardiovascular pharmacology 20070801
Title: Antihypertensive therapies.
Journal: Nature reviews. Drug discovery 20070801
Title: Dual inhibition of the renin system by aliskiren and valsartan.
Journal: Lancet (London, England) 20070721
Title: Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension: a randomised, double-blind trial.
Journal: Lancet (London, England) 20070721
Title: Aliskiren (Tekturna) a new weapon to battle the silent killer.
Journal: The Nurse practitioner 20070701
Title: A new weapon against hypertension. Recently approved medication lowers blood pressure, reducing risks of heart failure, stroke, heart attack, aneurysm, and kidney failure.
Journal: Heart advisor 20070601
Title: A brief response to Sealey and Laragh.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20070601
Title: Low-dose renin inhibitor and low-dose AT(1)-receptor blocker therapy ameliorate target-organ damage in rats harbouring human renin and angiotensinogen genes.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20070601
Title: Direct Renin inhibition with aliskiren in obese patients with arterial hypertension.
Journal: Hypertension (Dallas, Tex. : 1979) 20070501
Title: What new drugs can nephrologists look forward to in the next year or two?
Journal: Nature clinical practice. Nephrology 20070501
Title: Aliskiren, the first renin inhibitor for treating hypertension: reactive renin secretion may limit its effectiveness.
Journal: American journal of hypertension 20070501
Title: A new way to control blood pressure. Inactivating renin, which is made by the kidneys, may open the door to better blood pressure.
Journal: Harvard heart letter : from Harvard Medical School 20070501
Title: Aliskiren (Tekturna) for hypertension.
Journal: The Medical letter on drugs and therapeutics 20070409
Title: Angiotensin II reactivation and aldosterone escape phenomena in renin-angiotensin-aldosterone system blockade: is oral renin inhibition the solution?
Journal: Expert opinion on pharmacotherapy 20070401
Title: Pharmacokinetics, safety, and tolerability of the novel oral direct renin inhibitor aliskiren in elderly healthy subjects.
Journal: Journal of clinical pharmacology 20070401
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20070401
Title: [Does the rennin inhibitor aliskiren offer promising novel opportunities in the treatment of cardiovascular diseases?].
Journal: Vnitrni lekarstvi 20070401
Title: Identification of hot spots within druggable binding regions by computational solvent mapping of proteins.
Journal: Journal of medicinal chemistry 20070322
Title: Aliskiren, an oral renin inhibitor, provides dose-dependent efficacy and sustained 24-hour blood pressure control in patients with hypertension.
Journal: Journal of the American College of Cardiology 20070320
Title: Do we need yet another blocker of the renin-angiotensin system?
Journal: Journal of the American College of Cardiology 20070320
Title: Aliskiren for renin inhibition: a new class of antihypertensives.
Journal: The Annals of pharmacotherapy 20070301
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20070301
Title: Aliskiren reduces blood pressure and suppresses plasma renin activity in combination with a thiazide diuretic, an angiotensin-converting enzyme inhibitor, or an angiotensin receptor blocker.
Journal: Hypertension (Dallas, Tex. : 1979) 20070201
Title: Pharmacokinetics, safety, and tolerability of the oral Renin inhibitor aliskiren in patients with hepatic impairment.
Journal: Journal of clinical pharmacology 20070201
Title: [Global treatment of cardiovascular risk in the hypertensive patient].
Journal: Revista espanola de cardiologia 20070201
Title: Role of the vasodilator peptide angiotensin-(1-7) in cardiovascular drug therapy.
Journal: Vascular health and risk management 20070201
Title: Renin inhibition with aliskiren provides additive antihypertensive efficacy when used in combination with hydrochlorothiazide.
Journal: Journal of hypertension 20070101
Title: Aliskiren, an orally effective renin inhibitor, provides antihypertensive efficacy alone and in combination with valsartan.
Journal: American journal of hypertension 20070101
Title: Expanding the opportunities for blocking the renin-angiotensin system: introduction to a special supplement.
Journal: Reviews in cardiovascular medicine 20070101
Title: The efficacy of aliskiren, a direct renin inhibitor, in the treatment of hypertension.
Journal: Reviews in cardiovascular medicine 20070101
Title: [The best of hypertension in 2006].
Journal: Archives des maladies du coeur et des vaisseaux 20070101
Title: [The best of clinical pharmacology in 2006].
