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189388-22-5,MFCD01321063
Catalog No.:AA002DK4

189388-22-5 | L-Phenylalaninamide, L-tyrosyl-L-prolyl-L-tryptophyl-

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5mg
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10mg
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25mg
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002DK4
Chemical Name:
L-Phenylalaninamide, L-tyrosyl-L-prolyl-L-tryptophyl-
CAS Number:
189388-22-5
Molecular Formula:
C34H38N6O5
Molecular Weight:
610.7027
MDL Number:
MFCD01321063
SMILES:
Oc1ccc(cc1)C[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N)Cc1ccccc1)Cc1c[nH]c2c1cccc2)N
Properties
Computed Properties
 
Complexity:
1030  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
45  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
6  
Rotatable Bond Count:
12  
XLogP3:
2.4  

Literature

Title: Involvement of multiple µ-opioid receptor subtypes on the presynaptic or postsynaptic inhibition of spinal pain transmission.

Journal: Peptides 20140101

Title: Mapping of reinforcing and analgesic effects of the mu opioid agonist endomorphin-1 in the ventral midbrain of the rat.

Journal: Psychopharmacology 20121101

Title: Opiorphin highly improves the specific binding and affinity of MERF and MEGY to rat brain opioid receptors.

Journal: Regulatory peptides 20121010

Title: Synthesis and biological evaluation of an orally active glycosylated endomorphin-1.

Journal: Journal of medicinal chemistry 20120628

Title: Regulatory mechanism of body temperature in the central nervous system during the maintenance phase of hibernation in Syrian hamsters: involvement of β-endorphin.

Journal: Brain research 20120411

Title: Fast, selective, and sensitive analysis of low-abundance peptides in human plasma by electromembrane extraction.

Journal: Analytica chimica acta 20120224

Title: Lipo-endomorphin-1 derivatives with systemic activity against neuropathic pain without producing constipation.

Journal: PloS one 20120101

Title: Effects of endokinin A/B, endokinin C/D, and endomorphin-1 on the regulation of mean arterial blood pressure in rats.

Journal: Peptides 20111201

Title: Structural basis for inhibiting β-amyloid oligomerization by a non-coded β-breaker-substituted endomorphin analogue.

Journal: ACS chemical biology 20111118

Title: Morphine protects against intracellular amyloid toxicity by inducing estradiol release and upregulation of Hsp70.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20111109

Title: Short reaction of C-peptide, glucagon-like peptide-1, ghrelin and endomorphin-1 for different style diet in type 2 diabetic patients.

Journal: Chinese medical journal 20111101

Title: The antinociceptive potency of N-arachidonoyl-dopamine (NADA) and its interaction with endomorphin-1 at the spinal level.

Journal: Pharmacology, biochemistry, and behavior 20111001

Title: The inverse type II β-turn on D-Trp-Phe, a pharmacophoric motif for MOR agonists.

Journal: ChemMedChem 20110905

Title: Antinociception by endogenous ligands at peripheral level.

Journal: Ideggyogyaszati szemle 20110330

Title: Design, synthesis, pharmacological evaluation, and structure-activity study of novel endomorphin analogues with multiple structural modifications.

Journal: Journal of medicinal chemistry 20110310

Title: Synthesis and antinociceptive effects of endomorphin-1 analogs with C-terminal linked by oligoarginine.

Journal: Peptides 20110201

Title: Effects of endomorphins on human umbilical vein endothelial cells under high glucose.

Journal: Peptides 20110101

Title: Peripheral antinociceptive effects of the cyclic endomorphin-1 analog c[YpwFG] in a mouse visceral pain model.

Journal: Peptides 20101101

Title: G-protein-independent modulation of P-type calcium channels by mu-opioids in Purkinje neurons of rat.

Journal: Neuroscience letters 20100816

Title: Recent advances in endomorphin engineering.

Journal: ChemMedChem 20100802

Title: A protective effect of endomorphins on the oxidative injury of islet.

Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20100801

Title: micro-Opioid receptor stimulation in the medial subnucleus of the tractus solitarius inhibits gastric tone and motility by reducing local GABA activity.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20100801

Title: Peripheral antinociceptive effect of 2-arachidonoyl-glycerol and its interaction with endomorphin-1 in arthritic rat ankle joints.

