[1]Patent:WO2010/43877,2010,A1,.Locationinpatent:Page/Pagecolumn54;56
[1]JournalofMedicinalChemistry,2001,vol.44,#5,p.737-748
[2]Patent:EP1193270,2002,A2,.Locationinpatent:Page53-54,54-55,111,112
[1]JournalofMedicinalChemistry,2001,vol.44,#5,p.737-748
[1]JournalofMedicinalChemistry,2001,vol.44,#5,p.737-748
[1]JournalofMedicinalChemistry,2001,vol.44,#5,p.737-748
[1]JournalofMedicinalChemistry,2001,vol.44,p.737-748
[2]Patent:EP1193270,2002,A2.Locationinpatent:Page53-54,54-55,111,112
[1]JournalofMedicinalChemistry,2001,vol.44,p.737-748
[1]JournalofMedicinalChemistry,2001,vol.44,p.737-748
[1]JournalofMedicinalChemistry,2001,vol.44,p.737-748
[1]JournalofMedicinalChemistry,2001,vol.44,p.737-748
Title: Small molecule drugs - optimizing DNA damaging agent-based therapeutics.
Journal: Current opinion in pharmacology 20120801
Title: Pharmacokinetics, pharmacodynamics and metabolism of the dimeric pyrrolobenzodiazepine SJG-136 in rats.
Journal: Cancer chemotherapy and pharmacology 20110901
Title: Phase I pharmacokinetic and pharmacodynamic study of SJG-136, a novel DNA sequence selective minor groove cross-linking agent, in advanced solid tumors.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20110601
Title: The development of pyrrolobenzodiazepines as antitumour agents.
Journal: Expert opinion on investigational drugs 20110601
Title: A phase I trial of SJG-136 (NSC#694501) in advanced solid tumors.
Journal: Cancer chemotherapy and pharmacology 20100401
Title: Synthesis of a novel C2/C2'-aryl-substituted pyrrolo[2,1-c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate.
Journal: Bioorganic & medicinal chemistry letters 20091115
Title: The pyrrolobenzodiazepine dimer SJG-136 forms sequence-dependent intrastrand DNA cross-links and monoalkylated adducts in addition to interstrand cross-links.
Journal: Journal of the American Chemical Society 20090930
Title: Phase I study of sequence-selective minor groove DNA binding agent SJG-136 in patients with advanced solid tumors.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090315
Title: Remarkable enhancement in the DNA-binding ability of C2-fluoro substituted pyrrolo[2,1-c][1,4]benzodiazepines and their anticancer potential.
Journal: Bioorganic & medicinal chemistry 20090215
Title: ABCB1 genetic polymorphism influences the pharmacology of the new pyrrolobenzodiazepine derivative SJG-136.
Journal: The pharmacogenomics journal 20080801
Title: An asymmetric C8/C8'-tripyrrole-linked sequence-selective pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimer DNA interstrand cross-linking agent spanning 11 DNA base pairs.
Journal: Bioorganic & medicinal chemistry letters 20080315
Title: An assay combining high-performance liquid chromatography and mass spectrometry to measure DNA interstrand cross-linking efficiency in oligonucleotides of varying sequences.
Journal: Analytical biochemistry 20080301
Title: Determination of chemically reduced pyrrolobenzodiazepine SJG-136 in human plasma by HPLC-MS/MS: application to an anticancer phase I dose escalation study.
Journal: Journal of mass spectrometry : JMS 20080101
Title: Fludarabine-mediated suppression of the excision repair enzyme ERCC1 contributes to the cytotoxic synergy with the DNA minor groove crosslinking agent SJG-136 (NSC 694501) in chronic lymphocytic leukaemia cells.
Journal: British journal of cancer 20070716
Title: The hollow fibre model--facilitating anti-cancer pre-clinical pharmacodynamics and improving animal welfare.
Journal: International journal of oncology 20061201
Title: DNA interstrand crosslinking agents: synthesis, DNA interactions, and cytotoxicity of dimeric achiral seco-amino-CBI and conjugates of achiral seco-amino-CBI with pyrrolobenzodiazepine (PBD).
Journal: Bioorganic & medicinal chemistry letters 20061101
Title: Design, synthesis, and biophysical and biological evaluation of a series of pyrrolobenzodiazepine-poly(N-methylpyrrole) conjugates.
Journal: Journal of medicinal chemistry 20060907
Title: LC-MS/MS assay and dog pharmacokinetics of the dimeric pyrrolobenzodiazepine SJG-136 (NSC 694501).
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060807
Title: Time-dependent cytotoxicity induced by SJG-136 (NSC 694501): influence of the rate of interstrand cross-link formation on DNA damage signaling.
Journal: Molecular cancer therapeutics 20060601
Title: AACR-NCI-EORTC--17th symposium: Molecular targets and cancer therapeutics. 14-18th November 2005, Philadelphia, PA, USA.
Journal: IDrugs : the investigational drugs journal 20060101
Title: Direct liquid chromatography determination of the reactive imine SJG-136 (NSC 694501).
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050805
Title: Influence of P-glycoprotein expression on in vitro cytotoxicity and in vivo antitumour activity of the novel pyrrolobenzodiazepine dimer SJG-136.
Journal: European journal of cancer (Oxford, England : 1990) 20050801
Title: Sequence-selective interaction of the minor-groove interstrand cross-linking agent SJG-136 with naked and cellular DNA: footprinting and enzyme inhibition studies.
Journal: Biochemistry 20050322
Title: Synthesis of fluorinated analogues of SJG-136 and their DNA-binding potential.
Journal: Bioorganic & medicinal chemistry letters 20041115
Title: SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 1: cellular pharmacology, in vitro and initial in vivo antitumor activity.
Journal: Cancer research 20040915
Title: SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 2: efficacy evaluations.
Journal: Cancer research 20040915
Title: The novel sequence-specific DNA cross-linking agent SJG-136 (NSC 694501) has potent and selective in vitro cytotoxicity in human B-cell chronic lymphocytic leukemia cells with evidence of a p53-independent mechanism of cell kill.
Journal: Cancer research 20040915
Title: Preliminary pharmacokinetic and bioanalytical studies of SJG-136 (NSC 694501), a sequence-selective pyrrolobenzodiazepine dimer DNA-cross-linking agent.
Journal: Investigational new drugs 20040801
Title: Synthesis of the first example of a C2-C3/C2'-C3'-endo unsaturated pyrrolo[2,1-c][1,4]benzodiazepine dimer.
Journal: Bioorganic & medicinal chemistry letters 20011105
Title: Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity.
Journal: Journal of medicinal chemistry 20010301
Title: Gregson SJ, et al. Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity. J Med Chem. 2001 Mar 1;44(5):737-48.
Title: Mellinas-Gomez M, et al. Activity of the DNA minor groove cross-linking agent SG2000 (SJG-136) against canine tumours. BMC Vet Res. 2015 Aug 19;11:215.