Journal: Archives des maladies du coeur et des vaisseaux 20070101
Title: New drugs: aliskiren hemifumarate, lisdexamfetamine dimesylate, and lapatinib.
Journal: Journal of the American Pharmacists Association : JAPhA 20070101
Title: Pharmacokinetics of the oral direct renin inhibitor aliskiren alone and in combination with irbesartan in renal impairment.
Journal: Clinical pharmacokinetics 20070101
Title: Aliskiren: a review of its use in the management of hypertension.
Journal: Drugs 20070101
Title: Direct inhibition of renin as a cardiovascular pharmacotherapy: focus on aliskiren.
Journal: Cardiology in review 20070101
Title: Aliskiren: a novel renin inhibitor for hypertension.
Journal: Indian journal of physiology and pharmacology 20070101
Title: Updated meta-analytical approach to the efficacy of antihypertensive drugs in reducing blood pressure.
Journal: Clinical drug investigation 20070101
Title: Safety and efficacy of the oral direct renin inhibitor aliskiren in elderly patients with hypertension.
Journal: Blood pressure 20070101
Title: Aliskiren: an oral renin inhibitor for the treatment of hypertension.
Journal: Cardiology in review 20070101
Title: Antihypertensive efficacy, safety, and tolerability of the oral direct renin inhibitor aliskiren in patients with hypertension: a pooled analysis.
Journal: Journal of the American Society of Hypertension : JASH 20070101
Title: Opportunities for structure-based design of protease-directed drugs.
Journal: Current opinion in structural biology 20061201
Title: Aliskiren, a novel orally effective renin inhibitor, exhibits similar pharmacokinetics and pharmacodynamics in Japanese and Caucasian subjects.
Journal: British journal of clinical pharmacology 20061201
Title: Aliskiren, a novel oral renin inhibitor, provides dose-dependent efficacy and placebo-like tolerability in Japanese patients with hypertension.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20061201
Title: Renin inhibitors: An important advance in hypertension treatment?
Journal: International journal of clinical practice 20061101
Title: Lack of pharmacokinetic interactions of aliskiren, a novel direct renin inhibitor for the treatment of hypertension, with the antihypertensives amlodipine, valsartan, hydrochlorothiazide (HCTZ) and ramipril in healthy volunteers.
Journal: International journal of clinical practice 20061101
Title: Speedel staunches the renin cascade at its source.
Journal: Chemistry & biology 20061101
Title: The renin inhibitor aliskiren as novel treatment for cardiovascular disease.
Journal: Recent patents on cardiovascular drug discovery 20061101
Title: Oral renin inhibitors.
Journal: Lancet (London, England) 20061021
Title: Expanding the scope of the acyl-type radical addition reactions promoted by SmI2.
Journal: The Journal of organic chemistry 20061013
Title: Creating carbon-carbon bonds with samarium diiodide for the synthesis of modified amino acids and peptides.
Journal: Organic & biomolecular chemistry 20061007
Title: Prorenin induces intracellular signaling in cardiomyocytes independently of angiotensin II.
Journal: Hypertension (Dallas, Tex. : 1979) 20061001
Title: New drugs for hypertension: what do they offer?
Journal: Current hypertension reports 20061001
Title: Aliskiren: a renin inhibitor offering a new approach for the treatment of hypertension.
Journal: Expert opinion on investigational drugs 20061001
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20061001
Title: Imaging the renin-angiotensin system: an important target of anti-hypertensive therapy.
Journal: Advanced drug delivery reviews 20060915
Title: Potential side effects of renin inhibitors--mechanisms based on comparison with other renin-angiotensin blockers.
Journal: Expert opinion on drug safety 20060901
Title: Renin inhibition.
Journal: Current opinion in nephrology and hypertension 20060901
Title: Molecule of the Month. Aliskiren fumarate.
Journal: Drug news & perspectives 20060901
Title: [Renin-angiotensin system].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20060701
Title: [Trend of research and development of antihypertensive agents].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20060701
Title: Formal total synthesis of the potent renin inhibitor aliskiren: application of a SmI2-promoted acyl-like radical coupling.
Journal: The Journal of organic chemistry 20060623
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20060601
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20060501
Title: [Antihypertensive drugs in clinical development].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20060501
Title: [New strategy in the treatment of hypertension: inhibition of renin-angiotensin-aldosterone system with renin inhibitor].