Journal: Clinical and experimental pharmacology & physiology 20100501

Title: Design, synthesis and pharmacological characterization of endomorphin analogues with non-cyclic amino acid residues in position 2.

Journal: Basic & clinical pharmacology & toxicology 20100201

Title: Peripheral endomorphin-1 levels are suppressed in diabetic patients.

Journal: Diabetes research and clinical practice 20100201

Title: The effect of opioids and their antagonists on the nocifensive response of Caenorhabditis elegans to noxious thermal stimuli.

Journal: Invertebrate neuroscience : IN 20091201

Title: Immunoreactive endomorphin 2 is generated extracellularly in rat isolated L4,5 dorsal root ganglia by DPP-IV.

Journal: Regulatory peptides 20091009

Title: The peripheral antinociceptive effects of endomorphin-1 and kynurenic acid in the rat inflamed joint model.

Journal: Anesthesia and analgesia 20091001

Title: Chloroquine transport via the malaria parasite's chloroquine resistance transporter.

Journal: Science (New York, N.Y.) 20090925

Title: Inducible expression of functional mu opioid receptors in murine dendritic cells.

Journal: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 20090901

Title: Synthesis and evaluation of new endomorphin analogues modified at the Pro(2) residue.

Journal: Bioorganic & medicinal chemistry letters 20090801

Title: Biological activity of endomorphin and [Dmt1]endomorphin analogs with six-membered proline surrogates in position 2.

Journal: Bioorganic & medicinal chemistry 20090601

Title: The effects of endomorphins on striatal [3H]GABA release induced by electrical stimulation: an in vitro superfusion study in rats.

Journal: Neurochemical research 20090501

Title: Antinociceptive interactions between anandamide and endomorphin-1 at the spinal level.

Journal: Clinical and experimental pharmacology & physiology 20090401

Title: Endomorphin 1- and endomorphin 2-containing neurons in nucleus tractus solitarii send axons to the parabrachial nuclei in the rat.

Journal: Anatomical record (Hoboken, N.J. : 2007) 20090401

Title: Practical aspects of in vivo detection of neuropeptides by microdialysis coupled off-line to capillary LC with multistage MS.

Journal: Analytical chemistry 20090315

Title: P2X receptors in sensory neurons co-cultured with cancer cells exhibit a decrease in opioid sensitivity.

Journal: The European journal of neuroscience 20090101

Title: [Endomorphins--endogenous ligands of the mu-opioid receptor].

Journal: Postepy biochemii 20090101

Title: Functional coupling of mu-receptor-Galphai-tethered proteins in AtT20 cells.

Journal: Neuroreport 20081203

Title: Enzymatic degradation of endomorphins.

Journal: Peptides 20081101

Title: Mu-opioid receptor in the nucleus submedius: involvement in opioid-induced inhibition of mirror-image allodynia in a rat model of neuropathic pain.

Journal: Neurochemical research 20081001

Title: Endomorphins interact with the substance P (SP) aminoterminal SP(1-7) binding in the ventral tegmental area of the rat brain.

Journal: Peptides 20081001

Title: Capsaicin inhibits the in vitro binding of peptides selective for mu- and kappa-opioid, and nociceptin-receptors.

Journal: Brain research bulletin 20080930

Title: Endomorphin 1 effectively protects cadmium chloride-induced hepatic damage in mice.

Journal: Toxicology 20080929

Title: Possible involvement of dynorphin A release via mu1-opioid receptor on supraspinal antinociception of endomorphin-2.

Journal: Peptides 20080901

Title: (+)-Morphine attenuates the (-)-morphine-produced conditioned place preference and the mu-opioid receptor-mediated dopamine increase in the posterior nucleus accumbens of the rat.

Journal: European journal of pharmacology 20080610

Title: Differential cardiovascular effects of synthetic peptides derived from endomorphin-1 in anesthetized rats.

Journal: Peptides 20080601

Title: Synthesis and in vitro evaluation of a library of modified endomorphin 1 peptides.

Journal: Bioorganic & medicinal chemistry 20080601

Title: The spinal antinociceptive effects of endomorphins in rats: behavioral and G protein functional studies.

