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[2]Turner,SteveR.;Strohbach,JosephW.;Tommasi,RubenA.;Aristoff,PaulA.;Johnson,PaulD.;Skulnick,HarveyI.;Dolak,LesterA.;Seest,EricP.;Tomich,PaulK.;Bohanon,MichaelJ.;Horng,Miao-Miao;Lynn,JanetC.;Chong,Kong-Teck;Hinshaw,RogerR.;Watenpaugh,KeithD.;Janakiraman,MusiriN.;Thaisrivongs,Suvit[JournalofMedicinalChemistry,1998,vol.41,#18,p.3467-3476]
[1]JournalofMedicinalChemistry,1998,vol.41,p.3467-3476
Title: Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.
Journal: Chemical research in toxicology 20170515
Title: Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11).
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20131201
Title: P2' benzene carboxylic acid moiety is associated with decrease in cellular uptake: evaluation of novel nonpeptidic HIV-1 protease inhibitors containing P2 bis-tetrahydrofuran moiety.
Journal: Antimicrobial agents and chemotherapy 20131001
Title: Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance.
Journal: Chemistry & biology 20130919
Title: GRL-0519, a novel oxatricyclic ligand-containing nonpeptidic HIV-1 protease inhibitor (PI), potently suppresses replication of a wide spectrum of multi-PI-resistant HIV-1 variants in vitro.
Journal: Antimicrobial agents and chemotherapy 20130501
Title: Novel method to assess antiretroviral target trough concentrations using in vitro susceptibility data.
Journal: Antimicrobial agents and chemotherapy 20121101
Title: Short communication: Phenotypic protease inhibitor resistance and cross-resistance in the clinic from 2006 to 2008 and mutational prevalences in HIV from patients with discordant tipranavir and darunavir susceptibility phenotypes.
Journal: AIDS research and human retroviruses 20120901
Title: Activity of human immunodeficiency virus type 1 protease inhibitors against the initial autocleavage in Gag-Pol polyprotein processing.
Journal: Antimicrobial agents and chemotherapy 20120701
Title: Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Journal: Journal of medicinal chemistry 20120524
Title: Tipranavir in highly antiretroviral treatment-experienced patients: Results from a French prospective cohort.
Journal: Scandinavian journal of infectious diseases 20120101
Title: Boosted tipranavir versus darunavir in treatment-experienced patients: observational data from the randomized POTENT trial.
Journal: Drugs in R&D 20111201
Title: Tipranavir in the protease inhibitors arena.
Journal: Drugs in R&D 20111201
Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Journal: PLoS computational biology 20111201
Title: In vitro activity of antiretroviral drugs against Plasmodium falciparum.
Journal: Antimicrobial agents and chemotherapy 20111101
Title: Emerging HIV-1 resistance to tipranavir and darunavir in patients with virological failure to first-generation protease inhibitors in Taiwan.
Journal: International journal of STD & AIDS 20111101
Title: The higher barrier of darunavir and tipranavir resistance for HIV-1 protease.
Journal: Biochemical and biophysical research communications 20110909
Title: Effect of tipranavir/ritonavir combination on the pharmacokinetics of tadalafil in healthy volunteers.
Journal: Journal of clinical pharmacology 20110701
Title: Tipranavir/ritonavir induction of buprenorphine glucuronide metabolism in HIV-negative subjects chronically receiving buprenorphine/naloxone.
Journal: The American journal of drug and alcohol abuse 20110701
Title: Effects of tipranavir, darunavir, and ritonavir on platelet function, coagulation, and fibrinolysis in healthy volunteers.
Journal: Current HIV research 20110601
Title: Pharmacokinetic profile in late pregnancy and cord blood concentration of tipranavir and enfuvirtide.
Journal: International journal of STD & AIDS 20110501
Title: Lack of a pharmacokinetic interaction between steady-state tipranavir/ritonavir and single-dose valacyclovir in healthy volunteers.
Journal: European journal of clinical pharmacology 20110301
Title: Added value of deep sequencing relative to population sequencing in heavily pre-treated HIV-1-infected subjects.
Journal: PloS one 20110101
Title: Efficacy and safety of ritonavir dose reduction based on the tipranavir inhibitory quotient in HIV-infected patients on salvage antiretroviral therapy with tipranavir/ritonavir.
Journal: AIDS research and human retroviruses 20101101
Title: Novel protease inhibitors (PIs) containing macrocyclic components and 3(R),3a(S),6a(R)-bis-tetrahydrofuranylurethane that are potent against multi-PI-resistant HIV-1 variants in vitro.
Journal: Antimicrobial agents and chemotherapy 20100801
Title: Successful virological outcome in an HIV-infected individual with a three-class resistant variant and an insertion in the protease genome with a Tipranavir based regimen.