Journal: Orvosi hetilap 20060430
Title: Conformational changes in prorenin during renin inhibition in vitro and in vivo.
Journal: Journal of hypertension 20060301
Title: Direct renin inhibition with aliskiren in hypertension and target organ damage.
Journal: Clinical journal of the American Society of Nephrology : CJASN 20060301
Title: Renin inhibition with aliskiren: where are we now, and where are we going?
Journal: Journal of hypertension 20060201
Title: Inhibiting the renin-angiotensin system to prevent cardiovascular diseases: do we need a more comprehensive strategy?
Journal: Reviews in cardiovascular medicine 20060101
Title: Aliskiren exhibits similar pharmacokinetics in healthy volunteers and patients with type 2 diabetes mellitus.
Journal: Clinical pharmacokinetics 20060101
Title: Pharmacokinetic interactions of the oral renin inhibitor aliskiren with lovastatin, atenolol, celecoxib and cimetidine.
Journal: International journal of clinical pharmacology and therapeutics 20051101
Title: Complement activation in angiotensin II-induced organ damage.
Journal: Circulation research 20050930
Title: Renin inhibition: new potential for an old therapeutic target.
Journal: Hypertension (Dallas, Tex. : 1979) 20050901
Title: Aliskiren, a human renin inhibitor, ameliorates cardiac and renal damage in double-transgenic rats.
Journal: Hypertension (Dallas, Tex. : 1979) 20050901
Title: Alice Huxley and Nick Miles of Speedel on the company's pipeline and future plans. Interview by Christopher Watson and Stephen Carney.
Journal: Drug discovery today 20050701
Title: Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients.
Journal: Circulation 20050301
Title: Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats.
Journal: Journal of hypertension 20050201
Title: Aliskiren in hypertension: evidence for its potential therapeutic value.
Journal: Core evidence 20050101
Title: Pharmacologic demonstration of the synergistic effects of a combination of the renin inhibitor aliskiren and the AT1 receptor antagonist valsartan on the angiotensin II-renin feedback interruption.
Journal: Journal of the American Society of Nephrology : JASN 20041201
Title: Effect of the oral renin inhibitor aliskiren on the pharmacokinetics and pharmacodynamics of a single dose of warfarin in healthy subjects.
Journal: British journal of clinical pharmacology 20041001
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20040501
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20040101
Title: Blood pressure lowering in essential hypertension with an oral renin inhibitor, aliskiren.
Journal: Hypertension (Dallas, Tex. : 1979) 20031201
Title: Structure-based design of aliskiren, a novel orally effective renin inhibitor.
Journal: Biochemical and biophysical research communications 20030905
Title: Potential of renin inhibition in cardiovascular disease.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20030301
Title: Therapeutic potential of renin inhibitors in the management of cardiovascular disorders.
Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20030101
Title: Aliskiren (Speedel).
Journal: Current opinion in investigational drugs (London, England : 2000) 20021001
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20021001
Title: Gateways to Clinical Trials.
Journal: Methods and findings in experimental and clinical pharmacology 20020901
Title: Angiotensin II suppression in humans by the orally active renin inhibitor aliskiren (SPP100). Comparison with enalapril.
Journal: Current hypertension reports 20020801
Title: Angiotensin II suppression in humans by the orally active renin inhibitor Aliskiren (SPP100): comparison with enalapril.
Journal: Hypertension (Dallas, Tex. : 1979) 20020101
Title: Yuji Nakamura, et al. Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor. ACS Med. Chem. Lett., 2012, 3 (9), pp 754–758
Title: Wood JM, et al. Structure-based design of aliskiren, a novel orally effective renin inhibitor.Biochem Biophys Res Commun, 2003, 308(4), 698-705.
Title: Wang C, et al. Aliskiren targets multiple systems to alleviate cancer cachexia. Oncol Rep. 2016 Nov;36(5):3014-3022.
Title: Chang AY, et al. Interplay between brain stem angiotensins and monocyte chemoattractant protein-1 as a novel mechanism for pressor response after ischemic stroke. Neurobiol Dis. 2014 Nov;71:292-304.
Title: Buczko W, et al. Pharmacokinetics and pharmacodynamics of aliskiren, an oral direct renin inhibitor. Pharmacol Rep. 2008 Sep-Oct;60(5):623-31.
Title: Gradman AH, et al.Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients. Circulation, 2005, 111(8), 1012-1018.
