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230-17-1,MFCD00242913
Catalog No.:AA002LR6

230-17-1 | Benzo[c]cinnoline

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Price(USD)
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250mg
95%
in stock  
$80.00   $56.00
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1g
90%
in stock  
$186.00   $130.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA002LR6
Chemical Name:
Benzo[c]cinnoline
CAS Number:
230-17-1
Molecular Formula:
C12H8N2
Molecular Weight:
180.2053
MDL Number:
MFCD00242913
SMILES:
c1ccc2c(c1)c1ccccc1nn2
NSC Number:
86935
Properties
Properties
 
Form:
Solid  
MP:
156-159℃  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
183  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
2  
XLogP3:
2.4  

Downstream Synthesis Route

[1]Inoue,Hiroyasu;Hiroshima,Yukimi;Sakai,Toshihiko;Sakurai,Tadamitsu;Fukuda,Norio[BulletinoftheChemicalSocietyofJapan,1981,vol.54,#9,p.2829-2830]

[2]Chatterjee,Anamitra;König,Burkhard[AngewandteChemie-InternationalEdition,2019,vol.58,#40,p.14289-14294][Angew.Chem.,2019,vol.131,#40,p.14427-14432,6]

[3]Mugnier,Yves;Laviron,Etienne[JournalofOrganicChemistry,1988,vol.53,#24,p.5781-5783]

[4]Mugnier,Yves;Laviron,Etienne[JournalofOrganicChemistry,1988,vol.53,#24,p.5781-5783]

[5]Stone,IlanaB.;Jermaks,Janis;MacMillan,SamanthaN.;Lambert,TristanH.[AngewandteChemie-InternationalEdition,2018,vol.57,#38,p.12494-12498][Angew.Chem.,2018,vol.130,#38,p.12674-12678,5]

[6]CurrentPatentAssignee:HACOGES-US2778829,1955,A

[7]CurrentPatentAssignee:HACOGES-US2778829,1955,A

[1]Wada,Shinobu;Urano,Mika;Suzuki,Hitomi[JournalofOrganicChemistry,2002,vol.67,#23,p.8254-8257]

[2]Sakai,Norio;Asama,Shun;Anai,Satsuki;Konakahara,Takeo[Tetrahedron,2014,vol.70,#11,p.2027-2033]

[3]Kaur,Jaspreet;Pal,Bonamali[ChemicalCommunications,2015,vol.51,#40,p.8500-8503]

[4]Bjorsvik,Hans-Rene;Gonzalez,RaquelRodriguez;Liguori,Lucia[JournalofOrganicChemistry,2004,vol.69,#22,p.7720-7727]

[5]Locationinpatent:experimentalpartDehghanpour,Saeed;Afshariazar,Farzaneh;Assoud,Jalil[Polyhedron,2012,vol.35,#1,p.69-76]

[6]Ma,Yanfeng;Wu,Shanghui;Jiang,Shuxin;Xiao,Fuhong;Deng,Guo-Jun[ChineseJournalofChemistry,2021,vol.39,#12,p.3334-3338]

[7]Chang,Liu;Li,Jin;Wu,Na;Cheng,Xu[OrganicandBiomolecularChemistry,2021,vol.19,#11,p.2468-2472]

[8]Laskar,DhrubojyotiDey;Prajapati,Dipak;Sandhu,JagirS.[JournaloftheChemicalSociety.PerkintransactionsI,2000,#1,p.67-70]

[9]Badger;Pettit[JournaloftheChemicalSociety,1951,p.3211,3215]

[10]Pietra;Res[AnnalidiChimica,1958,vol.48,p.299,304]

[11]Moore;Furst[JournalofOrganicChemistry,1958,vol.23,p.1504]

[12]Wilshire,JohnF.K.[AustralianJournalofChemistry,1988,vol.41,#6,p.995-1001]

[13]Bhattacharjee,Argha;Hosoya,Hiromu;Ikeda,Hideaki;Nishi,Kohei;Tsurugi,Hayato;Mashima,Kazushi[Chemistry-AEuropeanJournal,2018,vol.24,#44,p.11278-11282]