Journal: Anesthesia and analgesia 20080601

Title: Opioid-induced regulation of mu-opioid receptor gene expression in the MCF-7 breast cancer cell line.

Journal: Biochemistry and cell biology = Biochimie et biologie cellulaire 20080601

Title: [Analysis of central mechanisms involved in gastric mucosal integrity].

Journal: Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology 20080601

Title: In vitro stability and permeability studies of liposomal delivery systems for a novel lipophilic endomorphin 1 analogue.

Journal: International journal of pharmaceutics 20080522

Title: YFa, a chimeric opioid peptide, induces kappa-specific antinociception with no tolerance development during 6 days of chronic treatment.

Journal: Journal of neuroscience research 20080515

Title: Internalisation of the mu-opioid receptor by endomorphin-1 and leu-enkephalin is dependant on aromatic amino acid residues.

Journal: Bioorganic & medicinal chemistry 20080415

Title: Endomorphins and morphine limit anoxia-reoxygenation-induced brain mitochondrial dysfunction in the mouse.

Journal: Life sciences 20080326

Title: Role of GABA B receptors in the endomorphin-1-, but not endomorphin-2-, induced dopamine efflux in the nucleus accumbens of freely moving rats.

Journal: European journal of pharmacology 20080310

Title: Role of GABAA receptors in the endomorphin-1-, but not endomorphin-2-, induced dopamine efflux in the nucleus accumbens of freely moving rats.

Journal: European journal of pharmacology 20080202

Title: Endomorphin-1 inhibits the activation and the development of a hyporesponsive-like phenotype in lipopolysaccharide- stimulated THP-1 monocytes.

Journal: International journal of immunopathology and pharmacology 20080101

Title: Search of the human proteome for endomorphin-1 and endomorphin-2 precursor proteins.

Journal: Life sciences 20071201

Title: From MIF-1 to endomorphin: the Tyr-MIF-1 family of peptides.

Journal: Peptides 20071201

Title: [N-allyl-Dmt1]-endomorphins are micro-opioid receptor antagonists lacking inverse agonist properties.

Journal: The Journal of pharmacology and experimental therapeutics 20071001

Title: Melatonin attenuates the development of antinociceptive tolerance to delta-, but not to mu-opioid receptor agonist in mice.

Journal: Behavioural brain research 20070822

Title: Colocalization and shared distribution of endomorphins with substance P, calcitonin gene-related peptide, gamma-aminobutyric acid, and the mu opioid receptor.

Journal: The Journal of comparative neurology 20070710

Title: Antinociceptive interactions of triple and quadruple combinations of endogenous ligands at the spinal level.

Journal: Brain research 20070625

Title: A Tyr-W-MIF-1 analog containing D-Pro2 discriminates among antinociception in mice mediated by different classes of mu-opioid receptors.

Journal: European journal of pharmacology 20070601

Title: Differential receptor binding characteristics of consecutive phenylalanines in micro-opioid specific peptide ligand endomorphin-2.

Journal: Bioorganic & medicinal chemistry 20070601

Title: In vitro characterization of the effects of endomorphin 1 and 2, endogenous ligands for mu-opioid receptors, on mouse colonic motility.

Journal: Biochemical pharmacology 20070501

Title: The in vitro pharmacology of the peripherally restricted opioid receptor antagonists, alvimopan, ADL 08-0011 and methylnaltrexone.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20070501

Title: Antidepressant-like effect of endomorphin-1 and endomorphin-2 in mice.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070401

Title: Comparison of the in vitro apparent permeability and stability of opioid mimetic compounds with that of the native peptide.

Journal: Bioorganic & medicinal chemistry letters 20070401

Title: Cardiovascular responses to intrathecal administration of endomorphins in anesthetized rats.

Journal: Peptides 20070401

Title: Structure-activity study on the spatial arrangement of the third aromatic ring of endomorphins 1 and 2 using an atypical constrained C terminus.

Journal: ChemMedChem 20070301

Title: Human dipeptidyl peptidase III acts as a post-proline-cleaving enzyme on endomorphins.

Journal: Biological chemistry 20070301

Title: Synthesis and characterization of potent and selective mu-opioid receptor antagonists, [Dmt(1), D-2-Nal(4)]endomorphin-1 (Antanal-1) and [Dmt(1), D-2-Nal(4)]endomorphin-2 (Antanal-2).