Journal: Irish journal of medical science 20100601
Title: A phenotype-genotype approach to predicting CYP450 and P-glycoprotein drug interactions with the mixed inhibitor/inducer tipranavir/ritonavir.
Journal: Clinical pharmacology and therapeutics 20100601
Title: Susceptibility of HIV-1 to tipranavir and other antiretroviral agents in treatment-experienced patients: The UTILIZE Study.
Journal: Current HIV research 20100601
Title: Hybrid-genetic algorithm based descriptor optimization and QSAR models for predicting the biological activity of Tipranavir analogs for HIV protease inhibition.
Journal: Journal of molecular graphics & modelling 20100601
Title: Metabolism-mediated drug interactions associated with ritonavir-boosted tipranavir in mice.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20100501
Title: Evaluating the substrate-envelope hypothesis: structural analysis of novel HIV-1 protease inhibitors designed to be robust against drug resistance.
Journal: Journal of virology 20100501
Title: The benefit of simplification from tipranavir/ritonavir 500/200 bid to 500/100 bid guided by therapeutic drug monitoring.
Journal: Therapeutic drug monitoring 20100401
Title: Activity of elvitegravir, a once-daily integrase inhibitor, against resistant HIV Type 1: results of a phase 2, randomized, controlled, dose-ranging clinical trial.
Journal: The Journal of infectious diseases 20100315
Title: Trends in uptake of recently approved antiretrovirals within a national healthcare system.
Journal: HIV medicine 20100301
Title: HIV type 1 antiretroviral resistance mutations in subtypes B, C, and F in the City of São Paulo, Brazil.
Journal: AIDS research and human retroviruses 20100301
Title: Short communication: evaluation of the effect of enfuvirtide in 11 HIV-1 vertically infected pediatric patients outside clinical trials.
Journal: AIDS research and human retroviruses 20100301
Title: Diagnosis and monitoring of HIV-1 group O-infected patients in Cameroun.
Journal: Journal of acquired immune deficiency syndromes (1999) 20100101
Title: Analysis of CYP3A4-HIV-1 protease drugs interactions by computational methods for Highly Active Antiretroviral Therapy in HIV/AIDS.
Journal: Journal of molecular graphics & modelling 20100101
Title: Pharmacokinetic characterization of three doses of tipranavir boosted with ritonavir on highly active antiretroviral therapy in treatment-experienced HIV-1 patients.
Journal: HIV clinical trials 20100101
Title: [Adverse reactions of atazanavir, fosamprenavir and tipranavir in 'real life'].
Journal: Therapie 20100101
Title: Do we need genotypic weighted resistance scores for antiretrovirals? The curious case of tipranavir.
Journal: Antiviral therapy 20100101
Title: Improving the prediction of virological response to tipranavir: the development and validation of a tipranavir-weighted mutation score.
Journal: Antiviral therapy 20100101
Title: Virologic and immunologic effectiveness of tipranavir/ritonavir (TPV/r)- versus darunavir/ritonavir (DRV/r)-based regimens in clinical practice.
Journal: Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) 20100101
Title: In vitro susceptibility and virological outcome to darunavir and lopinavir are independent of HIV type-1 subtype in treatment-naive patients.
Journal: Antiviral therapy 20100101
Title: Pharmacokinetic interactions between buprenorphine/naloxone and tipranavir/ritonavir in HIV-negative subjects chronically receiving buprenorphine/naloxone.
Journal: Drug and alcohol dependence 20091201
Title: Efficacy and safety of a salvage regimen based on tipranavir, enfuvirtide and three nucleoside analogues in HIV1 infected patients with clinical progression: 96-week evaluation.
Journal: Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 20091201
Title: Drugs in traditional drug classes (nucleoside reverse transcriptase inhibitor/nonnucleoside reverse transcriptase inhibitor/protease inhibitors) with activity against drug-resistant virus (tipranavir, darunavir, etravirine).
Journal: Current opinion in HIV and AIDS 20091101
Title: Cytotoxicological analysis of a gp120 binding aptamer with cross-clade human immunodeficiency virus type 1 entry inhibition properties: comparison to conventional antiretrovirals.
Journal: Antimicrobial agents and chemotherapy 20090701
Title: HIV protease inhibitors: recent clinical trials and recommendations on use.
Journal: Expert opinion on pharmacotherapy 20090701
Title: Clinical validation and applicability of different tipranavir/ritonavir genotypic scores in HIV-1 protease inhibitor-experienced patients.
Journal: Current HIV research 20090701
Title: Interactions of different inhibitors with active-site aspartyl residues of HIV-1 protease and possible relevance to pepsin.
Journal: Proteins 20090515
Title: Drug-excipient complexation in lipid based delivery systems: an investigation of the Tipranavir-1,3-dioctanolyglycerol complex.