[1]Dobbie;Fox;Gauge[JournaloftheChemicalSociety,1911,vol.99,p.1617]

[2]Chatterjee,Tanmay;Roh,Geum-Bee;Shoaib,MahbubulAlam;Suhl,Chang-Heon;Kim,JunSoo;Cho,Cheon-Gyu;Cho,EunJin[OrganicLetters,2017,vol.19,#7,p.1906-1909]

[1]Bjorsvik,Hans-Rene;Gonzalez,RaquelRodriguez;Liguori,Lucia[JournalofOrganicChemistry,2004,vol.69,#22,p.7720-7727]

[2]Yun,TaeHo;Park,MoonKeu;Han,ByungHee[JournalofChemicalResearch,Miniprint,1992,#10,p.2774-2788]

[3]Baik,Woonphil;Kim,DongIk;Koo,Sangho;Rhee,JongUk;Shin,SungHee;Kim,ByeongHyo[TetrahedronLetters,1997,vol.38,#5,p.845-848]

[4]Cardinale,Luana;JacobiVonWangelin,Axel;Konev,MikhailO.[OrganicLetters,2020]

[5]Fasani,Elisa;Amer,AtefM.;Albini,Angelo[Heterocycles,1994,vol.37,#2,p.985-992]

[6]Badger;Pettit[JournaloftheChemicalSociety,1951,p.3211,3215]

[1]Degrand,Chantal;Compagnon,Paul-Louis;Belot,Gerard;Jacquin,Dominique[JournalofOrganicChemistry,1980,vol.45,#7,p.1189-1196]

Literature

Title: Comparison of a homologous series of benzonaphthyridine anti-cancer agents in mice: divergence between tumour and plasma pharmacokinetics.

Journal: Cancer chemotherapy and pharmacology 20120701

Title: A rapid LC-MS/MS method for the quantitation of a series of benzonaphthyridine derivatives: application to in vivo pharmacokinetic and lipophilicity studies in drug development.

Journal: Journal of pharmaceutical and biomedical analysis 20120407

Title: In vivo and in vitro assessment of the action of SN 28049, a benzonaphthyridine derivative targeting topoisomerase II, on the murine Colon 38 carcinoma.

Journal: Investigational new drugs 20111201

Title: ATP and its N⁶-substituted analogues: parameterization, molecular dynamics simulation and conformational analysis.

Journal: Journal of molecular modeling 20110501

Title: Synthesis and anti-intestinal nematode activity of variously substituted benzonaphthyridine derivatives.

Journal: Molecules (Basel, Switzerland) 20110214

Title: Antiproliferative effect of aaptamine on human chronic myeloid leukemia K562 cells.

Journal: International journal of molecular sciences 20110101

Title: Absorption, distribution, excretion, and pharmacokinetics of 14C-pyronaridine tetraphosphate in male and female Sprague-Dawley rats.

Journal: Journal of biomedicine & biotechnology 20100101

Title: The reactivity patterns of low-coordinate iron-hydride complexes.

Journal: Journal of the American Chemical Society 20080521

Title: Effect of folate derivatives on the activity of antifolate drugs used against malaria and cancer.

Journal: Parasitology research 20080501

Title: Chain-length effects on molecular conformation in and chirality of self-assembled monolayers of alkoxylated benzo[c]cinnoline derivatives on highly oriented pyrolytic graphite.

Journal: The journal of physical chemistry. B 20060810

Title: Aaptamine, a spongean alkaloid, activates p21 promoter in a p53-independent manner.

Journal: Biochemical and biophysical research communications 20060331

Title: Neutral Cu4N12 and Ag4N12 metallacycles with a para-cyclophane framework assembled from copper(I) and silver(I) pyrazolates and pyridazine.

Journal: Chemical communications (Cambridge, England) 20050328

Title: Investigations of a novel process to the framework of benzo[c]cinnoline.

Journal: The Journal of organic chemistry 20041029

Title: Mechanisms of anion secretion in Calu-3 human airway epithelial cells by 7,8-benzoquinoline.

Journal: British journal of pharmacology 20030901

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