Journal: Journal of medicinal chemistry 20070208

Title: Transformation of mu-opioid receptor agonists into biologically potent mu-opioid receptor antagonists.

Journal: Bioorganic & medicinal chemistry 20070201

Title: Organization of endogenous opioids in the rostral agranular insular cortex of the rat.

Journal: The Journal of comparative neurology 20070120

Title: Paradoxical hyperalgesia induced by mu-opioid receptor agonist endomorphin-2, but not endomorphin-1, microinjected into the centromedial amygdala of the rat.

Journal: European journal of pharmacology 20070112

Title: Morphine-stimulated nitric oxide release in rabbit aqueous humor.

Journal: Experimental eye research 20070101

Title: The effects of endomorphins and diprotin A on striatal dopamine release induced by electrical stimulation-an in vitro superfusion study in rats.

Journal: Neurochemistry international 20061201

Title: Modulation of neuronal CXCR4 by the micro-opioid agonist DAMGO.

Journal: Journal of neurovirology 20061201

Title: Abnormal modulation of cholinergic neurotransmission by endomorphin 1 and endomorphin 2 in isolated bronchus of type 1 diabetic rats.

Journal: Peptides 20061101

Title: Endomorphin1 and endomorphin2, endogenous potent inhibitors of electrical field stimulation (EFS)-induced cholinergic contractions of rat isolated bronchus.

Journal: Peptides 20060701

Title: Involvement of spinal mu1-opioid receptors on the Tyr-d-Arg-Phe-sarcosine-induced antinociception.

Journal: European journal of pharmacology 20060701

Title: Partial and full agonism in endomorphin derivatives: comparison by null and operational model.

Journal: Peptides 20060601

Title: Functional characterization of opioid receptor ligands by aequorin luminescence-based calcium assay.

Journal: The Journal of pharmacology and experimental therapeutics 20060601

Title: Potent in vivo antinociception and opioid receptor preference of the novel analogue [Dmt1]endomorphin-1.

Journal: Pharmacology, biochemistry, and behavior 20060601

Title: Peripheral antinociceptive effects of exogenous and immune cell-derived endomorphins in prolonged inflammatory pain.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20060419

Title: Differential activation of G-proteins by mu-opioid receptor agonists.

Journal: British journal of pharmacology 20060301

Title: Protective effects of endomorphins, endogenous opioid peptides in the brain, on human low density lipoprotein oxidation.

Journal: The FEBS journal 20060301

Title: Endomorphin-2 and endomorphin-1 promote the extracellular amount of accumbal dopamine via nonopioid and mu-opioid receptors, respectively.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060201

Title: A new electrochemical HPLC method for analysis of enkephalins and endomorphins.

Journal: Journal of neuroscience methods 20060115

Title: C-terminal amide to alcohol conversion changes the cardiovascular effects of endomorphins in anesthetized rats.

Journal: Peptides 20060101

Title: The reciprocal connections of endomorphin 1- and endomorphin 2-containing neurons between the hypothalamus and nucleus tractus solitarii in the rat.

Journal: Neuroscience 20060101

Title: Inhibition by endomorphin-1 and endomorphin-2 of excitatory transmission in adult rat substantia gelatinosa neurons.

Journal: Neuroscience 20060101

Title: Endomorphins restored the endothelium-dependent relaxation of the rabbit aorta rings exposed to high D-glucose condition via NO-cGMP pathway.

Journal: Protein and peptide letters 20060101

Title: Endomorphin-1 is more potent than endomorphin-2 in inhibition of synaptic transmission in substantia gelatinosa of adult rat spinal cord.

Journal: The International journal of neuroscience 20051101

Title: Vasorelaxant responses to endomorphin1[psi] and endomorphin2[psi], analogues of endomorphins, in rat aorta rings.

Journal: Die Pharmazie 20051101

Title: Reduced suppression of CO2-induced ventilatory stimulation by endomorphins relative to morphine.

Journal: Brain research 20051019

Title: Chronic arthritis down-regulates peripheral mu-opioid receptor expression with concomitant loss of endomorphin 1 antinociception.

Journal: Arthritis and rheumatism 20051001

Title: Aromatic-aromatic and proline-aromatic interactions in endomorphin-1 and endomorphin-2.