Journal: Journal of pharmaceutical sciences 20090501
Title: Provider prescribing of 4 antiretroviral agents after implementation of drug use guidelines in the Department of Veterans Affairs.
Journal: Journal of managed care pharmacy : JMCP 20090501
Title: Reversal of major genotypic tipranavir mutations under long-term treatment with tipranavir/ritonavir itself with very limited optimized background, during deep salvage antiretroviral therapy.
Journal: Current HIV research 20090501
Title: Changes in darunavir/r resistance score after previous failure to tipranavir/r in HIV-1-infected multidrug-resistant patients.
Journal: Journal of acquired immune deficiency syndromes (1999) 20090201
Title: [Tipranavir: therapeutic drug monitoring in a pediatric patient with HIV infection].
Journal: Enfermedades infecciosas y microbiologia clinica 20090201
Title: Multidrug-experienced HIV-1-infected women demonstrated similar virological and immunological responses to tipranavir/ritonavir compared with men.
Journal: AIDS (London, England) 20090128
Title: A 12-year-old boy with multidrug-resistant human immunodeficiency virus type 1 successfully treated with HAART including ritonavir-boosted tipranavir oral solution and enfuvirtide.
Journal: European journal of medical research 20090128
Title: Hepatic safety of tipranavir plus ritonavir (TPV/r)-based antiretroviral combinations: effect of hepatitis virus co-infection and pre-existing fibrosis.
Journal: The Journal of antimicrobial chemotherapy 20090101
Title: Quantification of 8 HIV-protease inhibitors and 2 nonnucleoside reverse transcriptase inhibitors by ultra-performance liquid chromatography with diode array detection.
Journal: Clinical chemistry 20090101
Title: Impact of first-line protease inhibitors on predicted resistance to tipranavir in HIV-1-infected patients with virological failure.
Journal: BMC infectious diseases 20090101
Title: Comparison of the pharmacokinetics of apricitabine in the presence and absence of ritonavir-boosted tipranavir: a phase I, open-label, controlled, single-centre study.
Journal: Clinical drug investigation 20090101
Title: Hepatic profile analyses of tipranavir in Phase II and III clinical trials.
Journal: BMC infectious diseases 20090101
Title: [Desensitization to tipranavir caused by toxicodermia].
Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20090101
Title: Tipranavir: a new protease inhibitor for the pediatric population.
Journal: Expert review of anti-infective therapy 20081201
Title: Effects of boosted tipranavir and lopinavir on body composition, insulin sensitivity and adipocytokines in antiretroviral-naive adults.
Journal: AIDS (London, England) 20081112
Title: Tipranavir resistance associated mutations in protease inhibitor-naïve patients with HIV-1 subtype A/E infection.
Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20081101
Title: Drug toxicity, HIV progression, or comorbidity of aging: does tipranavir use increase the risk of intracranial hemorrhage?
Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20081101
Title: Intracranial hemorrhage and liver-associated deaths associated with tipranavir/ritonavir: review of cases from the FDA's Adverse Event Reporting System.
Journal: AIDS patient care and STDs 20081101
Title: [Role of the new molecules in antiretroviral therapy. Position of raltegravir].
Journal: Enfermedades infecciosas y microbiologia clinica 20081101
Title: Low trough levels of tipranavir in a combination antiretroviral therapy of tipranavir/ritonavir and tenofovir require therapeutic drug monitoring.
Journal: European journal of medical research 20081027
Title: Effect of ritonavir-boosted tipranavir or darunavir on the steady-state pharmacokinetics of elvitegravir.
Journal: Journal of acquired immune deficiency syndromes (1999) 20081001
Title: Tipranavir trials close unexpectedly.
Journal: AIDS patient care and STDs 20081001
Title: HIV-protease inhibitors block the enzymatic activity of purified Ste24p.
Journal: Biochemical and biophysical research communications 20080919
Title: Pattern and impact of emerging resistance mutations in treatment experienced patients failing darunavir-containing regimen.
Journal: AIDS (London, England) 20080912
Title: Efficacy, safety and tolerability of tipranavir coadministered with ritonavir in HIV-1-infected children and adolescents.
Journal: AIDS (London, England) 20080912
Title: Tipranavir effective and well tolerated in children.
Journal: AIDS patient care and STDs 20080901
Title: FDA notifications. New tipranavir solution approved.
Journal: AIDS alert 20080801
Title: Intracranial haemorrhage possibly related to Tipranavir in an HIV-1 patient with cryptococcal meningitis.
Journal: The Journal of infection 20080701
Title: New treatment options for HIV salvage patients: an overview of second generation PIs, NNRTIs, integrase inhibitors and CCR5 antagonists.
Journal: The Journal of infection 20080701
Title: New pediatric dosing information for Kaletra.
