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23599-69-1,MFCD09953815
Catalog No.:AA002NRA

23599-69-1 | Norisoboldine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
95%
in stock  
$61.00   $43.00
- +
5mg
95%
in stock  
$127.00   $89.00
- +
10mg
95%
in stock  
$223.00   $156.00
- +
25mg
95%
in stock  
$445.00   $312.00
- +
100mg
95%
in stock  
$711.00   $498.00
- +
250mg
95%
in stock  
$1,150.00   $805.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002NRA
Chemical Name:
Norisoboldine
CAS Number:
23599-69-1
Molecular Formula:
C18H19NO4
Molecular Weight:
313.3478
MDL Number:
MFCD09953815
SMILES:
COc1cc2c(cc1O)C[C@H]1c3c2c(O)c(cc3CCN1)OC
Properties
Computed Properties
 
Complexity:
433  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
2  
XLogP3:
2.3  

Literature

Title: Norisoboldine, an isoquinoline alkaloid, acts as an aryl hydrocarbon receptor ligand to induce intestinal Treg cells and thereby attenuate arthritis.

Journal: The international journal of biochemistry & cell biology 20160601

Title: Norisoboldine ameliorates collagen-induced arthritis through regulating the balance between Th17 and regulatory T cells in gut-associated lymphoid tissues.

Journal: Toxicology and applied pharmacology 20150101

Title: Norisoboldine, an Anti-Arthritis Alkaloid Isolated from Radix Linderae, Attenuates Osteoclast Differentiation and Inflammatory Bone Erosion in an Aryl Hydrocarbon Receptor-Dependent Manner.

Journal: International journal of biological sciences 20150101

Title: Norisoboldine inhibits the production of interleukin-6 in fibroblast-like synoviocytes from adjuvant arthritis rats through PKC/MAPK/NF-κB-p65/CREB pathways.

Journal: Journal of cellular biochemistry 20120801

Title: Norisoboldine, an alkaloid compound isolated from Radix Linderae, inhibits synovial angiogenesis in adjuvant-induced arthritis rats by moderating Notch1 pathway-related endothelial tip cell phenotype.

Journal: Experimental biology and medicine (Maywood, N.J.) 20120801

Title: Simultaneous determination of synephrine, arecoline, and norisoboldine in Chinese patent medicine Si-Mo-Tang oral liquid preparation by strong cation exchange high performance liquid chromatography.

Journal: Pharmaceutical biology 20120701

Title: Simultaneous determination of norisoboldine and its major metabolite in rat plasma by ultra-performance liquid chromatography-mass spectrometry and its application in a pharmacokinetic study.

Journal: Biomedical chromatography : BMC 20110301

Title: Norisoboldine inhibits the production of pro-inflammatory cytokines in lipopolysaccharide-stimulated RAW 264.7 cells by down-regulating the activation of MAPKs but not NF-κB.

Journal: Inflammation 20101201

Title: Characterization of new metabolites from in vivo biotransformation of norisoboldine by liquid chromatography/mass spectrometry and NMR spectroscopy.

Journal: Journal of pharmaceutical and biomedical analysis 20100905

Title: Therapeutic effect of norisoboldine, an alkaloid isolated from Radix Linderae, on collagen-induced arthritis in mice.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20100801

Title: [Determination of norisoboldine in Radix Lindera by RP-HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20091101

Title: [Evaluation of antioxidant activity of Radix Linderae and other two Chinese drugs using TLC-bioautography].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20061001

Title: Geographic distribution of three alkaloid chemotypes of Croton lechleri.

Journal: Journal of natural products 20020601

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