Journal: European journal of medicinal chemistry 20050701

Title: Modulation of synaptic transmission in the rat nucleus of the solitary tract by endomorphin-1.

Journal: Journal of neurophysiology 20050501

Title: [TIC4]endomorphins, analogues of endomorphins, have significantly enhanced vasorelaxant effects in rat aorta rings.

Journal: Protein and peptide letters 20050501

Title: Cardiovascular effects of endomorphins in alloxan-induced diabetic rats.

Journal: Peptides 20050401

Title: Differential mechanisms of antianalgesia induced by endomorphin-1 and endomorphin-2 in the ventral periaqueductal gray of the rat.

Journal: The Journal of pharmacology and experimental therapeutics 20050301

Title: Substance P and opioid peptidergic innervation of the anterior eye segment of the rat: an immunohistochemical study.

Journal: Journal of anatomy 20050301

Title: Effects of morphine and endomorphins on the polysynaptic reflex in the isolated rat spinal cord.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20050101

Title: Internalization and down-regulation of mu opioid receptors by endomorphins and morphine in SH-SY5Y human neuroblastoma cells.

Journal: Brain research 20041203

Title: Effects of nociceptin/orphanin FQ and endomorphin-1 on glutamate and GABA release, intracellular [Ca2+] and cell excitability in primary cultures of rat cortical neurons.

Journal: Neuropharmacology 20041101

Title: Analgesic tolerance and cross-tolerance to i.c.v. endomorphin-1, endomorphin-2, and morphine in mice.

Journal: Neuroscience letters 20040812

Title: Opposite conditioned place preference responses to endomorphin-1 and endomorphin-2 in the mouse.

Journal: Neuroscience letters 20040729

Title: Differential conditioned place preference responses to endomorphin-1 and endomorphin-2 microinjected into the posterior nucleus accumbens shell and ventral tegmental area in the rat.

Journal: The Journal of pharmacology and experimental therapeutics 20040501

Title: Morphine and endomorphin-1 differently influence pronociceptin/orphanin FQ system in neuropathic rats.

Journal: Pharmacology, biochemistry, and behavior 20040501

Title: Influence of ethanol dependence and methionine enkephalin antisense on serum endomorphin-1 and methionine enkephalin levels.

Journal: Alcoholism, clinical and experimental research 20040501

Title: Endomorphins exit the brain by a saturable efflux system at the basolateral surface of cerebral endothelial cells.

Journal: Experimental brain research 20040501

Title: Loss of vasomotor responsiveness to the mu-opioid receptor ligand endomorphin-1 in adjuvant monoarthritic rat knee joints.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20040401

Title: Supraspinal anti-allodynic and rewarding effects of endomorphins in rats.

Journal: Peptides 20040401

Title: DAMGO suppresses both excitatory and inhibitory synaptic transmission in supraoptic neurones of mouse hypothalamic slice preparations.

Journal: Journal of neuroendocrinology 20040301

Title: The antinociceptive potencies and interactions of endogenous ligands during continuous intrathecal administration: adenosine, agmatine, and endomorphin-1.

Journal: Anesthesia and analgesia 20040201

Title: Attenuation of knee joint inflammation by peripherally administered endomorphin-1.

Journal: Journal of molecular neuroscience : MN 20040101

Title: Reduced expression of a novel mu-opioid receptor (MOR) subtype MOR-1B in CXBK mice: implications of MOR-1B in the expression of MOR-mediated responses.

Journal: The European journal of neuroscience 20031201

Title: Lack of mu-opioid receptor-mediated G-protein activation in the spinal cord of mice lacking Exon 1 or Exons 2 and 3 of the MOR-1 gene.

Journal: Journal of pharmacological sciences 20031201

Title: Endomorphins, endogenous opioid peptides, provide antioxidant defense in the brain against free radical-induced damage.

Journal: Biochimica et biophysica acta 20031120

Title: Effects of endomorphin on substantia gelatinosa neurons in rat spinal cord slices.

Journal: British journal of pharmacology 20031101

Title: Intrathecal treatment with 6-hydroxydopamine or 5,7-dihydroxytryptamine blocks the antinociception induced by endomorphin-1 and endomorphin-2 given intracerebroventricularly in the mouse.