Journal: AIDS patient care and STDs 20080701
Title: Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Journal: Journal of medicinal chemistry 20080612
Title: Quality control of protease inhibitors.
Journal: Journal of pharmaceutical sciences 20080601
Title: Response of feline immunodeficiency virus (FIV) to tipranavir may provide new clues for development of broad-based inhibitors of retroviral proteases acting on drug-resistant HIV-1.
Journal: Current HIV research 20080601
Title: New protease inhibitors and non-nucleoside reverse transcriptase inhibitors.
Journal: Journal of HIV therapy 20080601
Title: Expected response to protease inhibitors of HIV-1 non-B subtype viruses according to resistance algorithms.
Journal: AIDS (London, England) 20080531
Title: European Commission grants full approval for Aptivus.
Journal: AIDS patient care and STDs 20080501
Title: [HIV therapy and adherence].
Journal: MMW Fortschritte der Medizin 20080428
Title: [Tipranavir optimizes the effect of recent antiretroviral substances. Encouraging options in multiple resistance].
Journal: MMW Fortschritte der Medizin 20080428
Title: Pharmacokinetics, safety, and efficacy of tipranavir boosted with ritonavir alone or in combination with other boosted protease inhibitors as part of optimized combination antiretroviral therapy in highly treatment-experienced patients (BI Study 1182.51).
Journal: Journal of acquired immune deficiency syndromes (1999) 20080401
Title: Characterization of a novel human immunodeficiency virus type 1 protease inhibitor, A-790742.
Journal: Antimicrobial agents and chemotherapy 20080401
Title: Inhibition of HIV-2 protease by HIV-1 protease inhibitors in clinical use.
Journal: Chemical biology & drug design 20080401
Title: Evidence for different susceptibility to tipranavir and darunavir in patients infected with distinct HIV-1 subtypes.
Journal: AIDS (London, England) 20080312
Title: Association between tipranavir plasma levels and virological response in HIV-infected patients.
Journal: AIDS research and human retroviruses 20080301
Title: High performance liquid chromatographic method for the determination of HIV-1 protease inhibitor tipranavir in plasma of patients during highly active antiretroviral therapy.
Journal: European journal of medical research 20080225
Title: Significant effects of tipranavir on platelet aggregation and thromboxane B2 formation in vitro and in vivo.
Journal: The Journal of antimicrobial chemotherapy 20080201
Title: [New therapeutic options in protracted HIV-infected patients with virological failure].
Journal: Medicina clinica 20080126
Title: Tipranavir exhibits different effects on opportunistic pathogenic fungi.
Journal: The Journal of infection 20080101
Title: Increased risk of bleeding with the use of tipranavir boosted with ritonavir in haemophilic patients.
Journal: Haemophilia : the official journal of the World Federation of Hemophilia 20080101
Title: Health-related quality of life and tolerability in treatment-experienced HIV-1-infected patients on tipranavir versus comparator regimens.
Journal: Antiviral therapy 20080101
Title: Successful use of a tipranavir/ritonavir-based antiretroviral regimen following development of viral resistance to darunavir.
Journal: HIV clinical trials 20080101
Title: Tipranavir: a review of its use in the management of HIV infection.
Journal: Drugs 20080101
Title: New resistance score for tipranavir.
Journal: AIDS reviews 20080101
Title: Cost-effectiveness of tipranavir in treatment-experienced HIV patients in the United States.
Journal: HIV clinical trials 20080101
Title: Clinically significant drug interaction between tipranavir-ritonavir and phenobarbital in an HIV-infected subject.
Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20071215
Title: FDA notifications. Tentative approval to Aptivus for combination ART.
Journal: AIDS alert 20071201
Title: Hill A, Moyle G. Relative antiviral efficacy of ritonavir-boosted darunavir and ritonavir-boosted tipranavir vs. control protease inhibitor in the POWER and RESIST trials. HIV Med 2007; 8: 259-264. Methodological accuracy in cross-trial comparisons of antiretroviral regimens in multitreated patients.
Journal: HIV medicine 20071101
Title: Relative antiviral efficacy should not be inferred from cross-trial comparisons.
Journal: HIV medicine 20071101
Title: Tipranavir: the first nonpeptidic protease inhibitor for the treatment of protease resistance.
Journal: Clinical therapeutics 20071101
Title: Aptivus capsules granted full FDA approval.
Journal: AIDS patient care and STDs 20071101
Title: Treatment response to ritonavir-boosted tipranavir versus ritonavir-boosted lopinavir in HIV-1 patients with higher lopinavir mutation scores.
Journal: AIDS (London, England) 20071018
Title: Potent inhibition of HIV-1 replication by novel non-peptidyl small molecule inhibitors of protease dimerization.