Journal: Journal of pharmacological sciences 20031101

Title: Morphine and endomorphins differentially regulate micro-opioid receptor mRNA in SHSY-5Y human neuroblastoma cells.

Journal: The Journal of pharmacology and experimental therapeutics 20030801

Title: Endomorphin-1 causes synovial hypoaemia in rat knee joints via a capsaicin-sensitive neural pathway.

Journal: Neuroscience letters 20030619

Title: Heterologous mu-opioid receptor adaptation by repeated stimulation of kappa-opioid receptor: up-regulation of G-protein activation and antinociception.

Journal: Journal of neurochemistry 20030601

Title: Antinociception by a peripherally administered novel endomorphin-1 analogue containing beta-proline.

Journal: European journal of pharmacology 20030523

Title: Stability against enzymatic hydrolysis of endomorphin-1 analogues containing beta-proline.

Journal: Organic & biomolecular chemistry 20030507

Title: Endomorphin-1, an endogenous mu-opioid receptor agonist, improves apomorphine-induced impairment of prepulse inhibition in mice.

Journal: Peptides 20030501

Title: The antitussive effects of endomorphin-1 and endomorphin-2 in mice.

Journal: European journal of pharmacology 20030425

Title: Nifedipine potentiates the antinociceptive effect of endomorphin-1 microinjected into the periaqueductal gray in rats.

Journal: Anesthesia and analgesia 20030401

Title: The effect of endomorphins on the release of 3H-norepinephrine from rat nucleus tractus solitarii slices.

Journal: Regulatory peptides 20030328

Title: Estrogen receptor-alpha is required for estrogen-induced mu-opioid receptor internalization.

Journal: Journal of neuroscience research 20030315

Title: Endomorphin-1 and -2 induce naloxone-precipitated withdrawal syndromes in rats.

Journal: Peptides 20030301

Title: Evaluation of endomorphin-1 on the activity of Na(+),K(+)-ATPase using in vitro and in vivo studies.

Journal: European journal of pharmacology 20030105

Title: The involvement of dopamine and nitric oxide in the endocrine and behavioural action of endomorphin-1.

Journal: Neuroscience 20030101

Title: Loss of mu-opioid receptor-mediated G-protein activation in the pons/medulla of mice lacking the exons 2 and 3 of mu-opioid receptor gene.

Journal: Neuroscience letters 20021225

Title: Endomorphin-1 and -2 immunoreactive cells in the hypothalamus are labeled by fluoro-gold injections to the ventral tegmental area.

Journal: The Journal of comparative neurology 20021216

Title: Cross-tolerance between the different mu-opioid receptor agonists endomorphin-1, endomorphin-2 and morphine at the spinal level in the rat.

Journal: Neuroscience letters 20021213

Title: Endomorphin analogues containing D-Pro2 discriminate different mu-opioid receptor mediated antinociception in mice.

Journal: British journal of pharmacology 20021201

Title: Spinal pretreatment with antisense oligodeoxynucleotides against exon-1, -4, or -8 of mu-opioid receptor clone leads to differential loss of spinal endomorphin-1-and endomorphin-2-induced antinociception in the mouse.

Journal: The Journal of pharmacology and experimental therapeutics 20021101

Title: [Analgesic effect of kynurenic acid].

Journal: Ideggyogyaszati szemle 20020920

Title: The structure of an endomorphin analogue incorporating 1-aminocyclohexane-1-carboxlylic acid for proline is similar to the beta-turn of Leu-enkephalin.

Journal: Biochemical and biophysical research communications 20020913

Title: Endomorphins suppress nociception-induced c-Fos and Zif/268 expression in the rat spinal dorsal horn.

Journal: European journal of pharmacology 20020906

Title: Endomorphins 1 and 2 inhibit IL-10 and IL-12 production and innate immune functions, and potentiate NF-kappaB DNA binding in THP-1 differentiated to macrophage-like cells.

Journal: Scandinavian journal of immunology 20020901

Title: In vitro quantitative study of the degradation of endomorphins.

Journal: Peptides 20020901

Title: Anatomical and functional correlation of the endomorphins with mu opioid receptor splice variants.