Journal: The Journal of biological chemistry 20070928
Title: Tipranavir: a new option for the treatment of drug-resistant HIV infection.
Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20070915
Title: Combined tipranavir and enfuvirtide use associated with higher plasma tipranavir concentrations but not with increased hepatotoxicity: sub-analysis from RESIST.
Journal: AIDS (London, England) 20070912
Title: In vitro antiviral activity of the novel, tyrosyl-based human immunodeficiency virus (HIV) type 1 protease inhibitor brecanavir (GW640385) in combination with other antiretrovirals and against a panel of protease inhibitor-resistant HIV.
Journal: Antimicrobial agents and chemotherapy 20070901
Title: Tipranavir/T20-based salvage regimens highly effective and durable against HIV-1 with evidence for genotypic predictability of response in clinical practice.
Journal: International journal of STD & AIDS 20070901
Title: Biotransformation and mass balance of tipranavir, a nonpeptidic protease inhibitor, when co-administered with ritonavir in Sprague-Dawley rats.
Journal: The Journal of pharmacy and pharmacology 20070901
Title: Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa.
Journal: Clinical pharmacology and therapeutics 20070801
Title: Long-term efficacy and safety of tipranavir boosted with ritonavir in HIV-1-infected patients failing multiple protease inhibitor regimens: 80-week data from a phase 2 study.
Journal: Journal of acquired immune deficiency syndromes (1999) 20070801
Title: Compromised immunologic recovery in patients receiving tipranavir/ritonavir coadministered with tenofovir and didanosine in Randomized Evaluation of Strategic Intervention in multidrug-resiStant patients with tipranavir (RESIST) studies.
Journal: Journal of acquired immune deficiency syndromes (1999) 20070801
Title: Trial of tipranavir versus darunavir in treatment-experienced patients enrolling.
Journal: AIDS patient care and STDs 20070801
Title: Tipranavir demonstrates potent and durable treatment response in HIV-positive women.
Journal: AIDS patient care and STDs 20070801
Title: Porphyria cutanea tarda in an HIV-1-infected patient after the initiation of tipranavir/ritonavir: case report.
Journal: AIDS (London, England) 20070711
Title: Mechanisms of pharmacokinetic and pharmacodynamic drug interactions associated with ritonavir-enhanced tipranavir.
Journal: Pharmacotherapy 20070601
Title: Relative antiviral efficacy of ritonavir-boosted darunavir and ritonavir-boosted tipranavir vs. control protease inhibitor in the POWER and RESIST trials.
Journal: HIV medicine 20070501
Title: A simple and sensitive assay for determining plasma tipranavir concentration in the clinical setting by new HPLC method.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070401
Title: Tipranavir: a new protease inhibitor for the treatment of antiretroviral-experienced HIV-infected patients.
Journal: Expert opinion on pharmacotherapy 20070401
Title: When and how to use tipranavir and darunavir.
Journal: The AIDS reader 20070401
Title: High-performance liquid chromatography assay for the determination of the HIV-protease inhibitor tipranavir in human plasma in combination with nine other antiretroviral medications.
Journal: Journal of pharmaceutical and biomedical analysis 20070312
Title: Modification of tandem mass spectrometric method to permit simultaneous quantification of 17 anti-HIV drugs which include atazanavir and tipranavir.
Journal: Clinica chimica acta; international journal of clinical chemistry 20070301
Title: Acute pancreatitis caused by tipranavir/ritonavir-induced hypertriglyceridaemia.
Journal: AIDS (London, England) 20070219
Title: Efficacy and safety of three doses of tipranavir boosted with ritonavir in treatment-experienced HIV type-1 infected patients.
Journal: AIDS research and human retroviruses 20070201
Title: Food and Drug Administration analysis of tipranavir clinical resistance in HIV-1-infected treatment-experienced patients.
Journal: AIDS (London, England) 20070111
Title: Anti-HIV agents. Tipranavir for treatment-experienced PHAs.
Journal: TreatmentUpdate 20070101
Title: Anti-HIV agents. Maraviroc--coming soon.
Journal: TreatmentUpdate 20070101
Title: SPRING: a new trial to evaluate tipranavir in heterogeneous treatment-experienced HIV populations.
Journal: AIDS reviews 20070101
Title: Drug interactions of tipranavir, a new HIV protease inhibitor.
Journal: Drug metabolism letters 20070101
Title: Tipranavir without ritonavir does not acutely induce peripheral insulin resistance in a rodent model.
Journal: Journal of acquired immune deficiency syndromes (1999) 20061215
Title: Intracranial hemorrhage with Aptivu.
Journal: AIDS patient care and STDs 20061201
Title: Efficacy of the protease inhibitors tipranavir plus ritonavir in treatment-experienced patients: 24-week analysis from the RESIST-1 trial.
Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20061115
Title: Ritonavir-boosted tipranavir demonstrates superior efficacy to ritonavir-boosted protease inhibitors in treatment-experienced HIV-infected patients: 24-week results of the RESIST-2 trial.
Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20061115
Title: Unexpected drug-drug interaction between tipranavir/ritonavir and enfuvirtide.
Journal: AIDS (London, England) 20061003
Title: Durable efficacy of tipranavir-ritonavir in combination with an optimised background regimen of antiretroviral drugs for treatment-experienced HIV-1-infected patients at 48 weeks in the Randomized Evaluation of Strategic Intervention in multi-drug reSistant patients with Tipranavir (RESIST) studies: an analysis of combined data from two randomised open-label trials.
Journal: Lancet (London, England) 20060805
Title: Liquid chromatographic assay for the non-peptidic protease inhibitor tipranavir in plasma.
Journal: Biomedical chromatography : BMC 20060801
Title: An update and review of antiretroviral therapy.
Journal: Pharmacotherapy 20060801
Title: Determination of tipranavir in human plasma by reverse phase liquid chromatography with UV detection using photodiode array.
Journal: Therapeutic drug monitoring 20060801
Title: New black box warning for ritonavir-boosted tipranavir.
Journal: AIDS clinical care 20060801
Title: Severe hepatotoxicity associated with the combination of enfuvirtide and tipranavir/ritonavir: case report.
Journal: AIDS (London, England) 20060713
Title: Prevention of mother-to-child transmission of multi-drug resistant HIV-1 using maternal therapy with both enfuvirtide and tipranavir.
Journal: AIDS (London, England) 20060626
Title: Susceptibility to protease inhibitors in HIV-2 primary isolates from patients failing antiretroviral therapy.
Journal: The Journal of antimicrobial chemotherapy 20060401
Title: Tipranavir (Aptivus) for HIV.
Journal: Obstetrics and gynecology 20060401
Title: A simple high performance liquid chromatography assay for monitoring plasma concentrations of tipranavir in HIV infected patients.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060307
Title: Determination of the novel non-peptidic HIV-protease inhibitor tipranavir by HPLC-UV after solid-phase extraction.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060217
Title: Practical perspectives on the use of tipranavir in combination with other medications: lessons learned from pharmacokinetic studies.
Journal: Journal of clinical pharmacology 20060201
Title: Quantification of tipranavir in human plasma by high-performance liquid chromatography with UV detection.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060102
Title: Tipranavir: a protease inhibitor for multi-drug resistant HIV-1.
Journal: Expert opinion on investigational drugs 20060101
Title: [Tipranavir (used with ritonavir)].
Journal: Revue de l'infirmiere 20060101
Title: New drugs: ramelteon, tipranavir, nepafenac, and deferasirox.
Journal: Journal of the American Pharmacists Association : JAPhA 20060101
Title: Tipranavir: PNU 140690, tipranivir.
Journal: Drugs in R&D 20060101
Title: 48-weeks of the RESIST trials.
Journal: AIDS reviews 20060101
Title: Three-year final results of the NEFA simplification trial.
Journal: AIDS reviews 20060101
Title: Tipranavir: a protease inhibitor for HIV salvage therapy.
Journal: The Annals of pharmacotherapy 20060101
Title: Concomitant use of an active boosted protease inhibitor with enfuvirtide in treatment-experienced, HIV-infected individuals: recent data and consensus recommendations.
Journal: HIV clinical trials 20060101
Title: Tipranavir: a novel nonpeptidic protease inhibitor of HIV.
Journal: Clinical pharmacokinetics 20060101
Title: New protease inhibitor offers clinicians hope for better salvage therapy.
Journal: HIV clinician 20060101
Title: Investigation of baseline susceptibility to protease inhibitors in HIV-1 subtypes C, F, G and CRF02_AG.
Journal: Antiviral therapy 20060101
Title: Detection of HIV protease inhibitors in alveolar epithelial lining fluid: relevance for modulation of pneumocystis infection in the course of HAART.
Journal: The Journal of eukaryotic microbiology 20060101
Title: The non-peptidic HIV protease inhibitor tipranavir and two synthetic peptidomimetics (TS98 and TS102) modulate Pneumocystis carinii growth and proteasome activity of HEL299 cell line.
Journal: The Journal of eukaryotic microbiology 20060101
Title: Drug interactions. Unexpected interaction between T-20 and some protease inhibitors.
Journal: TreatmentUpdate 20060101
Title: 48-week RESIST data confirms TPV benefit.
Journal: IAPAC monthly 20060101
Title: Structure elucidation and total synthesis of a unique group of trace impurities in Tipranavir drug product.
Journal: Magnetic resonance in chemistry : MRC 20051201
Title: Tipranavir.