Journal: The European journal of neuroscience 20020901

Title: The alpha9/alpha10-containing nicotinic ACh receptor is directly modulated by opioid peptides, endomorphin-1, and dynorphin B, proposed efferent cotransmitters in the inner ear.

Journal: Molecular and cellular neurosciences 20020801

Title: Ultrastructure of endomorphin-1 immunoreactivity in the rat dorsal pontine tegmentum: evidence for preferential targeting of peptidergic neurons in Barrington's nucleus rather than catecholaminergic neurons in the peri-locus coeruleus.

Journal: The Journal of comparative neurology 20020701

Title: The antinociceptive properties of endomorphin-1 and endomorphin-2 in the mouse.

Journal: Japanese journal of pharmacology 20020701

Title: Differential antinociceptive effects induced by intrathecally-administered endomorphin-1 and endomorphin-2 in mice.

Journal: Japanese journal of pharmacology 20020701

Title: Endomorphin-induced motivational effect: differential mechanism of endomorphin-1 and endomorphin-2.

Journal: Japanese journal of pharmacology 20020701

Title: Differential mechanism of G-protein activation induced by endogenous mu-opioid peptides, endomorphin and beta-endorphin.

Journal: Japanese journal of pharmacology 20020701

Title: Endomorphins 1 and 2 induce amnesia via selective modulation of dopamine receptors in mice.

Journal: European journal of pharmacology 20020620

Title: The antinociceptive effect of intrathecal kynurenic acid and its interaction with endomorphin-1 in rats.

Journal: European journal of pharmacology 20020607

Title: Endomorphin-1 analogues containing beta-proline are mu-opioid receptor agonists and display enhanced enzymatic hydrolysis resistance.

Journal: Journal of medicinal chemistry 20020606

Title: Opioid peptides endomorphin-1 and endomorphin-2 in the immune system in humans and in a rodent model of inflammation.

Journal: Annals of the New York Academy of Sciences 20020601

Title: Differential antagonism of endomorphin-1 and endomorphin-2 supraspinal antinociception by naloxonazine and 3-methylnaltrexone.

Journal: Peptides 20020501

Title: Endomorphins, Met-enkephalin, Tyr-MIF-1, and the P-glycoprotein efflux system.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20020301

Title: Involvement of mu(1)-opioid receptors and cholinergic neurotransmission in the endomorphins-induced impairment of passive avoidance learning in mice.

Journal: Behavioural brain research 20020201

Title: Activation of mu-opioid receptors inhibits lordosis behavior in estrogen and progesterone-primed female rats.

Journal: Hormones and behavior 20020201

Title: Endomorphins inhibit contractile responses of rat thoracic aorta rings induced by phenylephrine and angiotensin II in vitro.

Journal: Acta pharmacologica Sinica 20020101

Title: Release of [Met5]enkephalin from the spinal cord by intraventricularly administered endomorphin-2, but not endomorphin-1 in the anesthetized rat.

Journal: Neuroscience letters 20011204

Title: Endomorphin-1 improves scopolamine-induced impairment of short-term memory via mu1-opioid receptor in mice.

Journal: Neuroreport 20011204

Title: Acute antinociceptive tolerance and asymmetric cross-tolerance between endomorphin-1 and endomorphin-2 given intracerebroventricularly in the mouse.

Journal: The Journal of pharmacology and experimental therapeutics 20011201

Title: Analgesic effect of endomorphin-1.

Journal: Acta pharmacologica Sinica 20011101

Title: The synergistic antinociceptive interactions of endomorphin-1 with dexmedetomidine and/or S(+)-ketamine in rats.

Journal: Anesthesia and analgesia 20011001

Title: [Effects of intracerebroventricular administration of endomorphin-1 on blood pressure in anesthetized rats].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20011001

Title: Up-regulation of spinal mu-opioid receptor function to activate G-protein by chronic naloxone treatment.

Journal: Brain research 20010921

Title: Differential antinociceptive effects induced by intrathecally administered endomorphin-1 and endomorphin-2 in the mouse.

Journal: European journal of pharmacology 20010921

Title: Partial agonistic action of endomorphins in the mouse spinal cord.

Journal: Neuroscience letters 20010907

Title: Endomorphins 1 and 2 modulate chemotaxis, phagocytosis and superoxide anion production by microglia.

Journal: Journal of neuroimmunology 20010903

Title: Regional differences in peptide degradation by rat cerebral microvessels: a potential novel regulatory mechanism for communication between blood and brain.

Journal: Life sciences 20010803

Title: Differential antinociception induced by spinally administered endomorphin-1 and endomorphin-2 in the mouse.

Journal: The Journal of pharmacology and experimental therapeutics 20010801

Title: Progesterone blockade of estrogen activation of mu-opioid receptors regulates reproductive behavior.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20010801

Title: Effects of loperamide and other opioid-related substances on the transcriptional regulation of the rat pro-opiomelanocortin gene in AtT20 cells.

Journal: Neuroendocrinology 20010801

Title: Lack of the involvement of mu1-opioid receptor subtype on motivational effects induced by the endogenous mu-opioid receptor ligands endomorphin-1 and -2 in the mouse.

Journal: Neuroscience letters 20010727

Title: Saturable brain-to-blood transport of endomorphins.

Journal: Experimental brain research 20010701

Title: Influence of degradation on binding properties and biological activity of endomorphin 1.

Journal: Biochemical and biophysical research communications 20010615

Title: Endomorphin-1: induction of motor behavior and lack of receptor desensitization.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20010615

Title: Endomorphins 1 and 2, endogenous mu-opioid receptor agonists, impair passive avoidance learning in mice.

Journal: European journal of pharmacology 20010608

Title: Involvement of spinal protein kinase Cgamma in the attenuation of opioid mu-receptor-mediated G-protein activation after chronic intrathecal administration of [D-Ala2,N-MePhe4,Gly-Ol(5)]enkephalin.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20010601

Title: Receptor constants for endomorphin-1 and endomorphin-1-ol indicate differences in efficacy and receptor occupancy.

Journal: European journal of pharmacology 20010601

Title: Transbuccal peptide delivery: stability and in vitro permeation studies on endomorphin-1.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20010518

Title: Endomorphins and activation of the hypothalamo-pituitary-adrenal axis.

Journal: The Journal of endocrinology 20010401

Title: Role of cholecystokinin in the reduction of endomorphin-2-induced antinociception in diabetic mice.

Journal: European journal of pharmacology 20010323

Title: Differential effects of endomorphin-1 and -2 on amphetamine sensitization: neurochemical and behavioral aspects.

Journal: Synapse (New York, N.Y.) 20010301

Title: Effects of the endogenous opioid peptide, endomorphin 1, on supraoptic nucleus oxytocin and vasopressin neurones in vivo and in vitro.

Journal: British journal of pharmacology 20010301

Title: Vitamin B12 deficiency in untreated celiac disease.

Journal: The American journal of gastroenterology 20010301

Title: Effects of endomorphin-1 on open-field behavior and on the hypothalamic-pituitary-adrenal system.

Journal: Endocrine 20010301

Title: Different motivational effects induced by the endogenous mu-opioid receptor ligands endomorphin-1 and -2 in the mouse.

Journal: Neuroscience 20010101

Title: Endomorphin and mu-opioid receptors in mouse brain mediate the analgesic effect induced by 2 Hz but not 100 Hz electroacupuncture stimulation.

Journal: Neuroscience letters 20001124

Title: Differential cardiorespiratory effects of endomorphin 1, endomorphin 2, DAMGO, and morphine.

Journal: American journal of respiratory and critical care medicine 20000901

Title: G protein activation by endomorphins in the mouse periaqueductal gray matter.

Journal: Journal of biomedical science 20000101

Title: Endomorphin-1 and endomorphin-2 activate mu-opioid receptors in myenteric neurons of the guinea-pig small intestine.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19981201

Title: Endomorphins fully activate a cloned human mu opioid receptor.

Journal: FEBS letters 19981113

Title: A potent and selective endogenous agonist for the mu-opiate receptor.

Journal: Nature 19970403

Title: Goldberg IE, et al. Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain. J Pharmacol Exp Ther. 1998 Aug;286(2):1007-13.

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Tags:189388-22-5 Molecular Formula|189388-22-5 MDL|189388-22-5 SMILES|189388-22-5 L-Phenylalaninamide, L-tyrosyl-L-prolyl-L-tryptophyl-