Journal: Nature reviews. Drug discovery 20051201
Title: Protease inhibitors: the current status.
Journal: Journal of HIV therapy 20051201
Title: FDA notifications. Accelerated approval of tipranavir.
Journal: AIDS alert 20051101
Title: Tipranavir.
Journal: Drugs of today (Barcelona, Spain : 1998) 20051101
Title: Tipranavir (Aptivus) for HIV.
Journal: The Medical letter on drugs and therapeutics 20051010
Title: Selection and characterization of HIV-1 showing reduced susceptibility to the non-peptidic protease inhibitor tipranavir.
Journal: Antiviral research 20051001
Title: New drugs and dosage forms.
Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20050915
Title: Tipranavir gets approved.
Journal: AIDS patient care and STDs 20050901
Title: Boehringer drug for resistant HIV approved.
Journal: The AIDS reader 20050801
Title: Protease inhibitor get nod from panel.
Journal: AIDS patient care and STDs 20050801
Title: FDA approval: tipranavir.
Journal: AIDS clinical care 20050801
Title: New drugs.
Journal: HIV medicine 20050701
Title: FDA approves Aptivus (tipranavir).
Journal: The Hopkins HIV report : a bimonthly newsletter for healthcare providers 20050701
Title: FDA approves tipranavir.
Journal: IAPAC monthly 20050701
Title: Tipranavir (Aptivus): approval cautiously recommended.
Journal: AIDS treatment news 20050527
Title: [Perspectives: hope for therapy experienced patients. Tipranavir shows superior effectiveness with comparable safety].
Journal: MMW Fortschritte der Medizin 20050425
Title: Design of HIV-1 protease inhibitors active on multidrug-resistant virus.
Journal: Journal of medicinal chemistry 20050324
Title: Tipranavir: FDA advisory committee will meet May 19, hear experts, public comment.
Journal: AIDS treatment news 20050225
Title: Estimated extent of cross-resistance to ritonavir-boosted protease inhibitors among protease inhibitors-experienced patients: implications for tipranavir use.
Journal: AIDS patient care and STDs 20050201
Title: Tipranavir: a novel second-generation nonpeptidic protease inhibitor.
Journal: Expert review of anti-infective therapy 20050201
Title: Molecular significance of tipranavir related codon 33 protease gene mutations.
Journal: AIDS (London, England) 20050128
Title: New 2-bromomethyl-8-substituted-benzo[c]chromen-6-ones. Synthesis and biological properties.
Journal: Bioorganic & medicinal chemistry letters 20050103
Title: RESIST-1 results released.
Journal: AIDS patient care and STDs 20050101
Title: Updates on developments in HIV therapeutics.
Journal: The AIDS reader 20050101
Title: Tipranavir favored in RESIST-2.
Journal: AIDS patient care and STDs 20050101
Title: Meeting notes from ICAAC. Ritonavir-boosted tipranavir proves beneficial in treatment-experienced patients.
Journal: AIDS clinical care 20050101
Title: Tipranavir: a ritonavir-boosted protease inhibitor.
Journal: Drugs 20050101
Title: A lame duck, a dark horse, and a goat.
Journal: GMHC treatment issues : the Gay Men's Health Crisis newsletter of experimental AIDS therapies 20050101
Title: Aptivus in the hotseat. Excerpts from the FDA hearings.
Journal: GMHC treatment issues : the Gay Men's Health Crisis newsletter of experimental AIDS therapies 20050101
Title: Salvage therapy update.
Journal: Survival news (Atlanta, Ga.) 20050101
Title: New therapy for advanced HIV.
Journal: FDA consumer 20050101
Title: Anti-HIV agents. Tipranavir in treatment-experienced PHAs.
Journal: TreatmentUpdate 20050101
Title: A combined QM/MM approach to protein--ligand interactions: polarization effects of the HIV-1 protease on selected high affinity inhibitors.
Journal: Journal of medicinal chemistry 20041230
Title: Approval application for tipranavir.
Journal: AIDS patient care and STDs 20041201
Title: Codevelopment of new antiretrovirals in very treatment-experienced HIV-infected individuals.
Journal: Lancet (London, England) 20040901
Title: Management of HIV-infected patients with multidrug-resistant virus.
Journal: Current HIV/AIDS reports 20040901
Title: The influence of protease inhibitor resistance profiles on selection of HIV therapy in treatment-naive patients.
Journal: Antiviral therapy 20040601
Title: Simultaneous quantification of the new HIV protease inhibitors atazanavir and tipranavir in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040525
Title: [New protease inhibitor for PI pretreated patients. Tipranavir targets also multiresistant viruses].
Journal: MMW Fortschritte der Medizin 20040426
Title: A 14-day dose-response study of the efficacy, safety, and pharmacokinetics of the nonpeptidic protease inhibitor tipranavir in treatment-naive HIV-1-infected patients.
Journal: Journal of acquired immune deficiency syndromes (1999) 20040401
Title: Analysis of protease inhibitor combinations in vitro: activity of lopinavir, amprenavir and tipranavir against HIV type 1 wild-type and drug-resistant isolates.
Journal: The Journal of antimicrobial chemotherapy 20040301
Title: How flexible is tipranavir in complex with the HIV-1 protease active site?
Journal: AIDS (London, England) 20040220
Title: Tipranavir: the first nonpeptidic protease inhibitor.
Journal: BETA : bulletin of experimental treatments for AIDS : a publication of the San Francisco AIDS Foundation 20040101
Title: Initial therapy for human immunodeficiency virus: broadening the options.
Journal: HIV clinical trials 20040101
Title: Non-peptidic HIV protease inhibitors.
Journal: Current topics in medicinal chemistry 20040101
Title: Strategies for overcoming resistance in HIV-1 infected patients receiving HAART.
Journal: AIDS reviews 20040101
Title: Pharmacokinetic characterization of different dose combinations of coadministered tipranavir and ritonavir in healthy volunteers.
Journal: HIV clinical trials 20040101
Title: The RESIST trials--superiority of tipranavir over other PIs.
Journal: AIDS reviews 20040101
Title: Anti-HIV agents. Unexpected results from a tipranavir study.
Journal: TreatmentUpdate 20040101
Title: Tipranavir: a novel non-peptidic protease inhibitor for the treatment of HIV infection.
Journal: Expert opinion on investigational drugs 20031101
Title: Tipranavir: a protease inhibitor from a new class with distinct antiviral activity.
Journal: Journal of acquired immune deficiency syndromes (1999) 20030901
Title: Reviving protease inhibitors: new data and more options.
Journal: Journal of acquired immune deficiency syndromes (1999) 20030601
Title: [Treatment outcome with anti-HIV agent Tipranavir].
Journal: Deutsche medizinische Wochenschrift (1946) 20030509
Title: [Non-peptide protease inhibitor in phase III study. Tipranavir--control of multidrug resistant viruses].
Journal: MMW Fortschritte der Medizin 20030428
Title: Tipranavir.
Journal: Drugs 20030101
Title: Tipranavir.
Journal: Drugs 20030101
Title: Tipranavir.
Journal: Drugs 20030101
Title: Utilization of molybdenum- and palladium-catayzed dynamic kinetic asymmetric transformations for the preparation of tertiary and quaternary stereogenic centers: a concise synthesis of tipranavir.
Journal: Journal of the American Chemical Society 20021204
Title: Tipranavir reduces viral load.
Journal: AIDS patient care and STDs 20020901
Title: In vitro antiviral interaction of lopinavir with other protease inhibitors.
Journal: Antimicrobial agents and chemotherapy 20020701
Title: New antiretroviral may help failing PI regimens.
Journal: AIDS alert 20010901
Title: Two sulfonamides-containing dihydropyrone derivatives as HIV protease inhibitors.
Journal: Archiv der Pharmazie 20010701
Title: New antiretroviral agents.
Journal: The Hopkins HIV report : a bimonthly newsletter for healthcare providers 20010301
Title: New hope in tipranavir. New Boehringer-Ingelheim protease inhibitor may succeed where others fall short.
Journal: Positive living (Los Angeles, Calif.) 20010101
Title: 6-Hydroxy-1,3-dioxin-4-ones as non-peptidic HIV protease inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20001204
Title: Tipranavir inhibits broadly protease inhibitor-resistant HIV-1 clinical samples.
Journal: AIDS (London, England) 20000908
Title: In-vitro tipranavir susceptibility of HIV-1 isolates with reduced susceptibility to other protease inhibitors.
Journal: AIDS (London, England) 20000107
Title: Tipranavir (PNU-140690): a potent, orally bioavailable nonpeptidic HIV protease inhibitor of the 5,6-dihydro-4-hydroxy-2-pyrone sulfonamide class.
Journal: Journal of medicinal chemistry 19980827
Title: In vitro combination of PNU-140690, a human immunodeficiency virus type 1 protease inhibitor, with ritonavir against ritonavir-sensitive and -resistant clinical isolates.
Journal: Antimicrobial agents and chemotherapy 19971101
Title: Antiviral activity of the dihydropyrone PNU-140690, a new nonpeptidic human immunodeficiency virus protease inhibitor.
Journal: Antimicrobial agents and chemotherapy 19970501
Title: Structure-based design of HIV protease inhibitors: sulfonamide-containing 5,6-dihydro-4-hydroxy-2-pyrones as non-peptidic inhibitors.
Journal: Journal of medicinal chemistry 19961025
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